AutismKB 2.0

Annotation Detail for RBM5


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Basic Information Top
Gene Symbol:RBM5 ( FLJ39876,G15,LUCA15,RMB5 )
Gene Full Name: RNA binding motif protein 5
Band: 3p21.31
Quick LinksEntrez ID:10181; OMIM: 606884; Uniprot ID:RBM5_HUMAN; ENSEMBL ID: ENSG00000003756; HGNC ID: 9902
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
mRNA Processing
Gene Expression
No data
No data
Pathway IDPathway Name
500866mRNA Splicing - Major Pathway
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1934Cancer
2066Lung cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane affects the expression of RBM5 mRNAaffects expression 18648102
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of RBM5 mRNAincreases expression 20504355
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of RBM5 mRNAdecreases expression 17557909
D005472 Fluorouracil RBM5 protein affects the susceptibility to Fluorouracilaffects response to substance 15548681
C006253 pirinixic acid pirinixic acid results in decreased expression of RBM5 mRNAdecreases expression 18445702
D012643 Selenium Selenium results in increased expression of RBM5 mRNAincreases expression 19244175
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of RBM5 mRNAincreases expression 16267337
D014303 Trinitrotoluene Trinitrotoluene affects the expression of RBM5 mRNAaffects expression 21346803
C025643 vinclozolin vinclozolin affects the expression of RBM5 mRNAaffects expression 19015723
D014810 Vitamin E Vitamin E results in decreased expression of RBM5 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.3715322242 14514962 11752688
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 9.377525203
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2117505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.3018653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.2720127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.2714692618
MESH:D000230 Adenocarcinoma Fluorouracil 7.2717638652
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.913712494
MESH:D000236 Adenoma Benzo(a)pyrene 6.916695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.7116434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.7116835633
MESH:D000740 Anemia Fluorouracil 9.2315504547 16511603 17963324
MESH:D000740 Anemia Tetrachlorodibenzodioxin 9.2311748828
MESH:D001008 Anxiety Disorders vinclozolin 3.7819015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2919183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7615885639
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.2811289319 1440618
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.3519483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.3512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8715746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8317474063 20146248
MESH:D001943 Breast Neoplasms Fluorouracil 1.8316110121 19217205 16557594 18608205 16595493 15136595 18357371
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8320435547
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.1516050911
MESH:D002276 Carcinoid Tumor Fluorouracil 4.9316051944
MESH:D002277 Carcinoma Fluorouracil 8.6517121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.6516835633
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 3.157296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 3.1518930000 17971768 16799960 16332177 17088986 17045692
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 6.747296757
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 6.7418695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.7920419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 4.7917066447 16280240 16757204 18986760
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4516120746 18850075 18670907
MESH:D002386 Cataract Trinitrotoluene 3.9615817613 14694615
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.877505956
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 14.1219486331 9022650
MESH:D002779 Cholestasis Ethinyl Estradiol 14.1217110522 17681005 17333356 16919318 11677210 16105132 15861022
MESH:D002779 Cholestasis pirinixic acid 14.1219176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1616354765 8697196 12621046 15340226 15668235
MESH:D003092 Colitis Selenium 3.9917936198
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2617169374 17725105 17172411 16510598 17018589 15001691 16340194 18772588 17016597 17287894
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0017594712 18802399 17255274 16524972 15148649 20501625 16331619 16303861 18288408 16282729 18949393 18383874 17401013 18509181 14970324 17695437 18448328 17094418 15289873 16391804 17016601 17454858
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 9.7917141729 14669216
MESH:D000013 Congenital Abnormalities Trinitrotoluene 9.7915095906
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5210048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.5219769572
MESH:D003456 Cryptorchidism vinclozolin 4.5414966744
MESH:D003490 Cyanosis Trinitrotoluene 5.1418551238
MESH:D007644 Darier Disease Fluorouracil 5.0316733453
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.0112868966 11298694 8156756 18759878 14531868 8970840 2524372 11906362
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4918249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.673621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7017107852
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 9.399022650 18289764 16192314 1440618 18692083 9328219 6482804 11289319 18648102 8291058 6679447 7440962 9653073
MESH:D056486 Drug-Induced Liver Injury Selenium 9.3915131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.3920420201
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 9.3918551238 21346803
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8911462148
MESH:C538011 Eales disease Vitamin E 4.979068938
MESH:D004487 Edema pirinixic acid 7.1112083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.1111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1716714409 18230668 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3812538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.189294722 10568697
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.463581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.4616530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 7.4615173087 16785472 16337965 16481741 17638652
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1411564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.1215345470
MESH:D005234 Fatty Liver pirinixic acid 8.1219236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.286705139
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.1620067830
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.1716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.5716417039
MESH:D005910 Glioma Fluorouracil 2.9316145905
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.227505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.5018337622 15162350 15102660
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 11.5920471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 11.5911294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin E 11.5916080930
MESH:D006333 Heart Failure pirinixic acid 7.2820558911
MESH:D006333 Heart Failure Selenium 7.2817162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.716705139
MESH:D006529 Hepatomegaly pirinixic acid 15.7918467677 19176532 19772884 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 15.7915340226 16120746 12621046
MESH:D006529 Hepatomegaly Trinitrotoluene 15.7915817613
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7516863852 16490937
MESH:D019584 Hot Flashes Vitamin E 4.2414716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3116959395 16354765 18606429 8697196 15340226
MESH:D006943 Hyperglycemia pirinixic acid 3.3420558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.1515034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9618850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0216569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 11.9617937319
MESH:D007248 Infertility, Male Trinitrotoluene 11.9612150543
MESH:D007248 Infertility, Male vinclozolin 11.9616467254
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9312200463 12878042
MESH:D007251 Influenza, Human Selenium 11.8616624496
MESH:D007251 Influenza, Human Vitamin E 11.8616624496
MESH:D007333 Insulin Resistance pirinixic acid 2.7416306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.288074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5116580747
MESH:D007674 Kidney Diseases Vitamin E 2.8912488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.0616518626
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.966582329
MESH:D007680 Kidney Neoplasms Fluorouracil 7.9616985049
MESH:D007984 Leydig Cell Tumor vinclozolin 4.9716417039
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3015034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5015474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5012878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.5016169303
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.1620195826 21137059
MESH:D008113 Liver Neoplasms Fluorouracil 11.1616603448 18383874 17045692 15113037
MESH:D008113 Liver Neoplasms pirinixic acid 11.1620007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.1616984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.07598648 6587162 3712494 1399818
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.0712151625
MESH:D008171 Lung Diseases Vitamin E 3.2916863852
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.9820464547 6695378 18520028 20135361 18816296 20869020 17053015 20064080 18569708
MESH:D008175 Lung Neoplasms Fluorouracil 4.9815246190
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.9819555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 4.9811062179
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.0315086387
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.8615318939
MESH:D008654 Mesothelioma Selenium 2.8515107826
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.9716381670
MESH:D009062 Mouth Neoplasms Fluorouracil 8.9716757204 18986760
MESH:D009135 Muscular Diseases pirinixic acid 3.7216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2019151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1612213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0816411023
MESH:D009336 Necrosis Trinitrotoluene 5.0018551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.533581430
MESH:D009369 Neoplasms Benzo(a)pyrene 8.6811141357
MESH:D009369 Neoplasms Fluorouracil 8.6818600527 18239605 16928823
MESH:D009369 Neoplasms pirinixic acid 8.6817405874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4114600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.026679447
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.5516436463
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 9.766482804 4026338
MESH:D009784 Occupational Diseases Trinitrotoluene 9.7617852074 12819281 14694615
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.283988306
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.7215113037 16929163 19003803 16500647
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8711578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.707296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.736228378
MESH:D010954 Plasmacytoma Selenium 5.1515087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.2911118676 11222880 11896295 11399792
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 10.2918042343 19015723 18220299
MESH:D011469 Prostatic Diseases vinclozolin 5.1718220299
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5417292933
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.5418626508 19082440
MESH:D011471 Prostatic Neoplasms Vitamin E 2.5415084515
MESH:D011472 Prostatitis vinclozolin 5.1718629315
MESH:D011537 Pruritus Ethinyl Estradiol 3.5516919318 15861022
MESH:D012004 Rectal Neoplasms Fluorouracil 4.1618286688 15538739 16160472 18722050
MESH:D015427 Reperfusion Injury pirinixic acid 2.4619058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.503692021
MESH:D012640 Seizures Trinitrotoluene 3.5518551238
MESH:D012871 Skin Diseases Vitamin E 2.4818709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.7210029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7216192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.2116709447
MESH:D013163 Splenomegaly Trinitrotoluene 5.4215817613
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.462093021 20155912
MESH:D013274 Stomach Neoplasms Fluorouracil 2.4617522103 15786421 16951190 17172411 18396642 16424979 18567086 19015929 17498489 19084572
MESH:D020521 Stroke Vitamin E 3.6616517955
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.013712494 7505956 1399818 6582329 6587162
MESH:D014062 Tongue Neoplasms Fluorouracil 4.1516280240
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.178074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.1717053015
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.0416803524
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5014692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7114671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
Pathway ID Pathway Name
REACT:71 Gene Expression
REACT:1675 mRNA Processing
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA34267
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

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      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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