AutismKB 2.0

Annotation Detail for TNK2


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Basic Information Top
Gene Symbol:TNK2 ( ACK,ACK1,FLJ44758,FLJ45547,p21cdc42Hs )
Gene Full Name: tyrosine kinase, non-receptor, 2
Band: 3q29
Quick LinksEntrez ID:10188; OMIM: 606994; Uniprot ID:ACK1_HUMAN; ENSEMBL ID: ENSG00000061938; HGNC ID: 19297
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200057CDC42 signaling events
No data
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of TNK2 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of TNK2 mRNAaffects expression 17562736
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of TNK2 mRNAincreases expression 15766595
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TNK2 mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of TNK2 mRNAdecreases expression 17557909
D005419 Flavonoids Flavonoids results in increased expression of TNK2 mRNAincreases expression 15465739
D010936 Plant Extracts Plant Extracts results in increased expression of TNK2 mRNAincreases expression 15465739
C025299 polyphenols polyphenols results in increased expression of TNK2 mRNAincreases expression 15465739
C059514 resveratrol resveratrol results in increased expression of TNK2 mRNAincreases expression 12569576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TNK2 mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1311752688 15322242 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2617505938
MESH:D058186 Acute Kidney Injury resveratrol 4.0616538975
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8514692618
MESH:D000236 Adenoma resveratrol 3.4215688382
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6616835633
MESH:D000544 Alzheimer Disease Plant Extracts 4.7316962711
MESH:D000544 Alzheimer Disease resveratrol 4.7316162502 16183991
MESH:D000686 Amyloidosis Diethylstilbestrol 4.7215469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1411748828
MESH:D000799 Angioedema Acetaminophen 4.1610982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 13.0915885639
MESH:D001169 Arthritis, Experimental Plant Extracts 13.0914686799
MESH:D001169 Arthritis, Experimental resveratrol 13.0917115116
MESH:D050197 Atherosclerosis resveratrol 3.3816873680 17967414
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8915746008
MESH:D002545 Brain Ischemia Plant Extracts 11.4416041641
MESH:D002545 Brain Ischemia resveratrol 11.4417600658
MESH:D001943 Breast Neoplasms Diethylstilbestrol 1.9417129689 15324884
MESH:D001943 Breast Neoplasms resveratrol 1.9417651959 16393696 17534123
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9420435547
MESH:D002057 Burns, Chemical Plant Extracts 5.659625245
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 9.2016705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 9.203084413
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 9.2015948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Plant Extracts 9.2018834353
MESH:D006528 Carcinoma, Hepatocellular resveratrol 9.2019321006 16227395
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.8816675471
MESH:D002294 Carcinoma, Squamous Cell resveratrol 2.7616227395
MESH:D006332 Cardiomegaly Plant Extracts 7.3317645561
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 7.3316120746 18850075 18670907
MESH:D002318 Cardiovascular Diseases resveratrol 3.6115458977
MESH:D002386 Cataract Acetaminophen 2.6910977129
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3416835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0215861022 16105132 17333356 11677210 17110522 17681005 16919318
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1815668235 16354765 12621046 8697196 15340226
MESH:D003092 Colitis resveratrol 4.3916474422
MESH:D003110 Colonic Neoplasms polyphenols 4.1816293270
MESH:D003110 Colonic Neoplasms resveratrol 4.1816338953
MESH:D015179 Colorectal Neoplasms resveratrol 2.2216550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2417141729 14669216
MESH:D003327 Coronary Disease resveratrol 3.8716507316
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 15322242 10048152
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.7912952375 16002989
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.2718551238
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.9416873680
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D003928 Diabetic Nephropathies Plant Extracts 10.0019706694
MESH:D003928 Diabetic Nephropathies resveratrol 10.0016286809
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.4218551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.4212594235 18071297 16393943 17522070 2444490 17906064 12392966 14550746 19164858 10663392 12958197 11739529 10774834 16781746 14986274 19416960 16081117 14725611 17562736 16177239 19370779 15968718 16109766 19085960 16227642 18713872 19923254 19739265 16485898 11287661 11834606 11743745 19420014 12153990 15619225 12540782 11421492 12705907 10915739 11461765 11529661
MESH:D056486 Drug-Induced Liver Injury polyphenols 9.4219370779
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.4220420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9111462148
MESH:D004487 Edema Plant Extracts 12.8412787963
MESH:D004487 Edema resveratrol 12.848985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 12.8411000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2218230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.9312538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 9.9317872969
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.9816402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 3.5916804899 15700306
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.219294722 10568697
MESH:D004719 Endomyocardial Fibrosis Plant Extracts 6.0015268973
MESH:D020345 Enterocolitis, Necrotizing resveratrol 5.1117923197
MESH:D004827 Epilepsy Plant Extracts 3.8219439326 19700373
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.7315345470
MESH:D005234 Fatty Liver Plant Extracts 8.7315975614
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.7716513791 16534752 15751030 16611131 16002989
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.2120067830
MESH:D005756 Gastritis Acetaminophen 3.9916983495
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 5.2316452187
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4310048152 11294989
MESH:D006333 Heart Failure Plant Extracts 3.9818097624
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1512621046 16120746 15340226
MESH:D006561 Herpes Simplex Plant Extracts 11.0910715843
MESH:D006561 Herpes Simplex resveratrol 11.0916876885
MESH:D015658 HIV Infections Plant Extracts 3.7812878215
MESH:D019584 Hot Flashes Plant Extracts 5.0616566672 17454163 14716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3616354765 15340226 16959395 8697196 18606429
MESH:D006930 Hyperalgesia Acetaminophen 2.8616870215
MESH:D006937 Hypercholesterolemia resveratrol 4.2117188708
MESH:D020138 Hyperhomocysteinemia Plant Extracts 4.6416484555
MESH:D006949 Hyperlipidemias Plant Extracts 10.3515975614 15268973
MESH:D006949 Hyperlipidemias resveratrol 10.3516873680
MESH:D006965 Hyperplasia Diethylstilbestrol 4.6912960047 14722030
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9718850075 18670907
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.5017488730
MESH:D007021 Hypospadias Diethylstilbestrol 12.1216002989
MESH:D007021 Hypospadias Ethinyl Estradiol 12.1216945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.9117600658
MESH:D007246 Infertility Diethylstilbestrol 4.5915036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6217937319
MESH:D007249 Inflammation Flavonoids 16.9817296493
MESH:D007249 Inflammation Plant Extracts 16.9819332304 12787963 15997105 16366677
MESH:D007249 Inflammation polyphenols 16.9816366677
MESH:D007249 Inflammation resveratrol 16.9816366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 16.9812878042 12200463
MESH:D007251 Influenza, Human resveratrol 4.8616624496
MESH:D007414 Intestinal Neoplasms Plant Extracts 4.8112584176 12628509 12351151
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5416580747
MESH:D007674 Kidney Diseases Acetaminophen 2.3012587719 15629191
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 8.1216705839
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 8.1214681315 16762066 15003126
MESH:D007859 Learning Disorders Diethylstilbestrol 4.3217184923
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.7016087638
MESH:D008103 Liver Cirrhosis Plant Extracts 3.8417157831
MESH:D008106 Liver Cirrhosis, Experimental Plant Extracts 2.6815479170
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.6812878042
MESH:D008107 Liver Diseases Acetaminophen 6.9619784758 12969438 11587558 16611625 19014921 12587719 19460945 16610002
MESH:D008107 Liver Diseases Plant Extracts 6.9617034775
MESH:D008107 Liver Diseases polyphenols 6.9616698588
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4316871587 17185352
MESH:D008113 Liver Neoplasms Diethylstilbestrol 11.3515890375 16712894
MESH:D008113 Liver Neoplasms Plant Extracts 11.3519168119
MESH:D008113 Liver Neoplasms resveratrol 11.3520405173 19812893 19073162 19321006
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.3516984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2212151625
MESH:D008175 Lung Neoplasms Plant Extracts 2.6420869020
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.6411884234 19555203
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.4315166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.6115700306
MESH:D016393 Lymphoma, B-Cell resveratrol 4.5217088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 4.0414749477
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.8316002989
MESH:D015674 Mammary Neoplasms, Animal resveratrol 4.5315688416
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 3.238985016 11606380
MESH:D008545 Melanoma resveratrol 2.3917992120
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8319513568
MESH:D008659 Metabolic Diseases resveratrol 4.5817112576
MESH:D009101 Multiple Myeloma resveratrol 3.6117049120 16267019 17935668 17164350 16490592 14749477
MESH:D009134 Muscular Atrophy, Spinal resveratrol 5.1617962980
MESH:D009203 Myocardial Infarction resveratrol 3.1017015251 16525036 17125593 17188708 16317513 16456233
MESH:D017202 Myocardial Ischemia resveratrol 9.5617015251 17125593
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 9.5612213967
MESH:D009205 Myocarditis resveratrol 5.0417322642
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.1418551238
MESH:D009369 Neoplasms Diethylstilbestrol 2.8515313581
MESH:D009374 Neoplasms, Experimental resveratrol 4.268985016
MESH:D009421 Nervous System Malformations Diethylstilbestrol 10.4511399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.4514600291
MESH:D019954 Neurobehavioral Manifestations Plant Extracts 5.4417168769
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.9318514411
MESH:D019636 Neurodegenerative Diseases resveratrol 8.9317652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.6217929310
MESH:D009765 Obesity Plant Extracts 3.1820132043 19056576
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.6212819281 16049721
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 4.4817513867
MESH:D010146 Pain Acetaminophen 2.5616870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9111578682
MESH:D010212 Papilloma Plant Extracts 4.7515173996 16517061
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.4914722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.9316977796 15687265
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 18.0617184923
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 18.0616679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 18.0611222880 11118676 11399792 11896295
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.7517136230 15046698 15846301
MESH:D011471 Prostatic Neoplasms Plant Extracts 2.7517804756 14666653
MESH:D011471 Prostatic Neoplasms resveratrol 2.7517804756 17675339 17636462 15767336 16731767 17718901
MESH:D011537 Pruritus Ethinyl Estradiol 3.6016919318 15861022
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.9016325855
MESH:D015427 Reperfusion Injury resveratrol 3.3616317513 17520802 17058453 16314181 15827377
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012640 Seizures 2,4-dinitrotoluene 2.6618551238
MESH:D012878 Skin Neoplasms Plant Extracts 10.1015173996 16517061
MESH:D012878 Skin Neoplasms resveratrol 10.1015837718 8985016
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 10.1016192470
MESH:D013088 Spermatocele Diethylstilbestrol 12.8016709447 16002989
MESH:D013088 Spermatocele Ethinyl Estradiol 12.8016709447
MESH:D013276 Stomach Ulcer Plant Extracts 4.1018193104 18237397 17135157 15255614 12787963
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.6716321402
MESH:D013705 Temporomandibular Joint Disorders Plant Extracts 14.3617997062
MESH:D013705 Temporomandibular Joint Disorders polyphenols 14.3617997062
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3315669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D014062 Tongue Neoplasms resveratrol 4.4116227395
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.4216049721
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 5.4216712894 16452187 17306315
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.6010091137
MESH:D014581 Urticaria Acetaminophen 3.2010982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 10.3216175088
MESH:D002583 Uterine Cervical Neoplasms resveratrol 10.3217473185
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.4914652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 17.5216690809 15809267
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 17.5214692618
MESH:D014594 Uterine Neoplasms resveratrol 17.5217044934
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.6916002989 16513791
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7514671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Plant Extracts 11.4118097624
MESH:D018487 Ventricular Dysfunction, Left resveratrol 11.4117488730
MESH:D020257 Ventricular Remodeling Plant Extracts 5.6018097624
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
MESH:D014947 Wounds and Injuries Plant Extracts 4.4220213670 19894650
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00171 - Adenosine triphosphate Dietary supplement;Micronutrient
DB04367 - Debromohymenialdisine
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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