AutismKB 2.0

Annotation Detail for TSHZ1


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Basic Information Top
Gene Symbol:TSHZ1 ( NY-CO-33,SDCCAG33,TSH1 )
Gene Full Name: teashirt zinc finger homeobox 1
Band: 18q22.3
Quick LinksEntrez ID:10194; OMIM: NA; Uniprot ID:TSH1_HUMAN; ENSEMBL ID: ENSG00000179981; HGNC ID: 10669
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of TSHZ1 mRNAaffects expression 17562736
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TSHZ1 mRNAdecreases expression 20382639
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of TSHZ1 mRNAaffects expression 17484886
D016572 Cyclosporine Cyclosporine results in decreased expression of TSHZ1 mRNAdecreases expression 20106945
D004041 Dietary Fats Dietary Fats results in increased expression of TSHZ1 mRNAincreases expression 18042831
D005472 Fluorouracil Fluorouracil results in increased expression of TSHZ1 mRNAincreases expression 16584549
D015741 Metribolone Metribolone results in increased expression of TSHZ1 mRNAincreases expression 17010196
C041786 palm oil palm oil results in increased expression of TSHZ1 mRNAincreases expression 18042831
D018038 Sodium Selenite Sodium Selenite results in increased expression of TSHZ1 mRNAincreases expression 18175754
C004648 testosterone enanthate testosterone enanthate affects the expression of TSHZ1 mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TSHZ1 mRNAincreases expression 18691609
D014212 Tretinoin ALDH1A2 protein mutant form inhibits the reaction [Tretinoin results in increased expression of TSHZ1 mRNA]decreases reaction|increases expression 17035100
D014212 Tretinoin Tretinoin results in increased expression of TSHZ1 mRNAincreases expression 17035100
18230668
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0015322242 11752688 14514962
MESH:D000230 Adenocarcinoma Fluorouracil 2.4517638652
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.5316835633
MESH:D000505 Alopecia Tretinoin 3.7015955085
MESH:D000740 Anemia Fluorouracil 9.0316511603 15504547 17963324
MESH:D000740 Anemia Tetrachlorodibenzodioxin 9.0311748828
MESH:D000799 Angioedema Acetaminophen 4.0210982225
MESH:D001161 Arteriosclerosis Dietary Fats 4.0315238619
MESH:D001169 Arthritis, Experimental Tretinoin 3.1416412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2916292516
MESH:D001249 Asthma Tretinoin 2.3716456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001471 Barrett Esophagus Tretinoin 4.5316935849
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.3112125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.3116206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8315746008
MESH:D001943 Breast Neoplasms Dietary Fats 1.9620435547
MESH:D001943 Breast Neoplasms Fluorouracil 1.9618357371 15136595 16110121 18608205 16595493 19217205 16557594
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9620435547
MESH:D001943 Breast Neoplasms Tretinoin 1.9616873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.7416813970
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9210355542 16011737 15700767 16192424 16227642 18705752 15673190 3786805 15721981 16050911 16124888 16097048
MESH:D002276 Carcinoid Tumor Fluorouracil 4.8416051944
MESH:D002277 Carcinoma Fluorouracil 8.4817121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.4816835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.3316168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.703084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.7018788625
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 6.7017045692 18930000 16332177 17088986 16799960 17971768
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 6.701917145
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.0618695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 4.8218986760 17066447 16280240 16757204
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.8216096774 16051514
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4218850075 16120746 18670907
MESH:D002386 Cataract Acetaminophen 7.4310977129
MESH:D002386 Cataract Tretinoin 7.4317460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.8020889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.8012371664
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.7416129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2616835633
MESH:D002779 Cholestasis Cyclosporine 3.0019486331
MESH:D002822 Choriocarcinoma Tretinoin 5.3316461808
MESH:D019457 Chromosome Breakage Sodium Selenite 4.8915894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.908697196 12621046 15340226 16354765 15668235
MESH:D002972 Cleft Palate Tretinoin 5.909407595
MESH:D003092 Colitis Tretinoin 3.8417035595
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2517287894 17169374 17172411 17016597 16340194 15001691 17725105 18772588 17018589 16510598
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0016391804 16524972 18448328 15289873 18802399 18288408 20501625 15148649 17094418 18383874 17454858 16282729 17401013 17255274 14970324 18509181 17594712 16303861 16331619 17016601 17695437 18949393
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1614669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4815322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.489224671 9125849 17551590 8800419 10589399 14991402 9142499 9664655 9211117 16925845
MESH:D007644 Darier Disease Fluorouracil 4.9516733453
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.8716285004
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.2116109766 12705907 11834606 11739529 15619225 10915739 10663392 11287661 16485898 17906064 17522070 14725611 16081117 12540782 19085960 18071297 14986274 19416960 12392966 11743745 16393943 11461765 11421492 19739265 2444490 11529661 12958197 16781746 18713872 14550746 19923254 16177239 19420014 10774834 16227642 17562736 19164858 19370779 12153990 15968718 12594235
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 9.2116227642 6623471 3786805 6884620 4309450 10092053 9327722 2869522 3732212 15027814 7440962 11566570 15968718 10915739 19085960 7179309 16177239 21278145 19336974 15998439 17522070 7120509
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 9.2115131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.2120420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8411462148
MESH:D050171 Dyslipidemias Dietary Fats 3.5318367378
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 12.5315322242 18230668 16714409
MESH:D004489 Edema, Cardiac Tretinoin 12.5318230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.1816569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1210568697 9294722
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.6020426865
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.6016337965 15173087 16785472 17638652 16481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 9.1111564622
MESH:D005124 Eye Abnormalities Tretinoin 9.119664655 16938888
MESH:D005234 Fatty Liver Carbon Tetrachloride 13.7661145 15959796 12631006 17595544 19224547 12795759 16045604 16239168
MESH:D005234 Fatty Liver Cyclosporine 13.7619224547
MESH:D005234 Fatty Liver Dietary Fats 13.7618296743 17967931 19551842 19004024
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5911858732
MESH:D005355 Fibrosis Carbon Tetrachloride 29.3718705752
MESH:D005355 Fibrosis Cyclosporine 29.3712168785 12639820
MESH:D005355 Fibrosis Dietary Fats 29.3718296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 29.3720067830
MESH:D005355 Fibrosis Tretinoin 29.3717994277
MESH:D005756 Gastritis Acetaminophen 3.8516983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.378708960
MESH:D005909 Glioblastoma Tretinoin 3.0717312396
MESH:D005910 Glioma Fluorouracil 2.9116145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7710696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 8.0318337622 15102660 15162350
MESH:D006258 Head and Neck Neoplasms Tretinoin 8.0316096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.3316084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.7211294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 6.729664655 14991402
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5815720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4411000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7219900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0316120746 12621046 15340226
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.9217440010
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2218606429 16959395 15340226 16354765 8697196
MESH:D006930 Hyperalgesia Acetaminophen 7.9216870215
MESH:D006930 Hyperalgesia Tretinoin 7.9216870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.6916899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.7021332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.7116778211
MESH:D006949 Hyperlipidemias Dietary Fats 3.7321332399
MESH:D006973 Hypertension Cyclosporine 5.0710903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0718670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.2315338365
MESH:D007249 Inflammation Dietary Fats 5.0920412841
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.0912200463 12878042
MESH:D007333 Insulin Resistance Dietary Fats 7.7211836018 18457598
MESH:D007333 Insulin Resistance Sodium Selenite 7.7214714311
MESH:D007410 Intestinal Diseases Tretinoin 3.9017994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.3016580747
MESH:D007569 Jaw Abnormalities Tretinoin 10.3017551590 15992940
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6215604871
MESH:D007674 Kidney Diseases Acetaminophen 5.9915629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 5.9918776723 8314463 10903974
MESH:D007680 Kidney Neoplasms Cyclosporine 7.7012371664
MESH:D007680 Kidney Neoplasms Fluorouracil 7.7016985049
MESH:D007938 Leukemia Tretinoin 2.8217143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.8116482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0917596541 19850784 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2219035177 16788101 17107899 19029980 17712046 19075265 17368321 17649720 16140955 17361223 17301526 19225113 17339181 16891316 16935935 17506722 9834237 16823087 16766008 17294898 17217047 12679006 16331271 15748426 19642359
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.389224671
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.8211408273 16239168 16221502 17334410 17174718 21278145 17157831 11903743 16943688
MESH:D008103 Liver Cirrhosis Dietary Fats 6.8218296743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.5117766677 17869086 18205269 18472332 16192424 11481614 10355542 15057751 12632512 17976157 18376398 14716833 17557913 16638106 13678700 17922224 18339082 14620537 15818738 18317297 18187930 17698563 12586293 15338365 17721639 18412020 18279442 16011737 18429990 17805973 15996030 15673190 12445421 16116963 17714472 18395095 17640975 18420326 12958196 17761835 12898905 17900296 18156304 12445418 15876570 16015684 17525996 20821823 18251166 14716496 15362042 15052691 12667390 18395914 16027843 18054572 12741479 14512876 12546737 17565644 18418968 18210741 15123356 16248980 17631135 15730626 17708605 15959796 18006644 17823541 12632514 16097048 12649538 12666154 18472094 18166357 16033810 15650968 18277467 18705752 12609069 17944888 16136751 18481824 14748882 15925388 18263696 15931870 14724832 17481882 15370692 15893842 12389079
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5112878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.5116248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 3.9819460945 11587558 19014921 12587719 19784758 16611625 12969438 16610002
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.9816246199 16964402 15830285 17285989 15720792
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3015123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.7617185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.7614706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.6519294768
MESH:D008113 Liver Neoplasms Fluorouracil 7.6515113037 17045692 18383874 16603448
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.6516984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 5.9815583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.9812151625
MESH:D008175 Lung Neoplasms Fluorouracil 2.3715246190
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3719555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.9515086387
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.1814737004
MESH:D008527 Medulloblastoma Tretinoin 2.8217453147
MESH:D008545 Melanoma Tretinoin 1.9516752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7119513568
MESH:D008591 Meningomyelocele Tretinoin 4.5616940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9616801185
MESH:D009062 Mouth Neoplasms Fluorouracil 3.7116757204 18986760
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1417596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1112213967
MESH:D009369 Neoplasms Fluorouracil 5.3218600527 18239605 16928823
MESH:D009369 Neoplasms Tretinoin 5.3216946489 16594593
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3819348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.9414600291
MESH:D009421 Nervous System Malformations Tretinoin 9.949125849
MESH:D009436 Neural Tube Defects Tretinoin 3.129142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9618514411
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.5116436463
MESH:D009765 Obesity Dietary Fats 2.3120518802 19632207 16723640 17217161 18457598 21332399 20132043 18674790 11836018
MESH:D010051 Ovarian Neoplasms Tretinoin 2.3716936753
MESH:D010146 Pain Acetaminophen 6.8916870215
MESH:D010146 Pain Tretinoin 6.8916870215
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.4619003803 16500647 15113037 16929163
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.4615976015
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6918163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3212371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3411222880 11118676 11399792 11896295
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.3618626508 19082440
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.3618760546
MESH:D011507 Proteinuria Tretinoin 3.7216636307
MESH:D011565 Psoriasis Cyclosporine 2.2616882103
MESH:D011625 Pterygium Tretinoin 4.9516723453
MESH:D012004 Rectal Neoplasms Fluorouracil 4.1118722050 15538739 16160472 18286688
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9618990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.2216283617 16116481
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7216192470
MESH:D012878 Skin Neoplasms Tretinoin 5.7216467112
MESH:D013274 Stomach Neoplasms Fluorouracil 2.5318567086 19084572 16951190 17498489 19015929 16424979 18396642 17522103 17172411 15786421
MESH:D013274 Stomach Neoplasms Tretinoin 2.5317261132
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0812697716
MESH:D013964 Thyroid Neoplasms Tretinoin 3.1117045167 16026305
MESH:D014062 Tongue Neoplasms Fluorouracil 10.1816280240
MESH:D014062 Tongue Neoplasms Tretinoin 10.1816051514
MESH:D014376 Tuberculosis Tretinoin 3.2916040207
MESH:D014581 Urticaria Acetaminophen 3.0910982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 9.8016803524
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 9.8016129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.7816752155
MESH:D014605 Uveitis Cyclosporine 4.161336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7712125929
MESH:D014820 Vitiligo Tretinoin 4.1816761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4215886252
MESH:D015430 Weight Gain Dietary Fats 3.8316723640
MESH:D009396 Wilms Tumor Tretinoin 4.0716287080
MESH:D014985 Xerophthalmia Cyclosporine 4.6217120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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