AutismKB 2.0

Annotation Detail for ADAM10


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Basic Information Top
Gene Symbol:ADAM10 ( AD10,CD156c,HsT18717,MADM,kuz )
Gene Full Name: ADAM metallopeptidase domain 10
Band: 15q21.3
Quick LinksEntrez ID:102; OMIM: 602192; Uniprot ID:ADA10_HUMAN; ENSEMBL ID: ENSG00000137845; HGNC ID: 188
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05120Epithelial cell signaling in Helicobacter pylori infection
hsa05010Alzheimer's disease
Pathway IDPathway Name
Signaling by EGFR
Signaling by Notch
Pathway IDPathway Name
200013Notch signaling pathway
200052Presenilin action in Notch and Wnt signaling
Pathway IDPathway Name
P00003Alzheimer disease-amyloid secretase pathway
P00045Notch signaling pathway
Pathway IDPathway Name
500115Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1740Alzheimer's disease
1818Systemic scleroderma
1934Cancer
2089Creutzfeldt-Jakob syndrome
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of ADAM10 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ADAM10 mRNAaffects expression 16483693
D001151 Arsenic Arsenic results in decreased expression of ADAM10 mRNAdecreases expression 19654921
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ADAM10 mRNAdecreases expression 19150397
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of ADAM10 mRNAaffects expression 12734012
D002945 Cisplatin ADAM10 protein affects the susceptibility to Cisplatinaffects response to substance 16217747
D005419 Flavonoids Flavonoids results in increased expression of ADAM10 mRNAincreases expression 18035473
D005472 Fluorouracil TP53 protein affects the reaction [Fluorouracil results in decreased expression of ADAM10 mRNA]affects reaction|decreases expression 15016801
D007213 Indomethacin Indomethacin results in increased expression of ADAM10 mRNAincreases expression 16771604
D007529 Isoflavones Isoflavones results in increased expression of ADAM10 mRNAincreases expression 17374662
D008769 Methylnitronitrosoguanidine Methylnitronitrosoguanidine results in increased expression of ADAM10 mRNAincreases expression 12634122
D009151 Mustard Gas Mustard Gas results in increased expression of ADAM10 mRNAincreases expression 15674844
C006253 pirinixic acid pirinixic acid results in decreased expression of ADAM10 mRNAdecreases expression 18445702
D014212 Tretinoin Tretinoin results in increased expression of ADAM10 mRNAincreases expression 16279945
15972296
D014212 Tretinoin Tretinoin results in increased expression of ADAM10 proteinincreases expression 16279945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.6418287403
MESH:D058186 Acute Kidney Injury Cisplatin 4.0117670903 15814532 12690470
MESH:D055371 Acute Lung Injury pirinixic acid 3.1718653653
MESH:D000230 Adenocarcinoma Cisplatin 7.3617638652 11798837
MESH:D000230 Adenocarcinoma Fluorouracil 7.3617638652
MESH:D000230 Adenocarcinoma Indomethacin 7.3616537180
MESH:D000236 Adenoma Indomethacin 3.4811497255
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.5616434500
MESH:D018246 Adrenocortical Adenoma Arsenic 5.3117306315
MESH:D000505 Alopecia Isoflavones 9.7217569567
MESH:D000505 Alopecia Tretinoin 9.7215955085
MESH:D016301 Alveolar Bone Loss Indomethacin 5.4717225004
MESH:D000544 Alzheimer Disease Indomethacin 2.7117627676 15579461
MESH:D000740 Anemia Fluorouracil 3.7615504547 16511603 17963324
MESH:D000799 Angioedema Acetaminophen 3.9410982225
MESH:D001014 Aortic Aneurysm Indomethacin 4.9110231640
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 4.9410388637
MESH:D020261 Arsenic Poisoning Arsenic 2.8816251483 12569548 16835338 18414634
MESH:D018771 Arthralgia Indomethacin 5.272160914
MESH:D001169 Arthritis, Experimental Tretinoin 3.1116412693
MESH:D001172 Arthritis, Rheumatoid Indomethacin 4.8111248219
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.8116292516
MESH:D001249 Asthma Mustard Gas 5.0310378619
MESH:D001249 Asthma Tretinoin 5.0316456186
MESH:D050197 Atherosclerosis Arsenic 3.2819371607 12928151
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001471 Barrett Esophagus Tretinoin 4.4716935849
MESH:D001477 Bartter Syndrome Indomethacin 5.0610684365
MESH:D001768 Blister Mustard Gas 5.2419167455
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.1619483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.1616206674 16197459
MESH:D019046 Bone Marrow Neoplasms Cisplatin 4.9814601052
MESH:D001929 Brain Edema Indomethacin 5.1211481608
MESH:D002545 Brain Ischemia Indomethacin 4.5012524144
MESH:D001943 Breast Neoplasms marker/mechanism 16583263
MESH:D001943 Breast Neoplasms Cisplatin 2.0318382427 19526202
MESH:D001943 Breast Neoplasms Fluorouracil 2.0319217205 15136595 16110121 18357371 18608205 16595493 16557594
MESH:D001943 Breast Neoplasms Indomethacin 2.0317401462
MESH:D001943 Breast Neoplasms Tretinoin 2.0316443354 16873071 16166294
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.2415286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.0717687719 10378619
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.6716813970
MESH:D002056 Burns Indomethacin 4.7810459503
MESH:D002100 Cachexia Indomethacin 5.0916537180 15141370 11239499 15625704
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.8516124888 15700767 16011737 15673190 16097048 16227642 10355542 15721981 16192424 3786805 18705752 16050911
MESH:D002276 Carcinoid Tumor Fluorouracil 4.7616051944
MESH:D002277 Carcinoma Fluorouracil 3.6117121937
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.6217687452 15504454
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.2616168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 14.243084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 14.2416507464 17306315
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 14.2418788625
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 14.2417982673
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 14.2416799960 16332177 17971768 18930000 17088986 17045692
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 14.2416391822
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 14.241917145
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 4.8111053908
MESH:D018276 Carcinoma, Medullary Indomethacin 5.4318791128 14736730 11352223
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 3.0516685392 12023789
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 6.8318695887
MESH:D002292 Carcinoma, Renal Cell Indomethacin 6.8317341418
MESH:D002294 Carcinoma, Squamous Cell Arsenic 14.5315504454 18922899 17687452
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 14.536189445 17066447 18337622
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 14.5316280240 17066447 16757204 18986760
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 14.5315482327 12636206
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 14.5316096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.1318640142
MESH:D002318 Cardiovascular Diseases Arsenic 7.9419152805 15738583 17938729
MESH:D002318 Cardiovascular Diseases Isoflavones 7.9417689850
MESH:D002340 Carotid Artery Diseases Arsenic 4.3616973168 18022660
MESH:D002386 Cataract Acetaminophen 7.3310977129
MESH:D002386 Cataract Tretinoin 7.3317460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.2220889678
MESH:D002471 Cell Transformation, Neoplastic Methylnitronitrosoguanidine 7.222727394
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.6716129372
MESH:D002764 Cholecystitis Indomethacin 5.2711181007
MESH:D002779 Cholestasis pirinixic acid 2.8619176532
MESH:D002822 Choriocarcinoma Tretinoin 5.2616461808
MESH:D002972 Cleft Palate Tretinoin 2.699407595
MESH:D003092 Colitis Tretinoin 3.7817035595
MESH:D003110 Colonic Neoplasms Fluorouracil 3.9917018589 15001691 17016597 18772588 17169374 17725105 16340194 16510598 17287894 17172411
MESH:D003110 Colonic Neoplasms Indomethacin 3.9915786552 15637740 15963497 15936596 11260862 15625704
MESH:D015179 Colorectal Neoplasms Cisplatin 4.9215273666
MESH:D015179 Colorectal Neoplasms Fluorouracil 4.9218448328 17454858 17695437 17255274 16391804 17594712 16524972 16303861 15148649 15289873 18802399 18509181 20501625 17016601 16282729 18949393 17401013 18383874 16331619 18288408 14970324 17094418
MESH:D015179 Colorectal Neoplasms Indomethacin 4.9211197048 17054584 18059344 12606626
MESH:D015179 Colorectal Neoplasms Isoflavones 4.9217116718
MESH:D018352 Coronavirus Infections Indomethacin 5.8117302372
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.8216925845 10589399 9224671 14991402 9211117 9664655 9142499 8800419 17551590 9125849
MESH:D007644 Darier Disease Fluorouracil 4.8716733453
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4518249437
MESH:D003967 Diarrhea Indomethacin 3.867907874 7237001
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.7912540782 12153990 15619225 18071297 19923254 18713872 2444490 12705907 11743745 19416960 11739529 10663392 11529661 11287661 19420014 11461765 19164858 10915739 14550746 19739265 12594235 17906064 11421492 16781746 16227642 14725611 16485898 12392966 15968718 12958197 19370779 17522070 16393943 14986274 16109766 16177239 16081117 19085960 17562736 11834606 10774834
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 3.7911566570 19085960 17522070 10915739 15998439 21278145 6623471 15968718 9327722 16177239 7440962 2869522 16227642 10092053 4309450 3732212 6884620 19336974 3786805 15027814 7179309 7120509
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1919426721
MESH:D004362 Drug Toxicity Cisplatin 3.8919839026 12649298 15033597 12231392
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 5.2316133044 18043480 16326151 18446180 17190690 12774134
MESH:D004381 Duodenal Ulcer Indomethacin 4.2011535926 17202747 17329845 10671773 17045617 11595431 11991626 11595415 17151854 17351913 16699067
MESH:D004487 Edema Indomethacin 11.908985016 7907874 10653021 16100529 8273558 19703484 7990266
MESH:D004487 Edema Mustard Gas 11.9011428647 9260866 11428631 11402378
MESH:D004487 Edema pirinixic acid 11.9012083418
MESH:D004489 Edema, Cardiac Tretinoin 4.5618230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.1416569247
MESH:D004715 Endometriosis Indomethacin 4.2015652904
MESH:D019446 Endotoxemia Indomethacin 4.5818509659
MESH:D004751 Enteritis Indomethacin 4.8416328016 10567023 17763956
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 5.0617980183
MESH:D004802 Eosinophilia Indomethacin 4.1211298111
MESH:D004890 Erythema Mustard Gas 5.249357497
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 10.5720426865
MESH:D004938 Esophageal Neoplasms Cisplatin 10.5715173087 16481741 15464296 17638652 16785472
MESH:D004938 Esophageal Neoplasms Fluorouracil 10.5716481741 16785472 17638652 16337965 15173087
MESH:D004938 Esophageal Neoplasms Indomethacin 10.5711005569
MESH:D005124 Eye Abnormalities Tretinoin 3.629664655 16938888
MESH:D005234 Fatty Liver Carbon Tetrachloride 7.8617595544 15959796 19224547 12631006 61145 16045604 16239168 12795759
MESH:D005234 Fatty Liver pirinixic acid 7.8620131406 19236843
MESH:D005334 Fever Indomethacin 4.1711852909 17627676 10431976
MESH:D005354 Fibrosarcoma Indomethacin 4.9810962813
MESH:D005355 Fibrosis Carbon Tetrachloride 15.3518705752
MESH:D005355 Fibrosis Indomethacin 15.3517994277
MESH:D005355 Fibrosis Tretinoin 15.3517994277
MESH:D005499 Folliculitis Indomethacin 5.2711298111
MESH:D005534 Foot Diseases Arsenic 5.666392382
MESH:D005756 Gastritis Acetaminophen 11.4816983495
MESH:D005756 Gastritis Indomethacin 11.4815046732
MESH:D005909 Glioblastoma Indomethacin 7.4412870263
MESH:D005909 Glioblastoma Tretinoin 7.4417312396
MESH:D005910 Glioma Fluorouracil 6.3116145905
MESH:D005910 Glioma Indomethacin 6.3116487511 18371953
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 4.3311849393
MESH:D006073 Gout Indomethacin 5.4311248219
MESH:D006258 Head and Neck Neoplasms Cisplatin 18.7915464296 15102660
MESH:D006258 Head and Neck Neoplasms Fluorouracil 18.7915162350 15102660 18337622
MESH:D006258 Head and Neck Neoplasms Indomethacin 18.7915482327
MESH:D006258 Head and Neck Neoplasms Tretinoin 18.7916096774
MESH:D034381 Hearing Loss Cisplatin 4.3419898482
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.2616084493
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.4615464296
MESH:D006330 Heart Defects, Congenital Tretinoin 2.929664655 14991402
MESH:D006333 Heart Failure pirinixic acid 2.5720558911
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.6215633222
MESH:D006505 Hepatitis Carbon Tetrachloride 3.6619110552 19900420
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.7515135802
MESH:D006529 Hepatomegaly pirinixic acid 3.0719772884 19176532 18467677 16221962
MESH:D006689 Hodgkin Disease Cisplatin 3.6416200630 16170182
MESH:D019584 Hot Flashes Isoflavones 5.0814716179 17290160
MESH:D006930 Hyperalgesia Acetaminophen 13.3316870215
MESH:D006930 Hyperalgesia Indomethacin 13.3312727271
MESH:D006930 Hyperalgesia Tretinoin 13.3316870215
MESH:D034321 Hyperamylasemia Indomethacin 5.8117883296
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.6116899240
MESH:D006940 Hyperemia Indomethacin 5.0912524144
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.6416778211
MESH:D006943 Hyperglycemia pirinixic acid 3.2320558911
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.5117050553
MESH:D006949 Hyperlipidemias Indomethacin 4.2217546600
MESH:D006973 Hypertension Arsenic 2.8916076760 11953799 9931084
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.1615338365
MESH:D006987 Hypesthesia Arsenic 5.6616093927
MESH:D007077 Ileal Diseases Indomethacin 5.1210574470 18306037
MESH:D007079 Ileitis Indomethacin 5.4316133968 10651667 10647630
MESH:D007235 Infant, Premature, Diseases Indomethacin 5.4716133044
MESH:D007249 Inflammation Flavonoids 8.6717296493
MESH:D007249 Inflammation Indomethacin 8.6712568917 3291741 7812673
MESH:D007249 Inflammation Mustard Gas 8.6711402378 17524151 9357497 8975870 11428647 11428620 11428631 9260866 16001271
MESH:D007333 Insulin Resistance pirinixic acid 2.6616306350
MESH:D007410 Intestinal Diseases Indomethacin 10.1311855677 15831440 11686837 11713966 17994277 15610444 18236018 10210152 17329856
MESH:D007410 Intestinal Diseases Tretinoin 10.1317994277
MESH:D019586 Intracranial Hypertension Indomethacin 5.4715241188
MESH:D007569 Jaw Abnormalities Tretinoin 3.9515992940 17551590
MESH:D007579 Jejunal Diseases Indomethacin 5.1218306037 16133968 10574470
MESH:D007642 Keratosis Arsenic 5.0716930632 12749816
MESH:D007673 Kidney Cortex Necrosis Cisplatin 5.2415464296
MESH:D007674 Kidney Diseases Acetaminophen 10.3712587719 15629191
MESH:D007674 Kidney Diseases Cisplatin 10.3715190930 12231392 12649298 19839026 18289764
MESH:D007674 Kidney Diseases Indomethacin 10.3717190690
MESH:D007680 Kidney Neoplasms Fluorouracil 3.3516985049
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.8911231351
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 3.9512228301 10320625 11703811
MESH:D007938 Leukemia Tretinoin 2.7917143497
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 3.9615631656 10785260 16572323
MESH:D007951 Leukemia, Myeloid Tretinoin 3.7516932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 4.0918360721
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 4.0916294345 19850784 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 7.8717339181
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.8716935935 17506722 17294898 12679006 16823087 17368321 17301526 19029980 16788101 16766008 19075265 19225113 17361223 16331271 9834237 15748426 16140955 16891316 17339181 17649720 19035177 17217047 19642359 17712046 17107899
MESH:D007964 Leukocytosis Indomethacin 5.4716537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.8117980183
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.349224671
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.8111479899
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8316221502 16943688 17334410 17157831 17174718 21278145 11903743 11408273 16239168
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 5.0317869086 18418968 18472332 12667390 16638106 17525996 15338365 15673190 18412020 15362042 17922224 17708605 17805973 15123356 15818738 12741479 18251166 16027843 15931870 18156304 18395914 15730626 18376398 18187930 18210741 17761835 17714472 12445421 16248980 12958196 12546737 15996030 12898905 18339082 12649538 12632514 18472094 12632512 18277467 15876570 17557913 12586293 16136751 17766677 14748882 18429990 17481882 17631135 18263696 16192424 15057751 17640975 18279442 17721639 14716496 11481614 14716833 18205269 18054572 14512876 15925388 18481824 12666154 20821823 12609069 17900296 16097048 15370692 18166357 18006644 18317297 18420326 15650968 17823541 16033810 18705752 15959796 17698563 15052691 14620537 13678700 14724832 16011737 15893842 16015684 17976157 17944888 18395095 10355542 17565644 12445418 16116963 12389079
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 5.0318194892
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 5.0315474484
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 5.0316248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 6.6119014921 19460945 19784758 12969438 16610002 11587558 16611625 12587719
MESH:D008107 Liver Diseases Arsenic 6.6111134558
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.6115830285 16964402 15720792 16246199 17285989
MESH:D017093 Liver Failure Carbon Tetrachloride 4.2415123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.5817185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.5816899240 14706259
MESH:D008113 Liver Neoplasms Arsenic 10.8916368122
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 10.8919294768
MESH:D008113 Liver Neoplasms Fluorouracil 10.8916603448 17045692 15113037 18383874
MESH:D008113 Liver Neoplasms pirinixic acid 10.8920007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 2.6412014681 15583823
MESH:D008171 Lung Diseases Mustard Gas 3.4818702808 18161513
MESH:D008175 Lung Neoplasms Arsenic 6.7017976673 17306315 19168569
MESH:D008175 Lung Neoplasms Cisplatin 6.706189445 11798837 17225452
MESH:D008175 Lung Neoplasms Fluorouracil 6.7015246190
MESH:D008175 Lung Neoplasms Indomethacin 6.7011053908 11497255 16537180
MESH:D008175 Lung Neoplasms Mustard Gas 6.708781369 3148597
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.8715086387
MESH:D008527 Medulloblastoma Tretinoin 2.8017453147
MESH:D008545 Melanoma Cisplatin 3.5315577323 18176117 17761969 16809738 12883367 16432458 11135225 18505091 18332650 12393984 16248763 12374674 17023156
MESH:D008545 Melanoma Tretinoin 3.5316752155
MESH:D018328 Melanoma, Amelanotic Cisplatin 4.8615990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6419513568
MESH:D008591 Meningomyelocele Tretinoin 4.5016940565
MESH:D008654 Mesothelioma Cisplatin 3.2617638057
MESH:D053842 Microsatellite Instability Methylnitronitrosoguanidine 5.9717671175
MESH:D008881 Migraine Disorders Indomethacin 3.7111903285
MESH:D009062 Mouth Neoplasms Fluorouracil 8.9618986760 16757204
MESH:D009062 Mouth Neoplasms Indomethacin 8.9612636206
MESH:D009135 Muscular Diseases pirinixic acid 3.5816239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1117596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1619151258
MESH:D017202 Myocardial Ischemia Arsenic 4.0315371236
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9916411023
MESH:D009362 Neoplasm Metastasis Indomethacin 3.1911053908 16537180 11239499
MESH:D009369 Neoplasms Cisplatin 12.1116773208
MESH:D009369 Neoplasms Fluorouracil 12.1116928823 18600527 18239605
MESH:D009369 Neoplasms pirinixic acid 12.1117405874
MESH:D009369 Neoplasms Tretinoin 12.1116946489 16594593
MESH:D009374 Neoplasms, Experimental Indomethacin 4.2115625704 10663608
MESH:D009395 Nephritis, Interstitial Cisplatin 4.5915464296
MESH:D009421 Nervous System Malformations Tretinoin 3.849125849
MESH:D009436 Neural Tube Defects Arsenic 7.5416620997
MESH:D009436 Neural Tube Defects Tretinoin 7.549142499
MESH:D009447 Neuroblastoma Cisplatin 3.478761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.5518514411
MESH:D019636 Neurodegenerative Diseases Indomethacin 8.5512349958
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.788761367
MESH:D020078 Neurogenic Inflammation Arsenic 4.4317056641
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.4716436463
MESH:D009503 Neutropenia Mustard Gas 4.0316761898 7688884
MESH:D009765 Obesity pirinixic acid 1.8220558911
MESH:D007752 Obstetric Labor, Premature Indomethacin 5.276374098
MESH:D010003 Osteoarthritis Indomethacin 3.707009135
MESH:D010024 Osteoporosis Isoflavones 4.1316562857
MESH:D010051 Ovarian Neoplasms Arsenic 8.1017306315
MESH:D010051 Ovarian Neoplasms Cisplatin 8.106897625 17225452 19769630 15464296
MESH:D010051 Ovarian Neoplasms Tretinoin 8.1016936753
MESH:D010146 Pain Acetaminophen 11.5416870215
MESH:D010146 Pain Indomethacin 11.5413679232 17440234 3291741 17627676
MESH:D010146 Pain Tretinoin 11.5416870215
MESH:D010149 Pain, Postoperative Indomethacin 4.7818702446 12538197
MESH:D010190 Pancreatic Neoplasms Cisplatin 8.8219003803
MESH:D010190 Pancreatic Neoplasms Fluorouracil 8.8219003803 16929163 15113037 16500647
MESH:D010190 Pancreatic Neoplasms Tretinoin 8.8215976015
MESH:D010195 Pancreatitis Indomethacin 3.9815028970 17883296
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.8116537180
MESH:D020734 Parkinsonian Disorders Indomethacin 4.1712349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.8111903285
MESH:D010437 Peptic Ulcer Indomethacin 5.2311148446
MESH:D010518 Periodontitis Indomethacin 5.0117225004
MESH:D010523 Peripheral Nervous System Diseases Arsenic 10.2816093927
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 10.2815464296
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.0715371236 16905509 6392382
MESH:D010997 Pleural Neoplasms Cisplatin 5.4417638057
MESH:D011041 Poisoning Mustard Gas 3.8515727166
MESH:D047928 Premature Birth Indomethacin 5.2017000239
MESH:D011471 Prostatic Neoplasms Arsenic 2.7816140617
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.7818626508 19082440
MESH:D011471 Prostatic Neoplasms Isoflavones 2.7817219775 17571952 16365062 17374662
MESH:D011507 Proteinuria Arsenic 15.8721343184
MESH:D011507 Proteinuria Indomethacin 15.8711849393
MESH:D011507 Proteinuria Tretinoin 15.8716636307
MESH:D011537 Pruritus Mustard Gas 4.1718058305
MESH:D011625 Pterygium Tretinoin 4.8816723453
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9410334151 17266442 17720292 17894541 17620002
MESH:D012004 Rectal Neoplasms Fluorouracil 4.0615538739 18722050 18286688 16160472
MESH:D051437 Renal Insufficiency Cisplatin 4.4815464296
MESH:D015427 Reperfusion Injury pirinixic acid 2.4119058328
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.1616116481 16283617
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.4914601052
MESH:D012871 Skin Diseases Arsenic 5.1817938729 16702368 17453740 16353154 17548696 16759981 17050553 19834688 15952646 6392382 18709164
MESH:D012871 Skin Diseases Mustard Gas 5.1815451306 12880345 16961503
MESH:D012878 Skin Neoplasms Arsenic 5.9915504454 17050553 17976673 16251483 19538983 17029826
MESH:D012878 Skin Neoplasms Tretinoin 5.9916467112
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.4415464296
MESH:D013272 Stomach Diseases Indomethacin 4.5017638125 16113693 17207306 18209964 16280098 17160473 10486359 10192188 16184426 18545984 15038085 15472012 10215738
MESH:D013274 Stomach Neoplasms Cisplatin 4.8217522103 15958060 18396642
MESH:D013274 Stomach Neoplasms Fluorouracil 4.8216951190 17172411 19015929 17522103 16424979 18567086 18396642 19084572 15786421 17498489
MESH:D013274 Stomach Neoplasms Indomethacin 4.8215609394
MESH:D013274 Stomach Neoplasms Tretinoin 4.8217261132
MESH:D013276 Stomach Ulcer Indomethacin 3.6418209962 16150113 12467913 10750652 11595431 17895592 11729361 10878458 16252198 16631530 18299717 17977527 15138204 18543354 15104355 17135157 18087811 10423059 11145282 16934674 17627676 18193104 18431645 17657623 14567935 17918041 12500499 16169175 11523592 17654042 15255614 18726076 16755016 1323529 12077510 12787963 11595415 11906479 16397915 18181030 18237397 12498302
MESH:D013736 Testicular Neoplasms Cisplatin 4.6917225452 15464296
MESH:D013964 Thyroid Neoplasms Indomethacin 7.5318791128 11352223 14736730
MESH:D013964 Thyroid Neoplasms Tretinoin 7.5317045167 16026305
MESH:D014062 Tongue Neoplasms Fluorouracil 10.0016280240
MESH:D014062 Tongue Neoplasms Tretinoin 10.0016051514
MESH:D014376 Tuberculosis Tretinoin 3.2616040207
MESH:D014456 Ulcer Indomethacin 4.9810574470 17380554
MESH:D001749 Urinary Bladder Neoplasms Arsenic 5.5111144890 18640142 17306315 19429237 19322015 15987713 17976673
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 5.5117225452 12973940 15464296
MESH:D014581 Urticaria Acetaminophen 3.0310982225
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 16.2316803524
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 16.2316803524
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 16.2316129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.7116752155
MESH:D014625 Vaginal Neoplasms Cisplatin 4.6815577323
MESH:D014652 Vascular Diseases Arsenic 4.8217056641
MESH:D014820 Vitiligo Tretinoin 4.1216761959
MESH:D014839 Vomiting Cisplatin 11.8611897121
MESH:D014839 Vomiting Indomethacin 11.8611897121
MESH:D009396 Wilms Tumor Tretinoin 4.0216287080
Pathway ID Pathway Name
KEGG:05010 Alzheimer's disease
KEGG:05120 Epithelial cell signaling in Helicobacter pylori infection
REACT:9417 Signaling by EGFR
REACT:299 Signaling by Notch
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24505
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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