AutismKB 2.0

Annotation Detail for CDK5


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Basic Information Top
Gene Symbol:CDK5 ( PSSALRE )
Gene Full Name: cyclin-dependent kinase 5
Band: 7q36.1
Quick LinksEntrez ID:1020; OMIM: 123831; Uniprot ID:CDK5_HUMAN; ENSEMBL ID: ENSG00000164885; HGNC ID: 1774
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04360Axon guidance
hsa05010Alzheimer's disease
Pathway IDPathway Name
Axon guidance
Opioid Signalling
Pathway IDPathway Name
200182Trk receptor signaling mediated by the MAPK pathway
200121EPHA forward signaling
200077Glucocorticoid receptor regulatory network
200114Lissencephaly gene (LIS1) in neuronal migration and development
200051Reelin signaling pathway
Pathway IDPathway Name
P00007Axon guidance mediated by semaphorins
Pathway IDPathway Name
500077CRMPs in Sema3A signaling
500841DARPP-32 events
Related Diseases/Disorders Top
No data
No data
Desease Name
Alzheimer's disease
NEUROLOGICAL
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CDK5 mRNAaffects expression 16483693
D000643 Ammonium Chloride Ammonium Chloride results in increased cleavage of CDK5 proteinincreases cleavage 18722528
D000643 Ammonium Chloride CDK5 protein affects the susceptibility to Ammonium Chlorideaffects response to substance 18722528
D003913 Dextroamphetamine Dextroamphetamine results in increased activity of CDK5 proteinincreases activity 18991853
D003024 Clozapine Clozapine results in increased expression of CDK5 mRNAincreases expression 15860345
D016572 Cyclosporine Cyclosporine results in decreased expression of CDK5 mRNAdecreases expression 20106945
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of CDK5 mRNAincreases expression 15766595
D005473 Fluoxetine Fluoxetine results in decreased expression of CDK5 mRNAdecreases expression 17105902
D019833 Genistein Genistein results in increased expression of CDK5 proteinincreases expression 16149052
D006220 Haloperidol Haloperidol results in increased expression of CDK5 mRNAincreases expression 15860345
C015329 lycopene lycopene results in decreased expression of CDK5 proteindecreases expression 17337101
D008769 Methylnitronitrosoguanidine Methylnitronitrosoguanidine results in increased expression of CDK5 mRNAincreases expression 12634122
C008493 methylselenic acid methylselenic acid results in increased expression of CDK5 mRNAincreases expression 11830524
C104586 roscovitine roscovitine results in decreased activity of CDK5 proteindecreases activity 15741232
C017947 sodium arsenite sodium arsenite results in increased expression of CDK5 mRNAincreases expression 17879257
D018038 Sodium Selenite Sodium Selenite results in decreased expression of CDK5 mRNAdecreases expression 16705456
D014212 Tretinoin Tretinoin results in increased expression of CDK5 proteinincreases expression 16149052
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.6118287403
MESH:D000230 Adenocarcinoma Genistein 2.4811473722
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.7615276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.9616712894 17306315
MESH:D000380 Agranulocytosis Clozapine 5.1014617031 12649775 16160616
MESH:D000505 Alopecia Tretinoin 3.6415955085
MESH:D000686 Amyloidosis Diethylstilbestrol 4.5215469931
MESH:D001008 Anxiety Disorders Fluoxetine 4.9518083778
MESH:D001169 Arthritis, Experimental Tretinoin 3.0916412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2716292516
MESH:D001249 Asthma Tretinoin 2.3516456186
MESH:D001321 Autistic Disorder Fluoxetine 2.8418775368 19232924
MESH:D001321 Autistic Disorder Haloperidol 2.8418080171 19368416
MESH:D001471 Barrett Esophagus Tretinoin 4.4416935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.6416197459 16206674
MESH:D001943 Breast Neoplasms Diethylstilbestrol 2.0017129689 15324884
MESH:D001943 Breast Neoplasms Genistein 2.0016873071 17200150 16541309
MESH:D001943 Breast Neoplasms Tretinoin 2.0016873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.6416813970
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.2216168501
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 6.6616924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Genistein 6.6616924424
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 6.6616507464 17306315 15276417
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 6.661917145
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.7118572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.7116096774 16051514
MESH:D002318 Cardiovascular Diseases Genistein 3.3216332659
MESH:D002375 Catalepsy Haloperidol 4.9615215559 1977408
MESH:D002386 Cataract Tretinoin 3.1117460283
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.4512371664
MESH:D002471 Cell Transformation, Neoplastic Methylnitronitrosoguanidine 11.452727394
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 11.4520056578 19524636
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.6416129372
MESH:D002779 Cholestasis Cyclosporine 2.9419486331
MESH:D002822 Choriocarcinoma Tretinoin 5.2216461808
MESH:D019457 Chromosome Breakage Sodium Selenite 4.7915894690
MESH:D002972 Cleft Palate Tretinoin 2.689407595
MESH:D003072 Cognition Disorders Clozapine 5.0117123785
MESH:D003092 Colitis Tretinoin 3.7517035595
MESH:D003110 Colonic Neoplasms Genistein 2.2917182828
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.829664655 9224671 10589399 9142499 17551590 9211117 9125849 16925845 8800419 14991402
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.5916002989 12952375
MESH:D016757 Death, Sudden, Cardiac Haloperidol 4.8720210726
MESH:D003704 Dementia Haloperidol 4.6111575062
MESH:D003866 Depressive Disorder Fluoxetine 4.6215014590
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.8016285004
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 4.8316402076
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.8316647724
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.6215331141
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 2.2915131321
MESH:D050171 Dyslipidemias Clozapine 4.2016402076
MESH:D004487 Edema Fluoxetine 4.4012798668
MESH:D004489 Edema, Cardiac Tretinoin 4.5318230668
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 12.0616402032
MESH:D004714 Endometrial Hyperplasia Genistein 12.0616402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 12.6416804899 15700306
MESH:D016889 Endometrial Neoplasms Genistein 12.6411473722
MESH:D016889 Endometrial Neoplasms Tretinoin 12.6416569247
MESH:D005124 Eye Abnormalities Tretinoin 3.609664655 16938888
MESH:D005234 Fatty Liver Cyclosporine 2.8819224547
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.6716534752 16002989 16611131 15751030 16513791
MESH:D005355 Fibrosis Cyclosporine 8.8312639820 12168785
MESH:D005355 Fibrosis Tretinoin 8.8317994277
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 12.9816452187
MESH:D005833 Genital Neoplasms, Female sodium arsenite 12.9816452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.278708960
MESH:D005909 Glioblastoma Genistein 7.2716598420
MESH:D005909 Glioblastoma Tretinoin 7.2717312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.2016096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.2216084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.9114991402 9664655
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4715720958
MESH:D006689 Hodgkin Disease sodium arsenite 3.1812676792
MESH:D019584 Hot Flashes Fluoxetine 5.3714716179
MESH:D006930 Hyperalgesia Tretinoin 3.2316870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.6116778211
MESH:D006948 Hyperkinesis Clozapine 4.9616046005
MESH:D006965 Hyperplasia Diethylstilbestrol 4.4812960047 14722030
MESH:D006973 Hypertension Cyclosporine 2.1110903974
MESH:D007021 Hypospadias Diethylstilbestrol 4.6216002989
MESH:D007246 Infertility Diethylstilbestrol 4.3915036965
MESH:D007248 Infertility, Male sodium arsenite 3.0115346721 12646999
MESH:D007249 Inflammation Fluoxetine 3.8612798668
MESH:D007333 Insulin Resistance Sodium Selenite 3.2914714311
MESH:D007410 Intestinal Diseases Tretinoin 3.8117994277
MESH:D007569 Jaw Abnormalities Tretinoin 3.9317551590 15992940
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5015604871
MESH:D007674 Kidney Diseases Cyclosporine 6.078314463 10903974 18776723
MESH:D007674 Kidney Diseases sodium arsenite 6.0720008137
MESH:D007680 Kidney Neoplasms Cyclosporine 7.5312371664
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 7.5314681315 15003126 16762066
MESH:D007859 Learning Disorders Diethylstilbestrol 4.1017184923
MESH:D007938 Leukemia Genistein 10.8217468513 18980019
MESH:D007938 Leukemia roscovitine 10.8216275999
MESH:D007938 Leukemia Tretinoin 10.8217143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.7316932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0819850784 17596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.1719035177 19075265 17368321 16891316 17339181 17294898 17217047 16788101 19642359 17649720 17107899 9834237 16331271 17712046 16935935 12679006 17301526 17361223 16766008 17506722 19029980 16823087 16140955 19225113 15748426
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.339224671
MESH:D008064 Lipidoses Clozapine 8.7017567588
MESH:D008064 Lipidoses Fluoxetine 8.7017567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Genistein 2.6117823541
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.6116248980 18397230
MESH:D008113 Liver Neoplasms Diethylstilbestrol 4.8215890375 16712894
MESH:D008113 Liver Neoplasms sodium arsenite 4.8216712894 15276417
MESH:D008171 Lung Diseases sodium arsenite 3.1919095001
MESH:D008175 Lung Neoplasms sodium arsenite 1.8917306315 17077188 16712894 19931552 15276417
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.2015166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.4915700306
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.0914737004
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.5816002989
MESH:D008325 Mammary Neoplasms, Experimental Genistein 2.9614578162 12929590
MESH:D008527 Medulloblastoma Tretinoin 2.7917453147
MESH:D008545 Melanoma sodium arsenite 3.3516487513 19082730
MESH:D008545 Melanoma Tretinoin 3.3516752155
MESH:D008591 Meningomyelocele Tretinoin 4.4716940565
MESH:D001523 Mental Disorders Clozapine 13.7516856516
MESH:D001523 Mental Disorders Fluoxetine 13.7516856516
MESH:D001523 Mental Disorders Haloperidol 13.7516856516
MESH:D024821 Metabolic Syndrome X Clozapine 4.4319142101
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8516801185
MESH:D053842 Microsatellite Instability Methylnitronitrosoguanidine 5.9417671175
MESH:D009041 Motion Sickness Dextroamphetamine 5.581613127
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.0917596541
MESH:D009203 Myocardial Infarction Genistein 2.8717141266
MESH:D015428 Myocardial Reperfusion Injury Genistein 3.6817141266
MESH:D009207 Myoclonus Fluoxetine 5.938041377
MESH:D009369 Neoplasms Diethylstilbestrol 12.0815313581
MESH:D009369 Neoplasms lycopene 12.0817051425
MESH:D009369 Neoplasms sodium arsenite 12.0811559025
MESH:D009369 Neoplasms Tretinoin 12.0816946489 16594593
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.7120056578
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5017954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3118481113 19348381
MESH:D009421 Nervous System Malformations Diethylstilbestrol 16.7311399458
MESH:D009421 Nervous System Malformations Genistein 16.7316427766
MESH:D009421 Nervous System Malformations Tretinoin 16.739125849
MESH:D009436 Neural Tube Defects sodium arsenite 7.3712854658
MESH:D009436 Neural Tube Defects Tretinoin 7.379142499
MESH:D009765 Obesity Clozapine 3.0218515891 19142110
MESH:D009771 Obsessive-Compulsive Disorder Fluoxetine 5.4720418887
MESH:D010024 Osteoporosis Genistein 3.2719401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.1216169203
MESH:D010051 Ovarian Neoplasms Genistein 7.9819005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 7.9817306315 15276417
MESH:D010051 Ovarian Neoplasms Tretinoin 7.9816936753
MESH:D010146 Pain Fluoxetine 7.3812798668
MESH:D010146 Pain Tretinoin 7.3816870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.4715976015
MESH:D020774 Pick Disease of the Brain Fluoxetine 6.048041377
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.2314722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.7115687265 16977796
MESH:D011230 Precancerous Conditions Cyclosporine 3.2512371664
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 4.1617184923
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.1215846301 17136230 15046698
MESH:D011471 Prostatic Neoplasms Genistein 2.1215378649 16925846 15256057
MESH:D011471 Prostatic Neoplasms lycopene 2.1217337101 15084515
MESH:D011471 Prostatic Neoplasms methylselenic acid 2.1216205645
MESH:D011471 Prostatic Neoplasms roscovitine 2.1216140939
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.1216039940
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.1218760546
MESH:D011507 Proteinuria Tretinoin 3.6416636307
MESH:D011565 Psoriasis Cyclosporine 2.2416882103
MESH:D011595 Psychomotor Agitation Haloperidol 5.0011575062
MESH:D011618 Psychotic Disorders Clozapine 9.2215331141
MESH:D011618 Psychotic Disorders Haloperidol 9.2211575062
MESH:D011625 Pterygium Tretinoin 4.8416723453
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.1316283617 16116481
MESH:D012512 Sarcoma, Ewing's roscovitine 5.8216230394
MESH:D012559 Schizophrenia Clozapine 4.1120452607 20580759 17123785 18855531 11151749 20107430 20521320 16141801 19369910 17726453 20168265 11763009 18806925 20521326 17667964
MESH:D012559 Schizophrenia Haloperidol 4.1118513383 19369910 1830565 20107430
MESH:D020230 Serotonin Syndrome Fluoxetine 5.968704074
MESH:D012878 Skin Neoplasms sodium arsenite 5.8418572023 19524636
MESH:D012878 Skin Neoplasms Tretinoin 5.8416467112
MESH:D013088 Spermatocele Diethylstilbestrol 4.7716002989 16709447
MESH:D016135 Spinal Dysraphism sodium arsenite 3.8212854658
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D017180 Tachycardia, Ventricular Haloperidol 4.7420210726
MESH:D013964 Thyroid Neoplasms Tretinoin 3.0517045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 3.8116051514
MESH:D014376 Tuberculosis Tretinoin 3.2416040207
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 5.3016452187 17306315 16712894
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 5.3016712894 16452187 17306315 11723127
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 16.0516175088
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 16.0511813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 16.0516129372
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.2314652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 4.1015809267 16690809
MESH:D014604 Uveal Neoplasms Tretinoin 4.6716752155
MESH:D014605 Uveitis Cyclosporine 4.051336536
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.4816513791 16002989
MESH:D014652 Vascular Diseases sodium arsenite 4.4717056641
MESH:D014820 Vitiligo Tretinoin 4.0916761959
MESH:D015430 Weight Gain Clozapine 4.4920521320 20107430 16402076 17502770 16141801 20564506
MESH:D015431 Weight Loss Clozapine 5.1317933447
MESH:D009396 Wilms Tumor Tretinoin 3.9916287080
MESH:D014985 Xerophthalmia Cyclosporine 4.5017120751
Pathway ID Pathway Name
KEGG:05010 Alzheimer's disease
REACT:18266 Axon guidance
KEGG:04360 Axon guidance
REACT:604 Hemostasis
REACT:15295 Opioid Signalling
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26310
    • No data
    No data
    Releated drug ID Related drug Name
    PA152241909PP2
    PA164743471adenosine triphosphate
    PA449396dopamine
    PA450550morphine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB02052 inhibitor Indirubin-3'-Monoxime
    DB02116 inhibitor Olomoucine Enzyme Inhibitors
    DB02950 inhibitor Hymenialdisine
    DB03428 inhibitor SU9516
    DB03496 - Flavopiridol Antineoplastic Agents;Growth Inhibitors;Protein Kinase Inhibitors;Glycogen Phosphorylase inhibitor
    DB04014 - Alsterpaullone
    DB07364 - 6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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