AutismKB 2.0

Annotation Detail for CALCRL


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Basic Information Top
Gene Symbol:CALCRL ( CGRPR,CRLR )
Gene Full Name: calcitonin receptor-like
Band: 2q32.1
Quick LinksEntrez ID:10203; OMIM: 114190; Uniprot ID:CALRL_HUMAN; ENSEMBL ID: ENSG00000064989; HGNC ID: 16709
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04270Vascular smooth muscle contraction
hsa04080Neuroactive ligand-receptor interaction
Pathway IDPathway Name
Signaling by GPCR
No data
No data
Pathway IDPathway Name
500429Calcitonin-like ligand receptors
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1781Rheumatoid arthritis
2091Hypertension
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C068073 Am 580 Am 580 results in decreased expression of CALCRL mRNAdecreases expression 16982809
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CALCRL mRNAaffects expression 16483693
D001151 Arsenic Arsenic results in decreased expression of CALCRL mRNAdecreases expression 19654921
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of CALCRL mRNAdecreases expression 20713471
C006780 bisphenol A bisphenol A affects the expression of CALCRL mRNAaffects expression 20170705
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of CALCRL mRNAdecreases expression 17484886
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of CALCRL mRNAincreases expression 16713642
D016572 Cyclosporine Cyclosporine results in decreased expression of CALCRL mRNAdecreases expression 20106945
D004041 Dietary Fats Dietary Fats results in decreased expression of CALCRL mRNAdecreases expression 18721800
D004958 Estradiol Estradiol results in decreased expression of CALCRL mRNAdecreases expression 15469997
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of CALCRL mRNAaffects expression 20170705
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of CALCRL mRNAdecreases expression 17351261
D007545 Isoproterenol Isoproterenol results in increased expression of CALCRL mRNAincreases expression 17250927
D007545 Isoproterenol [Phenylephrine co-treated with Isoproterenol] results in increased expression of CALCRL mRNAaffects cotreatment|increases expression 17250927
D008748 Methylcholanthrene Methylcholanthrene results in decreased expression of CALCRL mRNAdecreases expression 20713471
C525458 N-(6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl)-4-(2-oxo-2,3-dihydro-1H-imidazo(4,5-b)pyridin-1-yl)piperidine-1-carboxamide N-(6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl)-4-(2-oxo-2,3-dihydro-1H-imidazo(4,5-b)pyridin-1-yl)piperidine-1-carboxamide binds to and results in decreased activity of CALCRL proteinaffects binding|decreases activity 19346171
C029938 nickel sulfate nickel sulfate results in increased expression of CALCRL mRNAincreases expression 16780908
C492454 olcegepant olcegepant binds to and results in decreased activity of CALCRL proteinaffects binding|decreases activity 19346171
D010126 Ozone Ozone results in decreased expression of CALCRL mRNAdecreases expression 17095637
17460151
D010656 Phenylephrine [Phenylephrine co-treated with Isoproterenol] results in increased expression of CALCRL mRNAaffects cotreatment|increases expression 17250927
C006253 pirinixic acid pirinixic acid results in increased expression of CALCRL mRNAincreases expression 17426115
D011374 Progesterone Progesterone results in increased expression of CALCRL mRNAincreases expression 15469997
C089730 rosiglitazone rosiglitazone results in decreased expression of CALCRL mRNAdecreases expression 16982809
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of CALCRL mRNAdecreases expression 18796159
D014028 Tobacco Smoke Pollution Tobacco Smoke Pollution results in increased expression of CALCRL mRNAincreases expression 18087596
D014635 Valproic Acid Valproic Acid results in increased expression of CALCRL mRNAincreases expression 19101580
C025643 vinclozolin vinclozolin affects the expression of CALCRL mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.7414514962 15322242 11752688
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 7.748875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.7719490988
MESH:D000138 Acidosis Ammonium Chloride 3.3918287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7717505938
MESH:D055371 Acute Lung Injury nickel sulfate 8.6119131640 12718980 11954676 16100012
MESH:D055371 Acute Lung Injury pirinixic acid 8.6118653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.7420464547 20127859
MESH:D000230 Adenocarcinoma Estradiol 6.7411473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.7414692618
MESH:D002282 Adenocarcinoma, Bronchiolo-Alveolar Tobacco Smoke Pollution 5.3615814487
MESH:D000236 Adenoma Benzo(a)pyrene 6.546695378
MESH:D000236 Adenoma Methylcholanthrene 6.5410545420 6695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.3316434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.3316835633
MESH:D018246 Adrenocortical Adenoma Arsenic 5.0417306315
MESH:D000544 Alzheimer Disease Ozone 4.3515513908
MESH:D000544 Alzheimer Disease rosiglitazone 4.3519621015
MESH:D000550 Amblyopia Valproic Acid 5.0617688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8011748828
MESH:D001008 Anxiety Disorders Valproic Acid 8.4017497229
MESH:D001008 Anxiety Disorders vinclozolin 8.4019015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9019183758
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 3.9617460149
MESH:D020261 Arsenic Poisoning Arsenic 2.8216251483 12569548 18414634 16835338
MESH:D001161 Arteriosclerosis Dietary Fats 9.3415238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.3411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5615885639
MESH:D001172 Arthritis, Rheumatoid Ozone 4.8715570426
MESH:D001172 Arthritis, Rheumatoid Tobacco Smoke Pollution 4.8719898480
MESH:D001249 Asthma Ozone 2.5916373670 17854713
MESH:D050197 Atherosclerosis Arsenic 6.6219371607 12928151
MESH:D050197 Atherosclerosis Methylcholanthrene 6.6211922910
MESH:D001321 Autistic Disorder Valproic Acid 2.0217507914 19460635 17688650 19232924 17157402 18396377 18316065 18177632 18775368 16609825 18940202 18985861 18558336 20603192 15238991
MESH:D001714 Bipolar Disorder Valproic Acid 2.9920046352 17594078
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.2519483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.2512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.6615746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.668888407
MESH:D001862 Bone Resorption bisphenol A 3.7111985600
MESH:D001919 Bradycardia Isoproterenol 10.386740701
MESH:D001919 Bradycardia Phenylephrine 10.3815306635
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.1717868700
MESH:D001930 Brain Injuries Progesterone 4.0915665606 15380490 15845082
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 3.6620146248 17474063
MESH:D001943 Breast Neoplasms bisphenol A 3.6617123778
MESH:D001943 Breast Neoplasms Dietary Fats 3.6620435547
MESH:D001943 Breast Neoplasms Estradiol 3.6616675129 17289903 17261762 12948864 18497071 14630087 19861407 17018787
MESH:D001943 Breast Neoplasms Methylcholanthrene 3.6617474063
MESH:D001943 Breast Neoplasms Progesterone 3.6615562024 16175315 17614352
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.6620435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.5416777450 14754758 18417511 17626835 15516495 19059883 18315731
MESH:D002100 Cachexia Ozone 4.5716183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2916111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.6116227642 16124888 15700767 16097048 3786805 16011737 16192424 18705752 16050911 10355542 15721981 15673190
MESH:D002277 Carcinoma Methylcholanthrene 7.8810545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.8816835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.5015504454 17687452
MESH:D006528 Carcinoma, Hepatocellular Arsenic 4.4817306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.4818788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.4816924424
MESH:D002278 Carcinoma in Situ bisphenol A 4.8217123778
MESH:D002289 Carcinoma, Non-Small-Cell Lung Tobacco Smoke Pollution 3.3711212258
MESH:D002294 Carcinoma, Squamous Cell Arsenic 7.3815504454 18922899 17687452
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.3820419170
MESH:D002294 Carcinoma, Squamous Cell Tobacco Smoke Pollution 7.3811212258
MESH:D002295 Carcinoma, Transitional Cell Arsenic 3.9318640142
MESH:D006332 Cardiomegaly Isoproterenol 11.047544033 11179087
MESH:D006332 Cardiomegaly Phenylephrine 11.0411179087 11754973 16170337 17124262 17287366 15728586
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 11.0418850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Arsenic 3.3319152805 15738583 17938729
MESH:D002340 Carotid Artery Diseases Arsenic 4.1618022660 16973168
MESH:D002386 Cataract Am 580 4.2517460283
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 10.5612371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 10.5618566989
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 10.5616192471
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.6520734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D002779 Cholestasis Cyclosporine 12.6119486331
MESH:D002779 Cholestasis Ethinyl Estradiol 12.6117110522 16919318 17333356 16105132 17681005 11677210 15861022
MESH:D002779 Cholestasis pirinixic acid 12.6119176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0315668235 15340226 16354765 12621046 8697196
MESH:D003092 Colitis Am 580 4.7917035595
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4220055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.428888407 17688650 16575769
MESH:D003456 Cryptorchidism vinclozolin 4.1714966744
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 3.5116823706 16780908 11298694
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3518249437
MESH:D003920 Diabetes Mellitus rosiglitazone 4.1517446233
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 4.3512642470
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3517107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.2719279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.3217187935
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 5.902869522 9327722 21278145 16227642 10915739 15968718 7440962 17522070 11566570 6623471 3732212 15998439 7179309 4309450 3786805 19085960 15027814 16177239 10092053 6884620 19336974 7120509
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 5.9020420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 5.901733752 19641884
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6311462148
MESH:D050171 Dyslipidemias Dietary Fats 3.3318367378
MESH:D004421 Dystonia Valproic Acid 3.891851702
MESH:D004487 Edema pirinixic acid 10.5712083418
MESH:D004487 Edema rosiglitazone 10.5712083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.5711000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7316714409 18230668 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.4812538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 8.4817692515
MESH:D016889 Endometrial Neoplasms Estradiol 2.8719148513 11473722 18566989
MESH:D004715 Endometriosis Progesterone 8.4316134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.439294722 10568697
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 3.983659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 3.7516628512 3922381
MESH:D004827 Epilepsy Valproic Acid 2.8518234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.446254150 6426943 7562514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.137750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.893659116
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 1.9716530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8911564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 34.5916045604 17595544 12795759 16239168 12631006 61145 15959796 19224547
MESH:D005234 Fatty Liver Cyclosporine 34.5919224547
MESH:D005234 Fatty Liver Dietary Fats 34.5919551842 18296743 19004024 17967931
MESH:D005234 Fatty Liver Ethinyl Estradiol 34.5915345470
MESH:D005234 Fatty Liver pirinixic acid 34.5919236843 20131406
MESH:D005234 Fatty Liver rosiglitazone 34.5919196556
MESH:D005234 Fatty Liver Valproic Acid 34.5914986274 19224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2911858732
MESH:D005315 Fetal Diseases Valproic Acid 4.7116575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.9618558336 8888407
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.7714633661 10962813
MESH:D005355 Fibrosis Carbon Tetrachloride 19.7318705752
MESH:D005355 Fibrosis Cyclosporine 19.7312168785 12639820
MESH:D005355 Fibrosis Dietary Fats 19.7318296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 19.7320067830
MESH:D005534 Foot Diseases Arsenic 5.396392382
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.7616973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.1316417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.058708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4210696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.1520471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.1511294989 10048152
MESH:D006333 Heart Failure Isoproterenol 7.0318097624
MESH:D006333 Heart Failure pirinixic acid 7.0320558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2515720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1811000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.4319900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 7.7018467677 16221962 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.7016120746 12621046 15340226
MESH:D006558 Herpes Genitalis Estradiol 4.8615709030
MESH:D019584 Hot Flashes Estradiol 3.5817088409
MESH:D006849 Hydrocephalus Valproic Acid 4.6917688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8715340226 8697196 18606429 16959395 16354765
MESH:D006930 Hyperalgesia rosiglitazone 3.7812083418
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3616899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.4421332399
MESH:D006943 Hyperglycemia pirinixic acid 3.0320558911
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.3017050553
MESH:D006949 Hyperlipidemias Dietary Fats 3.4521332399
MESH:D006973 Hypertension Arsenic 11.8516076760 11953799 9931084
MESH:D006973 Hypertension Cyclosporine 11.8510903974
MESH:D006973 Hypertension Phenylephrine 11.8512717712 8949925
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 11.8518850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9215338365
MESH:D006984 Hypertrophy Isoproterenol 10.4812791704
MESH:D006984 Hypertrophy Phenylephrine 10.4818502941 12791704
MESH:D006987 Hypesthesia Arsenic 5.3916093927
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6416945680 16569931
MESH:D007022 Hypotension Isoproterenol 4.636740701
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.2315869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3012013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.2817937319
MESH:D007248 Infertility, Male vinclozolin 6.2816467254
MESH:D007249 Inflammation Dietary Fats 14.9520412841
MESH:D007249 Inflammation Progesterone 14.9515869954
MESH:D007249 Inflammation rosiglitazone 14.9512083418
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 14.9512200463 12878042
MESH:D007249 Inflammation Tobacco Smoke Pollution 14.9518590791
MESH:D007333 Insulin Resistance bisphenol A 22.0116393666
MESH:D007333 Insulin Resistance Dietary Fats 22.0111836018 18457598
MESH:D007333 Insulin Resistance Estradiol 22.0116393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 22.0116306350
MESH:D007333 Insulin Resistance rosiglitazone 22.0116306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1816580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2715604871
MESH:D007642 Keratosis Arsenic 4.8212749816 16930632
MESH:D007674 Kidney Diseases Cyclosporine 5.6118776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 5.6115618244
MESH:D007680 Kidney Neoplasms Cyclosporine 6.8112371664
MESH:D007680 Kidney Neoplasms Estradiol 6.8115610895
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1217596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.4417339181
MESH:D007984 Leydig Cell Tumor vinclozolin 4.5616417039
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.3211903743 16239168 17174718 11408273 16221502 17334410 21278145 17157831 16943688
MESH:D008103 Liver Cirrhosis Dietary Fats 6.3218296743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.5012389079 16136751 15052691 14748882 15959796 17481882 11481614 17557913 12445418 17869086 16116963 18472332 14716496 12649538 16027843 18395914 16097048 18472094 17976157 18277467 15057751 15673190 18263696 15925388 14620537 15818738 12667390 12546737 14512876 17714472 15370692 15730626 18420326 15931870 18166357 18412020 17698563 18376398 17944888 16638106 18156304 18251166 16033810 12632514 18395095 12898905 15650968 17922224 17823541 12741479 16015684 16192424 15876570 15996030 17565644 18187930 18054572 15362042 14724832 17766677 12445421 15123356 10355542 12958196 17721639 18205269 18418968 15338365 12609069 13678700 20821823 12586293 14716833 18339082 12666154 18210741 18006644 17631135 17640975 17708605 16011737 16248980 18279442 17805973 17525996 12632512 18705752 17761835 15893842 17900296 18429990 18317297 18481824
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.5014716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.5015474484
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 6.5017347453 15980055
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.5012878042
MESH:D008107 Liver Diseases Arsenic 4.0911134558
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.0915830285 17285989 15720792 16246199 16964402
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9915123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.5416899240 14706259
MESH:D008113 Liver Neoplasms Arsenic 13.5416368122
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 13.5421137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 13.5419294768
MESH:D008113 Liver Neoplasms pirinixic acid 13.5420007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 13.5416984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 9.2615583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 9.26598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.2612151625
MESH:D008171 Lung Diseases Ozone 3.268266340 19066396
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.0917228818
MESH:D055370 Lung Injury Ozone 3.6820417186
MESH:D008175 Lung Neoplasms Arsenic 8.2917306315 17976673 19168569
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 8.2918569708 6695378 20464547 18520028 18816296 17053015 20064080 20135361 20869020
MESH:D008175 Lung Neoplasms Methylcholanthrene 8.2910545420 1399818 11893704 16337739 20970405 17909032 16271038 6695378 7750092 21163286 15390079 9230183 20512841
MESH:D008175 Lung Neoplasms Ozone 8.297614698 8597069
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.2911884234 19555203
MESH:D008175 Lung Neoplasms Tobacco Smoke Pollution 8.2916288123 3440675 12111688 11091918
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 9.4411408345 16891317 11807958 17203775
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 9.4417203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 9.4416827153
MESH:D020149 Manganese Poisoning Estradiol 4.3119453300
MESH:D024821 Metabolic Syndrome X rosiglitazone 4.2317261469
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.6216801185
MESH:D008679 Metaplasia Ozone 4.9310496685
MESH:D008881 Migraine Disorders N-(6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl)-4-(2-oxo-2,3-dihydro-1H-imidazo(4,5-b)pyridin-1-yl)piperidine-1-carboxamide 12.6219346171
MESH:D008881 Migraine Disorders olcegepant 12.6219346171
MESH:D008881 Migraine Disorders Valproic Acid 12.6218803445 18765137
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.3616381670
MESH:D009062 Mouth Neoplasms Tobacco Smoke Pollution 8.3615006635
MESH:D009135 Muscular Diseases pirinixic acid 3.3416239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.878888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.0617596541
MESH:D009203 Myocardial Infarction Isoproterenol 5.8019595682 19172585 16538859 16584858 17052832 15740881 16697266
MESH:D009203 Myocardial Infarction pirinixic acid 5.8019151258
MESH:D017202 Myocardial Ischemia Arsenic 8.5515371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.5512213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.8116810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.8116411023
MESH:D009369 Neoplasms Benzo(a)pyrene 4.5411141357
MESH:D009369 Neoplasms pirinixic acid 4.5417405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5617289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2717954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1418481113 19348381
MESH:D009421 Nervous System Malformations bisphenol A 15.3916427766 11399458
MESH:D009421 Nervous System Malformations Estradiol 15.3911399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 15.3914600291
MESH:D009436 Neural Tube Defects Arsenic 7.0816620997
MESH:D009436 Neural Tube Defects Valproic Acid 7.0816359493 8888407
MESH:D020078 Neurogenic Inflammation Arsenic 4.2117056641
MESH:D009765 Obesity Dietary Fats 4.2911836018 20518802 21332399 17217161 16723640 20132043 18674790 19632207 18457598
MESH:D009765 Obesity pirinixic acid 4.2920558911
MESH:D010049 Ovarian Diseases bisphenol A 4.8211985600
MESH:D010051 Ovarian Neoplasms Arsenic 7.6217306315
MESH:D010051 Ovarian Neoplasms Estradiol 7.6219401270
MESH:D010051 Ovarian Neoplasms Progesterone 7.6216525653 17393432
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5311578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0812520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.0116093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.8216905509 6392382 15371236
MESH:D010538 Peritonitis Ozone 3.9616369182
MESH:D011014 Pneumonia Ozone 4.2218381685 18929643 18007984
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3918163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.0812371664
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 21.8210548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 21.8211399792 11118676 11222880 11896295
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 21.8220603192
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 21.8218220299 18042343 19015723
MESH:D011469 Prostatic Diseases vinclozolin 4.7618220299
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 10.0320887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 10.0320887781
MESH:D011471 Prostatic Neoplasms Arsenic 2.1116140617
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.1117292933
MESH:D011471 Prostatic Neoplasms bisphenol A 2.1116740699
MESH:D011471 Prostatic Neoplasms Estradiol 2.1116740699
MESH:D011472 Prostatitis vinclozolin 4.7618629315
MESH:D011507 Proteinuria Arsenic 3.8421343184
MESH:D011537 Pruritus Ethinyl Estradiol 3.1416919318 15861022
MESH:D019310 Pseudolymphoma Valproic Acid 4.3711422049 12752131
MESH:D011565 Psoriasis Cyclosporine 2.1716882103
MESH:D011629 Puberty, Precocious bisphenol A 4.6110548101
MESH:D011654 Pulmonary Edema Isoproterenol 5.0810903255
MESH:D015427 Reperfusion Injury pirinixic acid 2.3019058328
MESH:D012135 Respiratory Sounds Tobacco Smoke Pollution 4.4518410779
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6718990726
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.0119155313
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8018045962
MESH:D012559 Schizophrenia Valproic Acid 2.0519110320 15737665
MESH:D012640 Seizures Valproic Acid 2.633137016 15475178 11738929 16876388 1511512 14763951 17978042 11044598
MESH:D012852 Sinusitis Phenylephrine 4.537327846
MESH:D012871 Skin Diseases Arsenic 2.7019834688 18709164 16353154 17453740 6392382 17938729 16702368 17548696 16759981 15952646 17050553
MESH:D012878 Skin Neoplasms Arsenic 12.9517029826 17050553 16251483 19538983 15504454 17976673
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 12.9519755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 12.9516192470
MESH:D012878 Skin Neoplasms Tobacco Smoke Pollution 12.9518590791
MESH:D013088 Spermatocele Ethinyl Estradiol 3.7716709447
MESH:D013119 Spinal Cord Injuries Progesterone 4.1116503802 15862959
MESH:D016135 Spinal Dysraphism Valproic Acid 3.6519490988
MESH:D013226 Status Epilepticus Valproic Acid 4.3712833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5520155912 2093021
MESH:D019966 Substance-Related Disorders bisphenol A 3.8116684133 16045194
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4611994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0115669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7312697716
MESH:D013978 Tibial Fractures Estradiol 4.5119048282
MESH:D014178 Translocation, Genetic Valproic Acid 5.0617262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.353119515
MESH:D001749 Urinary Bladder Neoplasms Arsenic 8.0918640142 11144890 19429237 17306315 15987713 17976673 19322015
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.0917053015
MESH:D001749 Urinary Bladder Neoplasms Tobacco Smoke Pollution 8.0912846360
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.478888407
MESH:D014591 Uterine Diseases bisphenol A 4.8414652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.1314692618
MESH:D014605 Uveitis Cyclosporine 3.811336536
MESH:D014652 Vascular Diseases Arsenic 4.5617056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4212125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3814671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Isoproterenol 4.9518097624
MESH:D020257 Ventricular Remodeling Isoproterenol 5.5118097624
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0815886252
MESH:D015430 Weight Gain Dietary Fats 3.5916723640
MESH:D014985 Xerophthalmia Cyclosporine 4.2717120751
Pathway ID Pathway Name
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:14797 Signaling by GPCR
KEGG:04270 Vascular smooth muscle contraction
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26033
    • Releated gene ID Related gene Name
    PA26033CALCRL
    No data
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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