AutismKB 2.0

Annotation Detail for CDK6


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Basic Information Top
Gene Symbol:CDK6 ( MGC59692,PLSTIRE )
Gene Full Name: cyclin-dependent kinase 6
Band: 7q21.2
Quick LinksEntrez ID:1021; OMIM: 603368; Uniprot ID:CDK6_HUMAN; ENSEMBL ID: ENSG00000105810; HGNC ID: 1777
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04110Cell cycle
hsa04115p53 signaling pathway
hsa05223Non-small cell lung cancer
hsa05222Small cell lung cancer
hsa05220Chronic myeloid leukemia
hsa05218Melanoma
hsa05212Pancreatic cancer
hsa05214Glioma
hsa05200Pathways in cancer
Pathway IDPathway Name
Cell Cycle, Mitotic
Pathway IDPathway Name
200038Coregulation of Androgen receptor activity
200130C-MYB transcription factor network
200158IL2 signaling events mediated by STAT5
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
rheumatoid arthritis
ER positive
height
Wegener's granulomatosis
CANCER
IMMUNE
DEVELOPMENTAL
Desease Name
Height
Hematological and biochemical traits
Rheumatoid arthritis
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of CDK6 mRNAdecreases expression 19933214
C054852 7-hydroxystaurosporine 7-hydroxystaurosporine results in decreased activity of CDK6 proteindecreases activity 14653808
D000082 Acetaminophen Acetaminophen affects the expression of CDK6 mRNAaffects expression 17562736
C430898 AGN 194204 AGN 194204 results in decreased expression of CDK6 proteindecreases expression 15318936
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CDK6 mRNAaffects expression 16483693
D000643 Ammonium Chloride Ammonium Chloride results in increased expression of CDK6 proteinincreases expression 16483693
D001554 Benzene [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of CDK6 mRNAaffects cotreatment|increases expression 17905399
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of CDK6 mRNAdecreases expression 20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CDK6 mRNAdecreases expression 20018196
19150397
D001599 Berberine Berberine results in decreased expression of CDK6 proteindecreases expression 16505103
C026105 butylidenephthalide butylidenephthalide results in decreased expression of CDK6 proteindecreases expression 16987298
C026105 butylidenephthalide butylidenephthalide results in decreased expression of CDK6 proteindecreases expression 16987298
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of CDK6 mRNAincreases expression 17484886
D003474 Curcumin Curcumin results in decreased expression of CDK6 proteindecreases expression 18156803
C045651 epigallocatechin gallate epigallocatechin gallate results in decreased expression of CDK6 proteindecreases expression 15142168
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of CDK6 mRNAaffects expression 17555576
C403899 HS 1030 HS 1030 results in decreased expression of CDK6 proteindecreases expression 15202011
C403900 HS 1183 HS 1183 results in decreased expression of CDK6 proteindecreases expression 15202011
C503536 HS-1199 HS-1199 results in decreased expression of CDK6 proteindecreases expression 15202011
C479128 HS 1200 HS 1200 results in decreased expression of CDK6 proteindecreases expression 15202011
C016517 indole-3-carbinol indole-3-carbinol analog inhibits the reaction [SP1 protein binds to CDK6 promoter]affects binding|decreases reaction 20570586
C016517 indole-3-carbinol indole-3-carbinol analog results in decreased activity of CDK6 proteindecreases activity 20570586
C016517 indole-3-carbinol indole-3-carbinol analog results in decreased expression of CDK6 proteindecreases expression 20570586
C016517 indole-3-carbinol indole-3-carbinol analog results in increased expression of CDK6 mRNAincreases expression 20570586
C016517 indole-3-carbinol indole-3-carbinol results in decreased expression of CDK6decreases expression 16082211
C506002 ircinin-1 ircinin-1 results in decreased expression of CDK6 mRNAdecreases expression 16163705
C506002 ircinin-1 ircinin-1 results in decreased expression of CDK6 proteindecreases expression 16163705
C051890 irinotecan irinotecan analog affects the expression of CDK6 mRNAaffects expression 18927307
C030957 methylmercury II [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of CDK6 mRNAaffects cotreatment|increases expression 17905399
C008493 methylselenic acid methylselenic acid promotes the reaction [CDKN2A protein binds to CDK6 protein]affects binding|increases reaction 17847021
C008493 methylselenic acid methylselenic acid results in decreased activity of [CDKN2A protein binds to CDK6 protein]affects binding|decreases activity 17847021
D037742 Nanotubes, Carbon Nanotubes, Carbon results in decreased expression of CDK6 mRNAdecreases expression 15585362
C482884 panduratin A panduratin A results in decreased expression of CDK6 proteindecreases expression 16497706
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CDK6 mRNAaffects binding|decreases expression|increases activity 19710929
D010936 Plant Extracts Plant Extracts results in decreased expression of CDK6 proteindecreases expression 15930460
C059514 resveratrol resveratrol results in decreased expression of CDK6 proteindecreases expression 16761963
D013467 Sulindac Sulindac results in decreased expression of CDK6 proteindecreases expression 16488075
D013629 Tamoxifen Tamoxifen affects the expression of CDK6 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CDK6 mRNAincreases expression 12377990
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of CDK6 mRNAdecreases expression 19933214
D014241 Trichloroethylene [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of CDK6 mRNAaffects cotreatment|increases expression 17905399
D014415 Tunicamycin Tunicamycin results in decreased expression of CDK6 mRNAdecreases expression 17127020
D015215 Zidovudine [Zidovudine co-treated with IFNA1 protein] results in decreased expression of CDK6 mRNAaffects cotreatment|decreases expression 20370541
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Sulindac 11.8714745880
MESH:D000008 Abdominal Neoplasms Tamoxifen 11.8714745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.5114514962 15322242 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.2218287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6017505938
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 4.499612607
MESH:D058186 Acute Kidney Injury resveratrol 8.0116538975
MESH:D058186 Acute Kidney Injury Sulindac 8.017897758
MESH:D055371 Acute Lung Injury pirinixic acid 2.8118653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.5820127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.5814692618
MESH:D000230 Adenocarcinoma Sulindac 6.5811910360
MESH:D000236 Adenoma Benzo(a)pyrene 10.176695378
MESH:D000236 Adenoma resveratrol 10.1715688382
MESH:D000236 Adenoma Sulindac 10.1710223192
MESH:D018248 Adenoma, Liver Cell pirinixic acid 8.7716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.7716835633
MESH:D011125 Adenomatous Polyposis Coli Sulindac 4.3111535846 11874996 19003578 17611924 12394442 16460482 15623613
MESH:D019973 Alcohol-Related Disorders Curcumin 4.7417887948
MESH:D000544 Alzheimer Disease Curcumin 6.3015590663
MESH:D000544 Alzheimer Disease Plant Extracts 6.3016962711
MESH:D000544 Alzheimer Disease resveratrol 6.3016183991 16162502
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6511748828
MESH:D000741 Anemia, Aplastic Benzene 4.1111369114 17661222 14761424
MESH:D000799 Angioedema Acetaminophen 3.5010982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.7419183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.1311256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 11.1715885639
MESH:D001169 Arthritis, Experimental Plant Extracts 11.1714686799
MESH:D001169 Arthritis, Experimental resveratrol 11.1717115116
MESH:D001172 Arthritis, Rheumatoid marker/mechanism 18794853
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.6516807698
MESH:D001249 Asthma epigallocatechin gallate 3.2816516891
MESH:D050197 Atherosclerosis Curcumin 6.2418704882
MESH:D050197 Atherosclerosis resveratrol 6.2416873680 17967414
MESH:D001321 Autistic Disorder Acetaminophen 1.4518445737
MESH:D001327 Autoimmune Diseases Curcumin 10.0019761891
MESH:D001327 Autoimmune Diseases epigallocatechin gallate 10.0019761891
MESH:D001778 Blood Coagulation Disorders pirinixic acid 7.7619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.7612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5515746008
MESH:D001855 Bone Marrow Diseases Benzene 4.8816183116
MESH:D001862 Bone Resorption Berberine 5.139881647
MESH:D001913 Bowen's Disease Sulindac 5.0111207687
MESH:D002545 Brain Ischemia Curcumin 15.1716770732
MESH:D002545 Brain Ischemia Plant Extracts 15.1716041641
MESH:D002545 Brain Ischemia resveratrol 15.1717600658
MESH:D001932 Brain Neoplasms Curcumin 3.6517596214
MESH:D001943 Breast Neoplasms Benzene 5.4611921183 17162533
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 5.4617474063 20146248
MESH:D001943 Breast Neoplasms Curcumin 5.4619250217 16243823 18593918 18462866
MESH:D001943 Breast Neoplasms indole-3-carbinol 5.4616082211
MESH:D001943 Breast Neoplasms resveratrol 5.4616393696 17534123 17651959
MESH:D001943 Breast Neoplasms Sulindac 5.4616642371
MESH:D001943 Breast Neoplasms Tamoxifen 5.4619084267 18855134 17261762 17440819 19288272 19059307 19200415 19244106 21152245 16273361 19011961 18984771 20859285 19066611 20390343 19142967 15668708 19410462 19189210 20005174 18629630 19487384 19155303 19103187 17893378 18997820 19115204 16873071 15565566 18425577 18815881 17242785 16202921 17049068 19221464 20065188 20135344 18351453 19189212 21138602 20544844 18821012 11161223 16818667 19289846
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 5.4620435547
MESH:D001943 Breast Neoplasms Trichloroethylene 5.4615986119
MESH:D002057 Burns, Chemical Plant Extracts 4.999625245
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.4515721981 16192424 10355542 16124888 16227642 16050911 15700767 16097048 3786805 18705752 15673190 16011737
MESH:D002277 Carcinoma Curcumin 7.4018593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.4016835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.1719066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.223084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 8.2218788625
MESH:D006528 Carcinoma, Hepatocellular Plant Extracts 8.2218834353
MESH:D006528 Carcinoma, Hepatocellular resveratrol 8.2216227395 19321006
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 8.2216924424
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.2516675471
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.8618414057
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 6.9920419170
MESH:D002294 Carcinoma, Squamous Cell Curcumin 6.9918462866
MESH:D002294 Carcinoma, Squamous Cell resveratrol 6.9916227395
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.3217572228
MESH:D006332 Cardiomegaly Plant Extracts 6.3417645561
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.3416120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases resveratrol 3.2415458977
MESH:D002386 Cataract Acetaminophen 2.3810977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.5020889678
MESH:D054506 Chloracne marker/mechanism 17101203
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.8816835633
MESH:D002779 Cholestasis Ethinyl Estradiol 6.9116919318 17333356 17681005 15861022 11677210 17110522 16105132
MESH:D002779 Cholestasis pirinixic acid 6.9119176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.968697196 15340226 12621046 15668235 16354765
MESH:D003092 Colitis Curcumin 8.6918200517 16804969 16782535
MESH:D003092 Colitis resveratrol 8.6916474422
MESH:D003103 Coloboma Curcumin 4.2518809619
MESH:D003110 Colonic Neoplasms Curcumin 7.8019359593 16340194
MESH:D003110 Colonic Neoplasms irinotecan 7.8017287894 17725105
MESH:D003110 Colonic Neoplasms resveratrol 7.8016338953
MESH:D003110 Colonic Neoplasms Sulindac 7.8012458338 12902858
MESH:D015179 Colorectal Neoplasms irinotecan 3.4517454858 16391804 16303861 18259882 18509181 17159606 15273666
MESH:D015179 Colorectal Neoplasms resveratrol 3.4516550006
MESH:D015179 Colorectal Neoplasms Sulindac 3.4518059344 11076880 10666051 11197048
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7817141729 14669216
MESH:D016510 Corneal Neovascularization Curcumin 4.5618497527
MESH:D003327 Coronary Disease resveratrol 3.5316507316
MESH:D019465 Craniofacial Abnormalities Benzene 2.5615643154
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5615322242 20055451 10048152
MESH:D003711 Demyelinating Diseases Tamoxifen 4.0319031437
MESH:D003872 Dermatitis Benzene 4.4315902427
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2718249437
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.5016873680
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 6.7418403477
MESH:D003924 Diabetes Mellitus, Type 2 epigallocatechin gallate 6.7416988119
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.7417107852
MESH:D003928 Diabetic Nephropathies Curcumin 19.1518204486
MESH:D003928 Diabetic Nephropathies Plant Extracts 19.1519706694
MESH:D003928 Diabetic Nephropathies resveratrol 19.1516286809
MESH:D003928 Diabetic Nephropathies Tamoxifen 19.1519279558
MESH:D003930 Diabetic Retinopathy Sulindac 4.8517621415 12861449
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.1019164858 10915739 19923254 14986274 10774834 11834606 16081117 16227642 19420014 18071297 17562736 11461765 19085960 19416960 16393943 17906064 16109766 17522070 16177239 11421492 19370779 11287661 2444490 12705907 12392966 12958197 12594235 11529661 18713872 16781746 16485898 14550746 11743745 12540782 15968718 19739265 11739529 14725611 15619225 10663392 12153990
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 8.1015027814 3732212 10092053 7120509 2869522 15968718 6884620 3786805 19336974 6623471 7179309 4309450 11566570 15998439 16227642 9327722 21278145 17522070 10915739 7440962 19085960 16177239
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.1020420201
MESH:D056486 Drug-Induced Liver Injury Trichloroethylene 8.107120509
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.7519426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.4011462148
MESH:D004362 Drug Toxicity Zidovudine 7.4015040536
MESH:D004381 Duodenal Ulcer Curcumin 3.7317351913
MESH:D004487 Edema pirinixic acid 14.0012083418
MESH:D004487 Edema Plant Extracts 14.0012787963
MESH:D004487 Edema resveratrol 14.008985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 14.0012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.5615322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 13.4912538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 13.4917872969
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 13.4919031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 2.8217893378 16202921 19155303 20544844
MESH:D004715 Endometriosis Sulindac 8.2215652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.229294722 10568697
MESH:D004719 Endomyocardial Fibrosis Plant Extracts 5.3315268973
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.5217923197
MESH:D004827 Epilepsy Plant Extracts 3.5519700373 19439326
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.7620426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 6.7616530937
MESH:D004938 Esophageal Neoplasms Sulindac 6.7612235107
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.7611564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 32.3116239168 12631006 15959796 19224547 17595544 16045604 12795759 61145
MESH:D005234 Fatty Liver Curcumin 32.3119297423
MESH:D005234 Fatty Liver Ethinyl Estradiol 32.3115345470
MESH:D005234 Fatty Liver pirinixic acid 32.3120131406 19236843
MESH:D005234 Fatty Liver Plant Extracts 32.3115975614
MESH:D005234 Fatty Liver Tamoxifen 32.3114986274 19224547
MESH:D005234 Fatty Liver Zidovudine 32.3118299183
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.0316709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1211858732
MESH:D018221 Fibromatosis, Abdominal Sulindac 11.8214745880
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 11.8214745880
MESH:D018222 Fibromatosis, Aggressive Sulindac 10.5119069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 10.5119069698
MESH:D005355 Fibrosis Carbon Tetrachloride 12.9018705752
MESH:D005355 Fibrosis Curcumin 12.9018705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 12.9020067830
MESH:D005756 Gastritis Acetaminophen 3.3316983495
MESH:D005764 Gastroesophageal Reflux Sulindac 4.6911910360
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.3618462866
MESH:D005909 Glioblastoma butylidenephthalide 7.3116987298
MESH:D005909 Glioblastoma Curcumin 7.3117596214
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2510696789
MESH:D006258 Head and Neck Neoplasms Curcumin 3.4318462866 18829502
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 5.8420471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.8410048152 11294989
MESH:D006333 Heart Failure pirinixic acid 6.5420558911
MESH:D006333 Heart Failure Plant Extracts 6.5418097624
MESH:D006402 Hematologic Diseases Benzene 10.0416183116
MESH:D006402 Hematologic Diseases Zidovudine 10.0412579204
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0311000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.2719900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 7.1616221962 18467677 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.1616120746 15340226 12621046
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.7117701891
MESH:D006561 Herpes Simplex Plant Extracts 8.9910715843
MESH:D006561 Herpes Simplex resveratrol 8.9916876885
MESH:D015658 HIV Infections Plant Extracts 6.4312878215
MESH:D015658 HIV Infections Zidovudine 6.4311141242 11698656 20032539 11363243 17358032
MESH:D019584 Hot Flashes Plant Extracts 4.4014716179 16566672 17454163
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7016354765 18606429 16959395 15340226 8697196
MESH:D006930 Hyperalgesia Acetaminophen 2.4416870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.1916899240
MESH:D006937 Hypercholesterolemia Curcumin 8.3818704882
MESH:D006937 Hypercholesterolemia resveratrol 8.3817188708
MESH:D006943 Hyperglycemia pirinixic acid 2.8920558911
MESH:D020138 Hyperhomocysteinemia Plant Extracts 4.1816484555
MESH:D006949 Hyperlipidemias Plant Extracts 8.5715268973 15975614
MESH:D006949 Hyperlipidemias resveratrol 8.5716873680
MESH:D006973 Hypertension Benzene 4.8617940673
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.8618670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.7515338365
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.0117488730
MESH:D007021 Hypospadias Ethinyl Estradiol 3.4816569931 16945680
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.3117600658
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.1512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.2617937319
MESH:D007249 Inflammation Curcumin 17.6216956363 17151092 18403477
MESH:D007249 Inflammation Plant Extracts 17.6215997105 16366677 12787963 19332304
MESH:D007249 Inflammation resveratrol 17.6216366677
MESH:D007249 Inflammation Sulindac 17.623291741
MESH:D007249 Inflammation Tamoxifen 17.6219457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 17.6212200463 12878042
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.0718200517 18596194
MESH:D007251 Influenza, Human resveratrol 4.2016624496
MESH:D007333 Insulin Resistance Berberine 7.1518563319
MESH:D007333 Insulin Resistance pirinixic acid 7.1516306350
MESH:D007414 Intestinal Neoplasms Curcumin 14.8510783313
MESH:D007414 Intestinal Neoplasms Plant Extracts 14.8512628509 12351151 12584176
MESH:D007414 Intestinal Neoplasms Sulindac 14.8512584176 10223192 12628509 10213222 12663524 12351151
MESH:D007417 Intestinal Polyps Sulindac 4.6711245490 12394442
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.0316580747
MESH:D007674 Kidney Diseases Acetaminophen 2.0112587719 15629191
MESH:D007680 Kidney Neoplasms Tamoxifen 6.7818625569
MESH:D007680 Kidney Neoplasms Zidovudine 6.7812579204
MESH:D007889 Leiomyoma Curcumin 4.2618555241
MESH:D007938 Leukemia Benzene 6.1417119257 18335105 15935818 14694614
MESH:D007938 Leukemia Curcumin 6.1418462866
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 8.9816106398
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 8.9820370541
MESH:D007951 Leukemia, Myeloid Benzene 4.0217506065
MESH:D015470 Leukemia, Myeloid, Acute marker/mechanism 18206229
MESH:D015470 Leukemia, Myeloid, Acute Benzene 2.6419478238
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.3616087638
MESH:D015458 Leukemia, T-Cell Curcumin 4.4416106398
MESH:D008064 Lipidoses Tamoxifen 2.9115342952 17567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.3111903743 11408273 17157831 16943688 21278145 17334410 17174718 16221502 16239168
MESH:D008103 Liver Cirrhosis Plant Extracts 6.3117157831
MESH:D008105 Liver Cirrhosis, Biliary Sulindac 4.0112468960
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 10.1816192424 15052691 17708605 18156304 17714472 14716833 12958196 18263696 18251166 15123356 12632512 18317297 13678700 15959796 17766677 15996030 15818738 17565644 18376398 16027843 17761835 18420326 18187930 17944888 16248980 15876570 17631135 12609069 18472094 18395095 18472332 17976157 18166357 16011737 15925388 17640975 17869086 12445421 15370692 17525996 18705752 12667390 15893842 18418968 15931870 12741479 18277467 18205269 12898905 18279442 12546737 16033810 14748882 10355542 15673190 17721639 15057751 16097048 14724832 15362042 15650968 12586293 16136751 17900296 12649538 18339082 18210741 18429990 18412020 16638106 16015684 20821823 14512876 12389079 17481882 12445418 17823541 18006644 18395914 14716496 16116963 14620537 12632514 17557913 17698563 17805973 18481824 17922224 12666154 15338365 18054572 15730626 11481614
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 10.1817355460 18006644 18705752
MESH:D008106 Liver Cirrhosis, Experimental epigallocatechin gallate 10.1817481882
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 10.1815474484
MESH:D008106 Liver Cirrhosis, Experimental Plant Extracts 10.1815479170
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 10.1818564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 10.1812878042
MESH:D008107 Liver Diseases Acetaminophen 11.5219014921 16611625 12969438 12587719 19784758 16610002 19460945 11587558
MESH:D008107 Liver Diseases Carbon Tetrachloride 11.5216246199 17285989 15720792 16964402 15830285
MESH:D008107 Liver Diseases Curcumin 11.5216956363
MESH:D008107 Liver Diseases Plant Extracts 11.5217034775
MESH:D008107 Liver Diseases Sulindac 11.5214986274 16867024
MESH:D017093 Liver Failure Carbon Tetrachloride 3.8315123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.4317185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.4316899240 14706259
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 19.8121137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 19.8119294768
MESH:D008113 Liver Neoplasms pirinixic acid 19.8115890375 20007298 16377806
MESH:D008113 Liver Neoplasms Plant Extracts 19.8119168119
MESH:D008113 Liver Neoplasms resveratrol 19.8119812893 19073162 19321006 20405173
MESH:D008113 Liver Neoplasms Tamoxifen 19.8116684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 19.8116984957
MESH:D008114 Liver Neoplasms, Experimental Benzene 12.4412562636
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 12.4415583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 12.4412151625
MESH:D008114 Liver Neoplasms, Experimental Trichloroethylene 12.447955063
MESH:D017563 Lung Diseases, Interstitial Benzene 4.4614698565
MESH:D008175 Lung Neoplasms Benzene 12.1512562636
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 12.1520064080 18816296 20869020 18569708 6695378 20135361 18520028 20464547 17053015
MESH:D008175 Lung Neoplasms Curcumin 12.1518462866 16243823 19359593
MESH:D008175 Lung Neoplasms Plant Extracts 12.1520869020
MESH:D008175 Lung Neoplasms Sulindac 12.1519359593 15713900
MESH:D008175 Lung Neoplasms Tamoxifen 12.1518625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 12.1511884234 19555203
MESH:D008175 Lung Neoplasms Zidovudine 12.1518800350
MESH:D008223 Lymphoma Benzene 7.0917119257 17584886
MESH:D008223 Lymphoma Curcumin 7.0918462866
MESH:D016393 Lymphoma, B-Cell resveratrol 3.9917088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.6014749477
MESH:D016399 Lymphoma, T-Cell Curcumin 4.3616173963
MESH:D015674 Mammary Neoplasms, Animal Benzene 14.8412562636
MESH:D015674 Mammary Neoplasms, Animal resveratrol 14.8415688416
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 14.8419428831
MESH:D008325 Mammary Neoplasms, Experimental Benzene 8.8411921183
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 8.8411606380 8985016
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 8.8419196722 14580682 19196723 11731420 16827153
MESH:D020149 Manganese Poisoning Tamoxifen 4.2019453300
MESH:D008527 Medulloblastoma marker/mechanism 19270706
MESH:D008545 Melanoma Curcumin 9.1018462866 17885582
MESH:D008545 Melanoma epigallocatechin gallate 9.1017992120 11746506
MESH:D008545 Melanoma resveratrol 9.1017992120
MESH:D008545 Melanoma Sulindac 9.1016642371
MESH:D008545 Melanoma Tamoxifen 9.1012393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.8415990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2419513568
MESH:D008569 Memory Disorders Curcumin 3.8317263510
MESH:D008659 Metabolic Diseases resveratrol 4.0717112576
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 5.4917358032
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.9316381670
MESH:D052016 Mucositis irinotecan 4.6717159606
MESH:D009101 Multiple Myeloma Benzene 10.8817119195
MESH:D009101 Multiple Myeloma Curcumin 10.8819372569
MESH:D009101 Multiple Myeloma resveratrol 10.8816490592 16267019 17049120 17164350 14749477 17935668
MESH:D009134 Muscular Atrophy, Spinal Curcumin 19.1717962980
MESH:D009134 Muscular Atrophy, Spinal epigallocatechin gallate 19.1717962980
MESH:D009134 Muscular Atrophy, Spinal resveratrol 19.1717962980
MESH:D009135 Muscular Diseases pirinixic acid 3.1716239165
MESH:D009203 Myocardial Infarction pirinixic acid 5.2519151258
MESH:D009203 Myocardial Infarction resveratrol 5.2517188708 16317513 16525036 16456233 17125593 17015251
MESH:D017202 Myocardial Ischemia resveratrol 8.1217125593 17015251
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.1212213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.6916411023
MESH:D009205 Myocarditis resveratrol 4.4217322642
MESH:D009361 Neoplasm Invasiveness Curcumin 4.0518495463
MESH:D009362 Neoplasm Metastasis irinotecan 5.4818259882
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.4819393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4019410462
MESH:D009369 Neoplasms Benzo(a)pyrene 10.5511141357
MESH:D009369 Neoplasms Berberine 10.5512415430
MESH:D009369 Neoplasms pirinixic acid 10.5517405874
MESH:D009369 Neoplasms Trichloroethylene 10.5511911487
MESH:D009374 Neoplasms, Experimental resveratrol 3.678985016
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 9.6912497104
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 9.6919189210 19200415 19196722
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 2.8914600291
MESH:D009423 Nervous System Neoplasms Curcumin 5.2818462866
MESH:D009436 Neural Tube Defects Benzene 3.4515643154
MESH:D019954 Neurobehavioral Manifestations Plant Extracts 4.8517168769
MESH:D009447 Neuroblastoma irinotecan 3.308761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 12.5918514411
MESH:D019636 Neurodegenerative Diseases resveratrol 12.5917652729
MESH:D019636 Neurodegenerative Diseases Sulindac 12.5917266991 16850258
MESH:D017599 Neuroectodermal Tumors irinotecan 4.398761367
MESH:D020078 Neurogenic Inflammation resveratrol 4.0917929310
MESH:D009765 Obesity Curcumin 7.0019297423
MESH:D009765 Obesity pirinixic acid 7.0020558911
MESH:D009765 Obesity Plant Extracts 7.0020132043 19056576
MESH:D009784 Occupational Diseases Benzene 3.8915727169 15576619 17119257 16737584 17178637 15935809 17479406 15612468 15913788
MESH:D010024 Osteoporosis Curcumin 3.2618719352
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 3.9417513867
MESH:D010051 Ovarian Neoplasms Benzene 4.8712562636
MESH:D010051 Ovarian Neoplasms Curcumin 4.8718462866 19020741
MESH:D010146 Pain Acetaminophen 6.0216870215
MESH:D010146 Pain Sulindac 6.023291741
MESH:D010190 Pancreatic Neoplasms Curcumin 5.3419401701 19196508 17440100
MESH:D010190 Pancreatic Neoplasms Sulindac 5.3411504793 16820089
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.3711578682
MESH:D010212 Papilloma Plant Extracts 4.1616517061 15173996
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9012520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2418163543
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 8.4616679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.4611399792 11896295 11222880 11118676
MESH:D011471 Prostatic Neoplasms AGN 194204 2.8216000583
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.8217292933
MESH:D011471 Prostatic Neoplasms Berberine 2.8216505103
MESH:D011471 Prostatic Neoplasms Curcumin 2.8218156803 10851300 12497104 11398177 18226269 15129424 18769126
MESH:D011471 Prostatic Neoplasms methylselenic acid 2.8216205645
MESH:D011471 Prostatic Neoplasms panduratin A 2.8216497706
MESH:D011471 Prostatic Neoplasms Plant Extracts 2.8214666653 17804756
MESH:D011471 Prostatic Neoplasms resveratrol 2.8216731767 17636462 15767336 17804756 17718901 17675339
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.8215067354
MESH:D011537 Pruritus Ethinyl Estradiol 2.9815861022 16919318
MESH:D011656 Pulmonary Emphysema Curcumin 4.2319168576
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.2416325855
MESH:D015427 Reperfusion Injury pirinixic acid 6.0019058328
MESH:D015427 Reperfusion Injury resveratrol 6.0017058453 17520802 16317513 15827377 16314181
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 3.7210666014 18379247
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5118990726
MESH:D012509 Sarcoma Curcumin 3.8218462866
MESH:D018805 Sepsis Curcumin 3.8018389075
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 12.2410029692 19755658
MESH:D012878 Skin Neoplasms Plant Extracts 12.2415173996 16517061
MESH:D012878 Skin Neoplasms resveratrol 12.2415837718 8985016
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 12.2416192470
MESH:D013088 Spermatocele Ethinyl Estradiol 10.4116709447
MESH:D013088 Spermatocele Tamoxifen 10.4116709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.7019457130
MESH:D013274 Stomach Neoplasms Benzene 4.4812562636
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.482093021 20155912
MESH:D013274 Stomach Neoplasms irinotecan 4.4815723263
MESH:D013274 Stomach Neoplasms Zidovudine 4.4817696246
MESH:D013276 Stomach Ulcer Curcumin 6.6916631530 19188055
MESH:D013276 Stomach Ulcer Plant Extracts 6.6917135157 18193104 18237397 12787963 15255614
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.1916321402
MESH:D013705 Temporomandibular Joint Disorders Plant Extracts 5.1317997062
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.8715669648
MESH:D013953 Thymus Neoplasms Benzene 4.6210850423
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.5612697716
MESH:D014062 Tongue Neoplasms resveratrol 3.9216227395
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 7.5417053015
MESH:D001749 Urinary Bladder Neoplasms Curcumin 7.5418593936
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 7.548653321 16712894 17572228
MESH:D014565 Urogenital Neoplasms Curcumin 4.9218462866
MESH:D014581 Urticaria Acetaminophen 2.6710982225
MESH:D002583 Uterine Cervical Neoplasms indole-3-carbinol 9.0516082211
MESH:D002583 Uterine Cervical Neoplasms resveratrol 9.0517473185
MESH:D014594 Uterine Neoplasms Benzene 20.2912562636
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 20.2914692618
MESH:D014594 Uterine Neoplasms resveratrol 20.2917044934
MESH:D014594 Uterine Neoplasms Sulindac 20.2918645019
MESH:D014625 Vaginal Neoplasms Zidovudine 4.4312579204
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2512125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2414671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Plant Extracts 9.4318097624
MESH:D018487 Ventricular Dysfunction, Left resveratrol 9.4317488730
MESH:D020257 Ventricular Remodeling Plant Extracts 4.9718097624
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9015886252
MESH:D014947 Wounds and Injuries Plant Extracts 3.9820213670 19894650
Pathway ID Pathway Name
KEGG:04110 Cell cycle
REACT:152 Cell Cycle, Mitotic
KEGG:05220 Chronic myeloid leukemia
KEGG:05214 Glioma
KEGG:05162 Measles
KEGG:05218 Melanoma
KEGG:05223 Non-small cell lung cancer
KEGG:04115 p53 signaling pathway
KEGG:05212 Pancreatic cancer
KEGG:05200 Pathways in cancer
KEGG:05222 Small cell lung cancer
KEGG:04530 Tight junction
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA103
    • No data
    Releated disease ID Related disease Name
    PA443434Arthritis, Rheumatoid
    Releated drug ID Related drug Name
    PA452621antineoplastic agents
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB03496 - Flavopiridol Antineoplastic Agents;Growth Inhibitors;Protein Kinase Inhibitors;Glycogen Phosphorylase inhibitor
    DB07379 - (2S)-2-({6-[(3-AMINO-5-CHLOROPHENYL)AMINO]-9-ISOPROPYL-9H-PURIN-2-YL}AMINO)-3-METHYLBUTAN-1-OL
    DB07795 - 3,7,3',4'-TETRAHYDROXYFLAVONE
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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