AutismKB 2.0

Annotation Detail for TRIB1


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Basic Information Top
Gene Symbol:TRIB1 ( C8FW,GIG2,SKIP1,TRB1 )
Gene Full Name: tribbles homolog 1 (Drosophila)
Band: 8q24.13
Quick LinksEntrez ID:10221; OMIM: 609461; Uniprot ID:TRIB1_HUMAN; ENSEMBL ID: ENSG00000173334; HGNC ID: 16891
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
CARDIOVASCULAR
METABOLIC
LDL cholesterol
triglycerides
Cardiovascular Diseases
cholesterol, total
Desease Name
Cholesterol, total
Response to statin therapy
Triglycerides
LDL cholesterol
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of TRIB1 mRNAaffects expression 21346803
C035208 2-amino-4,6-dinitrotoluene 2-amino-4,6-dinitrotoluene affects the expression of TRIB1 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of TRIB1 mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of TRIB1 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of TRIB1 proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of TRIB1 mRNAaffects expression 16483693
D017638 Asbestos, Crocidolite Asbestos, Crocidolite affects the expression of TRIB1 mRNAaffects expression 17331233
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of TRIB1 mRNAincreases expression 18687144
D001374 Azacitidine Azacitidine results in decreased expression of TRIB1 mRNAdecreases expression 19194470
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of TRIB1 mRNAincreases expression 20064835
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of TRIB1 mRNAincreases expression 15336504
D016572 Cyclosporine Cyclosporine results in increased expression of TRIB1 mRNAincreases expression 20106945
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of TRIB1 mRNAdecreases expression 18691550
D004052 Diethylnitrosamine IKBKB protein inhibits the reaction [Diethylnitrosamine results in decreased expression of TRIB1 mRNA]decreases expression|decreases reaction 18691550
D004052 Diethylnitrosamine MAPK14 protein inhibits the reaction [Diethylnitrosamine results in decreased expression of TRIB1 mRNA]decreases expression|decreases reaction 18691550
D002117 Calcitriol Calcitriol results in increased expression of TRIB1 mRNAincreases expression 16002434
D004128 Dimethylnitrosamine Dimethylnitrosamine results in increased expression of TRIB1 mRNAincreases expression 17547211
D004958 Estradiol Estradiol results in increased expression of TRIB1 mRNAincreases expression 20106945
C051890 irinotecan irinotecan analog results in increased expression of TRIB1 mRNAincreases expression 18927307
C008493 methylselenic acid methylselenic acid results in decreased expression of TRIB1 mRNAdecreases expression 18548127
D008942 Mitoxantrone TRIB1 protein affects the susceptibility to Mitoxantroneaffects response to substance 16217747
C022838 nickel chloride nickel chloride results in increased expression of TRIB1 mRNAincreases expression 17547211
D010634 Phenobarbital Phenobarbital results in decreased expression of TRIB1 mRNAdecreases expression 19270015
D019800 Phenol Phenol results in increased expression of TRIB1 mRNAincreases expression 17547211
C006253 pirinixic acid pirinixic acid results in increased expression of TRIB1 mRNAincreases expression 18445702
D020849 Raloxifene [Raloxifene co-treated with ESR2 protein] results in increased expression of TRIB1 mRNAaffects cotreatment|increases expression 19059307
D013629 Tamoxifen [Tamoxifen co-treated with ESR2 protein] results in increased expression of TRIB1 mRNAaffects cotreatment|increases expression 19059307
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of TRIB1 mRNAdecreases expression 19933214
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.3514745880
MESH:D000014 Abnormalities, Drug-Induced 2-amino-4,6-dinitrotoluene 13.287525203
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 13.286195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 13.2815322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.3718287403
MESH:D055371 Acute Lung Injury pirinixic acid 2.9418653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.8620127859 20464547
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 6.8616033868
MESH:D000230 Adenocarcinoma Estradiol 6.8611473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 15.093712494
MESH:D000236 Adenoma Benzo(a)pyrene 15.096695378
MESH:D000236 Adenoma Diethylnitrosamine 15.0910737359 6695378
MESH:D000236 Adenoma Dimethylnitrosamine 15.0919555203
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 23.2717620307 19052882 16434500 19061943 18056438 17162532
MESH:D018248 Adenoma, Liver Cell Phenobarbital 23.2717620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 23.2716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 23.2716835633
MESH:D000419 Albuminuria Raloxifene 4.4117451421 17308373
MESH:D000544 Alzheimer Disease Raloxifene 2.5015800139
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7811748828
MESH:D000799 Angioedema Acetaminophen 3.6510982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8819183758
MESH:D001321 Autistic Disorder Acetaminophen 1.4418445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.8311289319 1440618
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.1919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.1912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6415746008
MESH:D001859 Bone Neoplasms Phenol 5.0310556009
MESH:D001913 Bowen's Disease Phenol 5.5619293009
MESH:D001930 Brain Injuries Raloxifene 4.2916580743
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 3.6517474063 20146248
MESH:D001943 Breast Neoplasms Calcitriol 3.6511237771
MESH:D001943 Breast Neoplasms Diethylnitrosamine 3.6517474063
MESH:D001943 Breast Neoplasms Estradiol 3.6518497071 17261762 17289903 16675129 17018787 12948864 19861407 14630087
MESH:D001943 Breast Neoplasms Raloxifene 3.6517893378 17595753 15572757 17261762 15758505 16912660 15775269 17049068 17242785 16837676 17952589 17440819
MESH:D001943 Breast Neoplasms Tamoxifen 3.6521152245 20135344 16873071 20544844 20859285 15668708 17440819 20005174 20390343 18425577 19487384 18815881 19410462 17893378 19084267 19221464 19288272 18997820 19011961 19189212 21138602 19066611 19200415 19155303 17049068 18629630 17261762 19142967 19103187 16273361 20065188 18855134 18984771 17242785 16202921 16818667 19115204 18821012 19289846 11161223 19189210 15565566 18351453 19059307 19244106
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.6520435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2716111702
MESH:D002277 Carcinoma Dimethylnitrosamine 7.8519555203
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.8516835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.3219066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 16.3816705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 16.387296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 16.383084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 16.3821507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 16.3820727157 18785209 20514400 20007298 16935385 20512989 16681979 17428255 17055752 16779866 16569478 17138121 18056438 16830150 18788625 17173139 16878318 18665156 19208518 11831363 16328049 16288022 20432363 21159647 18691550 16540662 16502159 19519916 19919837 19822196 19418558 10737359 20214788 18393292 10672840 3084413 19335982 19052882 18210153 19701751 20084675 18494052 18978308 16698587 16807293 19171122 17761372 18506893 19383236 20935162 19107877 18971187 17978847 19394651 17162532 20101231 20524982 3581430 19539802
MESH:D006528 Carcinoma, Hepatocellular Estradiol 16.3816924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 16.3817173139 6705139 20935162 1701930 20007298
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 16.3816924424
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.597296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.3020419170
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 7.3011237771
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 7.3016033868
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 8.9417572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 8.9417572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2618850075 16120746 18670907
MESH:D002318 Cardiovascular Diseases Raloxifene 3.3115775269
MESH:D002386 Cataract Acetaminophen 2.4710977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 14.947505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 14.9412371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 14.942727394 7505956 17174075 21159647
MESH:D002471 Cell Transformation, Neoplastic Estradiol 14.9418566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.064080065
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.7919052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.7916835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 12.5719486331 9022650
MESH:D002779 Cholestasis Cyclosporine 12.5719486331
MESH:D002779 Cholestasis pirinixic acid 12.5719176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0316354765 12621046 8697196 15340226 15668235
MESH:D003072 Cognition Disorders Raloxifene 4.4315800139
MESH:D003110 Colonic Neoplasms irinotecan 2.5617287894 17725105
MESH:D015179 Colorectal Neoplasms Azacitidine 2.9519934284
MESH:D015179 Colorectal Neoplasms irinotecan 2.9516391804 16303861 15273666 18259882 17159606 17454858 18509181
MESH:D000013 Congenital Abnormalities 2-amino-4,6-dinitrotoluene 9.0215095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 9.0217141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2510048152 15322242 20055451
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.8318551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.1719031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.0017474826
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.6214531868 8970840 8156756 11298694 11906362 2524372 18759878 12868966
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3418249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.313621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.0620387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.0617107852
MESH:D003928 Diabetic Nephropathies Estradiol 14.0919279558
MESH:D003928 Diabetic Nephropathies Raloxifene 14.0917308373 15920148 17451421
MESH:D003928 Diabetic Nephropathies Tamoxifen 14.0919279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 17.8021346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2-amino-4,6-dinitrotoluene 17.8021346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 17.807440962 6679447 9022650 16192314 11289319 8291058 9653073 6482804 1440618 18692083 18289764 9328219 18648102
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 17.8012153990 12392966 11743745 16227642 18713872 10774834 19739265 17906064 12540782 11834606 16781746 19420014 14725611 16177239 11529661 19370779 10663392 12705907 11739529 2444490 14550746 16109766 15968718 12958197 19085960 16393943 11287661 12594235 14986274 17562736 19164858 19923254 15619225 16485898 11421492 19416960 10915739 17522070 18071297 11461765 16081117
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 17.8019107877
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 17.808172417
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 17.8020420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9119426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6211462148
MESH:D004421 Dystonia Phenobarbital 3.831851702
MESH:D004487 Edema pirinixic acid 10.4312083418
MESH:D004487 Edema Raloxifene 10.4315860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.4312711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7115322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 14.3815138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 14.3815845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 14.3819031437
MESH:D016889 Endometrial Neoplasms Estradiol 6.9818566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Tamoxifen 6.9816202921 20544844 19155303 17893378
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.869294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.923659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.6811558140 3922381
MESH:D004827 Epilepsy Phenobarbital 2.7920417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.386401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.067750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.833659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.9216302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.003581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.0016530937
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 7.0017016578
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8711564622
MESH:D005234 Fatty Liver Cyclosporine 22.8119224547
MESH:D005234 Fatty Liver Diethylnitrosamine 22.8120387270 21071580
MESH:D005234 Fatty Liver pirinixic acid 22.8119236843 20131406
MESH:D005234 Fatty Liver Raloxifene 22.8117473493
MESH:D005234 Fatty Liver Tamoxifen 22.8119224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1216709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2711858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.836705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.3414745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.9919069698
MESH:D005355 Fibrosis Cyclosporine 7.8512168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 7.8520067830
MESH:D005756 Gastritis Acetaminophen 3.4816983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.038708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.867505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4010696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.1220471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.1210048152 11294989
MESH:D006331 Heart Diseases Mitoxantrone 7.6516019553
MESH:D006331 Heart Diseases Raloxifene 7.6511110106
MESH:D006333 Heart Failure pirinixic acid 2.4220558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2315720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1611000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.336705139
MESH:D006529 Hepatomegaly Phenobarbital 13.2916109766
MESH:D006529 Hepatomegaly pirinixic acid 13.2919176532 18467677 19772884 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 13.2916120746 12621046 15340226
MESH:D006558 Herpes Genitalis Estradiol 4.8415709030
MESH:D019584 Hot Flashes Estradiol 3.5617088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8516959395 18606429 8697196 15340226 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.5516870215
MESH:D006943 Hyperglycemia pirinixic acid 3.0220558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.7515034207
MESH:D006973 Hypertension Cyclosporine 8.1610903974
MESH:D006973 Hypertension Raloxifene 8.1615787275 17577099
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.1618670907 18850075
MESH:D007249 Inflammation Diethylnitrosamine 7.6918785209
MESH:D007249 Inflammation Tamoxifen 7.6919457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.6912200463 12878042
MESH:D007333 Insulin Resistance Estradiol 6.7916627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 6.7916306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.838074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1616580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2515604871
MESH:D055623 Keratosis, Actinic Phenol 6.2519293009
MESH:D007674 Kidney Diseases Acetaminophen 9.3412587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 9.348314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 9.3415618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 21.6716705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 21.676582329
MESH:D007680 Kidney Neoplasms Cyclosporine 21.6712371664
MESH:D007680 Kidney Neoplasms Estradiol 21.6715610895
MESH:D007680 Kidney Neoplasms Tamoxifen 21.6718625569
MESH:D007889 Leiomyoma Raloxifene 4.3216973256
MESH:D007938 Leukemia Azacitidine 3.6019148494
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Mitoxantrone 3.7118172266
MESH:D007951 Leukemia, Myeloid Azacitidine 4.4519077051
MESH:D015470 Leukemia, Myeloid, Acute Azacitidine 2.9718720364 17596541
MESH:D054429 Leukemia, Myelomonocytic, Juvenile Azacitidine 5.0119299654
MESH:D008064 Lipidoses Tamoxifen 3.0217567588 15342952
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.2920032147 18522880 19638242 18665156 18407596
MESH:D008103 Liver Cirrhosis Phenobarbital 6.2921047994
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.0815034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 6.4717201889 15571005 16627068 15793283 17036385 14659978 17348192 15138612 18672772 16603200 15479170 15339415 14568256 15298665 15099470 17203207 15383259 17198567 17465448 12918455 17432682 15086199 15942678 16009107 17719030 12925901 14726149 17881167 15763062 18567088 14709902 18629640 15081153 18637143 15369754 17724770 18095165 17196135 15067225 16544323 16042886 15723089 18364076 15366600 17666798 15744066 15492853 18239293 15864749 15733078 17640959 16169303 15504291 18210741 15591649 18237412 16570917 17534399 18371158 15577212 14643895 16270385 15161499 15842777 15798949
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.4714716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.4715474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 6.4718564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.4712878042
MESH:D008107 Liver Diseases Acetaminophen 6.1911587558 12969438 12587719 19014921 19460945 19784758 16610002 16611625
MESH:D008107 Liver Diseases Diethylnitrosamine 6.1917034775
MESH:D008107 Liver Diseases Phenobarbital 6.1919363144
MESH:D017114 Liver Failure, Acute Acetaminophen 9.1216871587 17185352
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 9.1217457977
MESH:D008113 Liver Neoplasms Aflatoxin B1 24.7015890375 2125692 9163691 18177683
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 24.7020195826 21137059
MESH:D008113 Liver Neoplasms Diethylnitrosamine 24.7019254457 19255062 19294768 19551842 19642983 16942905 18977376 21278145 18978307 19996281 20501860 10737359 21071580 20434301 2862719 9163691 20101389 19850985 18648771 18644402 15175105 20492335 20118626 19090486 19833225 19690152 15885732 20452335 19426721 2422723 19073162 21167192 20405173 12771043 19427195 20583210 12112319 20137499 19638242 19499222 21047994 19256749 19812893 18754104
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 24.7015890375 3113478
MESH:D008113 Liver Neoplasms Phenobarbital 24.7019812893 19073162 19482888 15975961 21047994 8742319
MESH:D008113 Liver Neoplasms pirinixic acid 24.7015890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tamoxifen 24.7016684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 24.7016984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 21.846587162 1399818 3712494 598648
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 21.848603461
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 21.8419519916 18079962 19004024 18093689 16267830 2563599 19539802 17854601 19009564 3124819 17174075 18308698 9362446 21159647 18282651 18253720 18164116 18544905 16842330 18775883 19126423 17942915
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 21.841848544 15603536 6150874
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 21.8417172636 6150874 18308698 1399818 2563599
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 21.8412151625
MESH:D055370 Lung Injury Asbestos, Crocidolite 3.8417365036
MESH:D008175 Lung Neoplasms Aflatoxin B1 10.3314755239
MESH:D008175 Lung Neoplasms Azacitidine 10.3321224363
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 10.3320464547 6695378 18816296 20064080 18520028 20135361 18569708 20869020 17053015
MESH:D008175 Lung Neoplasms Diethylnitrosamine 10.3321163286 20970405 20512841 6695378
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 10.3316061637 11884234 19555203
MESH:D008175 Lung Neoplasms Tamoxifen 10.3318625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 10.3319555203 11884234
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.5719428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.5711408345 16891317 17203775 11807958
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 5.5711731420 14580682 16827153 19196722 19196723
MESH:D020149 Manganese Poisoning Estradiol 12.0019453300
MESH:D020149 Manganese Poisoning Tamoxifen 12.0019453300
MESH:D008545 Melanoma Tamoxifen 1.8619393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.9915990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3819513568
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.1116966607 16166281 18303189
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5916801185
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.3615863610
MESH:D009006 Monosomy Azacitidine 5.8919299654
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.0416381670
MESH:D052016 Mucositis irinotecan 4.8217159606
MESH:D009101 Multiple Myeloma Azacitidine 7.2819549372 18443271
MESH:D009101 Multiple Myeloma Raloxifene 7.2816497877
MESH:D009135 Muscular Diseases pirinixic acid 3.3216239165
MESH:D009190 Myelodysplastic Syndromes Azacitidine 3.9018720364 19805378 17596541 17611569
MESH:D009203 Myocardial Infarction pirinixic acid 2.0719151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8712213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.7716810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.7716411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.2817484760
MESH:D009232 Myxoma Raloxifene 5.3616343187
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.6718551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 12.973581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 12.973581430 9029167
MESH:D009362 Neoplasm Metastasis irinotecan 12.9718259882
MESH:D009362 Neoplasm Metastasis Tamoxifen 12.9719393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4519410462
MESH:D009369 Neoplasms Benzo(a)pyrene 7.7811141357
MESH:D009369 Neoplasms Mitoxantrone 7.7816640825
MESH:D009369 Neoplasms pirinixic acid 7.7817405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.8119189210 19200415 19196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5417289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2517954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1219348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 8.8511399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.8514600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.796679447
MESH:D009447 Neuroblastoma irinotecan 3.388761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.6618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.6620387270
MESH:D017599 Neuroectodermal Tumors irinotecan 4.548761367
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.9220387270
MESH:D009765 Obesity pirinixic acid 1.7720558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.3316049721 12819281
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 8.336482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.833988306
MESH:D010018 Osteomalacia Phenobarbital 4.1717016548
MESH:D010024 Osteoporosis Raloxifene 3.2819059307 15775268 17882678
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.0515579764 17823083 15758505 17893378
MESH:D010051 Ovarian Neoplasms Estradiol 2.1619401270
MESH:D010146 Pain Acetaminophen 6.5516870215
MESH:D010146 Pain Phenol 6.5517610455
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.0316540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.0316965848
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.307296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0612520081
MESH:D010392 Pemphigus Phenol 6.2516522979 17163923
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.286228378
MESH:D010864 Pilonidal Sinus Phenol 6.2515622588 19655223
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.7010923243
MESH:D011041 Poisoning Phenol 4.548825745
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3718163543
MESH:D011230 Precancerous Conditions Cyclosporine 14.3412371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 14.342563599
MESH:D011230 Precancerous Conditions Phenobarbital 14.342563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.0011222880 11399792 11896295 11118676
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.5915572423
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.7120887781
MESH:D011471 Prostatic Neoplasms Azacitidine 2.0718324645
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0717292933
MESH:D011471 Prostatic Neoplasms Calcitriol 2.0712479363 15754350 16644109 18247401 16289102
MESH:D011471 Prostatic Neoplasms Estradiol 2.0716740699
MESH:D011471 Prostatic Neoplasms methylselenic acid 2.0716205645
MESH:D011471 Prostatic Neoplasms Raloxifene 2.0716536755 16220300 15731164
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.0715067354
MESH:D019310 Pseudolymphoma Phenobarbital 4.3012752131
MESH:D011565 Psoriasis Cyclosporine 2.1616882103
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 2.9617975199 15814490 17322281 17365031
MESH:D011693 Purpura Raloxifene 5.3615770314
MESH:D015427 Reperfusion Injury pirinixic acid 2.2919058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6518990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.233692021
MESH:D012640 Seizures 2,4-dinitrotoluene 5.5018551238
MESH:D012640 Seizures Phenobarbital 5.503137016 11442880 16876388 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 4.636407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 8.8810029692 19755658
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 8.888532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.8816192470
MESH:D013088 Spermatocele Phenol 11.5418646496
MESH:D013088 Spermatocele Tamoxifen 11.5416709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.8519457130
MESH:D013158 Splenic Diseases Dimethylnitrosamine 5.0812587719
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.6020155912 2093021
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.6018456281
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 4.6016033868
MESH:D013274 Stomach Neoplasms irinotecan 4.6015723263
MESH:D020521 Stroke Raloxifene 3.6716837676
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7112697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 11.121399818 6582329 3712494 6587162 7505956
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 11.127505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 11.121399818
MESH:D013978 Tibial Fractures Estradiol 13.0719048282
MESH:D013978 Tibial Fractures Raloxifene 13.0719048282
MESH:D014277 Trigeminal Neuralgia Phenol 6.2516527771 10223447
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 15.0016049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 15.008074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 15.0017053015
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 15.0017572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 15.008653321 17572228 16712894
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.1210091137
MESH:D014581 Urticaria Acetaminophen 2.8010982225
MESH:D014605 Uveitis Cyclosporine 3.791336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4012125929
MESH:D054556 Venous Thromboembolism Raloxifene 5.0216837676
MESH:D014846 Vulvar Neoplasms Raloxifene 5.3616343187
MESH:D014860 Warts Phenol 5.9019122958
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0615886252
MESH:D014985 Xerophthalmia Cyclosporine 4.2517120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA134963922
    • No data
    Releated disease ID Related disease Name
    PA445425Prostatic Neoplasms
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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