AutismKB 2.0

Annotation Detail for COQ7


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Basic Information Top
Gene Symbol:COQ7 ( CAT5,CLK-1,CLK1 )
Gene Full Name: coenzyme Q7 homolog, ubiquinone (yeast)
Band: 16p12.3
Quick LinksEntrez ID:10229; OMIM: 601683; Uniprot ID:COQ7_HUMAN; ENSEMBL ID: ENSG00000167186; HGNC ID: 2244
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-5872ubiquinone-10 biosynthesis (eukaryotic)
Pathway IDPathway Name
hsa00130Ubiquinone and other terpenoid-quinone biosynthesis
hsa01100Metabolic pathways
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of COQ7 mRNAaffects expression 16483693
C002791 bismuth tripotassium dicitrate bismuth tripotassium dicitrate results in decreased expression of COQ7 mRNAdecreases expression 15912405
D004041 Dietary Fats Dietary Fats results in increased expression of COQ7 mRNAincreases expression 18042831
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of COQ7 mRNAaffects cotreatment|increases expression 17942748
D019833 Genistein Genistein results in increased expression of COQ7 mRNAincreases expression 17341692
C041786 palm oil palm oil results in increased expression of COQ7 mRNAincreases expression 18042831
C017947 sodium arsenite sodium arsenite results in increased expression of COQ7 mRNAincreases expression 19072884
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of COQ7 mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1811752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.9018287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3217505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.5314692618
MESH:D000230 Adenocarcinoma Genistein 4.5311473722
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7116835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.0815276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.2817306315 16712894
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1711748828
MESH:D001161 Arteriosclerosis Dietary Fats 10.9515238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 10.9511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8015885639
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9115746008
MESH:D001943 Breast Neoplasms Dietary Fats 1.8720435547
MESH:D001943 Breast Neoplasms Genistein 1.8716541309 16873071 17200150
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8720435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D006528 Carcinoma, Hepatocellular Genistein 3.2716924424
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 3.2715276417 16507464 17306315
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.4318572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4918670907 16120746 18850075
MESH:D002318 Cardiovascular Diseases Genistein 3.4616332659
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 3.1419524636 20056578
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3816835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0517110522 16919318 11677210 17681005 17333356 16105132 15861022
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1915340226 15668235 8697196 12621046 16354765
MESH:D003110 Colonic Neoplasms Genistein 2.3217182828
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2717141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 10048152 20055451
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.4916647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.4917107852
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5920420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9311462148
MESH:D050171 Dyslipidemias Dietary Fats 3.6218367378
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2818230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.4712538720
MESH:D004714 Endometrial Hyperplasia Genistein 4.9316402032
MESH:D016889 Endometrial Neoplasms Genistein 3.5111473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2510568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1911564622
MESH:D005234 Fatty Liver Dietary Fats 8.5419004024 19551842 18296743 17967931
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.5415345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D005355 Fibrosis Dietary Fats 9.6618296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.6620067830
MESH:D005833 Genital Neoplasms, Female sodium arsenite 5.0216452187
MESH:D005909 Glioblastoma Genistein 3.4016598420
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4411294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2015340226 16120746 12621046
MESH:D006689 Hodgkin Disease sodium arsenite 3.3612676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4216354765 8697196 16959395 15340226 18606429
MESH:D006937 Hypercholesterolemia Dietary Fats 3.8321332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.8721332399
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9818850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1216945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.1617937319
MESH:D007248 Infertility, Male sodium arsenite 7.1615346721 12646999
MESH:D007249 Inflammation Dietary Fats 5.2920412841
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.2912878042 12200463
MESH:D007333 Insulin Resistance Dietary Fats 3.2518457598 11836018
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5816580747
MESH:D007674 Kidney Diseases sodium arsenite 2.9220008137
MESH:D007938 Leukemia Genistein 3.1318980019 17468513
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9918296743
MESH:D008106 Liver Cirrhosis, Experimental Genistein 2.4617823541
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.4612878042
MESH:D008113 Liver Neoplasms sodium arsenite 4.7116712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.7116984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2412151625
MESH:D008171 Lung Diseases sodium arsenite 3.3219095001
MESH:D008175 Lung Neoplasms sodium arsenite 2.3617077188 15276417 17306315 19931552 16712894
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3611884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Genistein 3.0814578162 12929590
MESH:D008545 Melanoma sodium arsenite 2.0619082730 16487513
MESH:D009203 Myocardial Infarction Genistein 2.9417141266
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2112213967
MESH:D015428 Myocardial Reperfusion Injury Genistein 3.8417141266
MESH:D009369 Neoplasms sodium arsenite 2.6011559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.9720056578
MESH:D009421 Nervous System Malformations Genistein 10.5616427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.5614600291
MESH:D009436 Neural Tube Defects sodium arsenite 3.2912854658
MESH:D009765 Obesity Dietary Fats 2.3321332399 19632207 18674790 18457598 11836018 20132043 20518802 16723640 17217161
MESH:D010024 Osteoporosis Genistein 3.3919401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.3516169203
MESH:D010051 Ovarian Neoplasms Genistein 5.1919005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 5.1917306315 15276417
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9511578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5311222880 11118676 11399792 11896295
MESH:D011471 Prostatic Neoplasms Genistein 3.3115378649 15256057 16925846
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.3116039940
MESH:D011537 Pruritus Ethinyl Estradiol 3.6516919318 15861022
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012878 Skin Neoplasms sodium arsenite 5.9318572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.9316192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.3216709447
MESH:D016135 Spinal Dysraphism sodium arsenite 3.9812854658
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3715669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2812697716
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 2.5816712894 11723127 17306315 16452187
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.9911813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5814692618
MESH:D014652 Vascular Diseases sodium arsenite 4.7617056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7814671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
MESH:D015430 Weight Gain Dietary Fats 3.9516723640
Pathway ID Pathway Name
KEGG:01100 Metabolic pathways
KEGG:00130 Ubiquinone and other terpenoid-quinone biosynthesis
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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