AutismKB 2.0

Annotation Detail for MSLN


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Basic Information Top
Gene Symbol:MSLN ( MPF,SMRP )
Gene Full Name: mesothelin
Band: 16p13.3
Quick LinksEntrez ID:10232; OMIM: 601051; Uniprot ID:MSLN_HUMAN; ENSEMBL ID: ENSG00000102854; HGNC ID: 7371
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C010914 2,4-diaminotoluene 2,4-diaminotoluene results in increased expression of MSLN mRNAincreases expression 20713471
C029955 2-nitrotoluene 2-nitrotoluene results in increased expression of MSLN mRNAincreases expression 16460773
D000643 Ammonium Chloride Ammonium Chloride affects the expression of MSLN mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of MSLN mRNAincreases expression 20713471
C099813 bromochloroacetic acid bromochloroacetic acid results in increased expression of MSLN mRNAincreases expression 16460773
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of MSLN mRNAdecreases expression 15336504
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of MSLN mRNAdecreases expression 17557909
D015525 Fatty Acids, Omega-3 Fatty Acids, Omega-3 results in decreased expression of MSLN mRNAdecreases expression 16823509
D008727 Methotrexate MSLN protein affects the susceptibility to Methotrexateaffects response to substance 16217747
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of MSLN mRNAincreases expression 20713471
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of MSLN mRNAincreases expression 17616710
D043371 Fatty Acids, Omega-6 Fatty Acids, Omega-6 results in increased expression of MSLN mRNAincreases expression 16823509
D010126 Ozone Ozone results in increased expression of MSLN mRNAincreases expression 12763052
D011374 Progesterone Progesterone results in increased expression of MSLN mRNAincreases expression 17404688
D013755 Tetradecanoylphorbol Acetate [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of MSLN mRNAaffects cotreatment|affects expression 16979875
D015032 Zinc [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of MSLN mRNAaffects cotreatment|affects expression 16979875
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Methotrexate 4.2712039119
MESH:D000138 Acidosis Ammonium Chloride 3.5818287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9717505938
MESH:D000169 Acrodermatitis Zinc 5.4217202136 17190629 16889938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.1820464547 20127859
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.1814692618
MESH:D000236 Adenoma Benzo(a)pyrene 6.876695378
MESH:D000236 Adenoma Methylcholanthrene 6.876695378 10545420
MESH:D000544 Alzheimer Disease Ozone 4.4615513908
MESH:D000544 Alzheimer Disease Zinc 4.4616580781 16325427 16410023 17119284
MESH:D000755 Anemia, Sickle Cell Zinc 4.9116916123
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0919183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6615885639
MESH:D001172 Arthritis, Rheumatoid Methotrexate 4.9817286800
MESH:D001172 Arthritis, Rheumatoid Ozone 4.9815570426
MESH:D001249 Asthma Ozone 5.1816373670 17854713
MESH:D001249 Asthma Zinc 5.1817085522
MESH:D050197 Atherosclerosis Methylcholanthrene 3.4511922910
MESH:D001289 Attention Deficit Disorder with Hyperactivity Fatty Acids, Omega-3 9.2718448859
MESH:D001289 Attention Deficit Disorder with Hyperactivity Fatty Acids, Omega-6 9.2718448859
MESH:D001321 Autistic Disorder Fatty Acids, Omega-3 3.4816920077
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.3717868700
MESH:D001930 Brain Injuries Progesterone 11.0915665606 15380490 15845082
MESH:D001930 Brain Injuries Zinc 11.0917109824
MESH:D001943 Breast Neoplasms 2,4-diaminotoluene 2.3811921183
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.3817474063 20146248
MESH:D001943 Breast Neoplasms Methotrexate 2.3816978400
MESH:D001943 Breast Neoplasms Methylcholanthrene 2.3817474063
MESH:D001943 Breast Neoplasms Progesterone 2.3817614352 15562024 16175315
MESH:D016535 Bronchial Hyperreactivity Ozone 3.6817626835 18417511 14754758 15516495 19059883 18315731 16777450
MESH:D002100 Cachexia Ozone 4.7616183385
MESH:D002277 Carcinoma Methylcholanthrene 3.9710545420
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.6820419170
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 7.6818922899
MESH:D002294 Carcinoma, Squamous Cell Zinc 7.6816543248
MESH:D002318 Cardiovascular Diseases Zinc 3.6616936243
MESH:D002430 Cecal Neoplasms 2-nitrotoluene 5.6814688030
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 3.5016192471
MESH:D002779 Cholestasis Ethinyl Estradiol 2.8815861022 16105132 17110522 17681005 17333356 16919318 11677210
MESH:D019465 Craniofacial Abnormalities Methotrexate 3.199562676 12039119
MESH:D019465 Craniofacial Abnormalities Zinc 3.1919302082
MESH:D003550 Cystic Fibrosis Methotrexate 4.2419747007
MESH:D003882 Dermatomyositis Methotrexate 5.1320191521
MESH:D003920 Diabetes Mellitus Zinc 4.2116479319
MESH:D003929 Diabetic Neuropathies Progesterone 4.5117187935
MESH:D004487 Edema Tetradecanoylphorbol Acetate 3.628273558 9599246 15177302 7812673 16716910 8113982 11698051
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.0712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 9.0717692515
MESH:D004715 Endometriosis Progesterone 3.7716134523
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.3916530937
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 7.3915878914 15547721 15547733 16704527 16805852 15623463 16510608 15150132 15264214
MESH:D004938 Esophageal Neoplasms Zinc 7.3916543248
MESH:D005234 Fatty Liver Ethinyl Estradiol 2.8215345470
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.9614633661 10962813
MESH:D005756 Gastritis Zinc 4.8317241300
MESH:D006086 Graft vs Host Disease Methotrexate 5.1616518429
MESH:D006130 Growth Disorders Zinc 3.9617217573
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.6620471113
MESH:D006333 Heart Failure Zinc 3.6117162251
MESH:D006335 Heart Injuries Zinc 5.8017074742
MESH:D016481 Helicobacter Infections Zinc 4.5417241300
MESH:D006394 Hemangiosarcoma 2-nitrotoluene 5.0813678655
MESH:D006527 Hepatolenticular Degeneration Zinc 4.7017276780
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8216569931 16945680
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.4115869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.4917937319
MESH:D007249 Inflammation Fatty Acids, Omega-3 8.6917296493
MESH:D007249 Inflammation Progesterone 8.6915869954
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 8.698273558 15177302 7562506 7812673 11698051
MESH:D007511 Ischemia Zinc 4.6416584753
MESH:D007674 Kidney Diseases Zinc 3.3216960431
MESH:D007676 Kidney Failure, Chronic Zinc 4.4216518626
MESH:D007805 Language Development Disorders Methotrexate 5.119562676
MESH:D008103 Liver Cirrhosis Methotrexate 3.7014986274
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 2.0420195826 21137059
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 3.281399818 598648
MESH:D008171 Lung Diseases Ozone 3.388266340 19066396
MESH:D017563 Lung Diseases, Interstitial Methotrexate 5.0518516814
MESH:D055370 Lung Injury Ozone 3.8620417186
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.9320464547 20064080 20135361 20869020 18816296 17053015 6695378 18520028 18569708
MESH:D008175 Lung Neoplasms Methylcholanthrene 4.936695378 7750092 11893704 20970405 20512841 1399818 21163286 16337739 17909032 16271038 15390079 10545420 9230183
MESH:D008175 Lung Neoplasms Ozone 4.938597069 7614698
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 4.9311807781
MESH:D008223 Lymphoma Methotrexate 3.9517352296
MESH:D008325 Mammary Neoplasms, Experimental 2,4-diaminotoluene 14.4011921183
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 14.4017203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 14.408985016
MESH:D008325 Mammary Neoplasms, Experimental Zinc 14.4012773700
MESH:D008654 Mesothelioma marker/mechanism 18394747
MESH:D008679 Metaplasia Ozone 5.1410496685
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1916381670
MESH:D052016 Mucositis Methotrexate 5.3017488658
MESH:D019042 Muscle Neoplasms 2-nitrotoluene 6.7113678655
MESH:D009369 Neoplasms Benzo(a)pyrene 2.1711141357
MESH:D010051 Ovarian Neoplasms Progesterone 2.5217393432 16525653
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 3.1315976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6911578682
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 4.3118404319 18922899 8330346 12065085
MESH:D010538 Peritonitis Ozone 4.1416369182
MESH:D011014 Pneumonia Ozone 4.4118929643 18381685 18007984
MESH:D011225 Pre-Eclampsia Zinc 4.1817114810
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.3817292933
MESH:D011471 Prostatic Neoplasms Zinc 3.3816606632 16517595 12429649 16700911
MESH:D011537 Pruritus Ethinyl Estradiol 3.3316919318 15861022
MESH:D011565 Psoriasis Methotrexate 3.4317410198
MESH:D051437 Renal Insufficiency Methotrexate 4.7217352296
MESH:D012162 Retinal Degeneration Zinc 4.1316584753
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8618045962
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.5719755658 10029692
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 9.578532709
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 9.5718404319 12065085 8330346 11807781 8985016
MESH:D013088 Spermatocele Ethinyl Estradiol 3.9716709447
MESH:D013119 Spinal Cord Injuries Progesterone 4.3015862959 16503802
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.542093021 20155912
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 2.5412958204 17575124
MESH:D013576 Syndactyly Methotrexate 5.049562676
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6311994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1515669648
MESH:D014062 Tongue Neoplasms Zinc 4.4016543248
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.1817053015
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3114692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5414671159 15869587
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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