AutismKB 2.0

Annotation Detail for CDK8


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:CDK8 ( K35,MGC126074,MGC126075 )
Gene Full Name: cyclin-dependent kinase 8
Band: 13q12.13
Quick LinksEntrez ID:1024; OMIM: 603184; Uniprot ID:CDK8_HUMAN; ENSEMBL ID: ENSG00000132964; HGNC ID: 1779
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Gene Expression
No data
No data
Pathway IDPathway Name
500652Generic Transcription Pathway
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C112765 17-(allylamino)-17-demethoxygeldanamycin 17-(allylamino)-17-demethoxygeldanamycin results in decreased expression of CDK8 proteindecreases expression 17157164
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CDK8 mRNAdecreases expression 20382639
19150397
D002330 Carmustine Carmustine results in decreased expression of CDK8 mRNAdecreases expression 15980968
D019833 Genistein Genistein results in increased expression of CDK8 mRNAincreases expression 15378649
D037742 Nanotubes, Carbon Nanotubes, Carbon results in decreased expression of CDK8 mRNAdecreases expression 15585362
D011374 Progesterone Progesterone results in increased expression of CDK8 mRNAincreases expression 16888808
D011794 Quercetin Quercetin results in increased expression of CDK8 mRNAincreases expression 14715546
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Genistein 2.5311473722
MESH:D000743 Anemia, Hemolytic Quercetin 4.5217084956
MESH:D001260 Ataxia Telangiectasia Quercetin 5.3715336622
MESH:D001327 Autoimmune Diseases Quercetin 4.7719761891
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.7817868700
MESH:D001930 Brain Injuries Progesterone 4.6215845082 15380490 15665606
MESH:D001932 Brain Neoplasms Carmustine 4.6516187019
MESH:D001943 Breast Neoplasms Genistein 2.0216873071 17200150 16541309
MESH:D001943 Breast Neoplasms Progesterone 2.0217614352 15562024 16175315
MESH:D001943 Breast Neoplasms Quercetin 2.0218628248
MESH:D002105 Cadmium Poisoning Quercetin 5.9916962696
MESH:D006528 Carcinoma, Hepatocellular Genistein 3.3916924424
MESH:D006528 Carcinoma, Hepatocellular Quercetin 3.3919519916 12508355
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 5.3117234771
MESH:D006332 Cardiomegaly Quercetin 3.4519794523
MESH:D002318 Cardiovascular Diseases Genistein 3.4816332659
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.9020889678
MESH:D003110 Colonic Neoplasms 17-(allylamino)-17-demethoxygeldanamycin 6.3715993848
MESH:D003110 Colonic Neoplasms Genistein 6.3717182828
MESH:D003110 Colonic Neoplasms Quercetin 6.3716640504 11134977 19056647 19440933 17191121 15741050 17148506
MESH:D015179 Colorectal Neoplasms Quercetin 2.1918852136 18095365
MESH:D018500 Diabetes Insipidus, Nephrogenic 17-(allylamino)-17-demethoxygeldanamycin 6.6118854434
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.9719496084
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 2.5416647724
MESH:D003929 Diabetic Neuropathies Progesterone 4.8517187935
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 4.1117692515
MESH:D004714 Endometrial Hyperplasia Genistein 4.9916402032
MESH:D016889 Endometrial Neoplasms Genistein 3.5311473722
MESH:D004715 Endometriosis Progesterone 4.0316134523
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1320426865
MESH:D005355 Fibrosis Quercetin 4.2619474275
MESH:D005909 Glioblastoma Carmustine 13.0616187019
MESH:D005909 Glioblastoma Genistein 13.0616598420
MESH:D005909 Glioblastoma Quercetin 13.0619804834
MESH:D005910 Glioma Quercetin 3.1417643826
MESH:D006943 Hyperglycemia Quercetin 4.3011834736 18262572
MESH:D006973 Hypertension Quercetin 2.9418356687
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.7615869954
MESH:D007249 Inflammation Progesterone 2.7215869954
MESH:D007251 Influenza, Human Quercetin 4.9516624496
MESH:D007627 Keloid Quercetin 5.3117086741
MESH:D007674 Kidney Diseases Quercetin 3.2416962696
MESH:D007938 Leukemia Genistein 6.9617468513 18980019
MESH:D007938 Leukemia Quercetin 6.9617468513
MESH:D008106 Liver Cirrhosis, Experimental Genistein 2.8217823541
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 2.8212741479
MESH:D008113 Liver Neoplasms Quercetin 2.7518980244
MESH:D008114 Liver Neoplasms, Experimental Quercetin 3.2119519916
MESH:D008175 Lung Neoplasms Quercetin 2.1916280456
MESH:D017728 Lymphoma, Large-Cell, Anaplastic 17-(allylamino)-17-demethoxygeldanamycin 7.0117157164
MESH:D008325 Mammary Neoplasms, Experimental Genistein 6.7612929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.7611408345 17203775
MESH:D008545 Melanoma Carmustine 2.8912393984
MESH:D009203 Myocardial Infarction Genistein 6.3217141266
MESH:D009203 Myocardial Infarction Quercetin 6.3219595682
MESH:D015428 Myocardial Reperfusion Injury Genistein 9.4217141266
MESH:D015428 Myocardial Reperfusion Injury Quercetin 9.4219207477
MESH:D009369 Neoplasms Quercetin 2.9115185748
MESH:D009421 Nervous System Malformations Genistein 4.3616427766
MESH:D020078 Neurogenic Inflammation Quercetin 4.6717929310
MESH:D010024 Osteoporosis Genistein 3.4119401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 11.1716169203
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 11.1719495926
MESH:D010051 Ovarian Neoplasms Genistein 8.4219005980
MESH:D010051 Ovarian Neoplasms Progesterone 8.4216525653 17393432
MESH:D010051 Ovarian Neoplasms Quercetin 8.4219005980
MESH:D010190 Pancreatic Neoplasms Quercetin 2.9316965848
MESH:D011230 Precancerous Conditions Quercetin 4.2319056647
MESH:D011471 Prostatic Neoplasms Genistein 3.4216925846 15378649 15256057
MESH:D011471 Prostatic Neoplasms Quercetin 3.4214715546 17292933
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9318045962
MESH:D012554 Schistosomiasis japonica Quercetin 5.9916862918
MESH:D013119 Spinal Cord Injuries Progesterone 4.6816503802 15862959
MESH:D001749 Urinary Bladder Neoplasms Quercetin 2.8916720314
Pathway ID Pathway Name
REACT:15380 Diabetes pathways
REACT:71 Gene Expression
REACT:27166 Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26315
    • No data
    Releated disease ID Related disease Name
    PA446108Colorectal Neoplasms
    No data
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB03496 - Flavopiridol Antineoplastic Agents;Growth Inhibitors;Protein Kinase Inhibitors;Glycogen Phosphorylase inhibitor
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved