AutismKB 2.0

Annotation Detail for KCNMB2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:KCNMB2 ( MGC22431 )
Gene Full Name: potassium large conductance calcium-activated channel, subfamily M, beta member 2
Band: 3q26.32
Quick LinksEntrez ID:10242; OMIM: 605214; Uniprot ID:KCMB2_HUMAN; ENSEMBL ID: ENSG00000197584; HGNC ID: 6286
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04270Vascular smooth muscle contraction
Pathway IDPathway Name
Hemostasis
No data
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
CANCER
Acute lymphoblastic leukemia (childhood)
Desease Name
Acute lymphoblastic leukemia (childhood)
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of KCNMB2 mRNAaffects expression 16483693
C055494 caffeic acid phenethyl ester [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of KCNMB2 mRNAaffects cotreatment|decreases expression 20360939
D003474 Curcumin Curcumin results in decreased expression of KCNMB2 mRNAdecreases expression 17198877
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of KCNMB2 mRNAaffects cotreatment|decreases expression 20360939
D014415 Tunicamycin Tunicamycin results in increased expression of KCNMB2 mRNAincreases expression 17127020
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 4.1018287403
MESH:D000236 Adenoma Diethylnitrosamine 3.036695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.4417162532 19052882 18056438 19061943 16434500 17620307
MESH:D019973 Alcohol-Related Disorders Curcumin 5.6917887948
MESH:D000544 Alzheimer Disease Curcumin 2.6715590663
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.8016807698
MESH:D050197 Atherosclerosis Curcumin 3.5118704882
MESH:D001327 Autoimmune Diseases Curcumin 4.9819761891
MESH:D002545 Brain Ischemia Curcumin 4.8716770732
MESH:D001932 Brain Neoplasms Curcumin 4.2817596214
MESH:D001943 Breast Neoplasms Curcumin 2.3216243823 19250217 18462866 18593918
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.3217474063
MESH:D002277 Carcinoma Curcumin 4.1218593918
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 1.8716935385 18691550 19701751 20935162 10672840 21159647 18210153 16830150 17761372 18978308 20514400 11831363 19208518 19107877 19539802 10737359 16328049 16807293 18393292 19335982 17162532 20524982 20101231 18056438 19052882 17173139 18788625 20007298 16878318 19519916 3084413 19171122 16569478 16779866 20727157 17428255 17055752 16698587 19919837 17138121 20214788 19383236 16502159 19822196 18506893 16681979 17978847 18971187 18785209 16288022 20432363 18665156 3581430 19394651 20084675 20512989 18494052 19418558 16540662
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 3.0718414057
MESH:D002294 Carcinoma, Squamous Cell Curcumin 2.8418462866
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 3.0921159647 17174075 7505956 2727394
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 4.0119052882
MESH:D003092 Colitis Curcumin 4.6616782535 18200517 16804969
MESH:D003103 Coloboma Curcumin 4.9218809619
MESH:D003110 Colonic Neoplasms Curcumin 2.5519359593 16340194
MESH:D016510 Corneal Neovascularization Curcumin 5.3818497527
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 4.8318403477
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.8320387270
MESH:D003928 Diabetic Nephropathies Curcumin 4.3318204486
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 2.1319107877
MESH:D004381 Duodenal Ulcer Curcumin 4.4917351913
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.7316302075
MESH:D005234 Fatty Liver Curcumin 9.2919297423
MESH:D005234 Fatty Liver Diethylnitrosamine 9.2921071580 20387270
MESH:D005355 Fibrosis Curcumin 4.4718705752
MESH:D005770 Gastrointestinal Neoplasms Curcumin 5.1818462866
MESH:D005909 Glioblastoma Curcumin 3.6917596214
MESH:D006258 Head and Neck Neoplasms Curcumin 3.8818462866 18829502
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 5.5217701891
MESH:D006937 Hypercholesterolemia Curcumin 4.4318704882
MESH:D007249 Inflammation Curcumin 5.8218403477 17151092 16956363
MESH:D007249 Inflammation Diethylnitrosamine 5.8218785209
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.3218596194 18200517
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 11.2810783313
MESH:D007414 Intestinal Neoplasms Curcumin 11.2810783313
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 3.7315369732
MESH:D007889 Leiomyoma Curcumin 4.9818555241
MESH:D007938 Leukemia Curcumin 3.3918462866
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 4.5816106398
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 4.2116766008
MESH:D015458 Leukemia, T-Cell Curcumin 5.2016106398
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9919638242 20032147 18407596 18665156 18522880
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 2.2818006644 18705752 17355460
MESH:D008107 Liver Diseases Curcumin 4.5116956363
MESH:D008107 Liver Diseases Diethylnitrosamine 4.5117034775
MESH:D008113 Liver Neoplasms Diethylnitrosamine 2.3419254457 19427195 20101389 20118626 19812893 2422723 15175105 15885732 20452335 2862719 18648771 19833225 18754104 19073162 18977376 19850985 20501860 21047994 19426721 19642983 18644402 12112319 19690152 20137499 19294768 20583210 21278145 12771043 19638242 9163691 19499222 10737359 20492335 19256749 20405173 19255062 18978307 19996281 16942905 19090486 19551842 20434301 21071580 21167192
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 2.8318775883 21159647 19009564 19126423 18544905 19519916 18079962 18282651 16267830 2563599 19539802 18164116 18253720 17174075 17942915 18308698 17854601 18093689 19004024 3124819 9362446 16842330
MESH:D008175 Lung Neoplasms Curcumin 2.7219359593 18462866 16243823
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.7221163286 20970405 20512841 6695378
MESH:D008223 Lymphoma Curcumin 3.8318462866
MESH:D016399 Lymphoma, T-Cell Curcumin 5.1816173963
MESH:D008545 Melanoma Curcumin 2.4518462866 17885582
MESH:D008569 Memory Disorders Curcumin 4.5917263510
MESH:D009101 Multiple Myeloma Curcumin 3.7619372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 5.4617962980
MESH:D009361 Neoplasm Invasiveness Curcumin 4.8118495463
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.689029167 3581430
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 5.1412497104
MESH:D009423 Nervous System Neoplasms Curcumin 6.2418462866
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.6520387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.7320387270
MESH:D009765 Obesity Curcumin 2.8119297423
MESH:D010024 Osteoporosis Curcumin 3.6718719352
MESH:D010051 Ovarian Neoplasms Curcumin 2.9018462866 19020741
MESH:D010190 Pancreatic Neoplasms Curcumin 5.7717440100 19196508 19401701
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.7716540662
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.882563599
MESH:D011471 Prostatic Neoplasms Curcumin 3.6311398177 18156803 18226269 10851300 15129424 18769126 12497104
MESH:D011656 Pulmonary Emphysema Curcumin 4.8819168576
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 4.4310666014 18379247
MESH:D012509 Sarcoma Curcumin 4.4618462866
MESH:D018805 Sepsis Curcumin 4.3818389075
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013276 Stomach Ulcer Curcumin 3.8616631530 19188055
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.257505956
MESH:D001749 Urinary Bladder Neoplasms Curcumin 3.0018593936
MESH:D014565 Urogenital Neoplasms Curcumin 5.8018462866
Pathway ID Pathway Name
REACT:604 Hemostasis
KEGG:04270 Vascular smooth muscle contraction
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB01110 antagonist Miconazole Antifungal Agents
DB03861 - (2r,3r,4s,5r)-2-Acetamido-3,4-Dihydroxy-5-Hydroxymethyl-Piperidinium
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved