AutismKB 2.0

Annotation Detail for TIMM17B


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Basic Information Top
Gene Symbol:TIMM17B ( DXS9822,TIM17B )
Gene Full Name: translocase of inner mitochondrial membrane 17 homolog B (yeast)
Band: Xp11.23
Quick LinksEntrez ID:10245; OMIM: 300249; Uniprot ID:TI17B_HUMAN; ENSEMBL ID: ENSG00000126768; HGNC ID: 17310
Relate to Another Database: SFARIGene; denovo-db
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of TIMM17B mRNAaffects expression 21346803
D001241 Aspirin Aspirin results in increased expression of TIMM17B mRNAincreases expression 11906190
D019259 Lamivudine [Zidovudine co-treated with Lamivudine] results in increased expression of TIMM17B mRNAaffects cotreatment|increases expression 18313992
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of TIMM17B mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of TIMM17B mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TIMM17B mRNAaffects cotreatment|increases expression 17942748
D008694 Methamphetamine Methamphetamine results in decreased expression of TIMM17B mRNAdecreases expression 19149911
D013629 Tamoxifen Tamoxifen affects the expression of TIMM17B mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TIMM17B mRNAaffects cotreatment|increases expression 17942748
D014303 Trinitrotoluene Trinitrotoluene affects the expression of TIMM17B mRNAaffects expression 21346803
D015215 Zidovudine [Zidovudine co-treated with Lamivudine] results in increased expression of TIMM17B mRNAaffects cotreatment|increases expression 18313992
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.8714745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.5311752688 15322242 14514962
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 9.537525203
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2617505938
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 5.089612607
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8514692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6616835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1411748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7815885639
MESH:D055963 Asthma, Aspirin-Induced Aspirin 4.8712372130 20485159
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8915746008
MESH:D001932 Brain Neoplasms Aspirin 4.6115481559
MESH:D001943 Breast Neoplasms Aspirin 1.9615161893
MESH:D001943 Breast Neoplasms Tamoxifen 1.9618425577 19288272 20859285 11161223 18629630 17440819 16818667 19084267 19103187 19189210 19244106 19487384 18821012 16202921 18984771 17261762 20005174 17049068 19059307 21138602 17242785 19142967 20065188 19155303 18855134 19410462 16273361 18351453 19066611 19221464 19289846 21152245 18997820 15668708 18815881 20390343 17893378 19200415 16873071 19189212 20135344 19011961 20544844 15565566 19115204
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9620435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.7619066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 3.0616705839
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 3.0616924424
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.8117572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4718850075 18670907 16120746
MESH:D002386 Cataract Trinitrotoluene 3.9815817613 14694615
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3416835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0215861022 17681005 17110522 16919318 17333356 16105132 11677210
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1812621046 8697196 15668235 16354765 15340226
MESH:D003110 Colonic Neoplasms Aspirin 3.0112411196
MESH:D015179 Colorectal Neoplasms Aspirin 2.7517047198
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 9.8914669216 17141729
MESH:D000013 Congenital Abnormalities Trinitrotoluene 9.8915095906
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003490 Cyanosis 2,4-dinitrotoluene 12.1118551238
MESH:D003490 Cyanosis Trinitrotoluene 12.1118551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.6219031437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.6619279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.6018551238 21346803
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.6020420201
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 6.6018551238 21346803
MESH:D004362 Drug Toxicity Lamivudine 14.7715040536
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 14.7711462148
MESH:D004362 Drug Toxicity Zidovudine 14.7715040536
MESH:D004487 Edema Aspirin 7.7417259670
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.7411000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2218230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.7512538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.7519031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1717893378 16202921 20544844 19155303
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2110568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 14.4315345470
MESH:D005234 Fatty Liver Tamoxifen 14.4314986274 19224547
MESH:D005234 Fatty Liver Zidovudine 14.4318299183
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3516709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.8114745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.4719069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.2120067830
MESH:D005909 Glioblastoma Aspirin 4.0812870263
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006261 Headache Aspirin 5.2815240983
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4311294989 10048152
MESH:D006402 Hematologic Diseases Zidovudine 4.9312579204
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006509 Hepatitis B Lamivudine 5.3117703166
MESH:D019694 Hepatitis B, Chronic Lamivudine 5.3112044531 15631357 15274664 16476009 15309715
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.5915340226 16120746 12621046
MESH:D006529 Hepatomegaly Trinitrotoluene 9.5915817613
MESH:D015658 HIV Infections Lamivudine 7.3811141242 17530837 20032539 9296927
MESH:D015658 HIV Infections Zidovudine 7.3811698656 11363243 11141242 20032539 17358032
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3616354765 15340226 16959395 18606429 8697196
MESH:D012001 Hyperacusis Aspirin 6.0815240983
MESH:D006948 Hyperkinesis Methamphetamine 5.7917658665
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9718850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0716945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.3317937319
MESH:D007248 Infertility, Male Trinitrotoluene 7.3312150543
MESH:D007249 Inflammation Tamoxifen 5.2119457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.2112200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5416580747
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.5416705839
MESH:D007680 Kidney Neoplasms Tamoxifen 13.5418625569
MESH:D007680 Kidney Neoplasms Zidovudine 13.5412579204
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 4.6220370541
MESH:D008064 Lipidoses Tamoxifen 3.3015342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.3318564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3312878042
MESH:D008113 Liver Neoplasms Tamoxifen 4.6216684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.6216984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2212151625
MESH:D008175 Lung Neoplasms Tamoxifen 3.5718625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5711884234 19555203
MESH:D008175 Lung Neoplasms Zidovudine 3.5718800350
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.0419428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.7414580682 16827153 11731420 19196723 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.8719453300
MESH:D008545 Melanoma Tamoxifen 1.9012393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.4715990972
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 6.1617358032
MESH:D008881 Migraine Disorders Aspirin 4.2115240983
MESH:D009203 Myocardial Infarction Aspirin 3.6312692751
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D009325 Nausea Aspirin 5.5315240983
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.6518551238
MESH:D009336 Necrosis Trinitrotoluene 11.6518551238
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6119393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5719410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.3219200415 19189210 19196722
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4514600291
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.8716049721 12819281
MESH:D009784 Occupational Diseases Trinitrotoluene 9.8714694615 17852074 12819281
MESH:D010003 Osteoarthritis Aspirin 4.177009135
MESH:D010146 Pain Aspirin 4.026363464 6995502
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9111578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D010438 Peptic Ulcer Hemorrhage Aspirin 5.8211156591
MESH:D020795 Photophobia Aspirin 6.0815240983
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4811896295 11222880 11399792 11118676
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.1115067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.6015861022 16919318
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012206 Rhabdomyolysis Lamivudine 5.829296927
MESH:D012220 Rhinitis Aspirin 4.5712372130
MESH:D012640 Seizures 2,4-dinitrotoluene 6.6518551238
MESH:D012640 Seizures Trinitrotoluene 6.6518551238
MESH:D012851 Sinus Thrombosis, Intracranial Aspirin 5.5212269725
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1316192470
MESH:D013088 Spermatocele Ethinyl Estradiol 12.6516709447
MESH:D013088 Spermatocele Tamoxifen 12.6516709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.3219457130
MESH:D013163 Splenomegaly Trinitrotoluene 5.4615817613
MESH:D013274 Stomach Neoplasms Zidovudine 2.4817696246
MESH:D020521 Stroke Aspirin 4.5416403987
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8411994571
MESH:D013927 Thrombosis Aspirin 9.8117672075
MESH:D013927 Thrombosis Ethinyl Estradiol 9.8115669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.2716049721
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.2717572228 16712894 8653321
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.6010091137
MESH:D014581 Urticaria Aspirin 4.6620485159 10982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5414692618
MESH:D014625 Vaginal Neoplasms Zidovudine 5.0212579204
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7515869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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