AutismKB 2.0

Annotation Detail for CDK9


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Basic Information Top
Gene Symbol:CDK9 ( C-2k,CDC2L4,CTK1,PITALRE,TAK )
Gene Full Name: cyclin-dependent kinase 9
Band: 9q34.11
Quick LinksEntrez ID:1025; OMIM: 603251; Uniprot ID:CDK9_HUMAN; ENSEMBL ID: ENSG00000136807; HGNC ID: 1780
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Elongation arrest and recovery
Pausing and recovery of elongation
Transcription
Gene Expression
HIV Infection
No data
No data
Pathway IDPathway Name
500949RNA Polymerase II Pre-transcription Events
500741Formation of HIV-1 elongation complex containing HIV-1 Tat
500753Interactions of Tat with host cellular proteins
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1809HIV infection
1944Breast cancer
2067Primary tumor
2151Neuroblastoma
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of CDK9 mRNAaffects expression 21346803
C120275 2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone 2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone inhibits the reaction [CDK9 protein binds to CCNT1 protein]affects binding|decreases reaction 17631934
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in decreased expression of CDK9 mRNAdecreases expression 12419474
D000082 Acetaminophen Acetaminophen affects the expression of CDK9 mRNAaffects expression 17562736
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of CDK9 mRNAaffects expression 20382639
D002101 Cacodylic Acid Cacodylic Acid results in increased expression of CDK9 mRNAincreases expression 17720352
D020111 Chlorodiphenyl (54% Chlorine) Chlorodiphenyl (54% Chlorine) results in increased expression of CDK9 mRNAincreases expression 16934159
C415250 deferasirox deferasirox inhibits the reaction [CDK9 protein binds to CCNT1 protein]affects binding|decreases reaction 17631934
D006861 Hydrogen Peroxide Hydrogen Peroxide results in decreased expression of CDK9 mRNAdecreases expression 12419474
C015329 lycopene lycopene results in decreased expression of CDK9 proteindecreases expression 17337101
D037742 Nanotubes, Carbon Nanotubes, Carbon results in decreased expression of CDK9 mRNAdecreases expression 15585362
C475587 olomoucine II olomoucine II results in decreased activity of CDK9 proteindecreases activity 16003486
D011374 Progesterone Progesterone results in increased expression of CDK9 mRNAincreases expression 16888808
D018038 Sodium Selenite Sodium Selenite results in decreased expression of CDK9 mRNAdecreases expression 16705456
D014212 Tretinoin Tretinoin results in increased expression of CDK9 mRNAincreases expression 15753651
D014212 Tretinoin Tretinoin results in increased expression of CDK9 proteinincreases expression 15753651
C066075 vanadium pentoxide vanadium pentoxide results in decreased expression of CDK9 mRNAdecreases expression 17459161
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000505 Alopecia Tretinoin 3.6215955085
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 4.1010965797
MESH:D000799 Angioedema Acetaminophen 3.8710982225
MESH:D001169 Arthritis, Experimental Tretinoin 3.0816412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2616292516
MESH:D001249 Asthma Tretinoin 2.3416456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001471 Barrett Esophagus Tretinoin 4.4116935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.6116206674 16197459
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.3717868700
MESH:D001930 Brain Injuries Progesterone 4.2715845082 15380490 15665606
MESH:D001943 Breast Neoplasms Cacodylic Acid 2.1117474063
MESH:D001943 Breast Neoplasms Progesterone 2.1115562024 17614352 16175315
MESH:D001943 Breast Neoplasms Tretinoin 2.1116166294 16873071 16443354
MESH:D001991 Bronchitis vanadium pentoxide 6.2717459161
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.6116813970
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.1916168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.5316705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.533084413
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.531917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.2916051514 16096774
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 3.5116936243
MESH:D002386 Cataract Acetaminophen 7.2310977129
MESH:D002386 Cataract Tretinoin 7.2317460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.7320889678
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.6116129372
MESH:D002822 Choriocarcinoma Tretinoin 5.1916461808
MESH:D019457 Chromosome Breakage Sodium Selenite 4.7615894690
MESH:D002972 Cleft Palate Tretinoin 2.679407595
MESH:D003092 Colitis Tretinoin 3.7217035595
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.8217551590 8800419 16925845 9142499 10589399 9211117 14991402 9125849 9664655 9224671
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.0318551238
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.7816285004
MESH:D003929 Diabetic Neuropathies Progesterone 4.5117187935
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.0421346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.0416177239 12705907 11287661 17906064 19739265 18071297 16081117 11739529 16109766 18713872 11461765 11743745 14986274 17562736 16781746 2444490 14725611 11529661 10915739 19164858 19416960 11834606 19085960 10774834 15968718 12153990 12540782 14550746 12958197 16227642 16485898 16393943 19420014 12392966 17522070 10663392 19923254 15619225 12594235 11421492 19370779
MESH:D056486 Drug-Induced Liver Injury Chlorodiphenyl (54% Chlorine) 9.0417851650
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 9.0415131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1319426721
MESH:D004489 Edema, Cardiac Tretinoin 4.5018230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.7917692515
MESH:D016889 Endometrial Neoplasms Tretinoin 3.1116569247
MESH:D004715 Endometriosis Progesterone 3.7716134523
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.0720426865
MESH:D005124 Eye Abnormalities Tretinoin 3.589664655 16938888
MESH:D005355 Fibrosis Tretinoin 3.5317994277
MESH:D005756 Gastritis Acetaminophen 3.7116983495
MESH:D005909 Glioblastoma Tretinoin 3.0117312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.1916096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.1916084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.909664655 14991402
MESH:D015658 HIV Infections 2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone 8.2117631934
MESH:D015658 HIV Infections deferasirox 8.2117631934
MESH:D006930 Hyperalgesia Acetaminophen 7.6316870215
MESH:D006930 Hyperalgesia Tretinoin 7.6316870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.5816778211
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.4115869954
MESH:D007249 Inflammation Progesterone 2.6015869954
MESH:D007333 Insulin Resistance Sodium Selenite 3.2814714311
MESH:D007410 Intestinal Diseases Tretinoin 3.7817994277
MESH:D007569 Jaw Abnormalities Tretinoin 3.9017551590 15992940
MESH:D007674 Kidney Diseases Acetaminophen 2.2012587719 15629191
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 4.2816518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 2.9816705839
MESH:D007938 Leukemia Tretinoin 2.7717143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.7016482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0816294345 17596541 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.1519075265 17712046 19642359 17368321 17339181 15748426 17107899 16766008 16788101 16331271 17361223 9834237 16891316 16140955 19035177 17506722 19029980 17217047 12679006 16935935 17301526 17649720 19225113 17294898 16823087
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.319224671
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 1.8016248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 1.6316610002 16611625 12587719 12969438 19784758 19014921 11587558 19460945
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2416871587 17185352
MESH:D008175 Lung Neoplasms vanadium pentoxide 3.2212376484
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.0614737004
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 2.8711408345 17203775
MESH:D008527 Medulloblastoma Tretinoin 2.7817453147
MESH:D008545 Melanoma Tretinoin 1.9416752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5819513568
MESH:D008591 Meningomyelocele Tretinoin 4.4416940565
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.0817596541
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.8818551238
MESH:D009369 Neoplasms lycopene 5.5717051425
MESH:D009369 Neoplasms Tretinoin 5.5716946489 16594593
MESH:D009421 Nervous System Malformations Tretinoin 3.799125849
MESH:D009436 Neural Tube Defects Tretinoin 3.059142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8718514411
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.4312819281 16049721
MESH:D010051 Ovarian Neoplasms Progesterone 4.9216525653 17393432
MESH:D010051 Ovarian Neoplasms Tretinoin 4.9216936753
MESH:D010146 Pain Acetaminophen 6.5916870215
MESH:D010146 Pain Tretinoin 6.5916870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.4615976015
MESH:D010212 Papilloma Hydrogen Peroxide 4.1012065085
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 5.5311550810
MESH:D011471 Prostatic Neoplasms lycopene 3.8017337101 15084515
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.8018760546
MESH:D011507 Proteinuria Tretinoin 3.6116636307
MESH:D011625 Pterygium Tretinoin 4.8116723453
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.1116283617 16116481
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8618045962
MESH:D012640 Seizures 2,4-dinitrotoluene 2.5318551238
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 5.9412065085
MESH:D012878 Skin Neoplasms Tretinoin 5.9416467112
MESH:D013119 Spinal Cord Injuries Progesterone 4.3016503802 15862959
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013964 Thyroid Neoplasms Tretinoin 3.0316026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.7916051514
MESH:D014376 Tuberculosis Tretinoin 3.2316040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.5416049721
MESH:D001749 Urinary Bladder Neoplasms Cacodylic Acid 5.5415537745
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.3310091137
MESH:D014581 Urticaria Acetaminophen 2.9810982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.6816129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.6416752155
MESH:D014820 Vitiligo Tretinoin 4.0716761959
MESH:D009396 Wilms Tumor Tretinoin 3.9716287080
Pathway ID Pathway Name
REACT:1892 Elongation arrest and recovery
REACT:71 Gene Expression
REACT:6185 HIV Infection
REACT:769 Pausing and recovery of elongation
REACT:1788 Transcription
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26316
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB03496 - Flavopiridol Antineoplastic Agents;Growth Inhibitors;Protein Kinase Inhibitors;Glycogen Phosphorylase inhibitor
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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