AutismKB 2.0

Annotation Detail for SPRY2


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Basic Information Top
Gene Symbol:SPRY2 ( MGC23039,hSPRY2 )
Gene Full Name: sprouty homolog 2 (Drosophila)
Band: 13q31.1
Quick LinksEntrez ID:10253; OMIM: 602466; Uniprot ID:SPY2_HUMAN; ENSEMBL ID: ENSG00000136158; HGNC ID: 11270
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04630Jak-STAT signaling pathway
Pathway IDPathway Name
Signaling by EGFR
Pathway IDPathway Name
200033Signaling events mediated by PTP1B
200189FGF signaling pathway
200146Internalization of ErbB1
Pathway IDPathway Name
P00018EGF receptor signaling pathway
P00021FGF signaling pathway
Pathway IDPathway Name
500515EGFR downregulation
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1770Melanoma
1831Prostate cancer
2022Liver cancer
Desease Name
nonsyndromic cleft lip with or without cleft palate
DEVELOPMENTAL
Desease Name
Type 2 diabetes
Nonsyndromic cleft lip with or without cleft palate
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of SPRY2 mRNAdecreases expression 18648102
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in decreased expression of SPRY2 mRNAdecreases expression 12419474
D000082 Acetaminophen Acetaminophen affects the expression of SPRY2 mRNAaffects expression 17562736
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of SPRY2 mRNAincreases expression 18687144
C006780 bisphenol A bisphenol A affects the expression of SPRY2 mRNAaffects expression 20170705
D016572 Cyclosporine Cyclosporine results in increased expression of SPRY2 mRNAincreases expression 20106945
D002117 Calcitriol Calcitriol results in increased expression of SPRY2 mRNAincreases expression 16002434
D006861 Hydrogen Peroxide Hydrogen Peroxide results in decreased expression of SPRY2 mRNAdecreases expression 12419474
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of SPRY2 mRNAincreases expression 20713471
D008770 Methylnitrosourea Methylnitrosourea results in increased expression of SPRY2 mRNAincreases expression 17412507
C006253 pirinixic acid pirinixic acid results in increased expression of SPRY2 mRNAincreases expression 17426115
C017947 sodium arsenite sodium arsenite results in decreased expression of SPRY2 mRNAdecreases expression 19072884
D013654 Taurine Taurine results in increased expression of SPRY2 mRNAincreases expression 16579726
C081489 valsartan valsartan inhibits the reaction [AGT protein results in increased expression of SPRY2 mRNA]decreases reaction|increases expression 19225232
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.1718653653
MESH:D000230 Adenocarcinoma Methylnitrosourea 3.1315113128 15688392
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 7.013712494
MESH:D000236 Adenoma Methylcholanthrene 7.016695378 10545420
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.5616434500
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.8015276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.0017306315 16712894
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 4.1310965797
MESH:D000799 Angioedema Acetaminophen 3.9410982225
MESH:D050197 Atherosclerosis Methylcholanthrene 3.4811922910
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.121440618 11289319
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2019483382
MESH:D001862 Bone Resorption bisphenol A 3.9211985600
MESH:D001943 Breast Neoplasms bisphenol A 2.0717123778
MESH:D001943 Breast Neoplasms Calcitriol 2.0711237771
MESH:D001943 Breast Neoplasms Methylcholanthrene 2.0717474063
MESH:D001943 Breast Neoplasms Methylnitrosourea 2.0711306469 14633655 16253758
MESH:D002277 Carcinoma Methylcholanthrene 4.0110545420
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.587296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.583084413
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 4.5817306315 15276417 16507464
MESH:D002278 Carcinoma in Situ bisphenol A 5.0717123778
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.707296757
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 4.8611237771
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.8618572023
MESH:D006332 Cardiomegaly valsartan 4.2119597038
MESH:D009202 Cardiomyopathies valsartan 4.4716247790
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 8.0216936243
MESH:D002318 Cardiovascular Diseases valsartan 8.0211230374
MESH:D002386 Cataract Acetaminophen 7.6610977129
MESH:D002386 Cataract Methylnitrosourea 7.6612484553
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 21.537505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 21.5312371664
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 21.5316192471
MESH:D002471 Cell Transformation, Neoplastic Methylnitrosourea 21.532727394 7505956
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 21.5320056578 19524636
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 13.6219486331 9022650
MESH:D002779 Cholestasis Cyclosporine 13.6219486331
MESH:D002779 Cholestasis pirinixic acid 13.6219176532
MESH:D002971 Cleft Lip marker/mechanism 17576140
MESH:D002972 Cleft Palate marker/mechanism 17576140
MESH:D003324 Coronary Artery Disease valsartan 3.9117719468
MESH:D003384 Coxsackievirus Infections valsartan 5.9220392896
MESH:D019465 Craniofacial Abnormalities marker/mechanism 17576140
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.878156756 18759878 2524372 14531868 12868966 11298694 11906362 8970840
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4518249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.552952479 3621924
MESH:D003921 Diabetes Mellitus, Experimental valsartan 4.6411508273
MESH:D058065 Diabetic Cardiomyopathies Taurine 6.1316025228
MESH:D003928 Diabetic Nephropathies valsartan 4.8418630688 11427623
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.4718692083 1440618 9022650 18289764 6482804 7440962 9328219 16192314 8291058 6679447 9653073 18648102 11289319
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.4710663392 12958197 12705907 16177239 12594235 16227642 12153990 17522070 14550746 15968718 19164858 11421492 12540782 11834606 18071297 10915739 19416960 19085960 16393943 12392966 11739529 19420014 16781746 16109766 11461765 15619225 16485898 16081117 11529661 14986274 18713872 14725611 17562736 11743745 19370779 19923254 17906064 2444490 19739265 11287661 10774834
MESH:D056486 Drug-Induced Liver Injury Taurine 6.479328219
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1919426721
MESH:D004487 Edema pirinixic acid 2.5312083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 4.0015138306
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.123581430
MESH:D005234 Fatty Liver Cyclosporine 7.7419224547
MESH:D005234 Fatty Liver pirinixic acid 7.7420131406 19236843
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.126705139
MESH:D005354 Fibrosarcoma Methylcholanthrene 12.5014633661 10962813
MESH:D005354 Fibrosarcoma Methylnitrosourea 12.5011555667
MESH:D005355 Fibrosis Cyclosporine 9.3912639820 12168785
MESH:D005355 Fibrosis valsartan 9.3916893502
MESH:D005756 Gastritis Acetaminophen 3.7716983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.7616452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.308708960
MESH:D005910 Glioma Methylnitrosourea 3.589825942
MESH:D015432 Glomerulonephritis, Membranoproliferative valsartan 5.6116928621
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.107505956
MESH:D006333 Heart Failure pirinixic acid 7.4920558911
MESH:D006333 Heart Failure valsartan 7.4919027736
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5015720958
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.586705139
MESH:D006529 Hepatomegaly pirinixic acid 3.0718467677 19772884 19176532 16221962
MESH:D006689 Hodgkin Disease sodium arsenite 3.2012676792
MESH:D006930 Hyperalgesia Acetaminophen 2.7416870215
MESH:D006943 Hyperglycemia pirinixic acid 3.2320558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.0115034207
MESH:D006973 Hypertension Cyclosporine 5.6810903974
MESH:D006973 Hypertension valsartan 5.6818344623 10903974 20102058 16475468 11427623 12850387 12692753 18390891
MESH:D006974 Hypertension, Malignant valsartan 6.5111560862
MESH:D007248 Infertility, Male Methylnitrosourea 7.247193160
MESH:D007248 Infertility, Male sodium arsenite 7.2412646999 15346721
MESH:D007333 Insulin Resistance bisphenol A 7.4316393666
MESH:D007333 Insulin Resistance pirinixic acid 7.4316306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.128074119 9022650
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5415604871
MESH:D007674 Kidney Diseases Acetaminophen 14.7412587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 14.748314463 10903974 18776723
MESH:D007674 Kidney Diseases sodium arsenite 14.7420008137
MESH:D007674 Kidney Diseases valsartan 14.7410903974 12164870 16893502
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 4.3316518626
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.426582329
MESH:D007680 Kidney Neoplasms Cyclosporine 7.4212371664
MESH:D017880 Limb Deformities, Congenital Methylnitrosourea 4.2415526292
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.239327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.8715474484
MESH:D008106 Liver Cirrhosis, Experimental Taurine 3.8715931870 15893842
MESH:D008106 Liver Cirrhosis, Experimental valsartan 3.8715619341 16872305 15504291
MESH:D008107 Liver Diseases Acetaminophen 1.6412969438 16610002 12587719 19784758 16611625 11587558 19014921 19460945
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2917185352 16871587
MESH:D008113 Liver Neoplasms pirinixic acid 4.5515890375 20007298 16377806
MESH:D008113 Liver Neoplasms sodium arsenite 4.5516712894 15276417
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.273712494 6587162 1399818 598648
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 6.271399818 598648
MESH:D038061 Lower Extremity Deformities, Congenital Methylnitrosourea 5.5416080182
MESH:D008171 Lung Diseases sodium arsenite 3.2119095001
MESH:D055370 Lung Injury Asbestos, Crocidolite 4.0917365036
MESH:D008175 Lung Neoplasms marker/mechanism 15136453
MESH:D008175 Lung Neoplasms Methylcholanthrene 3.7116271038 21163286 20970405 1399818 15390079 9230183 17909032 16337739 20512841 7750092 10545420 6695378 11893704
MESH:D008175 Lung Neoplasms Methylnitrosourea 3.7118062963
MESH:D008175 Lung Neoplasms sodium arsenite 3.7119931552 16712894 17306315 17077188 15276417
MESH:D008223 Lymphoma Methylnitrosourea 4.0511418001 16257854
MESH:D016393 Lymphoma, B-Cell Methylnitrosourea 4.8314633661
MESH:D008325 Mammary Neoplasms, Experimental Methylnitrosourea 3.6112931682 16944150 17020996 15688392 19196723 11751437 16619500 15313902 10838139 11807958 10767621 14999141 16051031 15113128 16827153 14633655 17131329
MESH:D008545 Melanoma sodium arsenite 2.0416487513 19082730
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6419513568
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.2018303189 16966607 16166281
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8816801185
MESH:D009135 Muscular Diseases pirinixic acid 3.5816239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1619151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9916411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.493581430
MESH:D009369 Neoplasms Methylnitrosourea 8.5115533788
MESH:D009369 Neoplasms pirinixic acid 8.5117405874
MESH:D009369 Neoplasms sodium arsenite 8.5111559025
MESH:D009374 Neoplasms, Experimental Methylnitrosourea 9.6412696579
MESH:D009374 Neoplasms, Experimental sodium arsenite 9.6420056578
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3319348381 18481113
MESH:D009421 Nervous System Malformations bisphenol A 4.0411399458 16427766
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.376679447
MESH:D009436 Neural Tube Defects sodium arsenite 7.3712854658
MESH:D009442 Neurilemmoma Methylnitrosourea 5.5711555667
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9118514411
MESH:D009765 Obesity pirinixic acid 1.8220558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.476482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.123988306
MESH:D010049 Ovarian Diseases bisphenol A 5.0711985600
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.4517306315 15276417
MESH:D010146 Pain Acetaminophen 2.4316870215
MESH:D010190 Pancreatic Neoplasms Methylnitrosourea 3.3816965848
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 9.567296757
MESH:D010212 Papilloma Hydrogen Peroxide 9.5612065085
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 13.326228378
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 13.3211550810
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.9610923243
MESH:D011230 Precancerous Conditions Cyclosporine 3.2712371664
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 4.0310548101
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.8615572423
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.2620887781
MESH:D011471 Prostatic Neoplasms bisphenol A 2.1416740699
MESH:D011471 Prostatic Neoplasms Calcitriol 2.1418247401 16289102 12479363 16644109 15754350
MESH:D011471 Prostatic Neoplasms Methylnitrosourea 2.1415682402 12376480
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.1416039940
MESH:D011507 Proteinuria valsartan 4.9117664856 12164870 18344623
MESH:D011565 Psoriasis Cyclosporine 2.2416882103
MESH:D011629 Puberty, Precocious bisphenol A 4.8710548101
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 6.3017365031 15814490 17975199 17322281
MESH:D011658 Pulmonary Fibrosis valsartan 6.3017241526
MESH:D015427 Reperfusion Injury pirinixic acid 2.4119058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 9.253692021
MESH:D012162 Retinal Degeneration Methylnitrosourea 9.2518155124 18172121
MESH:D012175 Retinoblastoma Methylnitrosourea 5.5711555667
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 6.0512065085
MESH:D012878 Skin Neoplasms sodium arsenite 6.0519524636 18572023
MESH:D016135 Spinal Dysraphism sodium arsenite 3.8412854658
MESH:D013274 Stomach Neoplasms Methylnitrosourea 2.6915930296 16257854 18593901
MESH:D019966 Substance-Related Disorders bisphenol A 4.0716684133 16045194
MESH:D013953 Thymus Neoplasms Methylnitrosourea 5.3111418001
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.601399818 7505956 3712494 6587162 6582329
MESH:D013964 Thyroid Neoplasms Methylnitrosourea 7.603078959 7505956
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.158074119
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 5.1516712894 17306315 11723127 16452187
MESH:D014581 Urticaria Acetaminophen 3.0310982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.8211813266
MESH:D014591 Uterine Diseases bisphenol A 5.1114652134
MESH:D014605 Uveitis Cyclosporine 4.081336536
MESH:D014652 Vascular Diseases sodium arsenite 4.5117056641
MESH:D020257 Ventricular Remodeling valsartan 5.7819027736
MESH:D014985 Xerophthalmia Cyclosporine 4.5417120751
Pathway ID Pathway Name
KEGG:04630 Jak-STAT signaling pathway
REACT:9417 Signaling by EGFR
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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