AutismKB 2.0

Annotation Detail for DENND4A


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:DENND4A ( FLJ33949,IRLB,KIAA0476,MYCPBP )
Gene Full Name: DENN/MADD domain containing 4A
Band: 15q22.31
Quick LinksEntrez ID:10260; OMIM: 600382; Uniprot ID:MYCPP_HUMAN; ENSEMBL ID: ENSG00000174485; HGNC ID: 24321
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of DENND4A mRNAaffects expression 17562736
D016572 Cyclosporine Cyclosporine results in increased expression of DENND4A mRNAincreases expression 20106945
D002945 Cisplatin DENND4A protein results in decreased susceptibility to Cisplatindecreases response to substance 16734730
C051890 irinotecan irinotecan metabolite results in decreased expression of DENND4A mRNAdecreases expression 15956246
C051890 irinotecan irinotecan results in decreased expression of DENND4A mRNAdecreases expression 15956246
D014810 Vitamin E Vitamin E results in decreased expression of DENND4A mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D058186 Acute Kidney Injury Cisplatin 4.3312690470 15814532 17670903
MESH:D000230 Adenocarcinoma Cisplatin 2.8217638652 11798837
MESH:D000799 Angioedema Acetaminophen 4.4510982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D019046 Bone Marrow Neoplasms Cisplatin 5.5014601052
MESH:D001943 Breast Neoplasms Cisplatin 2.7719526202 18382427
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.4116050911
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.193084413
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 3.1917982673
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 3.1316685392 12023789
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 2.9018337622 17066447 6189445
MESH:D002386 Cataract Acetaminophen 2.7710977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.7612371664
MESH:D002779 Cholestasis Cyclosporine 3.1719486331
MESH:D003110 Colonic Neoplasms irinotecan 2.6417725105 17287894
MESH:D015179 Colorectal Neoplasms Cisplatin 2.9115273666
MESH:D015179 Colorectal Neoplasms irinotecan 2.9115273666 17159606 16303861 16391804 18509181 18259882 17454858
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9219769572
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6617522070 11739529 12392966 19739265 12958197 17906064 19420014 16081117 16227642 11461765 15619225 10915739 11421492 16781746 19164858 16177239 10774834 11287661 14550746 19416960 12594235 19085960 19923254 14986274 12153990 14725611 2444490 18713872 12540782 18071297 11529661 16109766 16393943 11834606 17562736 15968718 19370779 12705907 16485898 11743745 10663392
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.7119426721
MESH:D004362 Drug Toxicity Cisplatin 4.1115033597 19839026 12649298 12231392
MESH:C538011 Eales disease Vitamin E 5.329068938
MESH:D004938 Esophageal Neoplasms Cisplatin 2.8417638652 16785472 15464296 16481741 15173087
MESH:D005234 Fatty Liver Cyclosporine 3.2319224547
MESH:D005355 Fibrosis Cyclosporine 3.6212639820 12168785
MESH:D005756 Gastritis Acetaminophen 4.2916983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.768708960
MESH:D006258 Head and Neck Neoplasms Cisplatin 3.9415464296 15102660
MESH:D034381 Hearing Loss Cisplatin 4.6219898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.7315464296
MESH:D006330 Heart Defects, Congenital Vitamin E 3.1516080930
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.9615720958
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.8016490937 16863852
MESH:D006689 Hodgkin Disease Cisplatin 3.9116200630 16170182
MESH:D019584 Hot Flashes Vitamin E 4.5814716179
MESH:D006930 Hyperalgesia Acetaminophen 2.9916870215
MESH:D006973 Hypertension Cyclosporine 2.2010903974
MESH:D007251 Influenza, Human Vitamin E 4.8316624496
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 5.0515604871
MESH:D007673 Kidney Cortex Necrosis Cisplatin 5.7515464296
MESH:D007674 Kidney Diseases Acetaminophen 16.0015629191 12587719
MESH:D007674 Kidney Diseases Cisplatin 16.0015190930 19839026 18289764 12649298 12231392
MESH:D007674 Kidney Diseases Cyclosporine 16.0018776723 10903974 8314463
MESH:D007674 Kidney Diseases Vitamin E 16.0012488133
MESH:D007680 Kidney Neoplasms Cyclosporine 3.0412371664
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 5.4111231351
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 1.9016169303
MESH:D008107 Liver Diseases Acetaminophen 1.6912969438 11587558 16610002 16611625 19460945 12587719 19784758 19014921
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5816871587 17185352
MESH:D008171 Lung Diseases Vitamin E 3.4016863852
MESH:D008175 Lung Neoplasms Cisplatin 2.7917225452 11798837 6189445
MESH:D008175 Lung Neoplasms Vitamin E 2.7911062179
MESH:D008545 Melanoma Cisplatin 2.5116432458 18176117 18505091 18332650 15577323 12883367 17761969 12393984 17023156 16248763 16809738 12374674 11135225
MESH:D018328 Melanoma, Amelanotic Cisplatin 5.3115990972
MESH:D008546 Melanoma, Experimental Acetaminophen 4.0519513568
MESH:D008654 Mesothelioma Cisplatin 3.3617638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.4016801185
MESH:D052016 Mucositis irinotecan 5.5517159606
MESH:D009362 Neoplasm Metastasis irinotecan 3.2818259882
MESH:D009369 Neoplasms Cisplatin 3.0816773208
MESH:D009395 Nephritis, Interstitial Cisplatin 5.1015464296
MESH:D009402 Nephrosis, Lipoid Cyclosporine 5.0517954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.6119348381 18481113
MESH:D009447 Neuroblastoma Cisplatin 7.758761367
MESH:D009447 Neuroblastoma irinotecan 7.758761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1818514411
MESH:D017599 Neuroectodermal Tumors Cisplatin 13.338761367
MESH:D017599 Neuroectodermal Tumors irinotecan 13.338761367
MESH:D010051 Ovarian Neoplasms Cisplatin 2.9615464296 6897625 17225452 19769630
MESH:D010146 Pain Acetaminophen 2.6916870215
MESH:D010190 Pancreatic Neoplasms Cisplatin 3.0919003803
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.7515464296
MESH:D010997 Pleural Neoplasms Cisplatin 5.9517638057
MESH:D011230 Precancerous Conditions Cyclosporine 3.5512371664
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2515084515
MESH:D011565 Psoriasis Cyclosporine 2.3216882103
MESH:D051437 Renal Insufficiency Cisplatin 4.8915464296
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.8714601052
MESH:D012871 Skin Diseases Vitamin E 2.5118709164
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.9515464296
MESH:D013274 Stomach Neoplasms Cisplatin 2.9017522103 15958060 18396642
MESH:D013274 Stomach Neoplasms irinotecan 2.9015723263
MESH:D020521 Stroke Vitamin E 3.8116517955
MESH:D013736 Testicular Neoplasms Cisplatin 5.0315464296 17225452
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 3.0617225452 12973940 15464296
MESH:D014581 Urticaria Acetaminophen 3.3810982225
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 4.5516803524
MESH:D014605 Uveitis Cyclosporine 4.591336536
MESH:D014625 Vaginal Neoplasms Cisplatin 5.0915577323
MESH:D014839 Vomiting Cisplatin 5.3311897121
MESH:D014985 Xerophthalmia Cyclosporine 5.0517120751
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved