AutismKB 2.0

Annotation Detail for AKAP8


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Basic Information Top
Gene Symbol:AKAP8 ( AKAP95,DKFZp586B1222 )
Gene Full Name: A kinase (PRKA) anchor protein 8
Band: 19p13.12
Quick LinksEntrez ID:10270; OMIM: 604692; Uniprot ID:AKAP8_HUMAN; ENSEMBL ID: ENSG00000105127; HGNC ID: 378
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of AKAP8 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of AKAP8 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of AKAP8 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of AKAP8 mRNAaffects expression 16483693
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of AKAP8 mRNAincreases expression 20360939
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of AKAP8 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of AKAP8 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of AKAP8 mRNAaffects cotreatment|decreases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of AKAP8 mRNAdecreases expression 17557909
D011374 Progesterone Progesterone results in decreased expression of AKAP8 mRNAdecreases expression 18037150
D013629 Tamoxifen Tamoxifen affects the expression of AKAP8 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of AKAP8 mRNAaffects cotreatment|decreases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.8714745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1315322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.8418287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2617505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8514692618
MESH:D000236 Adenoma Diethylnitrosamine 2.966695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 11.0318056438 19061943 16434500 19052882 17162532 17620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.0316835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1411748828
MESH:D000799 Angioedema Acetaminophen 4.1610982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7815885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8915746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.6617868700
MESH:D001930 Brain Injuries Progesterone 4.5215380490 15665606 15845082
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9617474063
MESH:D001943 Breast Neoplasms Progesterone 1.9617614352 16175315 15562024
MESH:D001943 Breast Neoplasms Tamoxifen 1.9619059307 19221464 18855134 19142967 19289846 19189212 18997820 19189210 19244106 16202921 16273361 20135344 18821012 19084267 17242785 19155303 20065188 18351453 18425577 19011961 16818667 11161223 19066611 17893378 18629630 18815881 19200415 19410462 15668708 18984771 17261762 20859285 20544844 21152245 19487384 19288272 15565566 17440819 20390343 20005174 19103187 16873071 19115204 17049068 21138602
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9620435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.7619066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 9.1616705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 9.1616705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 9.163084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 9.1616288022 10672840 18210153 20514400 18506893 18788625 17978847 10737359 20524982 18971187 17138121 20512989 19539802 18665156 19171122 18393292 20935162 18494052 3084413 16502159 11831363 17761372 17428255 18691550 19052882 19208518 19701751 16681979 17173139 17162532 16807293 19418558 18785209 19383236 21159647 16878318 18978308 16569478 19335982 20432363 19394651 20101231 20007298 18056438 3581430 16328049 19822196 17055752 20084675 20727157 19519916 19107877 16698587 20214788 16830150 19919837 16779866 16935385 16540662
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 9.1616924424
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.8117572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4718670907 16120746 18850075
MESH:D002386 Cataract Acetaminophen 2.6910977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.156135515
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 7.157505956 21159647 2727394 17174075
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.9419052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.9416835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0215861022 16919318 17110522 16105132 11677210 17333356 17681005
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.188697196 16354765 15340226 12621046 15668235
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2414669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.7718551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.7718551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.6219031437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.3620387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3617107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.6619279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.7517187935
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 12.5821346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 12.5821346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.5816109766 18713872 10915739 16485898 19085960 11743745 11287661 18071297 19739265 12705907 19416960 17562736 16081117 12153990 16177239 11461765 12958197 12392966 11834606 14550746 16227642 14725611 17906064 12540782 14986274 11529661 16393943 16781746 19164858 19370779 11421492 11739529 15619225 10663392 19420014 17522070 15968718 12594235 2444490 19923254 10774834
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 12.5819107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.5820420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9111462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2218230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 16.7712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 16.7717692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 16.7719031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1720544844 17893378 19155303 16202921
MESH:D004715 Endometriosis Progesterone 9.5816134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.5810568697 9294722
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.4416302075
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005234 Fatty Liver Diethylnitrosamine 14.3321071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 14.3315345470
MESH:D005234 Fatty Liver Tamoxifen 14.3314986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3516709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.8114745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.4719069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.2120067830
MESH:D005756 Gastritis Acetaminophen 3.9916983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4310048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1516120746 15340226 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.368697196 18606429 15340226 16959395 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.8616870215
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9718850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0716945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.6615869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6217937319
MESH:D007249 Inflammation Diethylnitrosamine 12.7818785209
MESH:D007249 Inflammation Progesterone 12.7815869954
MESH:D007249 Inflammation Tamoxifen 12.7819457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 12.7812200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5416580747
MESH:D007674 Kidney Diseases Acetaminophen 2.3015629191 12587719
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.4316705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 13.4316705839
MESH:D007680 Kidney Neoplasms Tamoxifen 13.4318625569
MESH:D008064 Lipidoses Tamoxifen 3.3017567588 15342952
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9320032147 18665156 18522880 18407596 19638242
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.3318564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3312878042
MESH:D008107 Liver Diseases Acetaminophen 4.0512587719 16611625 19014921 12969438 19460945 19784758 11587558 16610002
MESH:D008107 Liver Diseases Diethylnitrosamine 4.0517034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4316871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 11.267678174
MESH:D008113 Liver Neoplasms Diethylnitrosamine 11.2621071580 18754104 21047994 12771043 21167192 19690152 19642983 12112319 16942905 20137499 2862719 19499222 20492335 19638242 10737359 9163691 20405173 18644402 19833225 19256749 20583210 21278145 19255062 19426721 19427195 19812893 19073162 19850985 19996281 18648771 18977376 19551842 19294768 19090486 15885732 20434301 20118626 20501860 2422723 15175105 20101389 18978307 20452335 19254457
MESH:D008113 Liver Neoplasms Tamoxifen 11.2616684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.2616984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.502876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.5018544905 18253720 16267830 18164116 18079962 18775883 19004024 19519916 2563599 19126423 17854601 18308698 21159647 3124819 19539802 9362446 19009564 16842330 17174075 17942915 18093689 18282651
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.5012151625
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.4820970405 21163286 20512841 6695378
MESH:D008175 Lung Neoplasms Tamoxifen 3.4818625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4819555203 11884234
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.0419428831
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.5017203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.5019196723 14580682 19196722 11731420 16827153
MESH:D020149 Manganese Poisoning Tamoxifen 4.8719453300
MESH:D008545 Melanoma Tamoxifen 1.9012393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.4715990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8319513568
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.3218551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.327678174 18551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.973581430 9029167
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.9719393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5719410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.3219189210 19196722 19200415
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4514600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.7618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.7620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.4420387270
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.5416049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.5416049721
MESH:D010051 Ovarian Neoplasms Progesterone 2.5816525653 17393432
MESH:D010146 Pain Acetaminophen 2.5616870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4816540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9111578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.732563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4811896295 11118676 11399792 11222880
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.1115067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.6016919318 15861022
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9118045962
MESH:D012640 Seizures 2,4-dinitrotoluene 6.3218551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.3218551238
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1316192470
MESH:D013088 Spermatocele Ethinyl Estradiol 12.6516709447
MESH:D013088 Spermatocele Tamoxifen 12.6516709447
MESH:D013119 Spinal Cord Injuries Progesterone 11.8416503802 15862959
MESH:D013119 Spinal Cord Injuries Tamoxifen 11.8419457130
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3315669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.147505956
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.7016049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.7016049721
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.7017572228 16712894 8653321
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.9610091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.9610091137
MESH:D014581 Urticaria Acetaminophen 3.2010982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5414692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7514671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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