AutismKB 2.0

Annotation Detail for STUB1


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Basic Information Top
Gene Symbol:STUB1 ( CHIP,HSPABP2,NY-CO-7,SDCCAG7,UBOX1 )
Gene Full Name: STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
Band: 16p13.3
Quick LinksEntrez ID:10273; OMIM: 607207; Uniprot ID:CHIP_HUMAN; ENSEMBL ID: ENSG00000103266; HGNC ID: 11427
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04141Protein processing in endoplasmic reticulum
hsa04120Ubiquitin mediated proteolysis
No data
Pathway IDPathway Name
200187Alpha-synuclein signaling
Pathway IDPathway Name
P00049Parkinson disease
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1740Alzheimer's disease
2055Spinocerebellar ataxias
2062Neurodegenerative disorder
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of STUB1 mRNAaffects expression 21346803
C016601 4-hydroxytamoxifen 4-hydroxytamoxifen inhibits the reaction [ESR1 protein binds to STUB1 protein]affects binding|decreases reaction 16037132
D000082 Acetaminophen Acetaminophen affects the expression of STUB1 mRNAaffects expression 17562736
D004958 Estradiol Estradiol inhibits the reaction [ESR1 protein binds to STUB1 protein]affects binding|decreases reaction 16037132
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of STUB1 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of STUB1 mRNAaffects cotreatment|increases expression 17942748
C070081 fulvestrant fulvestrant inhibits the reaction [ESR1 protein binds to STUB1 protein]affects binding|decreases reaction 16037132
C001277 geldanamycin geldanamycin promotes the reaction [ESR1 protein binds to STUB1 protein]affects binding|increases reaction 16037132
C001277 geldanamycin STUB1 protein promotes the reaction [geldanamycin results in increased degradation of ESR1 protein]increases degradation|increases reaction 16037132
D012643 Selenium Selenium results in increased expression of STUB1 mRNAincreases expression 19244175
D018038 Sodium Selenite Sodium Selenite results in increased expression of STUB1 mRNAincreases expression 18175754
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of STUB1 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of STUB1 mRNAdecreases expression 19465110
D014810 Vitamin E Vitamin E results in increased expression of STUB1 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0415322242 14514962 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1617505938
MESH:D000230 Adenocarcinoma Estradiol 4.3211473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.3214692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.5716835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0811748828
MESH:D000799 Angioedema Acetaminophen 4.0610982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7415885639
MESH:D001284 Atrophy fulvestrant 5.0111514358
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D001943 Breast Neoplasms Estradiol 1.9317289903 16675129 17261762 14630087 17018787 19861407 18497071 12948864
MESH:D001943 Breast Neoplasms fulvestrant 1.9318984771
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9320435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.6616111702
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.1116050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9116835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.6216705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.623084413
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.6216924424
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4418850075 16120746 18670907
MESH:D002386 Cataract Acetaminophen 2.6610977129
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.8618566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2916835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.9811677210 16105132 16919318 17681005 17333356 15861022 17110522
MESH:D019457 Chromosome Breakage Sodium Selenite 4.9315894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1516354765 12621046 8697196 15668235 15340226
MESH:D003092 Colitis Selenium 3.9517936198
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1817141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5210048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.5219769572
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.1918551238
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.9016285004
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.5419279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 12.4221346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.4216109766 11739529 11461765 17562736 11834606 12705907 19416960 18713872 19420014 16485898 15619225 19370779 2444490 12153990 12958197 11287661 14725611 12540782 12392966 14550746 16393943 10663392 10774834 11743745 15968718 18071297 16227642 10915739 14986274 11529661 16781746 12594235 19739265 17522070 19164858 11421492 16081117 19085960 19923254 17906064 16177239
MESH:D056486 Drug-Induced Liver Injury Selenium 12.4215131321
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 12.4215131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.4220420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:C538011 Eales disease Vitamin E 4.929068938
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1218230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3512538720
MESH:D016889 Endometrial Neoplasms 4-hydroxytamoxifen 8.0819148513
MESH:D016889 Endometrial Neoplasms Estradiol 8.0819148513 18566989 11473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1510568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1211564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 2.9515345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.1220067830
MESH:D005756 Gastritis Acetaminophen 3.8916983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.8010048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 6.8016080930
MESH:D006333 Heart Failure Selenium 3.1517162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0712621046 15340226 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7416863852 16490937
MESH:D006558 Herpes Genitalis Estradiol 5.2515709030
MESH:D019584 Hot Flashes Estradiol 10.7917088409
MESH:D019584 Hot Flashes Vitamin E 10.7914716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2618606429 8697196 16959395 16354765 15340226
MESH:D006930 Hyperalgesia Acetaminophen 2.8116870215
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9518670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9816945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.2317937319
MESH:D007248 Infertility, Male fulvestrant 7.2311514358
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9212200463 12878042
MESH:D007251 Influenza, Human Selenium 11.7016624496
MESH:D007251 Influenza, Human Vitamin E 11.7016624496
MESH:D007333 Insulin Resistance Estradiol 7.7316393666 16627594
MESH:D007333 Insulin Resistance Sodium Selenite 7.7314714311
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4816580747
MESH:D007674 Kidney Diseases Acetaminophen 10.4815629191 12587719
MESH:D007674 Kidney Diseases Estradiol 10.4815618244
MESH:D007674 Kidney Diseases Vitamin E 10.4812488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.0216518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.7616705839
MESH:D007680 Kidney Neoplasms Estradiol 7.7615610895
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.5314659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5312878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.5316169303
MESH:D008107 Liver Diseases Acetaminophen 1.6619784758 19460945 12587719 16611625 11587558 12969438 16610002 19014921
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3717185352 16871587
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.7616984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.1912151625
MESH:D008171 Lung Diseases Vitamin E 3.2716863852
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3411884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 2.3411062179
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.2114737004
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.3117203775 11807958 16891317 11408345
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.3115318939
MESH:D020149 Manganese Poisoning Estradiol 4.7019453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7419513568
MESH:D008654 Mesothelioma Selenium 2.8415107826
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1312213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.3916810080
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.0518551238
MESH:D009389 Neovascularization, Pathologic Estradiol 3.9317289903
MESH:D009421 Nervous System Malformations Estradiol 10.0111399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.0114600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9918514411
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.5612819281 16049721
MESH:D010051 Ovarian Neoplasms Estradiol 2.2519401270
MESH:D010146 Pain Acetaminophen 2.5016870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8411578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D010954 Plasmacytoma Selenium 5.1115087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3811118676 11399792 11896295 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.0220887781
MESH:D011471 Prostatic Neoplasms Estradiol 2.5616740699
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.5618760546
MESH:D011471 Prostatic Neoplasms Vitamin E 2.5615084515
MESH:D011537 Pruritus Ethinyl Estradiol 3.5115861022 16919318
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012640 Seizures 2,4-dinitrotoluene 2.6218551238
MESH:D012871 Skin Diseases Vitamin E 2.4718709164
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1016192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.1616709447
MESH:D020521 Stroke Vitamin E 3.6316517955
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D013978 Tibial Fractures Estradiol 4.9019048282
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 2.3316049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.5110091137
MESH:D014581 Urticaria Acetaminophen 3.1210982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4614692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6814671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
Pathway ID Pathway Name
KEGG:04141 Protein processing in endoplasmic reticulum
KEGG:04120 Ubiquitin mediated proteolysis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA36227
    • No data
    No data
    Releated drug ID Related drug Name
    PA449092colchicine
    PA449396dopamine
    PA451578tacrolimus
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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