AutismKB 2.0

Annotation Detail for STAG1


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Basic Information Top
Gene Symbol:STAG1 ( DKFZp781D1416,SA1 )
Gene Full Name: stromal antigen 1
Band: 3q22.3
Quick LinksEntrez ID:10274; OMIM: 604358; Uniprot ID:STAG1_HUMAN; ENSEMBL ID: ENSG00000118007; HGNC ID: 11354
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04110Cell cycle
Pathway IDPathway Name
Cell Cycle, Mitotic
DNA Replication
No data
No data
Pathway IDPathway Name
500909M Phase
500976Mitotic Prometaphase
500868Mitotic Metaphase/Anaphase Transition
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C010914 2,4-diaminotoluene 2,4-diaminotoluene results in decreased expression of STAG1 mRNAdecreases expression 20713471
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of STAG1 mRNAaffects expression 21346803
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of STAG1 proteinaffects expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of STAG1 mRNAdecreases expression 20106945
20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of STAG1 mRNAdecreases expression 19150397
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of STAG1 mRNAdecreases expression 15336504
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of STAG1 mRNAaffects expression 17484886
D016572 Cyclosporine Cyclosporine results in increased expression of STAG1 mRNAincreases expression 20106945
D004112 Dimercaprol Dimercaprol inhibits the reaction [Mustard Gas results in decreased expression of STAG1 mRNA]decreases expression|decreases reaction 16377760
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of STAG1 mRNAaffects cotreatment|increases expression 17942748
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of STAG1 mRNAaffects cotreatment|increases expression 17183730
C475919 hydroxytamoxifen hydroxytamoxifen results in increased expression of STAG1 mRNAincreases expression 16849584
D009151 Mustard Gas Dimercaprol inhibits the reaction [Mustard Gas results in decreased expression of STAG1 mRNA]decreases expression|decreases reaction 16377760
D009151 Mustard Gas Mustard Gas results in decreased expression of STAG1 mRNAdecreases expression 16377760
C045950 propiconazole propiconazole results in increased expression of STAG1 mRNAincreases expression 19363144
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of STAG1 mRNAaffects cotreatment|increases expression 17942748
C032910 triadimefon triadimefon results in increased expression of STAG1 mRNAincreases expression 19363144
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of STAG1 mRNAaffects cotreatment|increases expression 17183730
C025643 vinclozolin vinclozolin affects the expression of STAG1 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.1914514962 15322242 11752688
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 8.198875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.8919490988
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9117505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.1420464547 20127859
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.1414692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.636695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.3416835633
MESH:D000550 Amblyopia Valproic Acid 5.2017688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9111748828
MESH:D001008 Anxiety Disorders Valproic Acid 8.7317497229
MESH:D001008 Anxiety Disorders vinclozolin 8.7319015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0319183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6415885639
MESH:D001249 Asthma Mustard Gas 2.7010378619
MESH:D001321 Autistic Disorder Valproic Acid 2.0116609825 17507914 19460635 17157402 18940202 18558336 18775368 18985861 18177632 17688650 18396377 18316065 20603192 15238991 19232924
MESH:D001714 Bipolar Disorder Valproic Acid 3.0520046352 17594078
MESH:D001768 Blister Mustard Gas 5.1219167455
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.0012125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.9315746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.938888407
MESH:D001943 Breast Neoplasms 2,4-diaminotoluene 1.9311921183
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9317474063 20146248
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9320435547
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.1215286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.9517687719 10378619
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.7416011737 10355542 15673190 16050911 15721981 16192424 16124888 3786805 15700767 18705752 16227642 16097048
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7616835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.5616705839
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.5612619106 21507988 12907637
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.5618788625
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0420419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3418850075 16120746 18670907
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.4520889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.4512371664
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.6920734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1216835633
MESH:D002779 Cholestasis Cyclosporine 7.6619486331
MESH:D002779 Cholestasis Ethinyl Estradiol 7.6616105132 16919318 17110522 11677210 17333356 15861022 17681005
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 6.0916354765 15668235 15340226 12621046 8697196
MESH:D002972 Cleft Palate triadimefon 6.0916781842
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0214669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.8810048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities triadimefon 3.8816875885 15834900
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.8817688650 16575769 8888407
MESH:D003456 Cryptorchidism vinclozolin 4.3014966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.9718551238
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6617107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 8.8721346803 18551238
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 8.877120509 9327722 19085960 2869522 6623471 15027814 16177239 10915739 3786805 7440962 11566570 10092053 16227642 21278145 15998439 7179309 3732212 6884620 19336974 17522070 15968718 4309450
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.8720420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 8.8719641884 1733752
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7311462148
MESH:D004421 Dystonia Valproic Acid 4.011851702
MESH:D004487 Edema Mustard Gas 6.7111428647 11428631 11402378 9260866
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.7111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8715322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.1512538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.989294722 10568697
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.1117275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 3.893922381 16628512
MESH:D004827 Epilepsy Valproic Acid 2.9120417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.557562514 6254150 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.267750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.033659116
MESH:D004890 Erythema Mustard Gas 5.129357497
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.3120426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.3116530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9811564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 18.4317595544 12795759 16239168 61145 19224547 15959796 12631006 16045604
MESH:D005234 Fatty Liver Cyclosporine 18.4319224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 18.4315345470
MESH:D005234 Fatty Liver Valproic Acid 18.4319224547 14986274
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4211858732
MESH:D005315 Fetal Diseases Valproic Acid 4.8616575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.0918558336 8888407
MESH:D005355 Fibrosis Carbon Tetrachloride 14.4918705752
MESH:D005355 Fibrosis Cyclosporine 14.4912168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 14.4920067830
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.9016973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.2716417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.188708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5710696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.3720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.3710048152 11294989
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3915720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2911000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.5519900420 19110552
MESH:D006529 Hepatomegaly propiconazole 14.5117178688 17178689
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 14.5116120746 15340226 12621046
MESH:D006529 Hepatomegaly triadimefon 14.5117178688 17178689
MESH:D006849 Hydrocephalus Valproic Acid 4.8317688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0218606429 8697196 15340226 16354765 16959395
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.5016899240
MESH:D006973 Hypertension Cyclosporine 4.8910903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.8918670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.0515338365
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.5916612254
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7716569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.5617937319
MESH:D007248 Infertility, Male vinclozolin 6.5616467254
MESH:D007249 Inflammation Mustard Gas 4.978975870 11428647 17524151 16001271 9260866 11428620 9357497 11428631 11402378
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.9712878042 12200463
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.1916580747
MESH:D007569 Jaw Abnormalities triadimefon 10.1915834900 15992940
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.4115604871
MESH:D007674 Kidney Diseases Cyclosporine 2.318314463 10903974 18776723
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.1516705839
MESH:D007680 Kidney Neoplasms Cyclosporine 7.1512371664
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1416294345 17596541
MESH:D007984 Leydig Cell Tumor vinclozolin 4.7016417039
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.7817157831 16239168 11903743 16221502 16943688 17174718 11408273 21278145 17334410
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.2714716833 15818738 18263696 17922224 16033810 18279442 17766677 16248980 18418968 17761835 12666154 18376398 17976157 18339082 15893842 18251166 16136751 10355542 18277467 18395914 17944888 15123356 18006644 18412020 15876570 17557913 16011737 17805973 12389079 15730626 11481614 18210741 17640975 15996030 18420326 18205269 12445421 17708605 14716496 12586293 12609069 17721639 20821823 17714472 18395095 12741479 15057751 16638106 18472094 15362042 18187930 12546737 14620537 12632514 18705752 15673190 15959796 15338365 18481824 12898905 15650968 12958196 12445418 16015684 15925388 17869086 18156304 18429990 12649538 15052691 18317297 14724832 17565644 18054572 13678700 14748882 17481882 16192424 12632512 16116963 17631135 16027843 17698563 16097048 12667390 14512876 18166357 17525996 17900296 17823541 18472332 15931870 15370692
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.2712878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.7715830285 16964402 15720792 16246199 17285989
MESH:D008107 Liver Diseases propiconazole 6.7719363144
MESH:D008107 Liver Diseases triadimefon 6.7719363144
MESH:D017093 Liver Failure Carbon Tetrachloride 4.1215123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.6516899240 14706259
MESH:D008113 Liver Neoplasms Aflatoxin B1 17.7918177683 2125692 9163691 15890375
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 17.7920195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 17.7919294768
MESH:D008113 Liver Neoplasms propiconazole 17.7919028983
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 17.7916984957
MESH:D008113 Liver Neoplasms triadimefon 17.7919028983
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 18.398603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 18.3915583823 12014681
MESH:D008114 Liver Neoplasms, Experimental propiconazole 18.3917178689
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 18.3912151625
MESH:D008114 Liver Neoplasms, Experimental triadimefon 18.3917178689
MESH:D008171 Lung Diseases Mustard Gas 3.4218161513 18702808
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.2317228818
MESH:D008175 Lung Neoplasms Aflatoxin B1 4.8014755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.8020869020 18816296 20064080 18569708 6695378 18520028 20135361 20464547 17053015
MESH:D008175 Lung Neoplasms Mustard Gas 4.803148597 8781369
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.8011884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental 2,4-diaminotoluene 3.5511921183
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7616801185
MESH:D008881 Migraine Disorders Valproic Acid 3.1618765137 18803445
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1516381670
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.998888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.1317596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9812213967
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.8218551238
MESH:D009369 Neoplasms Benzo(a)pyrene 2.1511141357
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.4117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2418481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.1714600291
MESH:D009436 Neural Tube Defects Valproic Acid 3.1016359493 8888407
MESH:D009503 Neutropenia Mustard Gas 3.937688884 16761898
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.3912819281 16049721
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6511578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2212520081
MESH:D011041 Poisoning Mustard Gas 3.7615727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5218163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.1812371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 16.0411118676 11399792 11896295 11222880
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 16.0420603192
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 16.0418220299 18042343 19015723
MESH:D011469 Prostatic Diseases vinclozolin 4.9018220299
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9917292933
MESH:D011472 Prostatitis vinclozolin 4.9018629315
MESH:D011537 Pruritus Ethinyl Estradiol 9.4115861022 16919318
MESH:D011537 Pruritus Mustard Gas 9.4118058305
MESH:D019310 Pseudolymphoma Valproic Acid 4.5112752131 11422049
MESH:D011565 Psoriasis Cyclosporine 2.2116882103
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9117894541 17266442 17720292 17620002 10334151
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8018990726
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.1319155313
MESH:D012559 Schizophrenia Valproic Acid 2.0619110320 15737665
MESH:D012640 Seizures 2,4-dinitrotoluene 5.8418551238
MESH:D012640 Seizures Valproic Acid 5.8416876388 11044598 11738929 1511512 14763951 3137016 17978042 15475178
MESH:D012871 Skin Diseases Mustard Gas 2.7012880345 15451306 16961503
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.2810029692 19755658
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 9.288532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.2816192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.9116709447
MESH:D016135 Spinal Dysraphism Valproic Acid 3.7519490988
MESH:D013226 Status Epilepticus Valproic Acid 4.5112833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1115669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8712697716
MESH:D013964 Thyroid Neoplasms triadimefon 4.0517178689
MESH:D014178 Translocation, Genetic Valproic Acid 5.2017262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.493119515
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 4.9116049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 4.9117053015
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.608888407
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.2810091137
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2614692618
MESH:D014605 Uveitis Cyclosporine 3.961336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5014671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2215886252
MESH:D014985 Xerophthalmia Cyclosporine 4.4117120751
Pathway ID Pathway Name
KEGG:04110 Cell cycle
REACT:152 Cell Cycle, Mitotic
REACT:383 DNA Replication
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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