AutismKB 2.0

Annotation Detail for NET1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:NET1 ( ARHGEF8,NET1A )
Gene Full Name: neuroepithelial cell transforming 1
Band: 10p15.1
Quick LinksEntrez ID:10276; OMIM: 606450; Uniprot ID:ARHG8_HUMAN; ENSEMBL ID: ENSG00000173848; HGNC ID: 14592
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Signaling by GPCR
Signalling by NGF
Signaling by Rho GTPases
Pathway IDPathway Name
200050Regulation of RhoA activity
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1943Adenocarcinoma
Desease Name
PSYCH
attention deficit hyperactivity disorder
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of NET1 mRNAdecreases expression 19933214
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of NET1 mRNAdecreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of NET1 mRNAdecreases expression 20382639
D002857 Chromium LEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in decreased expression of NET1 mRNA]affects binding|decreases expression|increases reaction 16940432
C057862 cyanoginosin LR cyanoginosin LR results in increased expression of NET1 mRNAincreases expression 17654400
D016572 Cyclosporine Cyclosporine results in decreased expression of NET1 mRNAdecreases expression 20106945
D004041 Dietary Fats Dietary Fats results in decreased expression of NET1 mRNAdecreases expression 18042831
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of NET1 mRNAincreases expression 19100860
D002117 Calcitriol Calcitriol results in increased expression of NET1 mRNAincreases expression 16002434
D004958 Estradiol Estradiol affects the expression of NET1 mRNAaffects expression 15598610
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of NET1 mRNAincreases expression 17108234
D005038 Ethylnitrosourea Ethylnitrosourea results in increased expression of NET1 mRNAincreases expression 19100860
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in decreased expression of NET1 mRNAaffects cotreatment|decreases expression 17183730
D007213 Indomethacin Indomethacin results in increased expression of NET1 mRNAincreases expression 16984733
D009525 Niacin LEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in decreased expression of NET1 mRNA]affects binding|decreases expression|increases reaction 16940432
C029938 nickel sulfate nickel sulfate results in increased expression of NET1 mRNAincreases expression 16780908
D010126 Ozone Ozone results in decreased expression of NET1 mRNAdecreases expression 12763052
C041786 palm oil palm oil results in decreased expression of NET1 mRNAdecreases expression 18042831
C058305 phenethyl isothiocyanate phenethyl isothiocyanate results in decreased expression of NET1 mRNAdecreases expression 17616710
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of NET1 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of NET1 mRNAincreases expression 19482888
C006253 pirinixic acid pirinixic acid results in increased expression of NET1 mRNAincreases expression 16221962
18301758
C079198 S 1 (combination) NET1 protein results in increased susceptibility to S 1 (combination)increases response to substance 16734730
D018038 Sodium Selenite Sodium Selenite results in increased expression of NET1 mRNAincreases expression 18175754
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of NET1 mRNAdecreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of NET1 mRNAdecreases expression 19933214
D014212 Tretinoin Tretinoin results in increased expression of NET1 mRNAincreases expression 16249480
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in decreased expression of NET1 mRNAaffects cotreatment|decreases expression 17183730
C025643 vinclozolin vinclozolin affects the expression of NET1 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 12.876195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 12.8714514962 15322242 11752688
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 12.878875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.7219490988
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7117505938
MESH:D055371 Acute Lung Injury nickel sulfate 8.4411954676 16100012 19131640 12718980
MESH:D055371 Acute Lung Injury pirinixic acid 8.4418653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 9.6820464547 20127859
MESH:D000230 Adenocarcinoma Estradiol 9.6811473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 9.6814692618
MESH:D000230 Adenocarcinoma Indomethacin 9.6816537180
MESH:D000236 Adenoma Benzo(a)pyrene 14.966695378
MESH:D000236 Adenoma Diethylnitrosamine 14.9610737359 6695378
MESH:D000236 Adenoma Ethylnitrosourea 14.966695378
MESH:D000236 Adenoma Indomethacin 14.9611497255
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 22.9719052882 16434500 17620307 18056438 17162532 19061943
MESH:D018248 Adenoma, Liver Cell Phenobarbital 22.9717620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 22.9716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 22.9716835633
MESH:D000505 Alopecia Tretinoin 3.4415955085
MESH:D016301 Alveolar Bone Loss Indomethacin 5.1417225004
MESH:D000544 Alzheimer Disease Indomethacin 4.2517627676 15579461
MESH:D000544 Alzheimer Disease Ozone 4.2515513908
MESH:D000550 Amblyopia Valproic Acid 5.0017688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7511748828
MESH:D001008 Anxiety Disorders Valproic Acid 8.2617497229
MESH:D001008 Anxiety Disorders vinclozolin 8.2619015723
MESH:D001014 Aortic Aneurysm Indomethacin 4.6310231640
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 10.9619183758
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 10.9610388637
MESH:D001161 Arteriosclerosis Dietary Fats 9.1615238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.1611256880
MESH:D018771 Arthralgia Indomethacin 4.942160914
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.7415885639
MESH:D001169 Arthritis, Experimental Tretinoin 6.7416412693
MESH:D001172 Arthritis, Rheumatoid Indomethacin 7.1411248219
MESH:D001172 Arthritis, Rheumatoid Ozone 7.1415570426
MESH:D001172 Arthritis, Rheumatoid Tretinoin 7.1416292516
MESH:D001249 Asthma Ozone 4.7116373670 17854713
MESH:D001249 Asthma Tretinoin 4.7116456186
MESH:D001321 Autistic Disorder Valproic Acid 2.0318396377 18316065 16609825 18558336 19232924 18985861 19460635 20603192 18775368 17507914 17157402 15238991 17688650 18940202 18177632
MESH:D001471 Barrett Esophagus Tretinoin 4.1816935849
MESH:D001477 Bartter Syndrome Indomethacin 4.7610684365
MESH:D001714 Bipolar Disorder Valproic Acid 2.9617594078 20046352
MESH:D001778 Blood Coagulation Disorders pirinixic acid 14.0819483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 14.0812125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 14.0816206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.5415746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.548888407
MESH:D001927 Brain Diseases Ethylnitrosourea 4.6814991843
MESH:D001929 Brain Edema Indomethacin 4.7911481608
MESH:D002545 Brain Ischemia Indomethacin 4.1912524144
MESH:D001932 Brain Neoplasms Ethylnitrosourea 4.0916357521 16651633 15144691 18412241 16436596
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 5.6020146248 17474063
MESH:D001943 Breast Neoplasms Calcitriol 5.6011237771
MESH:D001943 Breast Neoplasms Chromium 5.6015986119
MESH:D001943 Breast Neoplasms Dietary Fats 5.6020435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 5.6017474063
MESH:D001943 Breast Neoplasms Estradiol 5.6017289903 17261762 12948864 16675129 14630087 17018787 18497071 19861407
MESH:D001943 Breast Neoplasms Indomethacin 5.6017401462
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 5.6020435547
MESH:D001943 Breast Neoplasms Tretinoin 5.6016166294 16443354 16873071
MESH:D016535 Bronchial Hyperreactivity Ozone 3.5017626835 18315731 19059883 15516495 18417511 14754758 16777450
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.3616813970
MESH:D002056 Burns Indomethacin 4.4810459503
MESH:D002100 Cachexia Indomethacin 11.6315625704 16537180 15141370 11239499
MESH:D002100 Cachexia Ozone 11.6316183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2316111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6216835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.9316168501
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 8.4716935385 17055752 10737359 18788625 18056438 19539802 20084675 19208518 16779866 20514400 20512989 3581430 16807293 16288022 18978308 18506893 11831363 16502159 20727157 19919837 18971187 17978847 16569478 19052882 19418558 17761372 16698587 18393292 17428255 16328049 20524982 19171122 19822196 20007298 20101231 18210153 19519916 17138121 20935162 10672840 17162532 19701751 16830150 3084413 19107877 19335982 19383236 17173139 19394651 16878318 18494052 20432363 16540662 18665156 20214788 21159647 16681979 18691550 18785209
MESH:D006528 Carcinoma, Hepatocellular Estradiol 8.4716924424
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 8.4716391822
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 8.471701930 20007298 6705139 17173139 20935162
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 8.471917145
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 4.5011053908
MESH:D018276 Carcinoma, Medullary Indomethacin 5.1211352223 18791128 14736730
MESH:D002289 Carcinoma, Non-Small-Cell Lung S 1 (combination) 3.9918212800 18347146
MESH:D002292 Carcinoma, Renal Cell Indomethacin 3.2717341418
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 13.6420419170
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 13.6411237771
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 13.6415482327 12636206
MESH:D002294 Carcinoma, Squamous Cell S 1 (combination) 13.6415984520
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 13.6416096774 16051514
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2418850075 16120746 18670907
MESH:D002386 Cataract Tretinoin 2.9617460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 19.4520889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 19.4512371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 19.4517174075 7505956 2727394 21159647
MESH:D002471 Cell Transformation, Neoplastic Estradiol 19.4518566989
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 19.4516003739
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.034080065
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 5.7517160924
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.3616129372
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.6320734317
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.6919052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.6916835633
MESH:D002764 Cholecystitis Indomethacin 4.9411181007
MESH:D002779 Cholestasis Cyclosporine 12.3819486331
MESH:D002779 Cholestasis Ethinyl Estradiol 12.3816919318 17333356 17681005 15861022 16105132 11677210 17110522
MESH:D002779 Cholestasis pirinixic acid 12.3819176532
MESH:D002822 Choriocarcinoma Tretinoin 4.9316461808
MESH:D019457 Chromosome Breakage Sodium Selenite 4.5315894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.458697196 12621046 15340226 15668235 16354765
MESH:D002972 Cleft Palate Tretinoin 5.459407595
MESH:D003092 Colitis Tretinoin 3.4817035595
MESH:D003093 Colitis, Ulcerative phenethyl isothiocyanate 3.5720423518
MESH:D003110 Colonic Neoplasms Indomethacin 2.5511260862 15637740 15936596 15625704 15786552 15963497
MESH:D015179 Colorectal Neoplasms Indomethacin 2.3511197048 12606626 17054584 18059344
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8714669216 17141729
MESH:D018352 Coronavirus Infections Indomethacin 5.4917302372
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.6120055451 15322242 10048152
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.6117551590 9664655 10589399 14991402 9142499 8800419 16925845 9125849 9211117 9224671
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.6117688650 8888407 16575769
MESH:D003456 Cryptorchidism vinclozolin 4.1214966744
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 3.4611298694 16823706 16780908
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3218249437
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.5916285004
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.0320387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.0317107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.2219279558
MESH:D003967 Diarrhea Indomethacin 3.587907874 7237001
MESH:D056486 Drug-Induced Liver Injury cyanoginosin LR 11.2917654400
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 11.2919107877
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 11.2915131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.2920420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 11.2919641884 1733752
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5911462148
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 4.9218043480 17190690 18446180 12774134 16326151 16133044
MESH:D004381 Duodenal Ulcer Indomethacin 3.9217202747 17329845 10671773 11535926 11595431 17045617 11595415 17151854 16699067 11991626 17351913
MESH:D050171 Dyslipidemias Dietary Fats 3.2918367378
MESH:D004421 Dystonia Phenobarbital 9.731851702
MESH:D004421 Dystonia Valproic Acid 9.731851702
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 5.7518357618
MESH:D004487 Edema Indomethacin 10.277907874 7990266 8985016 8273558 19703484 10653021 16100529
MESH:D004487 Edema pirinixic acid 10.2712083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.2711000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.1716714409 15322242 18230668
MESH:D004489 Edema, Cardiac Tretinoin 11.1718230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 8.3615138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.3612538720
MESH:D016889 Endometrial Neoplasms Estradiol 6.9211473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Tretinoin 6.9216569247
MESH:D004715 Endometriosis Indomethacin 8.4115652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.419294722 10568697
MESH:D019446 Endotoxemia Indomethacin 4.2718509659
MESH:D004751 Enteritis Indomethacin 4.5210567023 16328016 17763956
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 4.7617980183
MESH:D004802 Eosinophilia Indomethacin 3.8311298111
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 10.043659116
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 10.0417275665 3659116
MESH:D004828 Epilepsies, Partial Phenobarbital 9.203922381 11558140
MESH:D004828 Epilepsies, Partial Valproic Acid 9.2016628512 3922381
MESH:D004827 Epilepsy Phenobarbital 6.2820417680
MESH:D004827 Epilepsy Valproic Acid 6.2820417680 18234410
MESH:D004832 Epilepsy, Absence Phenobarbital 8.236401628
MESH:D004832 Epilepsy, Absence Valproic Acid 8.237562514 6426943 6254150
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 10.557750514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 10.557750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 9.723659116
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 9.723659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.8916302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.9220426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 6.9216530937
MESH:D004938 Esophageal Neoplasms Indomethacin 6.9211005569
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.2811564622
MESH:D005124 Eye Abnormalities Tretinoin 8.2816938888 9664655
MESH:D005234 Fatty Liver Cyclosporine 28.0419224547
MESH:D005234 Fatty Liver Dietary Fats 28.0417967931 19004024 19551842 18296743
MESH:D005234 Fatty Liver Diethylnitrosamine 28.0420387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 28.0415345470
MESH:D005234 Fatty Liver pirinixic acid 28.0420131406 19236843
MESH:D005234 Fatty Liver Valproic Acid 28.0414986274 19224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2311858732
MESH:D005315 Fetal Diseases Valproic Acid 4.6616575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.918888407 18558336
MESH:D005334 Fever Indomethacin 3.9211852909 17627676 10431976
MESH:D005354 Fibrosarcoma Indomethacin 4.6610962813
MESH:D005355 Fibrosis Cyclosporine 25.3412168785 12639820
MESH:D005355 Fibrosis Dietary Fats 25.3418296743
MESH:D005355 Fibrosis Indomethacin 25.3417994277
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 25.3420067830
MESH:D005355 Fibrosis Tretinoin 25.3417994277
MESH:D005499 Folliculitis Indomethacin 4.9411298111
MESH:D005706 Gallbladder Neoplasms S 1 (combination) 5.5419093184
MESH:D005756 Gastritis Indomethacin 4.5215046732
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.7016973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.0716417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.998708960
MESH:D005909 Glioblastoma Ethylnitrosourea 11.1916436596
MESH:D005909 Glioblastoma Indomethacin 11.1912870263
MESH:D005909 Glioblastoma Tretinoin 11.1917312396
MESH:D005910 Glioma Ethylnitrosourea 6.1818412241 16651633 16357521
MESH:D005910 Glioma Indomethacin 6.1818371953 16487511
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 4.1011849393
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3610696789
MESH:D006073 Gout Indomethacin 5.1211248219
MESH:D006258 Head and Neck Neoplasms Indomethacin 12.3115482327
MESH:D006258 Head and Neck Neoplasms S 1 (combination) 12.3115984520 18607998
MESH:D006258 Head and Neck Neoplasms Tretinoin 12.3116096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.9316084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 10.4020471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.4010048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 10.4014991402 9664655
MESH:D006333 Heart Failure pirinixic acid 2.4020558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1915720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1311000095
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.3615633222
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.4615135802
MESH:D006529 Hepatomegaly Phenobarbital 13.0816109766
MESH:D006529 Hepatomegaly pirinixic acid 13.0818467677 19176532 19772884 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 13.0815340226 16120746 12621046
MESH:D006558 Herpes Genitalis Estradiol 4.8015709030
MESH:D019584 Hot Flashes Estradiol 3.5217088409
MESH:D006849 Hydrocephalus Valproic Acid 4.6417688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8115340226 18606429 16959395 8697196 16354765
MESH:D006930 Hyperalgesia Indomethacin 7.4312727271
MESH:D006930 Hyperalgesia Tretinoin 7.4316870215
MESH:D034321 Hyperamylasemia Indomethacin 5.4917883296
MESH:D006937 Hypercholesterolemia Dietary Fats 3.3921332399
MESH:D006940 Hyperemia Indomethacin 4.7812524144
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.3416778211
MESH:D006943 Hyperglycemia pirinixic acid 2.9920558911
MESH:D006949 Hyperlipidemias Dietary Fats 8.6421332399
MESH:D006949 Hyperlipidemias Indomethacin 8.6417546600
MESH:D006973 Hypertension Cyclosporine 4.6610903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.6618670907 18850075
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.4016612254
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5816945680 16569931
MESH:D007077 Ileal Diseases Indomethacin 4.7910574470 18306037
MESH:D007079 Ileitis Indomethacin 5.1210651667 16133968 10647630
MESH:D007235 Infant, Premature, Diseases Indomethacin 5.1416133044
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.1617937319
MESH:D007248 Infertility, Male vinclozolin 6.1616467254
MESH:D007249 Inflammation Dietary Fats 11.0020412841
MESH:D007249 Inflammation Diethylnitrosamine 11.0018785209
MESH:D007249 Inflammation Indomethacin 11.007812673 3291741 12568917
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.0012878042 12200463
MESH:D007333 Insulin Resistance Dietary Fats 16.4318457598 11836018
MESH:D007333 Insulin Resistance Estradiol 16.4316393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 16.4316306350
MESH:D007333 Insulin Resistance Sodium Selenite 16.4314714311
MESH:D007410 Intestinal Diseases Indomethacin 9.1415610444 18236018 11686837 17329856 11855677 15831440 17994277 11713966 10210152
MESH:D007410 Intestinal Diseases Tretinoin 9.1417994277
MESH:D019586 Intracranial Hypertension Indomethacin 5.1415241188
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.2516580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.2515992940 17551590
MESH:D007579 Jejunal Diseases Indomethacin 4.7910574470 18306037 16133968
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2115604871
MESH:D007674 Kidney Diseases Chromium 13.4517934191
MESH:D007674 Kidney Diseases Cyclosporine 13.4510903974 18776723 8314463
MESH:D007674 Kidney Diseases Estradiol 13.4515618244
MESH:D007674 Kidney Diseases Indomethacin 13.4517190690
MESH:D007680 Kidney Neoplasms Cyclosporine 11.4312371664
MESH:D007680 Kidney Neoplasms Estradiol 11.4315610895
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 11.4317379185
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 3.7212228301 11703811 10320625
MESH:D007938 Leukemia Tretinoin 2.6617143497
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 3.7615631656 16572323 10785260
MESH:D007951 Leukemia, Myeloid Tretinoin 3.4916482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 5.9318360721
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 5.9319850784 16294345 17596541
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 5.9317596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.0117339181 19225113 19642359 17368321 17506722 17217047 16823087 16766008 17107899 16140955 17294898 9834237 17361223 16331271 19075265 16935935 17712046 19035177 16891316 15748426 12679006 19029980 16788101 17301526 17649720
MESH:D007964 Leukocytosis Indomethacin 5.1416537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.4917980183
MESH:D007984 Leydig Cell Tumor vinclozolin 4.5016417039
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.159224671
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.4911479899
MESH:D008103 Liver Cirrhosis Dietary Fats 10.3118296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 10.3120032147 18407596 18665156 18522880 19638242
MESH:D008103 Liver Cirrhosis Phenobarbital 10.3121047994
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.4114659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 6.4118194892
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.4115474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.4112878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 6.4116248980 18397230
MESH:D008107 Liver Diseases Diethylnitrosamine 3.9017034775
MESH:D008107 Liver Diseases Phenobarbital 3.9019363144
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 13.2921137059 20195826
MESH:D008113 Liver Neoplasms Diethylnitrosamine 13.2919499222 15885732 19690152 19255062 15175105 19073162 20452335 2422723 12771043 19294768 19812893 21167192 19426721 19996281 19254457 20583210 21278145 19551842 21047994 19090486 16942905 20405173 20137499 2862719 18754104 19850985 19427195 19642983 19833225 20434301 12112319 21071580 18644402 20492335 19638242 10737359 18648771 20501860 20101389 9163691 18978307 20118626 18977376 19256749
MESH:D008113 Liver Neoplasms Phenobarbital 13.2921047994 15975961 19073162 8742319 19812893 19482888
MESH:D008113 Liver Neoplasms pirinixic acid 13.2916377806 15890375 20007298
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 13.2916984957
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 8.9917942915 19539802 18282651 19126423 9362446 18093689 17854601 18079962 19519916 3124819 18253720 18544905 18164116 16267830 16842330 19009564 21159647 18775883 17174075 18308698 2563599 19004024
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 8.9918308698 1399818 2563599 17172636 6150874
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 8.9912151625
MESH:D008171 Lung Diseases Ozone 3.2319066396 8266340
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.0317228818
MESH:D055370 Lung Injury Ozone 3.6320417186
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 8.1817053015 18816296 6695378 18569708 20135361 20064080 18520028 20869020 20464547
MESH:D008175 Lung Neoplasms Diethylnitrosamine 8.1821163286 20512841 20970405 6695378
MESH:D008175 Lung Neoplasms Ethylnitrosourea 8.186695378 16019985 17703301 16271038
MESH:D008175 Lung Neoplasms Indomethacin 8.1816537180 11497255 11053908
MESH:D008175 Lung Neoplasms Ozone 8.187614698 8597069
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.1811884234 19555203
MESH:D008223 Lymphoma Ethylnitrosourea 3.7815790496
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 3.8514737004
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 4.8215375218
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.8216891317 11807958 11408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 5.8210767621 18041768 10838139
MESH:D020149 Manganese Poisoning Estradiol 4.2519453300
MESH:D008527 Medulloblastoma Tretinoin 2.7017453147
MESH:D008545 Melanoma Tretinoin 1.9116752155
MESH:D008579 Meningioma Ethylnitrosourea 5.7517943659
MESH:D008591 Meningomyelocele Tretinoin 4.2016940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5616801185
MESH:D008679 Metaplasia Ozone 4.8710496685
MESH:D008881 Migraine Disorders Indomethacin 7.1911903285
MESH:D008881 Migraine Disorders Valproic Acid 7.1918765137 18803445
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.0916381670
MESH:D009062 Mouth Neoplasms Indomethacin 8.0912636206
MESH:D009135 Muscular Diseases pirinixic acid 3.2816239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.828888407
MESH:D009190 Myelodysplastic Syndromes Tretinoin 6.9717596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 6.9717596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.0519151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8412213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.6716810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.6716411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.2517484760
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.659029167 3581430
MESH:D009362 Neoplasm Metastasis Indomethacin 5.6511239499 11053908 16537180
MESH:D009369 Neoplasms Benzo(a)pyrene 7.5311141357
MESH:D009369 Neoplasms pirinixic acid 7.5317405874
MESH:D009369 Neoplasms Tretinoin 7.5316946489 16594593
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 8.8016707424
MESH:D009374 Neoplasms, Experimental Indomethacin 8.8015625704 10663608
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5017289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0918481113 19348381
MESH:D009421 Nervous System Malformations Estradiol 15.0616427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 15.0614600291
MESH:D009421 Nervous System Malformations Tretinoin 15.069125849
MESH:D009436 Neural Tube Defects Tretinoin 6.829142499
MESH:D009436 Neural Tube Defects Valproic Acid 6.8216359493 8888407
MESH:D009442 Neurilemmoma Ethylnitrosourea 5.1917160924 16651423 16003739
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.9620387270
MESH:D019636 Neurodegenerative Diseases Indomethacin 7.9612349958
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.8920387270
MESH:D009765 Obesity Dietary Fats 4.2419632207 18674790 18457598 17217161 16723640 21332399 20518802 11836018 20132043
MESH:D009765 Obesity pirinixic acid 4.2420558911
MESH:D007752 Obstetric Labor, Premature Indomethacin 4.946374098
MESH:D009837 Oligodendroglioma Ethylnitrosourea 5.7517160924
MESH:D010003 Osteoarthritis Indomethacin 3.537009135
MESH:D010018 Osteomalacia Phenobarbital 4.1317016548
MESH:D010051 Ovarian Neoplasms Estradiol 4.5619401270
MESH:D010051 Ovarian Neoplasms Tretinoin 4.5616936753
MESH:D010146 Pain Indomethacin 6.3817627676 3291741 17440234 13679232
MESH:D010146 Pain Tretinoin 6.3816870215
MESH:D010149 Pain, Postoperative Indomethacin 4.4518702446 12538197
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 8.1216540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 8.1216965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 8.1215976015
MESH:D010195 Pancreatitis Indomethacin 3.7117883296 15028970
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4711578682
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.4916537180
MESH:D020734 Parkinsonian Disorders Indomethacin 3.9212349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.4911903285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0212520081
MESH:D010437 Peptic Ulcer Indomethacin 4.9211148446
MESH:D010518 Periodontitis Indomethacin 4.6817225004
MESH:D010538 Peritonitis Ozone 3.9116369182
MESH:D011014 Pneumonia Ozone 4.1718381685 18929643 18007984
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3418163543
MESH:D011230 Precancerous Conditions Cyclosporine 14.1612371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 14.162563599
MESH:D011230 Precancerous Conditions Phenobarbital 14.162563599
MESH:D047928 Premature Birth Indomethacin 4.9017000239
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 14.9111222880 11118676 11399792 11896295
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 14.9120603192
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 14.9118220299 19015723 18042343
MESH:D011469 Prostatic Diseases vinclozolin 4.7018220299
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.5515572423
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6820887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.1217292933
MESH:D011471 Prostatic Neoplasms Calcitriol 2.1212479363 16289102 16644109 18247401 15754350
MESH:D011471 Prostatic Neoplasms Estradiol 2.1216740699
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.1218760546
MESH:D011472 Prostatitis vinclozolin 4.7018629315
MESH:D011507 Proteinuria Indomethacin 8.6311849393
MESH:D011507 Proteinuria Tretinoin 8.6316636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.0915861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 11.4212752131
MESH:D019310 Pseudolymphoma Valproic Acid 11.4212752131 11422049
MESH:D011565 Psoriasis Cyclosporine 2.1516882103
MESH:D011625 Pterygium Tretinoin 4.5616723453
MESH:D015427 Reperfusion Injury pirinixic acid 2.2819058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6218990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 10.1616116481 16283617
MESH:D012208 Rhabdomyosarcoma Valproic Acid 10.1619155313
MESH:D012559 Schizophrenia Valproic Acid 2.0415737665 19110320
MESH:D012640 Seizures Phenobarbital 5.493137016 11442880 4039156 16876388
MESH:D012640 Seizures Valproic Acid 5.4911044598 1511512 16876388 15475178 3137016 17978042 14763951 11738929
MESH:D003294 Seizures, Febrile Phenobarbital 4.596407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 8.7610029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.7616192470
MESH:D012878 Skin Neoplasms Tretinoin 8.7616467112
MESH:D013088 Spermatocele Ethinyl Estradiol 3.7116709447
MESH:D016135 Spinal Dysraphism Valproic Acid 3.6119490988
MESH:D013226 Status Epilepticus Valproic Acid 4.3112833885
MESH:D013272 Stomach Diseases Indomethacin 4.1918545984 17207306 16113693 15038085 18209964 17160473 17638125 10215738 16280098 10486359 16184426 15472012 10192188
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 6.1620155912 2093021
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 6.1618456281
MESH:D013274 Stomach Neoplasms Indomethacin 6.1615609394
MESH:D013274 Stomach Neoplasms S 1 (combination) 6.1616557585 18506536 18553229
MESH:D013274 Stomach Neoplasms Tretinoin 6.1617261132
MESH:D013276 Stomach Ulcer Indomethacin 3.3911729361 12500499 16150113 12467913 16631530 18181030 18087811 16934674 10423059 17918041 11906479 15255614 11145282 17654042 17627676 18726076 16397915 17657623 11523592 11595415 18237397 16169175 17135157 12787963 15104355 11595431 12077510 18209962 18543354 18193104 17977527 17895592 18431645 12498302 18299717 14567935 10750652 16252198 10878458 16755016 15138204 1323529
MESH:D013733 Testicular Diseases phenethyl isothiocyanate 4.7215864552
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9615669648
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 4.9315790496
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6712697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 15.727505956
MESH:D013964 Thyroid Neoplasms Indomethacin 15.7214736730 18791128 11352223
MESH:D013964 Thyroid Neoplasms Phenobarbital 15.721399818
MESH:D013964 Thyroid Neoplasms Tretinoin 15.7216026305 17045167
MESH:D013978 Tibial Fractures Estradiol 4.4519048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.5916051514
MESH:D014178 Translocation, Genetic Valproic Acid 5.0017262798
MESH:D014376 Tuberculosis Tretinoin 3.0916040207
MESH:D014456 Ulcer Indomethacin 4.6610574470 17380554
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.293119515
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.0917053015
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.428888407
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.4816129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.0814692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.3816752155
MESH:D014605 Uveitis Cyclosporine 3.751336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3315869587 14671159
MESH:D014820 Vitiligo Tretinoin 3.8416761959
MESH:D014839 Vomiting Indomethacin 4.5211897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0215886252
MESH:D015430 Weight Gain Dietary Fats 3.5516723640
MESH:D009396 Wilms Tumor Tretinoin 3.7816287080
MESH:D014985 Xerophthalmia Cyclosporine 4.2117120751
Pathway ID Pathway Name
REACT:14797 Signaling by GPCR
REACT:11044 Signaling by Rho GTPases
REACT:11061 Signalling by NGF
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA164742175
    • No data
    No data
    Releated drug ID Related drug Name
    PA450218levonorgestrel
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved