AutismKB 2.0

Annotation Detail for UBE4B


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Basic Information Top
Gene Symbol:UBE4B ( E4,HDNB1,KIAA0684,UBOX3,UFD2,UFD2A )
Gene Full Name: ubiquitination factor E4B (UFD2 homolog, yeast)
Band: 1p36.22
Quick LinksEntrez ID:10277; OMIM: 613565; Uniprot ID:UBE4B_HUMAN; ENSEMBL ID: ENSG00000130939; HGNC ID: 12500
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04141Protein processing in endoplasmic reticulum
hsa04120Ubiquitin mediated proteolysis
No data
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of UBE4B mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of UBE4B mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of UBE4B mRNAaffects expression 17562736
C006632 arsenic trioxide arsenic trioxide results in increased expression of UBE4B mRNAincreases expression 20458559
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of UBE4B mRNAincreases expression 17606305
C031280 pyrazole pyrazole results in increased expression of UBE4B mRNAincreases expression 17945193
D012643 Selenium Selenium results in increased expression of UBE4B mRNAincreases expression 19244175
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of UBE4B mRNAincreases expression 18796159
D014810 Vitamin E Vitamin E results in increased expression of UBE4B mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1315322242 14514962 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2617505938
MESH:D000230 Adenocarcinoma arsenic trioxide 4.4419825857 11798837
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.4414692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6616835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1411748828
MESH:D000799 Angioedema Acetaminophen 4.1610982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7815885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.6616206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.6612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8915746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6920435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.5511589617
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.1916050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.7816705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.7816705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.783084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 6.7815553829 16217749 15073043 14691202 11135700
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.1919014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3112490120
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4718850075 18670907 16120746
MESH:D002386 Cataract Acetaminophen 2.6910977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.906135515
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3416835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0216919318 17333356 11677210 17681005 16105132 15861022 17110522
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1816354765 12621046 15340226 8697196 15668235
MESH:D003092 Colitis Selenium 4.0417936198
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2414669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 4.4212609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.8710525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.8720055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.8719769572
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.7718551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.7718551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.3215213294
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 15.9921346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 15.9921346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 15.9918713872 19739265 10915739 19420014 14550746 14986274 11739529 19416960 12705907 2444490 12540782 15619225 12153990 10774834 10663392 19370779 11287661 12594235 17906064 16485898 11529661 15968718 17562736 18071297 11461765 16393943 12392966 16081117 16781746 16227642 19085960 11834606 11421492 14725611 11743745 17522070 19923254 19164858 16109766 12958197 16177239
MESH:D056486 Drug-Induced Liver Injury pyrazole 15.9912499123
MESH:D056486 Drug-Induced Liver Injury Selenium 15.9915131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 15.9920420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9111462148
MESH:C538011 Eales disease Vitamin E 5.029068938
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2215322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.4212538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.219294722 10568697
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3512903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005234 Fatty Liver arsenic trioxide 8.4315073043
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.4315345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.2120067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5016904648
MESH:D005756 Gastritis Acetaminophen 3.9916983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.9010048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 6.9016080930
MESH:D006333 Heart Failure Selenium 3.1917162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1512621046 15340226 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7616490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.2914716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3615340226 8697196 18606429 16959395 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.8616870215
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9718670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0716569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6217937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9512200463 12878042
MESH:D007251 Influenza, Human Selenium 12.0416624496
MESH:D007251 Influenza, Human Vitamin E 12.0416624496
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5416580747
MESH:D007674 Kidney Diseases Acetaminophen 6.3315629191 12587719
MESH:D007674 Kidney Diseases Vitamin E 6.3312488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.0916518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.9416705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.9416705839
MESH:D007938 Leukemia arsenic trioxide 2.9215070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.0012560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.5916972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5814633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.9719077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1620471514 16467208 17050201 16968895 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3417649720 12018890 16966277 16330433 19225113 15213294 17869043 19642359 11161223 17217047 15622746 9834237 12679006 19075265 16823087 15748426 11468182 16331271 12712474 17712046 19035177 16112521 15336539 16891316 17107899
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5916882451
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3912878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.3916169303
MESH:D008107 Liver Diseases Acetaminophen 1.6716610002 12969438 11587558 16611625 12587719 19460945 19784758 19014921
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4317185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.797678174
MESH:D008113 Liver Neoplasms arsenic trioxide 7.7914682389
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.7916984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.516135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 10.5120377131
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.5112151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5115213294
MESH:D008171 Lung Diseases Vitamin E 3.3116863852
MESH:D008175 Lung Neoplasms arsenic trioxide 3.5119825857 11798837
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5119555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 3.5111062179
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.8815318939
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8319513568
MESH:D008654 Mesothelioma Selenium 2.8615107826
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2519417148 15949261 14977855 19549372 11468182
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.9918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2516882451 16105982
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.3218551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.327678174 18551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2016624393
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4514600291
MESH:D009436 Neural Tube Defects arsenic trioxide 3.2410525206
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0418514411
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.5416049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.5416049721
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4612452020 16624393 19769630
MESH:D010146 Pain Acetaminophen 2.5616870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.5815580305
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9111578682
MESH:D010235 Paraganglioma arsenic trioxide 4.3819927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D010954 Plasmacytoma Selenium 5.2115087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4811896295 11222880 11118676 11399792
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2519131511
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2515084515
MESH:D011537 Pruritus Ethinyl Estradiol 3.6016919318 15861022
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.2016646077
MESH:D012640 Seizures 2,4-dinitrotoluene 6.3218551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.3218551238
MESH:D012871 Skin Diseases Vitamin E 2.4818709164
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1316192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.2616709447
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D020521 Stroke Vitamin E 3.6816517955
MESH:D013733 Testicular Diseases pyrazole 5.106499806
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3315669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.2419014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.2415213294
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.7216049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.7216049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 8.7211780464 20435036 12845720 12973940
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.9610091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.9610091137
MESH:D014581 Urticaria Acetaminophen 3.2010982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5414692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7514671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
Pathway ID Pathway Name
KEGG:04141 Protein processing in endoplasmic reticulum
KEGG:04120 Ubiquitin mediated proteolysis
Pharmacogenomics Knowledge Base Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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