AutismKB 2.0

Annotation Detail for DNAJA2


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Basic Information Top
Gene Symbol:DNAJA2 ( CPR3,DJ3,DJA2,DNAJ,DNJ3,HIRIP4,PRO3015,RDJ2 )
Gene Full Name: DnaJ (Hsp40) homolog, subfamily A, member 2
Band: 16q11.2
Quick LinksEntrez ID:10294; OMIM: 611322; Uniprot ID:DNJA2_HUMAN; ENSEMBL ID: ENSG00000069345; HGNC ID: 14884
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04141Protein processing in endoplasmic reticulum
No data
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of DNAJA2 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of DNAJA2 mRNAaffects expression 21346803
D000643 Ammonium Chloride Ammonium Chloride affects the expression of DNAJA2 mRNAaffects expression 16483693
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of DNAJA2 mRNAdecreases expression 19150397
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of DNAJA2 mRNAaffects cotreatment|decreases expression 18544905
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with kojic acid] results in increased expression of DNAJA2 mRNAaffects cotreatment|increases expression 18544905
D004052 Diethylnitrosamine [Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of DNAJA2 mRNAaffects cotreatment|decreases expression 18253720
D011345 Fenofibrate [Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of DNAJA2 mRNAaffects cotreatment|decreases expression 18253720
D016627 Oxidopamine Oxidopamine results in increased expression of DNAJA2 mRNAincreases expression 12486162
D007213 Indomethacin Indomethacin results in decreased expression of DNAJA2 mRNAdecreases expression 16984733
D007213 Indomethacin Indomethacin results in increased expression of DNAJA2 mRNAincreases expression 18299717
C011890 kojic acid [Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of DNAJA2 mRNAaffects cotreatment|decreases expression 18544905
C011890 kojic acid [Diethylnitrosamine co-treated with kojic acid] results in increased expression of DNAJA2 mRNAaffects cotreatment|increases expression 18544905
C008281 limonene limonene results in increased expression of DNAJA2 mRNAincreases expression 12815608
D009151 Mustard Gas Mustard Gas results in increased expression of DNAJA2 mRNAincreases expression 15674844
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of DNAJA2 mRNAincreases expression 17616710
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of DNAJA2 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of DNAJA2 mRNAincreases expression 17426115
18301758
C052785 rebamipide rebamipide results in increased expression of DNAJA2 mRNAincreases expression 18299717
D014501 Uranium Uranium affects the expression of DNAJA2 mRNAaffects expression 15672453
C005460 uranyl acetate uranyl acetate affects the expression of DNAJA2 mRNAaffects expression 15672453
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.5818287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.1218653653
MESH:D000230 Adenocarcinoma Indomethacin 2.7816537180
MESH:D000236 Adenoma Diethylnitrosamine 6.936695378 10737359
MESH:D000236 Adenoma Indomethacin 6.9311497255
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 10.1619061943 16434500 19052882 18056438 17620307 17162532
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.1616434500
MESH:D016301 Alveolar Bone Loss Indomethacin 5.4017225004
MESH:D000544 Alzheimer Disease Indomethacin 2.7017627676 15579461
MESH:D001014 Aortic Aneurysm Indomethacin 4.8610231640
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 4.8810388637
MESH:D018771 Arthralgia Indomethacin 5.202160914
MESH:D001172 Arthritis, Rheumatoid Indomethacin 2.8211248219
MESH:D001249 Asthma Mustard Gas 2.7110378619
MESH:D001289 Attention Deficit Disorder with Hyperactivity Oxidopamine 4.6514699433
MESH:D001477 Bartter Syndrome Indomethacin 5.0010684365
MESH:D001768 Blister Mustard Gas 5.1819167455
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.1519483382
MESH:D001929 Brain Edema Indomethacin 5.0611481608
MESH:D002545 Brain Ischemia Indomethacin 4.4412524144
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.3817474063
MESH:D001943 Breast Neoplasms Indomethacin 2.3817401462
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.1815286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.0117687719 10378619
MESH:D002056 Burns Indomethacin 4.7210459503
MESH:D002100 Cachexia Indomethacin 5.0215141370 15625704 11239499 16537180
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.6116705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.6116705839
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.613084413 20512989 18393292 20007298 18210153 17162532 16779866 16830150 19335982 20524982 21159647 20101231 3581430 19107877 19822196 19383236 19052882 16807293 19539802 20432363 17761372 18494052 10672840 18056438 19701751 16681979 19919837 18691550 16328049 16540662 19171122 20935162 18506893 11831363 17173139 19519916 19208518 17428255 16698587 19394651 18978308 18971187 16569478 20084675 16502159 18665156 17055752 10737359 16288022 18785209 16878318 19418558 18788625 17138121 20727157 20514400 17978847 16935385 20214788
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 6.6116391822
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 4.7511053908
MESH:D018276 Carcinoma, Medullary Indomethacin 5.3714736730 11352223 18791128
MESH:D002292 Carcinoma, Renal Cell Indomethacin 3.3717341418
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 2.8515482327 12636206
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.196135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.1920889678
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 11.1917174075 21159647 2727394 7505956
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.6919052882
MESH:D002764 Cholecystitis Indomethacin 5.2011181007
MESH:D002779 Cholestasis pirinixic acid 2.8319176532
MESH:D003110 Colonic Neoplasms Indomethacin 2.5915637740 15963497 15936596 15625704 11260862 15786552
MESH:D015179 Colorectal Neoplasms Indomethacin 2.3612606626 17054584 18059344 11197048
MESH:D018352 Coronavirus Infections Indomethacin 5.7517302372
MESH:D003490 Cyanosis 2,4-dinitrotoluene 10.9418551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 10.9418551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4318249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.1920387270
MESH:D003967 Diarrhea Indomethacin 3.807237001 7907874
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.2421346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.2421346803 18551238
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.2419107877
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 5.1716326151 18043480 17190690 18446180 16133044 12774134
MESH:D004381 Duodenal Ulcer Indomethacin 4.1417151854 11595415 16699067 11991626 17329845 17202747 17045617 17351913 11535926 10671773 11595431
MESH:D050171 Dyslipidemias Fenofibrate 4.4316707586
MESH:D004487 Edema Indomethacin 11.6119703484 10653021 7907874 7990266 16100529 8273558 8985016
MESH:D004487 Edema Mustard Gas 11.6111428631 9260866 11428647 11402378
MESH:D004487 Edema pirinixic acid 11.6112083418
MESH:D016889 Endometrial Neoplasms Fenofibrate 4.0916569247
MESH:D004715 Endometriosis Indomethacin 4.1515652904
MESH:D019446 Endotoxemia Indomethacin 4.5218509659
MESH:D004751 Enteritis Indomethacin 4.7816328016 10567023 17763956
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 5.0017980183
MESH:D004802 Eosinophilia Indomethacin 4.0711298111
MESH:D004890 Erythema Mustard Gas 5.189357497
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.1516302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.3920426865
MESH:D004938 Esophageal Neoplasms Indomethacin 7.3911005569
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 7.3915547721 15264214 15150132 15547733 16704527 15623463 16805852 16510608 15878914
MESH:D005234 Fatty Liver Diethylnitrosamine 7.7021071580 20387270
MESH:D005234 Fatty Liver pirinixic acid 7.7020131406 19236843
MESH:D005334 Fever Indomethacin 4.1211852909 10431976 17627676
MESH:D005354 Fibrosarcoma Indomethacin 4.9110962813
MESH:D005355 Fibrosis Indomethacin 4.0817994277
MESH:D005499 Folliculitis Indomethacin 5.2011298111
MESH:D005756 Gastritis Indomethacin 4.7815046732
MESH:D005909 Glioblastoma Indomethacin 3.5612870263
MESH:D005910 Glioma Indomethacin 3.2318371953 16487511
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 4.2911849393
MESH:D006073 Gout Indomethacin 5.3711248219
MESH:D006258 Head and Neck Neoplasms Indomethacin 3.7415482327
MESH:D006333 Heart Failure pirinixic acid 2.5420558911
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.5715633222
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.6915135802
MESH:D006529 Hepatomegaly pirinixic acid 3.0116221962 19176532 19772884 18467677
MESH:D006930 Hyperalgesia Indomethacin 3.7712727271
MESH:D034321 Hyperamylasemia Indomethacin 5.7517883296
MESH:D006940 Hyperemia Indomethacin 5.0212524144
MESH:D006943 Hyperglycemia pirinixic acid 3.1920558911
MESH:D006949 Hyperlipidemias Indomethacin 4.1717546600
MESH:D007077 Ileal Diseases Indomethacin 5.0618306037 10574470
MESH:D007079 Ileitis Indomethacin 5.3710651667 16133968 10647630
MESH:D007235 Infant, Premature, Diseases Indomethacin 5.4016133044
MESH:D007249 Inflammation Diethylnitrosamine 8.4918785209
MESH:D007249 Inflammation Indomethacin 8.497812673 3291741 12568917
MESH:D007249 Inflammation Mustard Gas 8.4911428631 8975870 9357497 17524151 16001271 11428620 11428647 9260866 11402378
MESH:D007333 Insulin Resistance pirinixic acid 2.6316306350
MESH:D007410 Intestinal Diseases Indomethacin 10.4518236018 11713966 17994277 17329856 10210152 15831440 15610444 11686837 11855677
MESH:D007410 Intestinal Diseases rebamipide 10.4511686837
MESH:D019586 Intracranial Hypertension Indomethacin 5.4015241188
MESH:D007579 Jejunal Diseases Indomethacin 5.0618306037 10574470 16133968
MESH:D007674 Kidney Diseases Indomethacin 3.2717190690
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.3716705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.3716705839
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 3.9010320625 12228301 11703811
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 3.9315631656 10785260 16572323
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 2.6318360721
MESH:D007964 Leukocytosis Indomethacin 5.4016537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.7517980183
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.7511479899
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8218522880 18665156 18407596 20032147 19638242
MESH:D008106 Liver Cirrhosis, Experimental Fenofibrate 3.6815474484
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 3.6818194892
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.6815474484
MESH:D008107 Liver Diseases Diethylnitrosamine 4.7217034775
MESH:D008107 Liver Diseases limonene 4.721715830
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 10.757678174
MESH:D008113 Liver Neoplasms Diethylnitrosamine 10.7519255062 20101389 16942905 19690152 19551842 20137499 20501860 19812893 20118626 15175105 18978307 18977376 15885732 19638242 20492335 20452335 10737359 2862719 19427195 19254457 20405173 19642983 9163691 21167192 2422723 19426721 20583210 21278145 19090486 12771043 20434301 12112319 19256749 21071580 19996281 19499222 19850985 18648771 19833225 19294768 18644402 19073162 18754104 21047994
MESH:D008113 Liver Neoplasms Fenofibrate 10.7518978307
MESH:D008113 Liver Neoplasms pirinixic acid 10.7516377806 20007298 15890375
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 14.236135515 2876784 2876786
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 14.232563599 9362446 19126423 19009564 17174075 16267830 21159647 18544905 18164116 18308698 18253720 16842330 19004024 19539802 17942915 18079962 18282651 3124819 19519916 18775883 17854601 18093689
MESH:D008114 Liver Neoplasms, Experimental Fenofibrate 14.2318775883 18253720
MESH:D008114 Liver Neoplasms, Experimental kojic acid 14.2318544905
MESH:D008171 Lung Diseases Mustard Gas 3.4518161513 18702808
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.5820512841 20970405 21163286 6695378
MESH:D008175 Lung Neoplasms Indomethacin 3.5811053908 11497255 16537180
MESH:D008175 Lung Neoplasms Mustard Gas 3.588781369 3148597
MESH:D008881 Migraine Disorders Indomethacin 3.6711903285
MESH:D009062 Mouth Neoplasms Indomethacin 3.9912636206
MESH:D009135 Muscular Diseases pirinixic acid 3.5216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1419151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9516411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.4118551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.417678174 18551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.963581430 9029167
MESH:D009362 Neoplasm Metastasis Indomethacin 5.9616537180 11239499 11053908
MESH:D009369 Neoplasms pirinixic acid 1.9517405874
MESH:D009374 Neoplasms, Experimental Indomethacin 4.1510663608 15625704
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 14.3520387270
MESH:D019636 Neurodegenerative Diseases Indomethacin 14.3512349958
MESH:D019636 Neurodegenerative Diseases Oxidopamine 14.3518514411
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.1520387270
MESH:D009503 Neutropenia Mustard Gas 3.9816761898 7688884
MESH:D009765 Obesity pirinixic acid 1.8120558911
MESH:D007752 Obstetric Labor, Premature Indomethacin 5.206374098
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.9012819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.9016049721
MESH:D010003 Osteoarthritis Indomethacin 3.677009135
MESH:D010146 Pain Indomethacin 3.4617627676 13679232 17440234 3291741
MESH:D010149 Pain, Postoperative Indomethacin 4.7118702446 12538197
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4216540662
MESH:D010195 Pancreatitis Indomethacin 3.9315028970 17883296
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.7516537180
MESH:D010302 Parkinson Disease, Secondary Oxidopamine 5.4711771942 15893579
MESH:D020734 Parkinsonian Disorders Indomethacin 4.1212349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.7511903285
MESH:D010437 Peptic Ulcer Indomethacin 5.1711148446
MESH:D010518 Periodontitis Indomethacin 4.9417225004
MESH:D011041 Poisoning Mustard Gas 3.8015727166
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.552563599
MESH:D047928 Premature Birth Indomethacin 5.1417000239
MESH:D011507 Proteinuria Indomethacin 4.1711849393
MESH:D011537 Pruritus Mustard Gas 4.1118058305
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9317720292 17266442 10334151 17894541 17620002
MESH:D015427 Reperfusion Injury pirinixic acid 2.3919058328
MESH:D012640 Seizures 2,4-dinitrotoluene 5.8718551238
MESH:D012640 Seizures 2,6-dinitrotoluene 5.8718551238
MESH:D012871 Skin Diseases Mustard Gas 2.7112880345 15451306 16961503
MESH:D013272 Stomach Diseases Indomethacin 10.7918545984 16113693 16184426 18209964 16280098 10192188 17638125 10215738 10486359 15038085 15472012 17207306 17160473
MESH:D013272 Stomach Diseases rebamipide 10.7916184426
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.8418456281
MESH:D013274 Stomach Neoplasms Indomethacin 4.8415609394
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 4.8417575124 12958204
MESH:D013274 Stomach Neoplasms rebamipide 4.8415993841
MESH:D013276 Stomach Ulcer Indomethacin 3.5918237397 16169175 11523592 17654042 15138204 18209962 16755016 11595431 12498302 15255614 12077510 18299717 11145282 11729361 12467913 18726076 18087811 12500499 17627676 18181030 16397915 16934674 18431645 16252198 14567935 11595415 17135157 17895592 10423059 16631530 16150113 17977527 18543354 10878458 18193104 17657623 17918041 12787963 1323529 15104355 10750652 11906479
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.387505956
MESH:D013964 Thyroid Neoplasms Indomethacin 7.3818791128 14736730 11352223
MESH:D014456 Ulcer Indomethacin 4.9117380554 10574470
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.0116049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.0116049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.0610091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.0610091137
MESH:D014839 Vomiting Indomethacin 4.7811897121
Pathway ID Pathway Name
KEGG:04141 Protein processing in endoplasmic reticulum
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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