AutismKB 2.0

Annotation Detail for ADAR


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Basic Information Top
Gene Symbol:ADAR ( ADAR1,DRADA,DSH,DSRAD,G1P1,IFI-4,IFI4,K88DSRBP,P136 )
Gene Full Name: adenosine deaminase, RNA-specific
Band: 1q21.3
Quick LinksEntrez ID:103; OMIM: 146920; Uniprot ID:DSRAD_HUMAN; ENSEMBL ID: ENSG00000160710; HGNC ID: 225
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04623Cytosolic DNA-sensing pathway
Pathway IDPathway Name
mRNA Processing
No data
No data
Pathway IDPathway Name
500708mRNA Editing: A to I Conversion
500709Formation of editosomes by ADAR proteins
500710C6 deamination of adenosine
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1860Brain tumor
1970Virus disease
2131Keratoconjunctivitis Sicca
2146Lupus erythematosus
No data
No data
Desease Name
Dyschromatosis symmetrica hereditaria
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of ADAR mRNAaffects expression 21346803
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ADAR mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in increased expression of ADAR mRNAincreases expression 20458559
C006780 bisphenol A bisphenol A affects the expression of ADAR mRNAaffects expression 14967926
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of ADAR mRNAincreases expression 15003993
14729362
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of ADAR mRNAincreases expression 17484886
D010269 Paraquat [ADAR gene mutant form results in increased expression of DHD mRNA] which results in decreased susceptibility to Paraquatdecreases response to substance|increases expression 15530657
D010269 Paraquat ADAR protein affects the susceptibility to Paraquataffects response to substance 15530657
D012402 Rotenone Rotenone results in increased expression of ADAR mRNAincreases expression 19013527
D014501 Uranium Uranium affects the expression of ADAR mRNAaffects expression 15672453
C005460 uranyl acetate uranyl acetate affects the expression of ADAR mRNAaffects expression 15672453
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.8018287403
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3211798837 19825857
MESH:D000382 Agricultural Workers' Diseases Paraquat 4.0011874814
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 3.8416206674
MESH:D001862 Bone Resorption bisphenol A 4.0311985600
MESH:D001943 Breast Neoplasms bisphenol A 2.4517123778
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.5111589617
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.993786805 15700767 10355542 15721981 16124888 15673190 16011737 16050911 18705752 16192424 16097048 16227642
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.7316705839
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.7311135700 16217749 15073043 14691202 15553829
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.7318788625
MESH:D002278 Carcinoma in Situ bisphenol A 5.2317123778
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.1419014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.2812490120
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.3812609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8910525206
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.2318551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.2815213294
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 4.0318551238 21346803
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 4.0310915739 4309450 7179309 17522070 21278145 15968718 6884620 19085960 2869522 16227642 15998439 11566570 3786805 19336974 6623471 16177239 7120509 7440962 10092053 9327722 3732212 15027814
MESH:C535729 Dyschromatosis symmetrica hereditaria 1 marker/mechanism
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3412903497
MESH:D005234 Fatty Liver arsenic trioxide 8.4415073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.4412795759 16239168 16045604 12631006 17595544 15959796 61145 19224547
MESH:D005355 Fibrosis Carbon Tetrachloride 3.6718705752
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.4616904648
MESH:D005911 Gliosis Paraquat 5.4311124998
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7919900420 19110552
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7716899240
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3015338365
MESH:D007248 Infertility, Male Paraquat 3.364850670
MESH:D007333 Insulin Resistance bisphenol A 3.3916393666
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 3.1216705839
MESH:D007938 Leukemia arsenic trioxide 2.9115070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.9712560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.5416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5514633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.9319077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1617050201 16968895 16467208 20471514 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3216966277 9834237 19225113 17712046 16331271 12018890 15748426 19035177 11161223 15336539 16330433 12712474 17649720 17217047 16891316 19642359 19075265 17107899 16823087 16112521 15213294 11468182 15622746 12679006 17869043
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5516882451
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8917334410 16943688 11408273 11903743 21278145 16239168 16221502 17157831 17174718
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 1.7515362042 17708605 12586293 16015684 18429990 18376398 15123356 18472094 16192424 18251166 12632514 17922224 16248980 12649538 12741479 16638106 12898905 15931870 14724832 17714472 18156304 17698563 18205269 12389079 15893842 18006644 15338365 18054572 18395914 17869086 18279442 14620537 12546737 15925388 12667390 17761835 15996030 15818738 15673190 17481882 12958196 14512876 10355542 15370692 17805973 16136751 16027843 12445418 15730626 12609069 18412020 17565644 12632512 15057751 18210741 18166357 17631135 18277467 12445421 18481824 18339082 17944888 15650968 14748882 20821823 14716496 13678700 18472332 17766677 11481614 18418968 16011737 17557913 18263696 15876570 18705752 18187930 17900296 17640975 18395095 17721639 16097048 17525996 15959796 15052691 14716833 16116963 17823541 12666154 18317297 17976157 16033810 18420326
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1216964402 15830285 15720792 17285989 16246199
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3815123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.8516899240 14706259
MESH:D008113 Liver Neoplasms arsenic trioxide 4.8214682389
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.8219294768
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 6.3320377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.3315583823 12014681
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4815213294
MESH:D008175 Lung Neoplasms arsenic trioxide 1.8619825857 11798837
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2211468182 19417148 19549372 15949261 14977855
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.9418349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2316105982 16882451
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.0918551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.1616624393
MESH:D009410 Nerve Degeneration Paraquat 9.0816893418
MESH:D009410 Nerve Degeneration Rotenone 9.0815790535 18619942 17356569
MESH:D009421 Nervous System Malformations bisphenol A 4.1716427766 11399458
MESH:D009436 Neural Tube Defects arsenic trioxide 3.2210525206
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.5912819281 16049721
MESH:D010049 Ovarian Diseases bisphenol A 5.2311985600
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4512452020 16624393 19769630
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.5815580305
MESH:D010235 Paraganglioma arsenic trioxide 4.3519927285
MESH:D010300 Parkinson Disease Paraquat 5.7711445065 11124998 15451049 11181820 16510128 12911755 16140633 15824117
MESH:D010300 Parkinson Disease Rotenone 5.7718619942 18191903 16412576 19232380 11535288 16140633 11445065 19114014 15451049
MESH:D010302 Parkinson Disease, Secondary Paraquat 4.6516190885
MESH:D020734 Parkinsonian Disorders Rotenone 4.2415574749 15927086 18197244 15795934
MESH:D011014 Pneumonia Paraquat 4.6912504350
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 4.1910548101
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.3820887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.3019131511
MESH:D011471 Prostatic Neoplasms bisphenol A 3.3016740699
MESH:D011629 Puberty, Precocious bisphenol A 5.0210548101
MESH:D011658 Pulmonary Fibrosis Paraquat 2.9717997886 16324872
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 4.0911700416
MESH:D012135 Respiratory Sounds Paraquat 4.2711874814
MESH:D012162 Retinal Degeneration Paraquat 3.9916458197
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.1616646077
MESH:D012640 Seizures 2,4-dinitrotoluene 2.6418551238
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 2.768532709
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D019966 Substance-Related Disorders bisphenol A 4.2216045194 16684133
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.2219014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.2015213294
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.2816049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.2812845720 11780464 12973940 20435036
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.5510091137
MESH:D014591 Uterine Diseases bisphenol A 5.2714652134
Pathway ID Pathway Name
KEGG:04623 Cytosolic DNA-sensing pathway
KEGG:05162 Measles
REACT:1675 mRNA Processing
REACT:6900 Signaling in Immune system
Pharmacogenomics Knowledge Base Top
Drug Bank Top

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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