AutismKB 2.0

Annotation Detail for TNIP1


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Basic Information Top
Gene Symbol:TNIP1 ( ABIN-1,KIAA0113,NAF1,VAN )
Gene Full Name: TNFAIP3 interacting protein 1
Band: 5q33.1
Quick LinksEntrez ID:10318; OMIM: 607714; Uniprot ID:TNIP1_HUMAN; ENSEMBL ID: ENSG00000145901; HGNC ID: 16903
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
systemic lupus erythematosus
IMMUNE
psoriasis
Desease Name
Psoriasis
Systemic lupus erythematosus
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of TNIP1 mRNAaffects expression 17562736
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TNIP1 mRNAdecreases expression 19150397
D002251 Carbon Tetrachloride PPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of TNIP1 mRNA]affects reaction|increases expression 18038451
D016572 Cyclosporine Cyclosporine results in increased expression of TNIP1 mRNAincreases expression 20106945
D004391 Dust Dust results in increased expression of TNIP1 mRNAincreases expression 17805423
D004958 Estradiol Estradiol affects the expression of TNIP1 mRNAaffects expression 14699072
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of TNIP1 mRNAaffects binding|increases activity|increases expression 19710929
C059514 resveratrol resveratrol results in increased expression of TNIP1 mRNAincreases expression 17257620
D018038 Sodium Selenite Sodium Selenite results in increased expression of TNIP1 mRNAincreases expression 18175754
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D058186 Acute Kidney Injury resveratrol 4.0616538975
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D000230 Adenocarcinoma Estradiol 2.1411473722
MESH:D000236 Adenoma resveratrol 3.4215688382
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.7616434500
MESH:D000544 Alzheimer Disease resveratrol 2.6016162502 16183991
MESH:D000799 Angioedema Acetaminophen 4.1610982225
MESH:D001169 Arthritis, Experimental resveratrol 3.6217115116
MESH:D050197 Atherosclerosis resveratrol 3.3816873680 17967414
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3519483382
MESH:D002545 Brain Ischemia resveratrol 4.5717600658
MESH:D001943 Breast Neoplasms marker/mechanism 16298037
MESH:D001943 Breast Neoplasms Estradiol 2.2818497071 12948864 17018787 16675129 14630087 17289903 17261762 19861407
MESH:D001943 Breast Neoplasms resveratrol 2.2817651959 16393696 17534123
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.7516111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.0415673190 16124888 15721981 10355542 16227642 16097048 15700767 18705752 16011737 16050911 3786805 16192424
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.803084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.8018788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.8016924424
MESH:D006528 Carcinoma, Hepatocellular resveratrol 6.8016227395 19321006
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.8816675471
MESH:D002294 Carcinoma, Squamous Cell resveratrol 2.7616227395
MESH:D002318 Cardiovascular Diseases resveratrol 3.6115458977
MESH:D002386 Cataract Acetaminophen 2.6910977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.9520889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.9512371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 11.9518566989
MESH:D002779 Cholestasis Cyclosporine 8.2619486331
MESH:D002779 Cholestasis pirinixic acid 8.2619176532
MESH:D019457 Chromosome Breakage Sodium Selenite 5.0115894690
MESH:D003092 Colitis resveratrol 4.3916474422
MESH:D003110 Colonic Neoplasms resveratrol 2.4816338953
MESH:D015179 Colorectal Neoplasms resveratrol 2.2216550006
MESH:D003327 Coronary Disease resveratrol 3.8716507316
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.9616285004
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.9416873680
MESH:D003928 Diabetic Nephropathies Estradiol 9.6319279558
MESH:D003928 Diabetic Nephropathies resveratrol 9.6316286809
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.5316109766 11739529 11421492 19416960 16485898 12705907 10663392 11287661 15619225 18071297 16393943 14725611 12958197 12540782 17562736 16781746 19370779 19739265 14986274 11461765 11834606 11743745 19085960 17906064 16227642 10915739 11529661 14550746 19420014 12153990 12594235 19923254 17522070 18713872 16081117 10774834 12392966 16177239 2444490 19164858 15968718
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.533786805 11566570 17522070 10092053 4309450 15027814 9327722 10915739 7440962 7179309 16227642 21278145 16177239 15998439 19336974 6623471 15968718 3732212 19085960 6884620 7120509 2869522
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 6.5315131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4219426721
MESH:D004487 Edema pirinixic acid 7.5912083418
MESH:D004487 Edema resveratrol 7.598985016
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 4.2617872969
MESH:D016889 Endometrial Neoplasms Estradiol 3.1119148513 18566989 11473722
MESH:D020345 Enterocolitis, Necrotizing resveratrol 5.1117923197
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1120426865
MESH:D005234 Fatty Liver Carbon Tetrachloride 14.2816045604 15959796 12795759 17595544 19224547 16239168 61145 12631006
MESH:D005234 Fatty Liver Cyclosporine 14.2819224547
MESH:D005234 Fatty Liver pirinixic acid 14.2820131406 19236843
MESH:D005355 Fibrosis Carbon Tetrachloride 9.5418705752
MESH:D005355 Fibrosis Cyclosporine 9.5412168785 12639820
MESH:D005756 Gastritis Acetaminophen 3.9916983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.508708960
MESH:D006333 Heart Failure pirinixic acid 2.6520558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7115720958
MESH:D006505 Hepatitis Carbon Tetrachloride 3.8319900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 3.2516221962 19772884 19176532 18467677
MESH:D006558 Herpes Genitalis Estradiol 5.3515709030
MESH:D006561 Herpes Simplex resveratrol 4.4616876885
MESH:D019584 Hot Flashes Estradiol 4.0717088409
MESH:D006930 Hyperalgesia Acetaminophen 2.8616870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.8216899240
MESH:D006937 Hypercholesterolemia resveratrol 4.2117188708
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D006949 Hyperlipidemias resveratrol 4.2516873680
MESH:D006973 Hypertension Cyclosporine 2.1610903974
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3515338365
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.5017488730
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.9117600658
MESH:D007249 Inflammation resveratrol 2.9416366677
MESH:D007251 Influenza, Human resveratrol 4.8616624496
MESH:D007333 Insulin Resistance Estradiol 13.0716393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 13.0716306350
MESH:D007333 Insulin Resistance Sodium Selenite 13.0714714311
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7615604871
MESH:D007674 Kidney Diseases Acetaminophen 10.6212587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 10.628314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 10.6215618244
MESH:D007680 Kidney Neoplasms Cyclosporine 7.8512371664
MESH:D007680 Kidney Neoplasms Estradiol 7.8515610895
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.7016087638
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9116943688 11408273 17334410 16221502 21278145 17174718 11903743 16239168 17157831
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.5618418968 15673190 13678700 16248980 18251166 14716833 15362042 15338365 15996030 20821823 17714472 17698563 12632512 15959796 18376398 16116963 17525996 16136751 16027843 12389079 12741479 18166357 18156304 14620537 12546737 18006644 16192424 17823541 18279442 14748882 17721639 17565644 12958196 15925388 12586293 17869086 12667390 12632514 17631135 18277467 12445421 18263696 15123356 18420326 10355542 17900296 18412020 17922224 15876570 15370692 17766677 14724832 15818738 14512876 18205269 12666154 18339082 18705752 17557913 12609069 18429990 17708605 17640975 15931870 18187930 15052691 11481614 15057751 18395914 17944888 12898905 15730626 15650968 18472332 16033810 12445418 18210741 18317297 16015684 17976157 16097048 16638106 17481882 18395095 12649538 15893842 18481824 17805973 14716496 17761835 16011737 18054572 18472094
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.5614716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5615474484
MESH:D008107 Liver Diseases Acetaminophen 4.0519014921 11587558 19460945 12969438 19784758 16610002 12587719 16611625
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.0516246199 16964402 15830285 17285989 15720792
MESH:D017093 Liver Failure Carbon Tetrachloride 4.4215123358
MESH:D017114 Liver Failure, Acute Acetaminophen 10.0617185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 10.0614706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.8719294768
MESH:D008113 Liver Neoplasms pirinixic acid 7.8715890375 20007298 16377806
MESH:D008113 Liver Neoplasms resveratrol 7.8719321006 20405173 19812893 19073162
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 2.7315583823 12014681
MESH:D008180 Lupus Erythematosus, Systemic marker/mechanism 19838193 19838195
MESH:D016393 Lymphoma, B-Cell resveratrol 11.0217088997
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 11.0214737004
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 4.0414749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 4.5315688416
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.5711408345 16891317 17203775 11807958
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 6.578985016 11606380
MESH:D020149 Manganese Poisoning Estradiol 4.8019453300
MESH:D008545 Melanoma resveratrol 2.3917992120
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8319513568
MESH:D008659 Metabolic Diseases resveratrol 4.5817112576
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1116801185
MESH:D009101 Multiple Myeloma resveratrol 3.6117049120 14749477 16490592 17164350 17935668 16267019
MESH:D009134 Muscular Atrophy, Spinal resveratrol 5.1617962980
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009203 Myocardial Infarction pirinixic acid 5.9919151258
MESH:D009203 Myocardial Infarction resveratrol 5.9917125593 16317513 16525036 16456233 17015251 17188708
MESH:D017202 Myocardial Ischemia resveratrol 4.1717015251 17125593
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.7816810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.7816411023
MESH:D009205 Myocarditis resveratrol 5.0417322642
MESH:D009369 Neoplasms pirinixic acid 2.0317405874
MESH:D009374 Neoplasms, Experimental resveratrol 4.268985016
MESH:D009389 Neovascularization, Pathologic Estradiol 4.0217289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4719348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 3.8916427766 11399458
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.9318514411
MESH:D019636 Neurodegenerative Diseases resveratrol 8.9317652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.6217929310
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 4.4817513867
MESH:D010051 Ovarian Neoplasms Estradiol 2.2719401270
MESH:D010146 Pain Acetaminophen 2.5616870215
MESH:D011230 Precancerous Conditions Cyclosporine 3.4012371664
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 4.4616679765
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.0920887781
MESH:D011471 Prostatic Neoplasms Estradiol 2.5916740699
MESH:D011471 Prostatic Neoplasms resveratrol 2.5916731767 17804756 15767336 17636462 17718901 17675339
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.5918760546
MESH:D011565 Psoriasis marker/mechanism 20953190 19169254
MESH:D011565 Psoriasis Cyclosporine 2.2916882103
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.9016325855
MESH:D015427 Reperfusion Injury pirinixic acid 6.8719058328
MESH:D015427 Reperfusion Injury resveratrol 6.8715827377 17520802 17058453 16314181 16317513
MESH:D012878 Skin Neoplasms resveratrol 3.1115837718 8985016
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.6716321402
MESH:D013978 Tibial Fractures Estradiol 5.0019048282
MESH:D014062 Tongue Neoplasms resveratrol 4.4116227395
MESH:D014581 Urticaria Acetaminophen 3.2010982225
MESH:D002583 Uterine Cervical Neoplasms resveratrol 4.2917473185
MESH:D014594 Uterine Neoplasms resveratrol 4.3717044934
MESH:D014605 Uveitis Cyclosporine 4.301336536
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.5617488730
MESH:D014985 Xerophthalmia Cyclosporine 4.7617120751
Pathway ID Pathway Name
KEGG:04320 Dorso-ventral axis formation
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA128394573
    • No data
    Releated disease ID Related disease Name
    PA445451Psoriasis
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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