AutismKB 2.0

Annotation Detail for LAMC3


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Basic Information Top
Gene Symbol:LAMC3 ( DKFZp434E202 )
Gene Full Name: laminin, gamma 3
Band: 9q34.12
Quick LinksEntrez ID:10319; OMIM: 604349; Uniprot ID:LAMC3_HUMAN; ENSEMBL ID: ENSG00000050555; HGNC ID: 6494
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05146Amoebiasis
hsa05145Toxoplasmosis
hsa05222Small cell lung cancer
hsa04512ECM-receptor interaction
hsa04510Focal adhesion
hsa05200Pathways in cancer
Pathway IDPathway Name
Integrin cell surface interactions
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of LAMC3 mRNAaffects expression 21346803
C002202 4-oxoretinoic acid 4-oxoretinoic acid results in increased expression of LAMC3 mRNAincreases expression 15982314
C103303 alitretinoin alitretinoin results in increased expression of LAMC3 mRNAincreases expression 15982314
D015474 Isotretinoin Isotretinoin results in increased expression of LAMC3 mRNAincreases expression 15982314
D014212 Tretinoin Tretinoin metabolite results in increased expression of LAMC3 mRNAincreases expression 15982314
D014212 Tretinoin Tretinoin results in increased expression of LAMC3 mRNAincreases expression 15982314
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Isotretinoin 5.0718769834
MESH:D000015 Abnormalities, Multiple Isotretinoin 5.3518769834
MESH:D017486 Acneiform Eruptions Isotretinoin 6.9016232082
MESH:D000152 Acne Vulgaris Isotretinoin 6.0918769834 16185265
MESH:D000505 Alopecia Tretinoin 3.9015955085
MESH:D001169 Arthritis, Experimental Tretinoin 3.2816412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3316292516
MESH:D001249 Asthma Tretinoin 2.4316456186
MESH:D001471 Barrett Esophagus Tretinoin 4.8416935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.9816197459 16206674
MESH:D001927 Brain Diseases marker/mechanism 21572413
MESH:D001943 Breast Neoplasms alitretinoin 2.4716344269
MESH:D001943 Breast Neoplasms Tretinoin 2.4716166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 5.1316813970
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.7716168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 3.1416705839
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 3.141917145
MESH:D002294 Carcinoma, Squamous Cell Isotretinoin 5.3511237771
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 5.3516096774 16051514
MESH:D002386 Cataract Tretinoin 3.2817460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 5.1316129372
MESH:D002659 Child Development Disorders, Pervasive marker/mechanism 21572417
MESH:D002822 Choriocarcinoma Tretinoin 5.7716461808
MESH:D002972 Cleft Palate Tretinoin 2.799407595
MESH:D003092 Colitis Tretinoin 4.1917035595
MESH:D019465 Craniofacial Abnormalities Isotretinoin 3.1518769834 9879862
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.1510589399 9142499 17551590 8800419 16925845 9224671 9125849 9211117 14991402 9664655
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.5018551238
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 2.0418551238 21346803
MESH:D004489 Edema, Cardiac Tretinoin 5.0818230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.3216569247
MESH:D005124 Eye Abnormalities Tretinoin 3.849664655 16938888
MESH:D005355 Fibrosis Tretinoin 3.9917994277
MESH:D005909 Glioblastoma Tretinoin 3.2217312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.4116096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.7716084493
MESH:D006330 Heart Defects, Congenital Tretinoin 3.059664655 14991402
MESH:D006930 Hyperalgesia Tretinoin 3.5016870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 5.0516778211
MESH:D007410 Intestinal Diseases Tretinoin 4.2517994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.2717551590 15992940
MESH:D017492 Keratosis, Seborrheic alitretinoin 6.1816144296
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 3.2816705839
MESH:D007938 Leukemia Tretinoin 2.9217143497
MESH:D007951 Leukemia, Myeloid Tretinoin 4.0719285840 16482212 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1219850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3712679006 17339181 17301526 17294898 19029980 9834237 16935935 17712046 19225113 17107899 16140955 16331271 17506722 16891316 17368321 19642359 17217047 19075265 19035177 16766008 16823087 16788101 17649720 17361223 15748426
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.559224671
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 1.8118397230 16248980
MESH:D008175 Lung Neoplasms alitretinoin 3.2816413115
MESH:D008175 Lung Neoplasms Isotretinoin 3.2815899809
MESH:D008527 Medulloblastoma Tretinoin 2.9017453147
MESH:D008545 Melanoma Isotretinoin 3.8817237267
MESH:D008545 Melanoma Tretinoin 3.8816752155
MESH:D008591 Meningomyelocele Tretinoin 4.9116940565
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.2617596541
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.4018551238
MESH:D009369 Neoplasms alitretinoin 5.9016946489
MESH:D009369 Neoplasms Tretinoin 5.9016594593 16946489
MESH:D009421 Nervous System Malformations Tretinoin 4.229125849
MESH:D009436 Neural Tube Defects Tretinoin 3.279142499
MESH:D009447 Neuroblastoma Isotretinoin 4.2017368321
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.7816049721 12819281
MESH:D010051 Ovarian Neoplasms Tretinoin 2.4316936753
MESH:D010146 Pain Tretinoin 3.2016870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5615976015
MESH:D017499 Porokeratosis alitretinoin 6.6216144296
MESH:D011297 Prenatal Exposure Delayed Effects Isotretinoin 5.4218769834
MESH:D011507 Proteinuria Tretinoin 4.0116636307
MESH:D011596 Psychomotor Disorders Isotretinoin 6.4618769834
MESH:D011625 Pterygium Tretinoin 5.3316723453
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.5016116481 16283617
MESH:D012640 Seizures 2,4-dinitrotoluene 2.7618551238
MESH:D012878 Skin Neoplasms Tretinoin 2.7516467112
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013964 Thyroid Neoplasms Tretinoin 3.2916026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 4.1416051514
MESH:D014376 Tuberculosis Tretinoin 3.4316040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 2.3916049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.8610091137
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 4.0216129372
MESH:D014604 Uveal Neoplasms Tretinoin 5.2216752155
MESH:D014820 Vitiligo Tretinoin 4.5016761959
MESH:D009396 Wilms Tumor Tretinoin 4.2916287080
Pathway ID Pathway Name
KEGG:05146 Amoebiasis
KEGG:04512 ECM-receptor interaction
KEGG:04510 Focal adhesion
REACT:13552 Integrin cell surface interactions
KEGG:05200 Pathways in cancer
KEGG:05222 Small cell lung cancer
KEGG:05145 Toxoplasmosis
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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