AutismKB 2.0

Annotation Detail for CRISP3


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:CRISP3 ( Aeg2,CRISP-3,CRS3,MGC126588,SGP28,dJ442L6.3 )
Gene Full Name: cysteine-rich secretory protein 3
Band: 6p12.3
Quick LinksEntrez ID:10321; OMIM: NA; Uniprot ID:CRIS3_HUMAN; ENSEMBL ID: ENSG00000096006; HGNC ID: 16904
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1831Prostate cancer
1932Pancreatitis
2206Sicca syndrome
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of CRISP3 mRNAaffects cotreatment|increases expression 19619570
D004958 Estradiol Estradiol results in increased expression of CRISP3 mRNAincreases expression 19619570
C116926 rofecoxib rofecoxib results in increased expression of CRISP3 mRNAincreases expression 17070997
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of CRISP3 mRNAaffects cotreatment|increases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CRISP3 mRNAincreases expression 19619570
D014302 Trinitrobenzenesulfonic Acid Trinitrobenzenesulfonic Acid results in increased expression of CRISP3 mRNAincreases expression 17982090
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.4714514962 11752688 15322242
MESH:D000230 Adenocarcinoma Estradiol 2.1711473722
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 4.0116835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.3411748828
MESH:D001169 Arthritis, Experimental rofecoxib 4.5716690336
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.4712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.5115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 3.0015746008
MESH:D001943 Breast Neoplasms Estradiol 1.9017289903 16675129 14630087 12948864 17261762 19861407 17018787 18497071
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9020435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 5.0916111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.1216835633
MESH:D006528 Carcinoma, Hepatocellular Estradiol 1.7916924424
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5618670907 16120746 18850075
MESH:D002471 Cell Transformation, Neoplastic Estradiol 3.0318566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.5316835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2416354765 15340226 12621046 8697196 15668235
MESH:D003092 Colitis Trinitrobenzenesulfonic Acid 5.1011698051 17991707 17936198 16867261 18200517 18023891 16804969 16782535 16474422
MESH:D003093 Colitis, Ulcerative Trinitrobenzenesulfonic Acid 3.5417276891
MESH:D003110 Colonic Neoplasms rofecoxib 3.3512902858
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.4314669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2710048152 15322242 20055451
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7417107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.7819279558
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.6220420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.0511462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.8011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.6218230668 15322242 16714409
MESH:D016889 Endometrial Neoplasms Estradiol 3.2218566989 19148513 11473722
MESH:D004715 Endometriosis rofecoxib 10.6715652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 10.679294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.3111564622
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 4.0211858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 10.8620067830
MESH:D005355 Fibrosis Trinitrobenzenesulfonic Acid 10.8617994277
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.3210696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.5111294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.7611000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.4515340226 16120746 12621046
MESH:D006558 Herpes Genitalis Estradiol 5.7615709030
MESH:D019584 Hot Flashes Estradiol 4.4717088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.778697196 16959395 15340226 18606429 16354765
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0218670907 18850075
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 2.0312878042 12200463
MESH:D015212 Inflammatory Bowel Diseases Trinitrobenzenesulfonic Acid 3.7018200517
MESH:D007333 Insulin Resistance Estradiol 3.2116627594 16393666
MESH:D007410 Intestinal Diseases rofecoxib 12.3915831440
MESH:D007410 Intestinal Diseases Trinitrobenzenesulfonic Acid 12.3917994277
MESH:D007417 Intestinal Polyps rofecoxib 5.8311245490
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.7616580747
MESH:D007674 Kidney Diseases Estradiol 2.7815618244
MESH:D007680 Kidney Neoplasms Estradiol 3.3215610895
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.8014659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental rofecoxib 3.8017565644
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.8012878042
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.8316984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.3312151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2419555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.7911807958 16891317 17203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 5.2119453300
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.3412213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.5916810080
MESH:D009389 Neovascularization, Pathologic Estradiol 4.3617289903
MESH:D009421 Nervous System Malformations Estradiol 11.2016427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 11.2014600291
MESH:D010003 Osteoarthritis rofecoxib 4.5916690336
MESH:D010051 Ovarian Neoplasms Estradiol 2.3119401270
MESH:D010149 Pain, Postoperative rofecoxib 6.1118165598 16678543
MESH:D010195 Pancreatitis Trinitrobenzenesulfonic Acid 4.6617698068
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.9712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.0718163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.8211222880 11118676 11896295 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.3120887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.0216740699
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.3518990726
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.2016192470
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.6212697716
MESH:D013978 Tibial Fractures Estradiol 5.4119048282
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.3212125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.9715886252
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved