AutismKB 2.0

Annotation Detail for ABCA7


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Basic Information Top
Gene Symbol:ABCA7 ( ABCA-SSN,ABCX,FLJ40025 )
Gene Full Name: ATP-binding cassette, sub-family A (ABC1), member 7
Band: 19p13.3
Quick LinksEntrez ID:10347; OMIM: 605414; Uniprot ID:ABCA7_HUMAN; ENSEMBL ID: ENSG00000064687; HGNC ID: 37
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa02010ABC transporters
Pathway IDPathway Name
Transmembrane transport of small molecules
No data
No data
Pathway IDPathway Name
500331ABC-family proteins mediated transport
Related Diseases/Disorders Top
No data
No data
Desease Name
rheumatoid arthritis
Sjogren's syndrome
IMMUNE
lupus erythematosus
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of ABCA7 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of ABCA7 mRNAaffects expression 17562736
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of ABCA7 mRNAaffects expression 17555576
C006253 pirinixic acid pirinixic acid results in decreased expression of ABCA7 mRNAdecreases expression 17426115
D012643 Selenium Selenium results in increased expression of ABCA7 mRNAincreases expression 19244175
C004648 testosterone enanthate testosterone enanthate affects the expression of ABCA7 mRNAaffects expression 17440010
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.4617505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.4718653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8714692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.9416434500
MESH:D000544 Alzheimer Disease marker/mechanism 21460840
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8415885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.4719483382
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 2.9316705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.933084413
MESH:D002386 Cataract Acetaminophen 2.7510977129
MESH:D002779 Cholestasis Ethinyl Estradiol 8.5217681005 15861022 16105132 17110522 11677210 17333356 16919318
MESH:D002779 Cholestasis pirinixic acid 8.5219176532
MESH:D003092 Colitis Selenium 4.2017936198
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.4318551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5518249437
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.6518551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.6516109766 16781746 19085960 14725611 19416960 12705907 18071297 14550746 17522070 11287661 10774834 11529661 12958197 12540782 16081117 19739265 17562736 10915739 16177239 17906064 16227642 2444490 11461765 11739529 16485898 12153990 11421492 19420014 14986274 18713872 15968718 19164858 16393943 12594235 19370779 15619225 11834606 10663392 12392966 11743745 19923254
MESH:D056486 Drug-Induced Liver Injury Selenium 6.6515131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:D004487 Edema pirinixic acid 2.8012083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.5712538720
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.6515345470
MESH:D005234 Fatty Liver pirinixic acid 8.6520131406 19236843
MESH:D005756 Gastritis Acetaminophen 4.1916983495
MESH:D006333 Heart Failure pirinixic acid 7.5520558911
MESH:D006333 Heart Failure Selenium 7.5517162251
MESH:D006529 Hepatomegaly pirinixic acid 3.4118467677 16221962 19176532 19772884
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 6.2717440010
MESH:D006930 Hyperalgesia Acetaminophen 2.9516870215
MESH:D006943 Hyperglycemia pirinixic acid 3.4920558911
MESH:D007021 Hypospadias Ethinyl Estradiol 4.2316569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.8112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6817937319
MESH:D007251 Influenza, Human Selenium 4.7216624496
MESH:D007333 Insulin Resistance pirinixic acid 2.8216306350
MESH:D007674 Kidney Diseases Acetaminophen 2.3615629191 12587719
MESH:D007676 Kidney Failure, Chronic Selenium 4.2116518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 3.2416705839
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Acetaminophen 1.6916610002 12969438 11587558 19014921 12587719 19784758 16611625 19460945
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5416871587 17185352
MESH:D008113 Liver Neoplasms pirinixic acid 1.9120007298 16377806 15890375
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.9515318939
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D008654 Mesothelioma Selenium 2.8915107826
MESH:D009135 Muscular Diseases pirinixic acid 3.9216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2519151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1916411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.3218551238
MESH:D009369 Neoplasms pirinixic acid 2.0817405874
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1418514411
MESH:D009765 Obesity pirinixic acid 1.8720558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.7312819281 16049721
MESH:D010146 Pain Acetaminophen 2.6516870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.0411578682
MESH:D010954 Plasmacytoma Selenium 5.4115087411
MESH:D011537 Pruritus Ethinyl Estradiol 3.7715861022 16919318
MESH:D015427 Reperfusion Injury pirinixic acid 2.5219058328
MESH:D012640 Seizures 2,4-dinitrotoluene 2.7318551238
MESH:D013088 Spermatocele Ethinyl Estradiol 4.4616709447
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4415669648
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 2.3816049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.7810091137
MESH:D014581 Urticaria Acetaminophen 3.3310982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6814692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8715869587 14671159
Pathway ID Pathway Name
KEGG:02010 ABC transporters
REACT:15518 Transmembrane transport of small molecules
Pharmacogenomics Knowledge Base Top
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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