AutismKB 2.0

Annotation Detail for ABCA9


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Basic Information Top
Gene Symbol:ABCA9 ( DKFZp686F2450,EST640918,MGC75415 )
Gene Full Name: ATP-binding cassette, sub-family A (ABC1), member 9
Band: 17q24.2
Quick LinksEntrez ID:10350; OMIM: 612507; Uniprot ID:ABCA9_HUMAN; ENSEMBL ID: ENSG00000154258; HGNC ID: 39
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of ABCA9 mRNAdecreases expression 19933214
C006632 arsenic trioxide arsenic trioxide results in increased expression of ABCA9 mRNAincreases expression 20458559
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of ABCA9 mRNAdecreases expression 20713471
D008345 Manganese Manganese results in increased expression of ABCA9 mRNAincreases expression 17175027
C025340 manganese chloride manganese chloride results in increased expression of ABCA9 mRNAincreases expression 17175027
D012643 Selenium Selenium results in increased expression of ABCA9 mRNAincreases expression 18583539
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma arsenic trioxide 4.5711798837 19825857
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.5720464547 20127859
MESH:D000236 Adenoma Benzo(a)pyrene 2.826695378
MESH:D000756 Anemia, Sideroblastic Manganese 12.1416910769
MESH:D000756 Anemia, Sideroblastic manganese chloride 12.1416910769
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4919183758
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 4.0016206674
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0020146248 17474063
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.6811589617
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 1.9716217749 15073043 15553829 14691202 11135700
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.4019014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.4212490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1220419170
MESH:D003092 Colitis Selenium 4.2017936198
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.5712609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8910525206
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.4515213294
MESH:D056486 Drug-Induced Liver Injury Selenium 2.2415131321
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.6512903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.6516530937
MESH:D005234 Fatty Liver arsenic trioxide 3.6115073043
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.6416904648
MESH:D005909 Glioblastoma Manganese 4.1117043766
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.8020471113
MESH:D006333 Heart Failure Selenium 3.2517162251
MESH:D007251 Influenza, Human Selenium 4.7216624496
MESH:D007676 Kidney Failure, Chronic Selenium 4.2116518626
MESH:D007938 Leukemia arsenic trioxide 2.9615070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.1217077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.7716972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.6614633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.0919077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1820471514 16467208 17050201 16968895 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.4117107899 16331271 17712046 12679006 16112521 15748426 11468182 15336539 16330433 12018890 12712474 17217047 9834237 15622746 11161223 17869043 16966277 16823087 16891316 19642359 15213294 19075265 19225113 17649720 19035177
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.7316882451
MESH:D008113 Liver Neoplasms arsenic trioxide 4.8914682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.8920195826 21137059
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 2.9120377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5915213294
MESH:D008175 Lung Neoplasms arsenic trioxide 2.4911798837 19825857
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.4920464547 18816296 18520028 20869020 6695378 18569708 20135361 20064080 17053015
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.9515318939
MESH:D020149 Manganese Poisoning Manganese 6.0419453300 16551646 16568477
MESH:D008654 Mesothelioma Selenium 2.8915107826
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4316381670
MESH:D009069 Movement Disorders Manganese 5.3616551646
MESH:D009101 Multiple Myeloma arsenic trioxide 3.3211468182 19549372 15949261 14977855 19417148
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.1918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.3016105982 16882451
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.3416624393
MESH:D009369 Neoplasms Benzo(a)pyrene 2.3011141357
MESH:D009410 Nerve Degeneration Manganese 4.5116551646
MESH:D009436 Neural Tube Defects arsenic trioxide 3.3110525206
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4816624393 19769630 12452020
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.6115580305
MESH:D010235 Paraganglioma arsenic trioxide 4.5119927285
MESH:D010300 Parkinson Disease Manganese 3.4611181820
MESH:D020734 Parkinsonian Disorders Manganese 4.7716140633
MESH:D010954 Plasmacytoma Selenium 5.4115087411
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.1119131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1117292933
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.3416646077
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4919755658 10029692
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.4317007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.432093021 20155912
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.3219014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.4215213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.3920435036 11780464 12973940 12845720
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.3917053015
Pathway ID Pathway Name
KEGG:02010 ABC transporters
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24384
    • Releated gene ID Related gene Name
    PA24384ABCA9
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    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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