AutismKB 2.0

Annotation Detail for NPM2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:NPM2 ( MGC78655 )
Gene Full Name: nucleophosmin/nucleoplasmin 2
Band: 8p21.3
Quick LinksEntrez ID:10361; OMIM: 608073; Uniprot ID:NPM2_HUMAN; ENSEMBL ID: ENSG00000158806; HGNC ID: 7930
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C014347 decitabine decitabine results in decreased methylation of NPM2 promoterdecreases methylation 18055864
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of NPM2 mRNAincreases expression 20106945
D013752 Tetracycline Tetracycline results in increased expression of NPM2 mRNAincreases expression 16917069
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.5911752688 14514962 15322242
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 4.1216835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.3911748828
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.5312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.6615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 3.0215746008
MESH:D001943 Breast Neoplasms decitabine 2.0619208741 18320071
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0620435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.1616835633
MESH:D002294 Carcinoma, Squamous Cell decitabine 2.6919215824
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5818670907 18850075 16120746
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.5816835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2516354765 8697196 15668235 15340226 12621046
MESH:D003110 Colonic Neoplasms decitabine 2.3917616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1118981723
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.4817141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2715322242 10048152 20055451
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7417107852
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 4.3820420201
MESH:D056486 Drug-Induced Liver Injury Tetracycline 4.3817522070
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.0911462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.8512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.7716714409 15322242 18230668
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.9819294695
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.4710568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.3411564622
MESH:D005234 Fatty Liver Tetracycline 4.5316917069 19224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 4.1111858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.6020067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.4610696789
MESH:D006258 Head and Neck Neoplasms decitabine 3.7719215824
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.5310048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.8211000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.5412621046 16120746 15340226
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.9118606429 8697196 16959395 15340226 16354765
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0318850075 18670907
MESH:D007248 Infertility, Male decitabine 3.4817581917
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 2.0412200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.8216580747
MESH:D007938 Leukemia decitabine 3.2518980019 19235587
MESH:D007951 Leukemia, Myeloid decitabine 4.4919117987 18454857 17236224
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.4318206229 18460780 18704418 19010910 17679729 19387464
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 6.3318055864
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2512878042
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.8416984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.3512151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2419555203 11884234
MESH:D008223 Lymphoma decitabine 3.7319470736
MESH:D008545 Melanoma decitabine 2.2916505122 17785578
MESH:D009101 Multiple Myeloma decitabine 3.6518172295
MESH:D009190 Myelodysplastic Syndromes decitabine 3.6019157545 16882708 19010910 18608210
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.3812213967
MESH:D009369 Neoplasms decitabine 2.8919116145 19470736 17925555
MESH:D009395 Nephritis, Interstitial Tetracycline 5.659884423
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.8014600291
MESH:D010051 Ovarian Neoplasms decitabine 2.7519259094 19331143
MESH:D010190 Pancreatic Neoplasms decitabine 2.8919294695
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 5.1212520081
MESH:D010391 Pemphigoid, Bullous Tetracycline 6.3011026799
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.1418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.9311222880 11896295 11118676 11399792
MESH:D055728 Primary Myelofibrosis decitabine 5.3817616702
MESH:D017096 Prion Diseases Tetracycline 6.1610903871
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.4218990726
MESH:D012208 Rhabdomyosarcoma decitabine 4.9319155313
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.2116192470
MESH:D013274 Stomach Neoplasms decitabine 2.1019037991
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.7712697716
MESH:D013964 Thyroid Neoplasms decitabine 3.6717967635
MESH:D001749 Urinary Bladder Neoplasms decitabine 2.8519087683 17616700
MESH:D014604 Uveal Neoplasms decitabine 5.7817785578
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.4612125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 5.1215886252
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved