AutismKB 2.0

Annotation Detail for HMG20B


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Basic Information Top
Gene Symbol:HMG20B ( BRAF25,BRAF35,FLJ26127,HMGX2,HMGXB2,PP7706,SMARCE1r,SOXL,pp8857 )
Gene Full Name: high-mobility group 20B
Band: 19p13.3
Quick LinksEntrez ID:10362; OMIM: 605535; Uniprot ID:HM20B_HUMAN; ENSEMBL ID: ENSG00000064961; HGNC ID: 5002
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1848Embryoma
1860Brain tumor
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of HMG20B mRNAaffects expression 17562736
D005047 Etoposide HMG20B protein affects the susceptibility to Etoposideaffects response to substance 16217747
D005472 Fluorouracil Fluorouracil results in decreased expression of HMG20B mRNAdecreases expression 16709241
D016685 Mitomycin HMG20B protein affects the susceptibility to Mitomycinaffects response to substance 16217747
D008942 Mitoxantrone HMG20B protein affects the susceptibility to Mitoxantroneaffects response to substance 16217747
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of HMG20B mRNAincreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3115322242 14514962 11752688
MESH:D000230 Adenocarcinoma Fluorouracil 2.4817638652
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.8416835633
MESH:D000740 Anemia Fluorouracil 9.7115504547 16511603 17963324
MESH:D000740 Anemia Tetrachlorodibenzodioxin 9.7111748828
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.3115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9515746008
MESH:D019046 Bone Marrow Neoplasms Etoposide 5.6814601052
MESH:D001943 Breast Neoplasms Etoposide 1.9716322251
MESH:D001943 Breast Neoplasms Fluorouracil 1.9719217205 16110121 15136595 16557594 18608205 18357371 16595493
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9720435547
MESH:D002276 Carcinoid Tumor Fluorouracil 5.1916051944
MESH:D002277 Carcinoma Fluorouracil 9.0417121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 9.0416835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.063084413
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 3.0616332177 17088986 17045692 16799960 18930000 17971768
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.1418695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 2.5618986760 16757204 17066447 16280240
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5218850075 18670907 16120746
MESH:D002386 Cataract Acetaminophen 2.7510977129
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4516835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2116354765 8697196 15668235 15340226 12621046
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2717016597 15001691 17287894 16510598 17172411 17725105 18772588 17169374 17018589 16340194
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0017094418 20501625 16391804 17401013 15289873 18802399 14970324 16282729 18448328 18383874 17016601 16331619 17255274 15148649 18288408 18509181 17594712 17454858 18949393 16524972 16303861 17695437
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3414669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D007644 Darier Disease Fluorouracil 5.2516733453
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.8116177239 18713872 11421492 10774834 11287661 11739529 14725611 17562736 16781746 11743745 16109766 19923254 12705907 16393943 12958197 12392966 19085960 19164858 11834606 15619225 16227642 12153990 16081117 19370779 17906064 12594235 10915739 14550746 14986274 10663392 19416960 12540782 19739265 11529661 11461765 16485898 18071297 2444490 17522070 19420014 15968718
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.8120420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9911462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.4216714409 15322242 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.339294722 10568697
MESH:D004938 Esophageal Neoplasms Fluorouracil 2.5117638652 15173087 16481741 16337965 16785472
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2411564622
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8711858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3620067830
MESH:D005756 Gastritis Acetaminophen 4.1916983495
MESH:D005910 Glioma Fluorouracil 2.9716145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.1210696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.5915102660 15162350 18337622
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4710048152 11294989
MESH:D006331 Heart Diseases Mitoxantrone 4.3616019553
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6611000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.3115340226 12621046 16120746
MESH:D006561 Herpes Simplex Etoposide 5.0210809021
MESH:D006689 Hodgkin Disease Etoposide 4.1516135485 18180244 15147373 16200630 17606976
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.5718606429 8697196 16959395 15340226 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.9516870215
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0018670907 18850075
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9912878042 12200463
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6616580747
MESH:D007674 Kidney Diseases Acetaminophen 2.3615629191 12587719
MESH:D007680 Kidney Neoplasms Fluorouracil 3.5716985049
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Mitoxantrone 3.9018172266
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2512878042
MESH:D008107 Liver Diseases Acetaminophen 1.6919784758 11587558 19460945 16610002 12969438 12587719 19014921 16611625
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5417185352 16871587
MESH:D008113 Liver Neoplasms Fluorouracil 8.1518383874 17045692 15113037 16603448
MESH:D008113 Liver Neoplasms Mitomycin 8.1515113037
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 8.1516984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2812151625
MESH:D008175 Lung Neoplasms Fluorouracil 2.4215246190
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.4211884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.2515086387
MESH:D008223 Lymphoma Etoposide 4.1412556972 12854902
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D009062 Mouth Neoplasms Fluorouracil 3.8716757204 18986760
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2712213967
MESH:D009369 Neoplasms Fluorouracil 5.9818600527 18239605 16928823
MESH:D009369 Neoplasms Mitoxantrone 5.9816640825
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5914600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1418514411
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.6416436463
MESH:D010146 Pain Acetaminophen 2.6516870215
MESH:D010190 Pancreatic Neoplasms Etoposide 9.4319003803
MESH:D010190 Pancreatic Neoplasms Fluorouracil 9.4316929163 15113037 16500647 19003803
MESH:D010190 Pancreatic Neoplasms Mitomycin 9.4315113037
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.7712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.9418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.6511896295 11118676 11222880 11399792
MESH:D011471 Prostatic Neoplasms Etoposide 3.5417172428
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.5418626508 19082440
MESH:D012004 Rectal Neoplasms Fluorouracil 4.3015538739 18286688 16160472 18722050
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2218990726
MESH:D012512 Sarcoma, Ewing's Etoposide 5.0914601052
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1716192470
MESH:D013274 Stomach Neoplasms Fluorouracil 2.0018396642 16951190 17522103 19015929 16424979 18567086 19084572 17498489 15786421 17172411
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.4212697716
MESH:D014062 Tongue Neoplasms Fluorouracil 4.2916280240
MESH:D014581 Urticaria Acetaminophen 3.3310982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.1816803524
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.1212125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.7715886252
Pathway ID Pathway Name
REACT:604 Hemostasis
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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