AutismKB 2.0

Annotation Detail for TUBA1B


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Basic Information Top
Gene Symbol:TUBA1B ( K-ALPHA-1 )
Gene Full Name: tubulin, alpha 1b
Band: 12q13.12
Quick LinksEntrez ID:10376; OMIM: 602530; Uniprot ID:TBA1B_HUMAN; ENSEMBL ID: ENSG00000123416; HGNC ID: 18809
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04145Phagosome
hsa04540Gap junction
hsa05130Pathogenic Escherichia coli infection
Pathway IDPathway Name
Metabolism of proteins
Pathway IDPathway Name
200006Signaling events mediated by PRL
200019Signaling events mediated by HDAC Class II
200020Signaling events mediated by HDAC Class III
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1762Lewy body disease
1894Abortion
1944Breast cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C015802 2,6-dichloro-4-nitrophenol 2,6-dichloro-4-nitrophenol results in increased expression of TUBA1B mRNAincreases expression 11227219
D000643 Ammonium Chloride Ammonium Chloride affects the expression of TUBA1B mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in increased expression of TUBA1B mRNAincreases expression 20458559
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of TUBA1B mRNAdecreases expression 12419474
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of TUBA1B proteindecreases expression 15050405
C099555 CD 437 CD 437 results in decreased expression of TUBA1B mRNAdecreases expression 12958071
D004391 Dust Dust results in decreased expression of TUBA1B mRNAdecreases expression 17805423
C473896 HTI-286 TUBA1B protein mutant form results in decreased susceptibility to HTI-286decreases response to substance 15486199
D006861 Hydrogen Peroxide Hydrogen Peroxide results in decreased expression of TUBA1B mRNAdecreases expression 12419474
D012643 Selenium Selenium results in increased expression of TUBA1B mRNAincreases expression 19244175
C009250 sevoflurane sevoflurane affects the expression of TUBA1B mRNAaffects expression 15967596
D014810 Vitamin E Vitamin E results in increased expression of TUBA1B mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.7518287403
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3111798837 19825857
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 3.8116206674
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.4811589617
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.1116050911
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 1.9615553829 14691202 16217749 11135700 15073043
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.0919014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.2512490120
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 3.6116936243
MESH:D003092 Colitis Selenium 3.9517936198
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.3512609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.7510525206
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.7519769572
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.2415213294
MESH:D056486 Drug-Induced Liver Injury Selenium 2.2115131321
MESH:C538011 Eales disease Vitamin E 4.929068938
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3412903497
MESH:D005234 Fatty Liver arsenic trioxide 3.4315073043
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.4216904648
MESH:D006330 Heart Defects, Congenital Vitamin E 3.0516080930
MESH:D006333 Heart Failure Selenium 3.1517162251
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7416863852 16490937
MESH:D019584 Hot Flashes Vitamin E 4.1914716179
MESH:D007251 Influenza, Human Selenium 11.7016624496
MESH:D007251 Influenza, Human Vitamin E 11.7016624496
MESH:D007674 Kidney Diseases Vitamin E 2.8812488133
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 10.5016518626
MESH:D007676 Kidney Failure, Chronic Selenium 10.5016518626
MESH:D007859 Learning Disorders sevoflurane 4.9519212262
MESH:D007938 Leukemia arsenic trioxide 2.8915070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.9312560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.5016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5314633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.9019077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1617050201 19850784 20471514 16968895 16467208
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3017869043 11468182 15213294 17217047 19075265 16112521 11161223 16330433 19225113 19035177 16891316 16331271 16966277 17712046 12679006 12018890 15622746 15748426 9834237 17649720 17107899 19642359 15336539 12712474 16823087
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5116882451
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 1.9016169303
MESH:D008113 Liver Neoplasms arsenic trioxide 2.3914682389
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 2.8120377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4615213294
MESH:D008171 Lung Diseases Vitamin E 3.2716863852
MESH:D008175 Lung Neoplasms arsenic trioxide 2.5711798837 19825857
MESH:D008175 Lung Neoplasms Vitamin E 2.5711062179
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.8515318939
MESH:D008569 Memory Disorders sevoflurane 4.9119212262
MESH:D008654 Mesothelioma Selenium 2.8415107826
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2015949261 19417148 14977855 19549372 11468182
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.8918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2216882451 16105982
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.1216624393
MESH:D009436 Neural Tube Defects arsenic trioxide 3.2010525206
MESH:D010051 Ovarian Neoplasms arsenic trioxide 5.3616624393 19769630 12452020
MESH:D010051 Ovarian Neoplasms CD 437 5.3617474084
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.5715580305
MESH:D010212 Papilloma Hydrogen Peroxide 4.2612065085
MESH:D010235 Paraganglioma arsenic trioxide 4.3119927285
MESH:D010954 Plasmacytoma Selenium 5.1115087411
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2719131511
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2715084515
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.1216646077
MESH:D012871 Skin Diseases Vitamin E 2.4718709164
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 6.1712065085
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 6.178532709
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D020521 Stroke Vitamin E 3.6316517955
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.1919014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.1515213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.6511780464 20435036 12973940 12845720
MESH:D001749 Urinary Bladder Neoplasms CD 437 5.6516720286
Pathway ID Pathway Name
REACT:18266 Axon guidance
REACT:152 Cell Cycle, Mitotic
REACT:17056 Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
REACT:383 DNA Replication
KEGG:04540 Gap junction
REACT:604 Hemostasis
REACT:11123 Membrane Trafficking
REACT:17015 Metabolism of proteins
KEGG:05130 Pathogenic Escherichia coli infection
KEGG:04145 Phagosome
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB01873 - Epothilone D Cytochrome P450Epok inhibitor
DB03010 - Epothilone B Antineoplastic Agents;Tubulin Modulators
DB07574 - 2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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