AutismKB 2.0

Annotation Detail for IRF9


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Basic Information Top
Gene Symbol:IRF9 ( IRF-9,ISGF3,ISGF3G,p48 )
Gene Full Name: interferon regulatory factor 9
Band: 14q12
Quick LinksEntrez ID:10379; OMIM: 147574; Uniprot ID:IRF9_HUMAN; ENSEMBL ID: ENSG00000213928; HGNC ID: 6131
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05160Hepatitis C
hsa04630Jak-STAT signaling pathway
No data
Pathway IDPathway Name
200110IFN-gamma pathway
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of IRF9 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of IRF9 mRNAincreases expression 18648102
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of IRF9 mRNAaffects expression 21346803
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of IRF9 mRNAincreases expression 20106945
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of IRF9 mRNAincreases expression 15003993
14729362
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of IRF9 mRNAaffects expression 17484886
D016572 Cyclosporine Cyclosporine results in increased expression of IRF9 mRNAincreases expression 20106945
D004610 Ellagic Acid Ellagic Acid results in increased expression of IRF9 mRNAincreases expression 12002526
D004958 Estradiol Estradiol affects the expression of IRF9 mRNAaffects expression 15598610
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of IRF9 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of IRF9 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of IRF9 mRNAaffects cotreatment|increases expression 17942748
D005472 Fluorouracil Fluorouracil results in increased expression of IRF9 mRNAincreases expression 16101138
17039268
D010126 Ozone Ozone results in decreased expression of IRF9 mRNAdecreases expression 16183385
C059514 resveratrol resveratrol results in increased expression of IRF9 mRNAincreases expression 12002526
D012402 Rotenone Rotenone results in decreased expression of IRF9 mRNAdecreases expression 19013527
C010327 salinomycin salinomycin results in decreased expression of IRF9 mRNAdecreases expression 19682730
D012643 Selenium [Selenium co-treated with Vitamin E] results in decreased expression of IRF9 mRNAaffects cotreatment|decreases expression 19244175
D012643 Selenium Selenium results in increased expression of IRF9 mRNAincreases expression 19244175
D013629 Tamoxifen Tamoxifen affects the expression of IRF9 mRNAaffects expression 17555576
C004648 testosterone enanthate testosterone enanthate affects the expression of IRF9 mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of IRF9 mRNAincreases expression 20106945
16704738
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of IRF9 mRNAaffects cotreatment|increases expression 17942748
D014212 Tretinoin Tretinoin results in increased expression of IRF9 mRNAincreases expression 18230668
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in decreased expression of IRF9 mRNAaffects cotreatment|decreases expression 19244175
D014810 Vitamin E Vitamin E results in increased expression of IRF9 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.4414745880
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 8.127525203
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.1214514962 15322242 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.8417505938
MESH:D058186 Acute Kidney Injury resveratrol 3.7516538975
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 9.9320464547 20127859
MESH:D000230 Adenocarcinoma Estradiol 9.9311473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 9.9314692618
MESH:D000230 Adenocarcinoma Fluorouracil 9.9317638652
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 10.823712494
MESH:D000236 Adenoma Benzo(a)pyrene 10.826695378
MESH:D000236 Adenoma resveratrol 10.8215688382
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.2716835633
MESH:D000505 Alopecia Tretinoin 3.5315955085
MESH:D000544 Alzheimer Disease Ozone 4.3015513908
MESH:D000544 Alzheimer Disease resveratrol 4.3016162502 16183991
MESH:D000740 Anemia Fluorouracil 8.3517963324 16511603 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.3511748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9619183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.3611256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 11.8815885639
MESH:D001169 Arthritis, Experimental resveratrol 11.8817115116
MESH:D001169 Arthritis, Experimental Tretinoin 11.8816412693
MESH:D001172 Arthritis, Rheumatoid Ozone 4.5815570426
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.5816292516
MESH:D001249 Asthma Ozone 4.8417854713 16373670
MESH:D001249 Asthma Tretinoin 4.8416456186
MESH:D050197 Atherosclerosis resveratrol 3.2117967414 16873680
MESH:D001471 Barrett Esophagus Tretinoin 4.2916935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.9111289319 1440618
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.6012125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 8.6016206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6915746008
MESH:D002545 Brain Ischemia resveratrol 4.1717600658
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 4.6520146248 17474063
MESH:D001943 Breast Neoplasms Estradiol 4.6517289903 19861407 12948864 18497071 16675129 14630087 17018787 17261762
MESH:D001943 Breast Neoplasms Fluorouracil 4.6518608205 18357371 16557594 16595493 15136595 16110121 19217205
MESH:D001943 Breast Neoplasms resveratrol 4.6516393696 17651959 17534123
MESH:D001943 Breast Neoplasms salinomycin 4.6519682730
MESH:D001943 Breast Neoplasms Tamoxifen 4.6519189212 20390343 19221464 18997820 17893378 17261762 18815881 20859285 18351453 18425577 19115204 20065188 17049068 19103187 19011961 19066611 15565566 21152245 15668708 16818667 11161223 17440819 20544844 18984771 19084267 20005174 20135344 19059307 19189210 19200415 19155303 19244106 18629630 21138602 19142967 19288272 18855134 19410462 16202921 16873071 16273361 19289846 17242785 18821012 19487384
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.6520435547
MESH:D001943 Breast Neoplasms Tretinoin 4.6516166294 16443354 16873071
MESH:D016535 Bronchial Hyperreactivity Ozone 3.5919059883 15516495 17626835 18417511 14754758 18315731 16777450
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.4816813970
MESH:D002100 Cachexia Ozone 4.6316183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.3516111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 9.5716050911 16227642 18705752 15673190 16192424 15721981 3786805 15700767 16011737 16097048 16124888 10355542
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 9.5716050911
MESH:D002276 Carcinoid Tumor Fluorouracil 4.5616051944
MESH:D002277 Carcinoma Fluorouracil 7.8917121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.8916835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.4019066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.0516168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 16.6416705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 16.643581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 16.6418788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 16.6416924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 16.6417088986 17045692 16799960 16332177 17971768 18930000
MESH:D006528 Carcinoma, Hepatocellular resveratrol 16.6419321006 16227395
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 16.6416924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 16.641917145
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.4816675471
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 6.337296757
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 6.3318695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 10.5520419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 10.5516757204 17066447 16280240 18986760
MESH:D002294 Carcinoma, Squamous Cell resveratrol 10.5516227395
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 10.5516096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.5217572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3118850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases resveratrol 3.4015458977
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 7.4014694615
MESH:D002386 Cataract Tretinoin 7.4017460283
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 10.707505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 10.7012371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 10.7018566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.4816129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0716835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 12.919022650 19486331
MESH:D002779 Cholestasis Cyclosporine 12.9119486331
MESH:D002779 Cholestasis Ethinyl Estradiol 12.9116105132 17333356 17681005 15861022 16919318 17110522 11677210
MESH:D002822 Choriocarcinoma Tretinoin 5.0516461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.6115668235 8697196 16354765 15340226 12621046
MESH:D002972 Cleft Palate Tretinoin 5.619407595
MESH:D003092 Colitis resveratrol 15.4116474422
MESH:D003092 Colitis Selenium 15.4117936198
MESH:D003092 Colitis Tretinoin 15.4117035595
MESH:D003110 Colonic Neoplasms Fluorouracil 3.8515001691 16510598 17725105 17287894 17016597 18772588 17172411 16340194 17018589 17169374
MESH:D003110 Colonic Neoplasms resveratrol 3.8516338953
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.6517594712 16282729 14970324 17454858 17016601 17401013 15289873 17094418 16391804 18383874 18448328 18509181 18288408 16303861 18949393 16524972 17255274 15148649 16331619 18802399 20501625 17695437
MESH:D015179 Colorectal Neoplasms resveratrol 2.6516550006
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 8.8715095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 8.8714669216 17141729
MESH:D003327 Coronary Disease resveratrol 3.6816507316
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.7015322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.7014991402 17551590 9664655 16925845 9224671 10589399 9125849 8800419 9142499 9211117
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.7019769572
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.9118551238
MESH:D007644 Darier Disease Fluorouracil 4.6816733453
MESH:D003711 Demyelinating Diseases Tamoxifen 4.2519031437
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.7018759878 11906362 12868966 14531868 8156756 2524372 11298694 8970840
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.392952479 3621924
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.6816873680
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6417107852
MESH:D003928 Diabetic Nephropathies Estradiol 14.4819279558
MESH:D003928 Diabetic Nephropathies resveratrol 14.4816286809
MESH:D003928 Diabetic Nephropathies Tamoxifen 14.4819279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 14.8421346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 14.8418692083 9328219 18289764 1440618 18648102 9022650 8291058 7440962 6679447 9653073 6482804 11289319 16192314
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 14.8421346803
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 14.8421278145 4309450 2869522 10915739 6884620 19085960 3732212 17522070 11566570 15968718 19336974 16177239 7179309 7440962 6623471 16227642 7120509 9327722 3786805 15998439 15027814 10092053
MESH:D056486 Drug-Induced Liver Injury Selenium 14.8415131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 14.8420420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6811462148
MESH:C538011 Eales disease Vitamin E 4.609068938
MESH:D004487 Edema resveratrol 6.538985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.5312711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.5915322242 18230668 16714409
MESH:D004489 Edema, Cardiac Tretinoin 11.5918230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 14.7312538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 14.7317872969
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 14.7319031437
MESH:D016889 Endometrial Neoplasms Estradiol 12.0119148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Tamoxifen 12.0119155303 20544844 16202921 17893378
MESH:D016889 Endometrial Neoplasms Tretinoin 12.0116569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.9210568697 9294722
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.7417923197
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.073581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.0716530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 7.0715173087 16481741 16337965 16785472 17638652
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.5611564622
MESH:D005124 Eye Abnormalities Tretinoin 8.5616938888 9664655
MESH:D005234 Fatty Liver Carbon Tetrachloride 17.9261145 12631006 16239168 15959796 19224547 12795759 16045604 17595544
MESH:D005234 Fatty Liver Cyclosporine 17.9219224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 17.9215345470
MESH:D005234 Fatty Liver Tamoxifen 17.9214986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1716709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3511858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.916705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.4214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.0719069698
MESH:D005355 Fibrosis Carbon Tetrachloride 20.2418705752
MESH:D005355 Fibrosis Cyclosporine 20.2412168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 20.2420067830
MESH:D005355 Fibrosis Tretinoin 20.2417994277
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.118708960
MESH:D005909 Glioblastoma Tretinoin 2.9317312396
MESH:D005910 Glioma Fluorouracil 2.8316145905
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.937505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4910696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 7.5518337622 15162350 15102660
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.5516096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.0516084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 15.4920471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 15.4910048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 15.499664655 14991402
MESH:D006330 Heart Defects, Congenital Vitamin E 15.4916080930
MESH:D006333 Heart Failure Selenium 3.0117162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3115720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2311000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 8.876705139
MESH:D006505 Hepatitis Carbon Tetrachloride 8.8719900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.7812621046 15340226 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6616490937 16863852
MESH:D006558 Herpes Genitalis Estradiol 4.9315709030
MESH:D006561 Herpes Simplex resveratrol 4.0716876885
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.6417440010
MESH:D019584 Hot Flashes Estradiol 9.7017088409
MESH:D019584 Hot Flashes Vitamin E 9.7014716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9416354765 15340226 16959395 8697196 18606429
MESH:D006930 Hyperalgesia Tretinoin 3.1216870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.4216899240
MESH:D006937 Hypercholesterolemia resveratrol 3.9017188708
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.4616778211
MESH:D006949 Hyperlipidemias resveratrol 3.9216873680
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.8315034207
MESH:D006973 Hypertension Cyclosporine 4.8110903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.8118670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9815338365
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.2017488730
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7016569931 16945680
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.5417600658
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3612013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.4117937319
MESH:D007249 Inflammation resveratrol 8.0016366677
MESH:D007249 Inflammation Tamoxifen 8.0019457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.0012878042 12200463
MESH:D007251 Influenza, Human resveratrol 18.0216624496
MESH:D007251 Influenza, Human Selenium 18.0216624496
MESH:D007251 Influenza, Human Vitamin E 18.0216624496
MESH:D007333 Insulin Resistance Estradiol 2.8916627594 16393666
MESH:D007410 Intestinal Diseases Tretinoin 3.6617994277
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.919022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.5916580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.5915992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.3415604871
MESH:D007674 Kidney Diseases Cyclosporine 9.6918776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 9.6915618244
MESH:D007674 Kidney Diseases Vitamin E 9.6912488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.7816518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 27.9216705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 27.926582329
MESH:D007680 Kidney Neoplasms Cyclosporine 27.9212371664
MESH:D007680 Kidney Neoplasms Estradiol 27.9215610895
MESH:D007680 Kidney Neoplasms Fluorouracil 27.9216985049
MESH:D007680 Kidney Neoplasms Tamoxifen 27.9218625569
MESH:D007938 Leukemia Tretinoin 2.7217143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.6016482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0617596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 7.5316087638
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.5317339181 17712046 17107899 17301526 17649720 19029980 17361223 16766008 19035177 17217047 16823087 15748426 19642359 16331271 16891316 17368321 17294898 16140955 19075265 19225113 9834237 17506722 16935935 12679006 16788101
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.239224671
MESH:D008064 Lipidoses Tamoxifen 3.0817567588 15342952
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.7516943688 16221502 11408273 16239168 17334410 17174718 21278145 11903743 17157831
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.1315034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 8.5615362042 16136751 18187930 17805973 18339082 18210741 12586293 12649538 11481614 15370692 18418968 12632514 18429990 18376398 18420326 17761835 12741479 16015684 17900296 16248980 20821823 18251166 10355542 12898905 15996030 18006644 18395095 15925388 12958196 15052691 12609069 17557913 16033810 14716496 15650968 18472332 17640975 18472094 17944888 14512876 18156304 18395914 15057751 12389079 18705752 12445418 17721639 17708605 14724832 15730626 17525996 17481882 15893842 15931870 18481824 18412020 18279442 17922224 18166357 18277467 13678700 17714472 16027843 17869086 17631135 15338365 16192424 18054572 12632512 14620537 12445421 14748882 15876570 15818738 14716833 17698563 12667390 15673190 12546737 12666154 15123356 16638106 16097048 17823541 17766677 17565644 18205269 18317297 15959796 17976157 16116963 16011737 18263696
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 8.5614659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 8.5618564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.5612878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 8.5618397230 16248980
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 8.5616169303
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.0615830285 16964402 15720792 17285989 16246199
MESH:D017093 Liver Failure Carbon Tetrachloride 4.0515123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.5916899240 14706259
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 17.4520195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 17.4519294768
MESH:D008113 Liver Neoplasms Fluorouracil 17.4515113037 17045692 18383874 16603448
MESH:D008113 Liver Neoplasms resveratrol 17.4519812893 19073162 19321006 20405173
MESH:D008113 Liver Neoplasms Tamoxifen 17.4516684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 17.4516984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 9.38598648 3712494 1399818 6587162
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 9.3812014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.3812151625
MESH:D008171 Lung Diseases Ozone 7.2719066396 8266340
MESH:D008171 Lung Diseases Vitamin E 7.2716863852
MESH:D055370 Lung Injury Ozone 3.7420417186
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 8.3818816296 17053015 18569708 20135361 20464547 20869020 6695378 18520028 20064080
MESH:D008175 Lung Neoplasms Fluorouracil 8.3815246190
MESH:D008175 Lung Neoplasms Ozone 8.387614698 8597069
MESH:D008175 Lung Neoplasms Tamoxifen 8.3818625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.3811884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 8.3811062179
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.6815086387
MESH:D016393 Lymphoma, B-Cell resveratrol 4.1917088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.7814749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 9.6415688416
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 9.6419428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 18.0911408345 11807958 16891317 17203775
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 18.098985016 11606380
MESH:D008325 Mammary Neoplasms, Experimental salinomycin 18.0919682730
MESH:D008325 Mammary Neoplasms, Experimental Selenium 18.0915318939
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 18.0911731420 19196723 14580682 19196722 16827153
MESH:D020149 Manganese Poisoning Estradiol 12.2919453300
MESH:D020149 Manganese Poisoning Tamoxifen 12.2919453300
MESH:D008527 Medulloblastoma Tretinoin 2.7417453147
MESH:D008545 Melanoma resveratrol 5.0317992120
MESH:D008545 Melanoma Tamoxifen 5.0312393984 19393235
MESH:D008545 Melanoma Tretinoin 5.0316752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.0715990972
MESH:D008591 Meningomyelocele Tretinoin 4.3216940565
MESH:D008654 Mesothelioma Selenium 2.7515107826
MESH:D008659 Metabolic Diseases resveratrol 4.2717112576
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.6816801185
MESH:D008679 Metaplasia Ozone 5.0010496685
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.2516381670
MESH:D009062 Mouth Neoplasms Fluorouracil 8.2516757204 18986760
MESH:D009101 Multiple Myeloma resveratrol 3.3917049120 14749477 16490592 17935668 17164350 16267019
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.7617962980
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.0217596541
MESH:D009203 Myocardial Infarction resveratrol 2.9816317513 17188708 17015251 16525036 16456233 17125593
MESH:D017202 Myocardial Ischemia resveratrol 8.7217015251 17125593
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.7212213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.1916810080
MESH:D009205 Myocarditis resveratrol 4.6517322642
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.7518551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.553581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.5519393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4819410462
MESH:D009369 Neoplasms Benzo(a)pyrene 7.9711141357
MESH:D009369 Neoplasms Fluorouracil 7.9718600527 18239605 16928823
MESH:D009369 Neoplasms Tretinoin 7.9716594593 16946489
MESH:D009374 Neoplasms, Experimental resveratrol 3.898985016
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.8919189210 19200415 19196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.6217289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.3417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1919348381 18481113
MESH:D009410 Nerve Degeneration Rotenone 3.7915790535 17356569 18619942
MESH:D009421 Nervous System Malformations Estradiol 15.7116427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 15.7114600291
MESH:D009421 Nervous System Malformations Tretinoin 15.719125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 6.996679447
MESH:D009436 Neural Tube Defects Tretinoin 6.999142499
MESH:D019636 Neurodegenerative Diseases resveratrol 3.7217652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.2917929310
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.3616436463
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 14.5912819281 16049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 14.596482804 4026338
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 14.5914694615
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.913988306
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 4.1517513867
MESH:D010051 Ovarian Neoplasms Estradiol 4.6919401270
MESH:D010051 Ovarian Neoplasms Tretinoin 4.6916936753
MESH:D010146 Pain Tretinoin 2.8116870215
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.2116500647 16929163 19003803 15113037
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.2115976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5811578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.387296757
MESH:D010300 Parkinson Disease Rotenone 2.9419114014 18191903 15451049 19232380 11445065 16140633 11535288 16412576 18619942
MESH:D020734 Parkinsonian Disorders Rotenone 3.9818197244 15927086 15574749 15795934
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1412520081
MESH:D010538 Peritonitis Ozone 4.0216369182
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.366228378
MESH:D010954 Plasmacytoma Selenium 4.7815087411
MESH:D011014 Pneumonia Ozone 4.2918929643 18381685 18007984
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4518163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.1312371664
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 9.2316679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.2311399792 11222880 11118676 11896295
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.7820887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8817292933
MESH:D011471 Prostatic Neoplasms Estradiol 1.8816740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 1.8819082440 18626508
MESH:D011471 Prostatic Neoplasms resveratrol 1.8817718901 17675339 15767336 17804756 16731767 17636462
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.8815067354
MESH:D011471 Prostatic Neoplasms Vitamin E 1.8815084515
MESH:D011507 Proteinuria Tretinoin 3.5016636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.2015861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.1916882103
MESH:D011625 Pterygium Tretinoin 4.6816723453
MESH:D012004 Rectal Neoplasms Fluorouracil 3.9218722050 15538739 18286688 16160472
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.4816325855
MESH:D015427 Reperfusion Injury resveratrol 3.2216314181 15827377 16317513 17520802 17058453
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7318990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.293692021
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.9916116481 16283617
MESH:D012640 Seizures 2,4-dinitrotoluene 2.4618551238
MESH:D012871 Skin Diseases Vitamin E 2.4118709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 17.3819755658 10029692
MESH:D012878 Skin Neoplasms resveratrol 17.3815837718 8985016
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 17.388532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 17.3816192470
MESH:D012878 Skin Neoplasms Tretinoin 17.3816467112
MESH:D013088 Spermatocele Ethinyl Estradiol 11.2116709447
MESH:D013088 Spermatocele Tamoxifen 11.2116709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.9319457130
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.3020155912 2093021
MESH:D013274 Stomach Neoplasms Fluorouracil 3.3018567086 18396642 16951190 17522103 19084572 16424979 19015929 17498489 17172411 15786421
MESH:D013274 Stomach Neoplasms Tretinoin 3.3017261132
MESH:D020521 Stroke Vitamin E 3.4316517955
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.3816321402
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0615669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8012697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 6.857505956 6582329 1399818 6587162 3712494
MESH:D013964 Thyroid Neoplasms Tretinoin 6.8517045167 16026305
MESH:D013978 Tibial Fractures Estradiol 4.5819048282
MESH:D014062 Tongue Neoplasms Fluorouracil 16.0116280240
MESH:D014062 Tongue Neoplasms resveratrol 16.0116227395
MESH:D014062 Tongue Neoplasms Tretinoin 16.0116051514
MESH:D014376 Tuberculosis Tretinoin 3.1616040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 11.5516049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 11.558074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 11.5517053015
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 11.5516712894 17572228 8653321
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.2110091137
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 15.3416803524
MESH:D002583 Uterine Cervical Neoplasms resveratrol 15.3417473185
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 15.3416129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 9.1414692618
MESH:D014594 Uterine Neoplasms resveratrol 9.1417044934
MESH:D014604 Uveal Neoplasms Tretinoin 4.5016752155
MESH:D014605 Uveitis Cyclosporine 3.881336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4912125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4414671159 15869587
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.1917488730
MESH:D014820 Vitiligo Tretinoin 3.9516761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1415886252
MESH:D009396 Wilms Tumor Tretinoin 3.8716287080
MESH:D014985 Xerophthalmia Cyclosporine 4.3417120751
Pathway ID Pathway Name
KEGG:05160 Hepatitis C
KEGG:04630 Jak-STAT signaling pathway
KEGG:05162 Measles
KEGG:04380 Osteoclast differentiation
REACT:6900 Signaling in Immune system
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA162392259
    • No data
    Releated disease ID Related disease Name
    PA443624Carcinoma, Renal Cell
    Releated drug ID Related drug Name
    PA164749376interferon alfacon-1
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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