AutismKB 2.0

Annotation Detail for BPNT1


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Basic Information Top
Gene Symbol:BPNT1 ( PIP )
Gene Full Name: 3'(2'), 5'-bisphosphate nucleotidase 1
Band: 1q41
Quick LinksEntrez ID:10380; OMIM: 604053; Uniprot ID:BPNT1_HUMAN; ENSEMBL ID: ENSG00000162813; HGNC ID: 1096
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00920Sulfur metabolism
hsa01100Metabolic pathways
Pathway IDPathway Name
Biological oxidations
No data
No data
Pathway IDPathway Name
500213Cytosolic sulfonation of small molecules
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of BPNT1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of BPNT1 mRNAaffects expression 21346803
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of BPNT1 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of BPNT1 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of BPNT1 mRNAaffects expression 16483693
D016572 Cyclosporine Cyclosporine results in decreased expression of BPNT1 mRNAdecreases expression 20106945
D005492 Folic Acid Folic Acid affects the expression of BPNT1 proteinaffects expression 16251605
D006918 Hydroxyurea Hydroxyurea results in increased mutagenesis of BPNT1 geneincreases mutagenesis 16868089
D008770 Methylnitrosourea Methylnitrosourea results in increased mutagenesis of BPNT1 geneincreases mutagenesis 16868089
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of BPNT1 mRNAincreases expression 16054898
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 9.287525203
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.2811752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.8018287403
MESH:D058186 Acute Kidney Injury Folic Acid 4.5017003819 16595132 16316344
MESH:D000230 Adenocarcinoma Methylnitrosourea 3.1515113128 15688392
MESH:D000236 Adenoma Folic Acid 3.8816963246
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6116835633
MESH:D000544 Alzheimer Disease Folic Acid 3.0817116317
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1111748828
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D001321 Autistic Disorder Acetaminophen 2.1618445737
MESH:D001321 Autistic Disorder Folic Acid 2.1621388746
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8715746008
MESH:D001943 Breast Neoplasms Folic Acid 2.0816777985
MESH:D001943 Breast Neoplasms Methylnitrosourea 2.0816253758 11306469 14633655
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0820435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.6416705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.6416705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.643084413
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4518850075 16120746 18670907
MESH:D002318 Cardiovascular Diseases Folic Acid 4.0616755160
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 13.0514694615
MESH:D002386 Cataract Acetaminophen 13.0510977129
MESH:D002386 Cataract Methylnitrosourea 13.0512484553
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.966135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.9612371664
MESH:D002471 Cell Transformation, Neoplastic Methylnitrosourea 11.967505956 2727394
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002779 Cholestasis Cyclosporine 3.0419486331
MESH:D002971 Cleft Lip Folic Acid 4.0621254359
MESH:D002972 Cleft Palate Folic Acid 6.3121254359 8946559
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 6.3115668235 8697196 15340226 12621046 16354765
MESH:D015179 Colorectal Neoplasms Folic Acid 2.7016963246 17116713 17087956 16985020 17245555
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 9.7015095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 9.7014669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.6318551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.6318551238
MESH:D003924 Diabetes Mellitus, Type 2 Folic Acid 4.6916886840
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.6917107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 12.5121346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 12.5118551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 12.5121346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.5111287661 12705907 10663392 12958197 14550746 11421492 11529661 16781746 11743745 17522070 12540782 14725611 18071297 11461765 11739529 19416960 18713872 16227642 12153990 11834606 17906064 19739265 10915739 14986274 16393943 12392966 12594235 15619225 17562736 2444490 16081117 10774834 16485898 19164858 16109766 19420014 19923254 16177239 19085960 19370779 15968718
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.5120420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8911462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1715322242 18230668 16714409
MESH:D016889 Endometrial Neoplasms Folic Acid 4.1117301261
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.189294722 10568697
MESH:D017889 Exfoliation Syndrome Folic Acid 5.7316504073
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1411564622
MESH:D005234 Fatty Liver Cyclosporine 3.0319224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D005354 Fibrosarcoma Methylnitrosourea 5.4711555667
MESH:D005355 Fibrosis Cyclosporine 9.2112639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.2120067830
MESH:D005756 Gastritis Acetaminophen 12.1816983495
MESH:D005756 Gastritis Folic Acid 12.1817171786
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.468708960
MESH:D005901 Glaucoma Folic Acid 5.2616504073
MESH:D005910 Glioma Methylnitrosourea 3.629825942
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006330 Heart Defects, Congenital Folic Acid 7.1417286298 16524890
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 7.1410048152 11294989
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1116120746 15340226 12621046
MESH:D006679 HIV Seropositivity Folic Acid 5.7317209195
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3116959395 15340226 16354765 18606429 8697196
MESH:D006930 Hyperalgesia Acetaminophen 2.8416870215
MESH:D020138 Hyperhomocysteinemia Folic Acid 4.6516865747 16397167 16433478 16755160 16395265
MESH:D006973 Hypertension Cyclosporine 5.1410903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1418670907 18850075
MESH:D007248 Infertility, Male Methylnitrosourea 3.907193160
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9312878042 12200463
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5116580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7115604871
MESH:D007674 Kidney Diseases Acetaminophen 6.1015629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 6.108314463 10903974 18776723
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.2216705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 13.2216705839
MESH:D007680 Kidney Neoplasms Cyclosporine 13.2212371664
MESH:D007951 Leukemia, Myeloid Hydroxyurea 5.1816532439
MESH:D017880 Limb Deformities, Congenital Methylnitrosourea 4.3215526292
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008107 Liver Diseases Acetaminophen 4.3819784758 12587719 16610002 16611625 19014921 11587558 12969438 19460945
MESH:D008107 Liver Diseases Folic Acid 4.3816877991
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4017185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.567678174
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.5616984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.072876786 6135515 2876784
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.0712151625
MESH:D038061 Lower Extremity Deformities, Congenital Methylnitrosourea 5.6816080182
MESH:D008175 Lung Neoplasms Methylnitrosourea 2.6418062963
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.6419555203 11884234
MESH:D008180 Lupus Erythematosus, Systemic Folic Acid 3.3817718048
MESH:D008223 Lymphoma Methylnitrosourea 4.1311418001 16257854
MESH:D016393 Lymphoma, B-Cell Methylnitrosourea 4.9514633661
MESH:D008325 Mammary Neoplasms, Experimental Methylnitrosourea 3.6815313902 14999141 10767621 15688392 15113128 10838139 14633655 16944150 16827153 12931682 11807958 17131329 16619500 16051031 17020996 19196723 11751437
MESH:D019767 Maxillofacial Abnormalities Folic Acid 5.9316832597
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0516801185
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1612213967
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.1518551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.1518551238 7678174
MESH:D009369 Neoplasms Methylnitrosourea 3.3815533788
MESH:D009374 Neoplasms, Experimental Methylnitrosourea 4.6912696579
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4418481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4114600291
MESH:D009436 Neural Tube Defects Folic Acid 4.0617438019
MESH:D009442 Neurilemmoma Methylnitrosourea 5.7211555667
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0118514411
MESH:D009503 Neutropenia Folic Acid 4.6916322990
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 16.1212819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 16.1216049721
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 16.1214694615
MESH:D010146 Pain Acetaminophen 2.5316870215
MESH:D010190 Pancreatic Neoplasms Methylnitrosourea 3.4116965848
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3712371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4311896295 11222880 11118676 11399792
MESH:D011471 Prostatic Neoplasms Methylnitrosourea 4.0812376480 15682402
MESH:D011565 Psoriasis Cyclosporine 2.2816882103
MESH:D051437 Renal Insufficiency Folic Acid 4.9915728788
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012162 Retinal Degeneration Methylnitrosourea 4.5418172121 18155124
MESH:D012175 Retinoblastoma Methylnitrosourea 5.7211555667
MESH:D012559 Schizophrenia Folic Acid 2.9116641680
MESH:D012640 Seizures 2,4-dinitrotoluene 6.2518551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.2518551238
MESH:D012871 Skin Diseases Folic Acid 3.2818709164
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1116192470
MESH:D013118 Spinal Cord Diseases Folic Acid 5.7316361298
MESH:D013274 Stomach Neoplasms Folic Acid 3.1317171786
MESH:D013274 Stomach Neoplasms Methylnitrosourea 3.1315930296 18593901 16257854
MESH:D020521 Stroke Folic Acid 4.4616517955
MESH:D013953 Thymus Neoplasms Methylnitrosourea 5.4711418001
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D013964 Thyroid Neoplasms Methylnitrosourea 4.053078959 7505956
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.2116049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.2116049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.8010091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.8010091137
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D014605 Uveitis Cyclosporine 4.251336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
MESH:D014985 Xerophthalmia Cyclosporine 4.7117120751
Pathway ID Pathway Name
REACT:13433 Biological oxidations
KEGG:01100 Metabolic pathways
KEGG:00920 Sulfur metabolism
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB03131 - Beta-Mercaptoethanol
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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