AutismKB 2.0

Annotation Detail for TUBB3


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Basic Information Top
Gene Symbol:TUBB3 ( CFEOM3A,TUBB4,beta-4 )
Gene Full Name: tubulin, beta 3
Band: 16q24.3
Quick LinksEntrez ID:10381; OMIM: 602661; Uniprot ID:TBB3_HUMAN; ENSEMBL ID: ENSG00000198211; HGNC ID: 20772
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04145Phagosome
hsa04540Gap junction
hsa05130Pathogenic Escherichia coli infection
Pathway IDPathway Name
Metabolism of proteins
No data
Pathway IDPathway Name
P00029Huntington disease
P00016Cytoskeletal regulation by Rho GTPase
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1934Cancer
No data
No data
Desease Name
Fibrosis of extraocular muscles, congenital, 3A
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C049325 1,2-dithiol-3-thione 1,2-dithiol-3-thione results in increased expression of TUBB3 mRNAincreases expression 15302862
C075773 4-phenylbutyric acid [4-phenylbutyric acid affects the acetylation of HDAC1 protein] which affects the expression of TUBB3 proteinaffects acetylation|affects expression 18497984
C075773 4-phenylbutyric acid [4-phenylbutyric acid affects the acetylation of MECP2 protein] which affects the expression of TUBB3 proteinaffects acetylation|affects expression 18497984
C075773 4-phenylbutyric acid 4-phenylbutyric acid affects the expression of TUBB3 proteinaffects expression 18497984
C075773 4-phenylbutyric acid [decitabine co-treated with 4-phenylbutyric acid] affects the expression of TUBB3 proteinaffects cotreatment|affects expression 18497984
D000082 Acetaminophen Acetaminophen affects the expression of TUBB3 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of TUBB3 mRNAaffects expression 16483693
D000643 Ammonium Chloride Ammonium Chloride results in decreased expression of TUBB3 proteindecreases expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of TUBB3 mRNAincreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TUBB3 mRNAdecreases expression 20382639
C018021 cobaltous chloride cobaltous chloride results in increased expression of TUBB3 mRNAincreases expression 16772336
C018021 cobaltous chloride cobaltous chloride results in increased expression of TUBB3 proteinincreases expression 16772336
D016572 Cyclosporine Cyclosporine results in increased expression of TUBB3 mRNAincreases expression 20106945
C014347 decitabine decitabine affects the expression of TUBB3 mRNAaffects expression 18497984
C014347 decitabine decitabine affects the expression of TUBB3 proteinaffects expression 18497984
C014347 decitabine [decitabine co-treated with 4-phenylbutyric acid] affects the expression of TUBB3 proteinaffects cotreatment|affects expression 18497984
D003676 Deferoxamine Deferoxamine results in increased expression of TUBB3 mRNAincreases expression 16772336
D003907 Dexamethasone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of TUBB3 mRNAaffects cotreatment|decreases expression 16054899
D004642 Emodin Emodin results in decreased expression of TUBB3 mRNAdecreases expression 16045814
D004958 Estradiol Estradiol results in increased expression of TUBB3 mRNAincreases expression 19466750
D004958 Estradiol Estradiol results in increased expression of TUBB3 proteinincreases expression 19466750
D004958 Estradiol fulvestrant inhibits the reaction [Estradiol results in increased expression of TUBB3 mRNA]decreases reaction|increases expression 19466750
D004958 Estradiol Tamoxifen inhibits the reaction [Estradiol results in increased expression of TUBB3 mRNA]decreases reaction|increases expression 19466750
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of TUBB3 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TUBB3 mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of TUBB3 mRNAincreases expression 17108234
C070081 fulvestrant fulvestrant inhibits the reaction [Estradiol results in increased expression of TUBB3 mRNA]decreases reaction|increases expression 19466750
C056933 fumonisin B1 fumonisin B1 results in increased expression of TUBB3 mRNAincreases expression 16221962
D017313 Fenretinide Fenretinide results in increased expression of TUBB3 proteinincreases expression 17110918
D015056 1-Methyl-3-isobutylxanthine [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of TUBB3 mRNAaffects cotreatment|decreases expression 16054899
C091888 monoisoamyl-2,3-dimercaptosuccinate monoisoamyl-2,3-dimercaptosuccinate affects the expression of TUBB3 mRNAaffects expression 19615344
C091888 monoisoamyl-2,3-dimercaptosuccinate monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [sodium arsenite results in decreased expression of TUBB3 mRNA]decreases expression|decreases reaction 19615344
C073402 PD 123319 PD 123319 inhibits the reaction [AGT protein results in increased expression of TUBB3 protein]decreases reaction|increases expression 17068200
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of TUBB3 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of TUBB3 mRNAincreases expression 15302862
C089730 rosiglitazone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of TUBB3 mRNAaffects cotreatment|decreases expression 16054899
C010327 salinomycin salinomycin results in decreased expression of TUBB3 mRNAdecreases expression 19682730
C017947 sodium arsenite sodium arsenite results in increased expression of TUBB3 mRNAincreases expression 20308225
C017947 sodium arsenite monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [sodium arsenite results in decreased expression of TUBB3 mRNA]decreases expression|decreases reaction 19615344
C017947 sodium arsenite sodium arsenite results in decreased expression of TUBB3 mRNAdecreases expression 19615344
D013629 Tamoxifen Tamoxifen inhibits the reaction [Estradiol results in increased expression of TUBB3 mRNA]decreases reaction|increases expression 19466750
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TUBB3 mRNAincreases expression 20106945
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TUBB3 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TUBB3 mRNAincreases expression 17942748
D014212 Tretinoin Tretinoin results in increased expression of TUBB3 proteinincreases expression 16646664
D014212 Tretinoin AKT1 protein inhibits the reaction [Tretinoin results in increased expression of TUBB3 protein]decreases reaction|increases expression 16613989
D014212 Tretinoin DKK1 protein promotes the reaction [Tretinoin results in increased expression of TUBB3 protein]increases expression|increases reaction 17064353
D014212 Tretinoin FGF2 protein promotes the reaction [Tretinoin results in increased expression of TUBB3 protein]increases expression|increases reaction 16009726
D014212 Tretinoin Tretinoin results in increased expression of TUBB3 proteinincreases expression 16009726
17064353
16613989
D014303 Trinitrotoluene Trinitrotoluene affects the expression of TUBB3 mRNAaffects expression 21346803
D014635 Valproic Acid Valproic Acid affects the expression of TUBB3 proteinaffects expression 19460635
C081489 valsartan valsartan promotes the reaction [AGT protein results in increased expression of TUBB3 protein]increases expression|increases reaction 17068200
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.2614745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 12.6815322242 14514962 11752688
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 12.687525203
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 12.688875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.6819490988
MESH:D000138 Acidosis Ammonium Chloride 3.2818287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6617505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.8618653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 9.5720127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 9.5711473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 9.5714692618
MESH:D000230 Adenocarcinoma Fenretinide 9.5710697514
MESH:D000236 Adenoma Benzo(a)pyrene 2.496695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 8.9716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.9716835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.4215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.6217306315 16712894
MESH:D000505 Alopecia Tretinoin 3.4015955085
MESH:D000544 Alzheimer Disease rosiglitazone 2.7919621015
MESH:D000550 Amblyopia Valproic Acid 4.9517688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7111748828
MESH:D000799 Angioedema Acetaminophen 3.5610982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.3517497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8019183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.1911256880
MESH:D001169 Arthritis, Experimental Dexamethasone 11.2917659584
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 11.2915885639
MESH:D001169 Arthritis, Experimental Tretinoin 11.2916412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2016292516
MESH:D001249 Asthma Tretinoin 2.2616456186
MESH:D001284 Atrophy fulvestrant 4.5811514358
MESH:D001321 Autistic Disorder Acetaminophen 1.8518445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8518396377 15238991 16609825 20603192 18775368 18985861 19232924 18558336 18177632 18940202 17688650 17507914 19460635 18316065 17157402
MESH:D001471 Barrett Esophagus Tretinoin 4.1416935849
MESH:D001714 Bipolar Disorder Valproic Acid 2.9417594078 20046352
MESH:D001778 Blood Coagulation Disorders pirinixic acid 13.8219483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 13.8212125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 13.8216206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.4315746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.438888407
MESH:D001932 Brain Neoplasms Fenretinide 4.1116187019
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 6.7020146248 17474063
MESH:D001943 Breast Neoplasms decitabine 6.7019208741 18320071
MESH:D001943 Breast Neoplasms Deferoxamine 6.7015993339
MESH:D001943 Breast Neoplasms Estradiol 6.7017261762 16675129 17018787 12948864 19861407 17289903 18497071 14630087
MESH:D001943 Breast Neoplasms Fenretinide 6.7016601279
MESH:D001943 Breast Neoplasms fulvestrant 6.7018984771
MESH:D001943 Breast Neoplasms salinomycin 6.7019682730
MESH:D001943 Breast Neoplasms Tamoxifen 6.7017440819 19289846 19189210 21138602 15565566 19200415 18815881 16818667 19011961 17049068 17893378 17242785 19221464 19487384 15668708 19103187 20859285 18629630 16873071 18997820 19189212 19410462 19115204 18821012 19084267 19155303 20544844 18984771 20390343 19142967 18425577 19244106 20135344 19059307 20065188 18855134 18351453 19288272 16273361 19066611 11161223 21152245 20005174 16202921 17261762
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 6.7020435547
MESH:D001943 Breast Neoplasms Tretinoin 6.7016873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.3116813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.1816111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5816835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.2319066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.8716168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 10.753084413
MESH:D006528 Carcinoma, Hepatocellular Estradiol 10.7516924424
MESH:D006528 Carcinoma, Hepatocellular Fenretinide 10.7516270382 17159502
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 10.7516507464 15276417 17306315
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 10.7516924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 10.751917145
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 13.4320419170
MESH:D002294 Carcinoma, Squamous Cell decitabine 13.4319215824
MESH:D002294 Carcinoma, Squamous Cell Fenretinide 13.4316274795
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 13.4318572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 13.4316051514 16096774
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.3717572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.6118850075 18670907 16120746
MESH:D006332 Cardiomegaly valsartan 6.6119597038
MESH:D009202 Cardiomyopathies valsartan 4.2616247790
MESH:D002318 Cardiovascular Diseases valsartan 4.1111230374
MESH:D002386 Cataract Acetaminophen 11.4610977129
MESH:D002386 Cataract Tretinoin 11.4617460283
MESH:D002386 Cataract Trinitrotoluene 11.4614694615 15817613
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 14.4520889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 14.4512371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 14.4518566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 14.4519524636 20056578
MESH:D018290 Cervical Intraepithelial Neoplasia Fenretinide 12.0416154183
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 12.0416129372
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.6120734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D002779 Cholestasis Cyclosporine 12.1619486331
MESH:D002779 Cholestasis Ethinyl Estradiol 12.1616919318 11677210 16105132 17333356 17681005 15861022 17110522
MESH:D002779 Cholestasis pirinixic acid 12.1619176532
MESH:D002822 Choriocarcinoma Tretinoin 4.8716461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.3715668235 16354765 12621046 8697196 15340226
MESH:D002972 Cleft Palate Tretinoin 5.379407595
MESH:D003092 Colitis Tretinoin 3.4317035595
MESH:D003110 Colonic Neoplasms decitabine 3.7817616700
MESH:D003110 Colonic Neoplasms Dexamethasone 3.7815824018
MESH:D015179 Colorectal Neoplasms decitabine 2.8218981723
MESH:D015179 Colorectal Neoplasms Fenretinide 2.8217273769
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 8.5017141729 14669216
MESH:D000013 Congenital Abnormalities Trinitrotoluene 8.5015095906
MESH:D003324 Coronary Artery Disease valsartan 3.8017719468
MESH:D003384 Coxsackievirus Infections valsartan 5.5620392896
MESH:D019465 Craniofacial Abnormalities Dexamethasone 5.1417728286
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.1410048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 5.148800419 17551590 9664655 16925845 9125849 10589399 14991402 9142499 9224671 9211117
MESH:D019465 Craniofacial Abnormalities Valproic Acid 5.1417688650 8888407 16575769
MESH:D003490 Cyanosis Trinitrotoluene 4.6518551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.0919031437
MESH:D017449 Dermatitis, Allergic Contact cobaltous chloride 6.6015059100 16823706 11298694
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 6.6012438553
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3018249437
MESH:D003920 Diabetes Mellitus rosiglitazone 4.0717446233
MESH:D003921 Diabetes Mellitus, Experimental valsartan 4.3711508273
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 4.2512642470
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.2517107852
MESH:D003928 Diabetic Nephropathies Estradiol 13.7919279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 13.7919279558
MESH:D003928 Diabetic Nephropathies valsartan 13.7911427623 18630688
MESH:D003967 Diarrhea Dexamethasone 3.447237001
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 11.1014725611 17522070 17906064 10663392 16781746 10774834 12705907 19370779 19739265 12958197 19416960 12594235 18713872 17562736 10915739 19164858 11461765 19420014 11287661 16485898 12153990 14986274 18071297 16109766 11834606 12392966 19923254 11529661 16227642 12540782 11743745 19085960 15619225 14550746 16393943 16177239 2444490 11421492 16081117 15968718 11739529
MESH:D056486 Drug-Induced Liver Injury fumonisin B1 11.1016221962
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.1020420201
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 11.1018551238 21346803
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 11.101733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8119426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5611462148
MESH:D004421 Dystonia Valproic Acid 3.791851702
MESH:D004485 Eczema Dexamethasone 4.1912438553
MESH:D004487 Edema Dexamethasone 14.4319703484
MESH:D004487 Edema pirinixic acid 14.4312083418
MESH:D004487 Edema rosiglitazone 14.4312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 14.4312711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.0016714409 18230668 15322242
MESH:D004489 Edema, Cardiac Tretinoin 11.0018230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.0612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.0619031437
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.8319294695
MESH:D016889 Endometrial Neoplasms Estradiol 11.3818566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Tamoxifen 11.3816202921 19155303 20544844 17893378
MESH:D016889 Endometrial Neoplasms Tretinoin 11.3816569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.7810568697 9294722
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 3.883659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 3.633922381 16628512
MESH:D004827 Epilepsy Valproic Acid 2.7920417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.367562514 6254150 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.027750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.793659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.1020426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.1016530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.1511564622
MESH:D005124 Eye Abnormalities Tretinoin 8.159664655 16938888
MESH:D005234 Fatty Liver Cyclosporine 27.4719224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 27.4715345470
MESH:D005234 Fatty Liver pirinixic acid 27.4719236843 20131406
MESH:D005234 Fatty Liver rosiglitazone 27.4719196556
MESH:D005234 Fatty Liver Tamoxifen 27.4719224547 14986274
MESH:D005234 Fatty Liver Valproic Acid 27.4719224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.0716709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1811858732
MESH:D005315 Fetal Diseases Valproic Acid 4.6016575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.868888407 18558336
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.2514745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.9019069698
MESH:D005355 Fibrosis Cyclosporine 24.8612639820 12168785
MESH:D005355 Fibrosis Emodin 24.8619474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 24.8620067830
MESH:D005355 Fibrosis Tretinoin 24.8617994277
MESH:D005355 Fibrosis valsartan 24.8616893502
OMIM:600638 FIBROSIS OF EXTRAOCULAR MUSCLES, CONGENITAL, 3A, WITH OR WITHOUT EXTRAOCULAR INVOLVEMENT marker/mechanism
MESH:D005756 Gastritis Acetaminophen 3.3916983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.4016452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.948708960
MESH:D005909 Glioblastoma Fenretinide 6.8416187019
MESH:D005909 Glioblastoma Tretinoin 6.8417312396
MESH:D015432 Glomerulonephritis, Membranoproliferative valsartan 5.2816928621
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3110696789
MESH:D006258 Head and Neck Neoplasms decitabine 7.2119215824
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.2116096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.8716084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 10.2320471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.2310048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 10.239664655 14991402
MESH:D006333 Heart Failure pirinixic acid 6.8220558911
MESH:D006333 Heart Failure valsartan 6.8219027736
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1415720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0911000095
MESH:D006529 Hepatomegaly fumonisin B1 18.4916221962
MESH:D006529 Hepatomegaly pirinixic acid 18.4919176532 18467677 16221962 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 18.4912621046 16120746 15340226
MESH:D006529 Hepatomegaly Trinitrotoluene 18.4915817613
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 2.977520565
MESH:D006558 Herpes Genitalis Estradiol 4.7515709030
MESH:D006689 Hodgkin Disease sodium arsenite 2.9312676792
MESH:D019584 Hot Flashes Estradiol 3.4717088409
MESH:D006849 Hydrocephalus Valproic Acid 4.5917688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7615340226 16959395 16354765 18606429 8697196
MESH:D006930 Hyperalgesia Acetaminophen 11.8316870215
MESH:D006930 Hyperalgesia rosiglitazone 11.8312083418
MESH:D006930 Hyperalgesia Tretinoin 11.8316870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.2916778211
MESH:D006943 Hyperglycemia pirinixic acid 2.9420558911
MESH:D006973 Hypertension Cyclosporine 11.5310903974
MESH:D006973 Hypertension Dexamethasone 11.5317042910
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 11.5318850075 18670907
MESH:D006973 Hypertension valsartan 11.5320102058 18344623 16475468 18390891 12850387 12692753 11427623 10903974
MESH:D006974 Hypertension, Malignant valsartan 6.1311560862
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5416945680 16569931
MESH:D007077 Ileal Diseases 1-Methyl-3-isobutylxanthine 5.1618306037
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2012013081
MESH:D007248 Infertility, Male decitabine 19.1717581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 19.1717937319
MESH:D007248 Infertility, Male fulvestrant 19.1711514358
MESH:D007248 Infertility, Male sodium arsenite 19.1715346721 12646999
MESH:D007248 Infertility, Male Trinitrotoluene 19.1712150543
MESH:D007249 Inflammation Dexamethasone 10.8011099482 8960868
MESH:D007249 Inflammation rosiglitazone 10.8012083418
MESH:D007249 Inflammation Tamoxifen 10.8019457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 10.8012200463 12878042
MESH:D007333 Insulin Resistance Estradiol 11.3416393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 11.3416306350
MESH:D007333 Insulin Resistance rosiglitazone 11.3416306350
MESH:D007410 Intestinal Diseases Tretinoin 3.4917994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.1016580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.1017551590 15992940
MESH:D007579 Jejunal Diseases 1-Methyl-3-isobutylxanthine 5.1618306037
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.1615604871
MESH:D007674 Kidney Diseases Acetaminophen 17.3612587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 17.3618776723 8314463 10903974
MESH:D007674 Kidney Diseases Estradiol 17.3615618244
MESH:D007674 Kidney Diseases sodium arsenite 17.3620008137
MESH:D007674 Kidney Diseases valsartan 17.3610903974 16893502 12164870
MESH:D007680 Kidney Neoplasms Cyclosporine 11.0712371664
MESH:D007680 Kidney Neoplasms Estradiol 11.0715610895
MESH:D007680 Kidney Neoplasms Tamoxifen 11.0718625569
MESH:D007938 Leukemia decitabine 5.9618980019 19235587
MESH:D007938 Leukemia Tretinoin 5.9617143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Emodin 4.7717077332
MESH:D007951 Leukemia, Myeloid decitabine 8.7318454857 19117987 17236224
MESH:D007951 Leukemia, Myeloid Tretinoin 8.7316932348 19285840 16482212
MESH:D015470 Leukemia, Myeloid, Acute decitabine 8.3719010910 18704418 19387464 18460780 18206229 17679729
MESH:D015470 Leukemia, Myeloid, Acute Deferoxamine 8.3720368581
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 8.3716294345 17596541 19850784
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 8.3717596541 16294345
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.1818055864
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.9717361223 17368321 17294898 17107899 17301526 15748426 16823087 19642359 16935935 17506722 16891316 19029980 17649720 16140955 16788101 12679006 19075265 9834237 16766008 17339181 19035177 16331271 17217047 19225113 17712046
MESH:D007972 Leukoplakia, Oral Fenretinide 5.7616707609
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.119224671
MESH:D008064 Lipidoses Tamoxifen 2.9617567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 14.9716718785
MESH:D008106 Liver Cirrhosis, Experimental Emodin 14.9715288473
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 14.9714659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 14.9715474484
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 14.9717347453 15980055
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 14.9718564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 14.9712878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 14.9718397230 16248980
MESH:D008106 Liver Cirrhosis, Experimental valsartan 14.9716872305 15619341 15504291
MESH:D008107 Liver Diseases Acetaminophen 1.5619014921 12969438 19460945 16611625 12587719 19784758 16610002 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 2.9916871587 17185352
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 13.0620195826 21137059
MESH:D008113 Liver Neoplasms pirinixic acid 13.0620007298 16377806 15890375
MESH:D008113 Liver Neoplasms sodium arsenite 13.0615276417 16712894
MESH:D008113 Liver Neoplasms Tamoxifen 13.0616684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 13.0616984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 1.9412151625
MESH:D008171 Lung Diseases sodium arsenite 2.9919095001
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 3.9817228818
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.1920064080 18520028 20869020 20464547 18569708 17053015 18816296 20135361 6695378
MESH:D008175 Lung Neoplasms Dexamethasone 6.1915824018 11195469
MESH:D008175 Lung Neoplasms sodium arsenite 6.1917077188 17306315 16712894 19931552 15276417
MESH:D008175 Lung Neoplasms Tamoxifen 6.1918625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.1919555203 11884234
MESH:D008223 Lymphoma decitabine 3.2219470736
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.4819428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 16.9717203775 16891317 11408345 11807958
MESH:D008325 Mammary Neoplasms, Experimental Fenretinide 16.9710697514
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 16.9716827153
MESH:D008325 Mammary Neoplasms, Experimental salinomycin 16.9719682730
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 16.9711731420 19196722 14580682 19196723 16827153
MESH:D020149 Manganese Poisoning Estradiol 11.7019453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.7019453300
MESH:D008527 Medulloblastoma Tretinoin 2.6717453147
MESH:D008545 Melanoma decitabine 9.2316505122 17785578
MESH:D008545 Melanoma Fenretinide 9.2316270382
MESH:D008545 Melanoma sodium arsenite 9.2319082730 16487513
MESH:D008545 Melanoma Tamoxifen 9.2312393984 19393235
MESH:D008545 Melanoma Tretinoin 9.2316752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.9015990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2919513568
MESH:D008591 Meningomyelocele Tretinoin 4.1516940565
MESH:D024821 Metabolic Syndrome X rosiglitazone 4.1517261469
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5016801185
MESH:D008881 Migraine Disorders Valproic Acid 2.9918803445 18765137
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.0816381670
MESH:D009062 Mouth Neoplasms Fenretinide 8.0816274795
MESH:D009101 Multiple Myeloma decitabine 6.8718172295
MESH:D009101 Multiple Myeloma Dexamethasone 6.8716118317 15744524 15867202
MESH:D009135 Muscular Diseases pirinixic acid 3.2316239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.788888407
MESH:D009190 Myelodysplastic Syndromes decitabine 16.2816882708 19010910 19157545 18608210
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 16.289809623
MESH:D009190 Myelodysplastic Syndromes Tretinoin 16.2817596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 16.2817596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.0319151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8012213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.5516810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.5516411023
MESH:D009336 Necrosis Trinitrotoluene 4.4918551238
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.4419393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4219410462
MESH:D009369 Neoplasms 4-phenylbutyric acid 21.9119116145
MESH:D009369 Neoplasms Benzo(a)pyrene 21.9111141357
MESH:D009369 Neoplasms decitabine 21.9117925555 19116145 19470736
MESH:D009369 Neoplasms Fenretinide 21.9117353921 15958647
MESH:D009369 Neoplasms pirinixic acid 21.9117405874
MESH:D009369 Neoplasms sodium arsenite 21.9111559025
MESH:D009369 Neoplasms Tretinoin 21.9116594593 16946489
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.3920056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.7219189210 19196722 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 3.4517289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.1617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0519348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 14.7911399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 14.7914600291
MESH:D009421 Nervous System Malformations Tretinoin 14.799125849
MESH:D009436 Neural Tube Defects sodium arsenite 11.1112854658
MESH:D009436 Neural Tube Defects Tretinoin 11.119142499
MESH:D009436 Neural Tube Defects Valproic Acid 11.118888407 16359493
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.6518514411
MESH:D009472 Neuronal Ceroid-Lipofuscinoses Fenretinide 5.4016303764
MESH:D009765 Obesity pirinixic acid 1.7520558911
MESH:D009784 Occupational Diseases Trinitrotoluene 4.1014694615 17852074 12819281
MESH:D010051 Ovarian Neoplasms marker/mechanism 18497984
MESH:D010051 Ovarian Neoplasms decitabine 14.0119259094 19331143
MESH:D010051 Ovarian Neoplasms Estradiol 14.0119401270
MESH:D010051 Ovarian Neoplasms Fenretinide 14.0116133793
MESH:D010051 Ovarian Neoplasms sodium arsenite 14.0117306315 15276417
MESH:D010051 Ovarian Neoplasms Tretinoin 14.0116936753
MESH:D010146 Pain Acetaminophen 5.8516870215
MESH:D010146 Pain Tretinoin 5.8516870215
MESH:D010190 Pancreatic Neoplasms decitabine 8.1719294695
MESH:D010190 Pancreatic Neoplasms Fenretinide 8.1715580305
MESH:D010190 Pancreatic Neoplasms Tretinoin 8.1715976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4311578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9612520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2918163543
MESH:D011230 Precancerous Conditions Cyclosporine 2.9912371664
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.3921297632
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.5311399792 11896295 11222880 11118676
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 8.5320603192
MESH:D055728 Primary Myelofibrosis decitabine 4.4517616702
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6320887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8917292933
MESH:D011471 Prostatic Neoplasms Estradiol 1.8916740699
MESH:D011471 Prostatic Neoplasms Fenretinide 1.8917024972
MESH:D011471 Prostatic Neoplasms sodium arsenite 1.8916039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.8915067354
MESH:D011507 Proteinuria Tretinoin 8.7316636307
MESH:D011507 Proteinuria valsartan 8.7312164870 18344623 17664856
MESH:D011537 Pruritus Ethinyl Estradiol 3.0316919318 15861022
MESH:D019310 Pseudolymphoma Valproic Acid 4.2611422049 12752131
MESH:D011565 Psoriasis Cyclosporine 2.1316882103
MESH:D011625 Pterygium Tretinoin 4.5116723453
MESH:D011658 Pulmonary Fibrosis valsartan 3.7117241526
MESH:D015427 Reperfusion Injury pirinixic acid 2.2519058328
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 3.7618379247 11700416
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5718990726
MESH:D012162 Retinal Degeneration Fenretinide 4.2016303925
MESH:D012208 Rhabdomyosarcoma decitabine 17.0219155313
MESH:D012208 Rhabdomyosarcoma Tretinoin 17.0216116481 16283617
MESH:D012208 Rhabdomyosarcoma Valproic Acid 17.0219155313
MESH:D012559 Schizophrenia Valproic Acid 2.0319110320 15737665
MESH:D012640 Seizures Trinitrotoluene 5.6618551238
MESH:D012640 Seizures Valproic Acid 5.6611738929 14763951 17978042 3137016 1511512 16876388 15475178 11044598
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 16.5210029692 19755658
MESH:D012878 Skin Neoplasms Fenretinide 16.5216467112
MESH:D012878 Skin Neoplasms sodium arsenite 16.5218572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 16.5216192470
MESH:D012878 Skin Neoplasms Tretinoin 16.5216467112
MESH:D013088 Spermatocele Ethinyl Estradiol 10.6116709447
MESH:D013088 Spermatocele Tamoxifen 10.6116709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.7619457130
MESH:D016135 Spinal Dysraphism sodium arsenite 8.8412854658
MESH:D016135 Spinal Dysraphism Valproic Acid 8.8419490988
MESH:D013163 Splenomegaly Trinitrotoluene 4.9315817613
MESH:D013226 Status Epilepticus Valproic Acid 4.2612833885
MESH:D013272 Stomach Diseases Dexamethasone 4.0415472012
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.212093021 20155912
MESH:D013274 Stomach Neoplasms decitabine 3.2119037991
MESH:D013274 Stomach Neoplasms Tretinoin 3.2117261132
MESH:D013276 Stomach Ulcer Dexamethasone 3.2515138204
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3611994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9215669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6212697716
MESH:D013964 Thyroid Neoplasms decitabine 6.6017967635
MESH:D013964 Thyroid Neoplasms Tretinoin 6.6017045167 16026305
MESH:D013978 Tibial Fractures Estradiol 4.4019048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.5516051514
MESH:D014178 Translocation, Genetic Valproic Acid 4.9517262798
MESH:D014376 Tuberculosis Tretinoin 3.0616040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.243119515
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 14.6217053015
MESH:D001749 Urinary Bladder Neoplasms decitabine 14.6219087683 17616700
MESH:D001749 Urinary Bladder Neoplasms Fenretinide 14.6216720286
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 14.6216712894 16452187 11723127 17306315
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 14.6217572228 16712894 8653321
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.378888407
MESH:D014581 Urticaria Acetaminophen 2.7210982225
MESH:D002583 Uterine Cervical Neoplasms Fenretinide 14.5616154183
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 14.5611813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 14.5616129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.0314692618
MESH:D014604 Uveal Neoplasms decitabine 11.8817785578
MESH:D014604 Uveal Neoplasms Tretinoin 11.8816752155
MESH:D014605 Uveitis Cyclosporine 10.821336536
MESH:D014605 Uveitis Dexamethasone 10.821336536
MESH:D014652 Vascular Diseases sodium arsenite 4.1417056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2915869587 14671159
MESH:D020257 Ventricular Remodeling valsartan 5.4219027736
MESH:D014820 Vitiligo Tretinoin 3.7916761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9615886252
MESH:D009396 Wilms Tumor Tretinoin 3.7316287080
MESH:D014985 Xerophthalmia Cyclosporine 4.1617120751
Pathway ID Pathway Name
REACT:18266 Axon guidance
REACT:152 Cell Cycle, Mitotic
REACT:383 DNA Replication
KEGG:04540 Gap junction
REACT:604 Hemostasis
REACT:11123 Membrane Trafficking
REACT:17015 Metabolism of proteins
KEGG:05130 Pathogenic Escherichia coli infection
KEGG:04145 Phagosome
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB01873 - Epothilone D Cytochrome P450Epok inhibitor
DB03010 - Epothilone B Antineoplastic Agents;Tubulin Modulators
DB04845 antagonist Ixabepilone Antineoplastic Agents
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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