AutismKB 2.0

Annotation Detail for TUBB2C


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:TUBB2C ( TUBB2 )
Gene Full Name: tubulin, beta 2C
Band: 9q34
Quick LinksEntrez ID:10383; OMIM: 602660; Uniprot ID:TBB2C_HUMAN; ENSEMBL ID: ENSG00000188229; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04145Phagosome
hsa04540Gap junction
hsa05130Pathogenic Escherichia coli infection
Pathway IDPathway Name
Cell Cycle, Mitotic
Metabolism of proteins
No data
Pathway IDPathway Name
P00029Huntington disease
P00016Cytoskeletal regulation by Rho GTPase
Pathway IDPathway Name
500383Loss of proteins required for interphase microtubule organization from the centrosome
500384Loss of Nlp from mitotic centrosomes
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1934Cancer
2028Nasopharyngeal cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C014211 2,3,7,8-tetrachlorodibenzofuran 2,3,7,8-tetrachlorodibenzofuran affects the expression of TUBB2C mRNAaffects expression 18343893
D000082 Acetaminophen Acetaminophen affects the expression of TUBB2C mRNAaffects expression 17562736
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of TUBB2C mRNAincreases expression 20498004
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TUBB2C mRNAdecreases expression 20382639
C032036 bromobenzene bromobenzene results in increased expression of TUBB2C mRNAincreases expression 12628495
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of TUBB2C mRNAincreases expression 19100860
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of TUBB2C mRNAincreases expression 19638242
D004958 Estradiol Estradiol results in decreased expression of TUBB2C mRNAdecreases expression 16835292
17912697
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of TUBB2C mRNAincreases expression 19400957
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of TUBB2C mRNAaffects expression 17351261
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of TUBB2C mRNAincreases expression 19400957
D005038 Ethylnitrosourea Ethylnitrosourea results in increased expression of TUBB2C mRNAincreases expression 19100860
D005472 Fluorouracil TUBB2C protein affects the susceptibility to Fluorouracilaffects response to substance 15548681
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of TUBB2C mRNAincreases expression 20713471
C006253 pirinixic acid pirinixic acid results in increased expression of TUBB2C mRNAincreases expression 18301758
C009277 sodium arsenate sodium arsenate results in increased expression of TUBB2C mRNAincreases expression 16882884
C017947 sodium arsenite sodium arsenite results in decreased expression of TUBB2C mRNAdecreases expression 19072884
D013629 Tamoxifen Tamoxifen results in increased expression of TUBB2C mRNAincreases expression 19400957
D013629 Tamoxifen Tamoxifen results in increased expression of TUBB2C mRNAincreases expression 19400957
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the expression of TUBB2C mRNAaffects expression 18343893
D014810 Vitamin E Vitamin E results in increased expression of TUBB2C mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.5514745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.8415322242 14514962 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9417505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.1018653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 10.1220464547 20127859
MESH:D000230 Adenocarcinoma Estradiol 10.1211473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 10.1214692618
MESH:D000230 Adenocarcinoma Fluorouracil 10.1217638652
MESH:D000236 Adenoma Benzo(a)pyrene 15.946695378
MESH:D000236 Adenoma Diethylnitrosamine 15.946695378 10737359
MESH:D000236 Adenoma Ethylnitrosourea 15.946695378
MESH:D000236 Adenoma Methylcholanthrene 15.9410545420 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 17.2419052882 19061943 16434500 17620307 18056438 17162532
MESH:D018248 Adenoma, Liver Cell pirinixic acid 17.2416434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 17.2416835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.7015276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.9017306315 16712894
MESH:D000740 Anemia Fluorouracil 8.6215504547 17963324 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.6211748828
MESH:D000799 Angioedema Acetaminophen 3.8410982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0619183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6515885639
MESH:D050197 Atherosclerosis Methylcholanthrene 3.4411922910
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.7119483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.7112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7515746008
MESH:D001927 Brain Diseases Ethylnitrosourea 4.8614991843
MESH:D001932 Brain Neoplasms Ethylnitrosourea 4.2716357521 15144691 16436596 16651633 18412241
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 3.7620146248 17474063
MESH:D001943 Breast Neoplasms Diethylnitrosamine 3.7617474063
MESH:D001943 Breast Neoplasms Estradiol 3.7617261762 12948864 17289903 18497071 14630087 17018787 19861407 16675129
MESH:D001943 Breast Neoplasms Fluorouracil 3.7616595493 18357371 19217205 16110121 15136595 18608205 16557594
MESH:D001943 Breast Neoplasms Methylcholanthrene 3.7617474063
MESH:D001943 Breast Neoplasms Tamoxifen 3.7620859285 19221464 19410462 19103187 17261762 18351453 19288272 18855134 19189212 19244106 19200415 16273361 15565566 17242785 20390343 18997820 19487384 11161223 17440819 18821012 21152245 18984771 20544844 20065188 17049068 19155303 19115204 16818667 16873071 18425577 21138602 19011961 19189210 18629630 17893378 19084267 16202921 19066611 20135344 19142967 18815881 20005174 19059307 15668708 19289846
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.7620435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.4516111702
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.9216050911
MESH:D002276 Carcinoid Tumor Fluorouracil 4.6716051944
MESH:D002277 Carcinoma Fluorouracil 13.8917121937
MESH:D002277 Carcinoma Methylcholanthrene 13.8910545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 13.8916835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.4919066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 11.363084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 11.3616698587 16569478 18785209 17055752 16779866 19383236 18506893 16878318 19418558 16935385 20935162 18494052 19822196 19208518 20432363 18788625 19539802 16502159 10737359 20512989 16540662 19107877 20727157 20214788 19052882 18978308 17428255 16328049 17761372 20514400 18665156 20101231 11831363 17162532 18393292 19919837 16288022 10672840 20524982 17173139 3084413 18210153 18971187 17138121 20007298 20084675 19335982 19394651 17978847 3581430 18691550 16681979 19519916 21159647 19171122 16807293 18056438 16830150 19701751
MESH:D006528 Carcinoma, Hepatocellular Estradiol 11.3616924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 11.3616799960 17088986 18930000 17971768 17045692 16332177
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 11.3616507464 17306315 15276417
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 11.3616924424
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.0118695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.5020419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 7.5018986760 16280240 17066447 16757204
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 7.5018572023
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.6017572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3518850075 18670907 16120746
MESH:D002386 Cataract Acetaminophen 2.5710977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 26.2020889678
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 26.202727394 7505956 21159647 17174075
MESH:D002471 Cell Transformation, Neoplastic Estradiol 26.2018566989
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 26.2016003739
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 26.2016192471
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 26.2019524636 20056578
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 5.9817160924
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.2619052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.2616835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.6911677210 16105132 16919318 17681005 17333356 15861022 17110522
MESH:D002779 Cholestasis pirinixic acid 7.6919176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0916354765 12621046 15340226 8697196 15668235
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2317172411 18772588 17169374 17725105 17016597 16510598 17287894 15001691 16340194 17018589
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0018509181 17695437 15289873 16524972 16391804 16282729 17594712 18802399 14970324 20501625 16303861 18448328 17454858 17401013 18949393 18288408 17094418 18383874 15148649 16331619 17255274 17016601
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0417141729 14669216
MESH:D019465 Craniofacial Abnormalities sodium arsenate 3.8710525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.8710048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.8719769572
MESH:D007644 Darier Disease Fluorouracil 4.7816733453
MESH:D003711 Demyelinating Diseases Tamoxifen 4.3519031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4118249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.2020387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.2017107852
MESH:D003928 Diabetic Nephropathies Estradiol 8.7819279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.7819279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 11.9811743745 11461765 11739529 19416960 11287661 16177239 10915739 14986274 12540782 14725611 10663392 12958197 12153990 19370779 11529661 17562736 18071297 19923254 18713872 16485898 12705907 14550746 19420014 10774834 16393943 19739265 17522070 12594235 2444490 12392966 16227642 11834606 15968718 15619225 19085960 16081117 16781746 17906064 11421492 19164858 16109766
MESH:D056486 Drug-Induced Liver Injury bromobenzene 11.9812628495 10092053
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 11.9819107877
MESH:D056486 Drug-Induced Liver Injury sodium arsenate 11.9818186108
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.9820420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1019426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7411462148
MESH:C538011 Eales disease Vitamin E 4.709068938
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 5.9818357618
MESH:D004487 Edema pirinixic acid 6.4812083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.4812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9018230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.8912538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.8919031437
MESH:D016889 Endometrial Neoplasms Estradiol 7.3418566989 19148513 11473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.3416202921 20544844 19155303 17893378
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0010568697 9294722
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.1216302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.2020426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.2016530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 7.2017638652 16481741 15173087 16785472 16337965
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0011564622
MESH:D005234 Fatty Liver Diethylnitrosamine 18.6021071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 18.6015345470
MESH:D005234 Fatty Liver pirinixic acid 18.6019236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 18.6019224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2216709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4411858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.5214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.1719069698
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.9314633661 10962813
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.9320067830
MESH:D005756 Gastritis Acetaminophen 3.6816983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.6716452187
MESH:D005909 Glioblastoma Ethylnitrosourea 3.8216436596
MESH:D005910 Glioma Ethylnitrosourea 6.3216357521 16651633 18412241
MESH:D005910 Glioma Fluorouracil 6.3216145905
MESH:D018149 Glucose Intolerance sodium arsenate 5.0619446573
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5910696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.3715102660 15162350 18337622
MESH:D006330 Heart Defects, Congenital 2,3,7,8-tetrachlorodibenzofuran 15.9311294989
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 15.9320471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 15.9311294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin E 15.9316080930
MESH:D006333 Heart Failure pirinixic acid 2.5220558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3211000095
MESH:D006529 Hepatomegaly pirinixic acid 8.2219772884 16221962 19176532 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.2216120746 15340226 12621046
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6916863852 16490937
MESH:D006558 Herpes Genitalis Estradiol 5.0315709030
MESH:D006689 Hodgkin Disease sodium arsenite 3.1312676792
MESH:D019584 Hot Flashes Estradiol 10.0517088409
MESH:D019584 Hot Flashes Vitamin E 10.0514716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0518606429 16959395 8697196 15340226 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.6816870215
MESH:D006943 Hyperglycemia pirinixic acid 3.1620558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9018670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8016945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4412013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.5917937319
MESH:D007248 Infertility, Male sodium arsenite 6.5912646999 15346721
MESH:D007249 Inflammation Diethylnitrosamine 8.2018785209
MESH:D007249 Inflammation Tamoxifen 8.2019457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.2012200463 12878042
MESH:D007251 Influenza, Human Vitamin E 4.2116624496
MESH:D007333 Insulin Resistance Estradiol 7.1516627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 7.1516306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3216580747
MESH:D007674 Kidney Diseases Acetaminophen 14.3415629191 12587719
MESH:D007674 Kidney Diseases Estradiol 14.3415618244
MESH:D007674 Kidney Diseases sodium arsenite 14.3420008137
MESH:D007674 Kidney Diseases Vitamin E 14.3412488133
MESH:D007680 Kidney Neoplasms Estradiol 17.6815610895
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 17.6817379185
MESH:D007680 Kidney Neoplasms Fluorouracil 17.6816985049
MESH:D007680 Kidney Neoplasms Tamoxifen 17.6818625569
MESH:D008064 Lipidoses Tamoxifen 3.1415342952 17567588
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8120032147 18407596 18522880 19638242 18665156
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.7014716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.7015474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 6.7018564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.7012878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 6.7016169303
MESH:D008107 Liver Diseases Acetaminophen 3.8911587558 19460945 19784758 12969438 16610002 19014921 12587719 16611625
MESH:D008107 Liver Diseases Diethylnitrosamine 3.8917034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2216871587 17185352
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 21.8120195826 21137059
MESH:D008113 Liver Neoplasms Diethylnitrosamine 21.8119850985 16942905 19294768 18754104 19254457 20118626 18648771 19256749 18977376 12112319 15175105 20501860 20101389 20137499 21167192 9163691 20434301 20452335 15885732 19812893 19833225 2862719 20583210 19638242 12771043 19426721 18978307 19090486 2422723 19690152 21278145 20405173 20492335 10737359 19642983 18644402 21071580 19427195 19996281 19499222 19073162 21047994 19255062 19551842
MESH:D008113 Liver Neoplasms Fluorouracil 21.8116603448 18383874 17045692 15113037
MESH:D008113 Liver Neoplasms pirinixic acid 21.8115890375 20007298 16377806
MESH:D008113 Liver Neoplasms sodium arsenite 21.8116712894 15276417
MESH:D008113 Liver Neoplasms Tamoxifen 21.8116684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 21.8116984957
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 9.813124819 19539802 19519916 18308698 18253720 17854601 18093689 16842330 18775883 19009564 9362446 21159647 18079962 16267830 18164116 18282651 18544905 19126423 17942915 19004024 2563599 17174075
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 9.81598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.8112151625
MESH:D008171 Lung Diseases sodium arsenite 7.3919095001
MESH:D008171 Lung Diseases Vitamin E 7.3916863852
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 15.4320464547 20869020 20064080 6695378 17053015 20135361 18520028 18569708 18816296
MESH:D008175 Lung Neoplasms Diethylnitrosamine 15.4321163286 20970405 20512841 6695378
MESH:D008175 Lung Neoplasms Ethylnitrosourea 15.436695378 16271038 16019985 17703301
MESH:D008175 Lung Neoplasms Fluorouracil 15.4315246190
MESH:D008175 Lung Neoplasms Methylcholanthrene 15.4320970405 6695378 16337739 21163286 15390079 20512841 16271038 10545420 1399818 17909032 7750092 11893704 9230183
MESH:D008175 Lung Neoplasms sodium arsenite 15.4319931552 17306315 16712894 15276417 17077188
MESH:D008175 Lung Neoplasms Tamoxifen 15.4318625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 15.4311884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 15.4311062179
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.7815086387
MESH:D008223 Lymphoma Ethylnitrosourea 3.9215790496
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 5.0315375218
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.7519428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 9.9817203775 11807958 11408345 16891317
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 9.9810767621 10838139 18041768
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 9.9814580682 16827153 19196723 19196722 11731420
MESH:D020149 Manganese Poisoning Estradiol 12.6519453300
MESH:D020149 Manganese Poisoning Tamoxifen 12.6519453300
MESH:D008545 Melanoma sodium arsenite 3.3119082730 16487513
MESH:D008545 Melanoma Tamoxifen 3.3119393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.1715990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5519513568
MESH:D008579 Meningioma Ethylnitrosourea 5.9817943659
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.4716381670
MESH:D009062 Mouth Neoplasms Fluorouracil 8.4716757204 18986760
MESH:D009135 Muscular Diseases pirinixic acid 3.4916239165
MESH:D009139 Musculoskeletal Abnormalities sodium arsenate 4.8418186108
MESH:D009203 Myocardial Infarction pirinixic acid 2.1319151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0012213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.1916810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.1916411023
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.703581430 9029167
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.7019393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5119410462
MESH:D009369 Neoplasms Benzo(a)pyrene 11.7711141357
MESH:D009369 Neoplasms Fluorouracil 11.7718239605 16928823 18600527
MESH:D009369 Neoplasms pirinixic acid 11.7717405874
MESH:D009369 Neoplasms sodium arsenite 11.7711559025
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 9.3316707424
MESH:D009374 Neoplasms, Experimental sodium arsenite 9.3320056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.0019196722 19189210 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 3.7217289903
MESH:D009421 Nervous System Malformations Estradiol 9.4111399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.4114600291
MESH:D009436 Neural Tube Defects sodium arsenate 7.6011749123 10525206 19446573 18186108
MESH:D009436 Neural Tube Defects sodium arsenite 7.6012854658
MESH:D009442 Neurilemmoma Ethylnitrosourea 5.4117160924 16003739 16651423
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.1218514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.1220387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.1220387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.4216436463
MESH:D009765 Obesity pirinixic acid 1.8120558911
MESH:D009837 Oligodendroglioma Ethylnitrosourea 5.9817160924
MESH:D010051 Ovarian Neoplasms Estradiol 4.8219401270
MESH:D010051 Ovarian Neoplasms sodium arsenite 4.8215276417 17306315
MESH:D010146 Pain Acetaminophen 2.3716870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.3016540662
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.3015113037 16929163 19003803 16500647
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6711578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2512520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5418163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.532563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.1811118676 11896295 11399792 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.8720887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8817292933
MESH:D011471 Prostatic Neoplasms Estradiol 1.8816740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 1.8818626508 19082440
MESH:D011471 Prostatic Neoplasms sodium arsenite 1.8816039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.8815067354
MESH:D011471 Prostatic Neoplasms Vitamin E 1.8815084515
MESH:D011537 Pruritus Ethinyl Estradiol 3.3016919318 15861022
MESH:D012004 Rectal Neoplasms Fluorouracil 3.9918286688 15538739 16160472 18722050
MESH:D015427 Reperfusion Injury pirinixic acid 2.3819058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8218990726
MESH:D012871 Skin Diseases Vitamin E 2.4418709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.3419755658 10029692
MESH:D012878 Skin Neoplasms sodium arsenite 9.3418572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.3416192470
MESH:D013088 Spermatocele Ethinyl Estradiol 11.5616709447
MESH:D013088 Spermatocele Tamoxifen 11.5616709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.0319457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.7812854658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.3420155912 2093021
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.3418456281
MESH:D013274 Stomach Neoplasms Fluorouracil 3.3418396642 19084572 19015929 15786421 16951190 17498489 16424979 17522103 18567086 17172411
MESH:D020521 Stroke Vitamin E 3.5016517955
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1315669648
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 5.1515790496
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9012697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 2.977505956
MESH:D013978 Tibial Fractures Estradiol 4.6919048282
MESH:D014062 Tongue Neoplasms Fluorouracil 3.9716280240
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.2617053015
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 8.2616452187 11723127 17306315 16712894
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.268653321 17572228 16712894
MESH:D014581 Urticaria Acetaminophen 2.9610982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 9.4216803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 9.4211813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2814692618
MESH:D014652 Vascular Diseases sodium arsenite 4.4217056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5912125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5214671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2515886252
Pathway ID Pathway Name
REACT:18266 Axon guidance
REACT:152 Cell Cycle, Mitotic
REACT:383 DNA Replication
KEGG:04540 Gap junction
REACT:604 Hemostasis
REACT:11123 Membrane Trafficking
REACT:17015 Metabolism of proteins
KEGG:05130 Pathogenic Escherichia coli infection
KEGG:04145 Phagosome
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00518 antagonist Albendazole Anthelmintics;Anticestodal Agents;Antiprotozoal Agents;Tubulin Modulators
DB00643 antagonist Telmin B Syringe Formula Antinematodal Agents;Tubulin Modulators
DB01873 - Epothilone D Cytochrome P450Epok inhibitor
DB03010 - Epothilone B Antineoplastic Agents;Tubulin Modulators
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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