AutismKB 2.0

Annotation Detail for NOD1


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Basic Information Top
Gene Symbol:NOD1 ( CARD4,CLR7.1,NLRC1 )
Gene Full Name: nucleotide-binding oligomerization domain containing 1
Band: 7p14.3
Quick LinksEntrez ID:10392; OMIM: 605980; Uniprot ID:NOD1_HUMAN; ENSEMBL ID: ENSG00000106100; HGNC ID: 16390
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05120Epithelial cell signaling in Helicobacter pylori infection
hsa04621NOD-like receptor signaling pathway
hsa05131Shigellosis
Pathway IDPathway Name
Signaling in Immune system
No data
Pathway IDPathway Name
P00020FAS signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1772Peptic ulcer
1834Sarcoidosis
1857Porcine reproductive and respiratory syndrome
1894Abortion
1918Atherosclerosis
1998Enteritis
2052Infection
2053Colon cancer
2094Ulcerative colitis
2142Acne
2231Arthritis
Desease Name
duodenal ulcer gastritis
IMMUNE
Crohn's disease
INFECTION
Crohn Disease
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C090942 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [NOD1 protein results in increased secretion of IL8 protein]decreases reaction|increases secretion 16365441
C034330 FK 156 FK 156 binds to and results in increased activity of NOD1 proteinaffects binding|increases activity 16299289
C039537 FK 565 FK 565 binds to and results in increased activity of NOD1 proteinaffects binding|increases activity 16299289
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of NOD1 mRNAaffects cotreatment|increases expression 17183730
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of NOD1 mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 4.028875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.3019490988
MESH:D000550 Amblyopia Valproic Acid 5.8517688650
MESH:D001008 Anxiety Disorders Valproic Acid 3.8617497229
MESH:D001321 Autistic Disorder Valproic Acid 1.9819460635 15238991 18396377 18985861 18940202 17507914 17157402 18558336 19232924 18316065 16609825 20603192 18775368 17688650 18177632
MESH:D001714 Bipolar Disorder Valproic Acid 3.2320046352 17594078
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.618888407
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.8120734317
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.9017688650 8888407 16575769
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 2.2519641884 1733752
MESH:D004421 Dystonia Valproic Acid 4.451851702
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.6417275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.533922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0920417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.916426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.787750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.603659116
MESH:D005234 Fatty Liver Valproic Acid 3.6719224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 5.5016575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.578888407 18558336
MESH:D006849 Hydrocephalus Valproic Acid 5.4117688650
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 5.1116612254
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1917596541 16294345
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.8717228818
MESH:D008881 Migraine Disorders Valproic Acid 3.4418803445 18765137
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.408888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.3317596541
MESH:D009436 Neural Tube Defects Valproic Acid 3.3416359493 8888407
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.3720603192
MESH:D019310 Pseudolymphoma Valproic Acid 5.1511422049 12752131
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.5819155313
MESH:D012559 Schizophrenia Valproic Acid 2.1015737665 19110320
MESH:D012640 Seizures Valproic Acid 2.9617978042 15475178 16876388 1511512 11738929 14763951 3137016 11044598
MESH:D016135 Spinal Dysraphism Valproic Acid 4.0619490988
MESH:D013226 Status Epilepticus Valproic Acid 5.1512833885
MESH:D014178 Translocation, Genetic Valproic Acid 5.8517262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 5.063119515
MESH:D014564 Urogenital Abnormalities Valproic Acid 5.138888407
Pathway ID Pathway Name
KEGG:05120 Epithelial cell signaling in Helicobacter pylori infection
KEGG:04621 NOD-like receptor signaling pathway
KEGG:05131 Shigellosis
REACT:6900 Signaling in Immune system
Pharmacogenomics Knowledge Base Top
Drug Bank Top

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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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