AutismKB 2.0

Annotation Detail for DLC1


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Basic Information Top
Gene Symbol:DLC1 ( ARHGAP7,FLJ21120,HP,STARD12,p122-RhoGAP )
Gene Full Name: deleted in liver cancer 1
Band: 8p22
Quick LinksEntrez ID:10395; OMIM: 604258; Uniprot ID:RHG07_HUMAN; ENSEMBL ID: ENSG00000164741; HGNC ID: 2897
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Signaling by Rho GTPases
Pathway IDPathway Name
200050Regulation of RhoA activity
Pathway IDPathway Name
P00047PDGF signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1934Cancer
No data
No data
Desease Name
Colorectal cancer, somatic
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of DLC1 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of DLC1 mRNAaffects expression 16483693
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of DLC1 mRNAdecreases expression 17484886
D003520 Cyclophosphamide Cyclophosphamide results in increased expression of DLC1 mRNAincreases expression 17403535
D016572 Cyclosporine Cyclosporine results in decreased expression of DLC1 mRNAdecreases expression 20106945
C014347 decitabine decitabine affects the methylation of DLC1 promoteraffects methylation 17571247
D004317 Doxorubicin DLC1 protein affects the susceptibility to Doxorubicinaffects response to substance 16217747
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of DLC1 mRNAaffects cotreatment|decreases expression 19619570
D004958 Estradiol Estradiol results in increased expression of DLC1 mRNAincreases expression 19619570
D005472 Fluorouracil TP53 protein affects the reaction [Fluorouracil results in decreased expression of DLC1 mRNA]affects reaction|decreases expression 15016801
C051890 irinotecan irinotecan analog results in decreased expression of DLC1 mRNAdecreases expression 18927307
C008493 methylselenic acid methylselenic acid results in increased expression of DLC1 mRNAincreases expression 12517777
D015735 Mifepristone Mifepristone inhibits the reaction [Progesterone results in increased expression of DLC1 mRNA]decreases reaction|increases expression 15674352
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of DLC1 mRNAaffects binding|increases activity|increases expression 19710929
D011374 Progesterone Mifepristone inhibits the reaction [Progesterone results in increased expression of DLC1 mRNA]decreases reaction|increases expression 15674352
D011374 Progesterone Progesterone results in increased expression of DLC1 mRNAincreases expression 15674352
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of DLC1 mRNAaffects cotreatment|decreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of DLC1 mRNAdecreases expression 19619570
D019772 Topotecan DLC1 protein affects the susceptibility to Topotecanaffects response to substance 16217747
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.8714514962 15322242 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.5818287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.1218653653
MESH:D000230 Adenocarcinoma Doxorubicin 7.1717418594
MESH:D000230 Adenocarcinoma Estradiol 7.1711473722
MESH:D000230 Adenocarcinoma Fluorouracil 7.1717638652
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.9716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.9716835633
MESH:D000419 Albuminuria Doxorubicin 4.5521441931
MESH:D000740 Anemia Fluorouracil 8.6916511603 15504547 17963324
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.6911748828
MESH:D000799 Angioedema Acetaminophen 3.8710982225
MESH:D001161 Arteriosclerosis Cyclophosphamide 4.6115014928
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.7819483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.7812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7615746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.7314601052
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.3717868700
MESH:D001930 Brain Injuries Progesterone 4.2715665606 15845082 15380490
MESH:D001932 Brain Neoplasms Doxorubicin 3.8117150277
MESH:D001943 Breast Neoplasms Cyclophosphamide 3.7817020986 18234424 18323546 11325840 16978400 17388661 12006526 15136595 15093573
MESH:D001943 Breast Neoplasms decitabine 3.7819208741 18320071
MESH:D001943 Breast Neoplasms Doxorubicin 3.7816264153 15993339 15939500 16595493 19526202 17426702 15136595 18382427 16096432 16935488 17983394 15634643 17369602 11325840 18628466 15668708 18695136 15692762 16826403 16322301 15994142 15567936 18234424 16115903
MESH:D001943 Breast Neoplasms Estradiol 3.7817018787 18497071 12948864 19861407 17289903 16675129 14630087 17261762
MESH:D001943 Breast Neoplasms Fluorouracil 3.7815136595 16110121 19217205 18608205 16595493 16557594 18357371
MESH:D001943 Breast Neoplasms Progesterone 3.7817614352 16175315 15562024
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.7820435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.4816111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.7916050911 16011737 16192424 16227642 15721981 15673190 15700767 16124888 3786805 16097048 18705752 10355542
MESH:D002276 Carcinoid Tumor Doxorubicin 12.4616051944
MESH:D002276 Carcinoid Tumor Fluorouracil 12.4616051944
MESH:D002277 Carcinoma Fluorouracil 8.1917121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.1916835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 11.413084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 11.4118788625
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 11.4119701751
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 11.4118059187 16234567 16023760 17876044
MESH:D006528 Carcinoma, Hepatocellular Estradiol 11.4116924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 11.4118930000 17045692 16799960 17088986 17971768 16332177
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 4.9116152834
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 10.9116201981
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 10.9116201981 1485588
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 10.9118695887
MESH:D002294 Carcinoma, Squamous Cell decitabine 7.6519215824
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 7.656189445
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 7.6516757204 18986760 17066447 16280240
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3716120746 18670907 18850075
MESH:D009202 Cardiomyopathies Doxorubicin 3.5315792986 16242529 17382496 17131338 16455267 17007740 16612575 16109756 15811867 17519947 16278810 18627295 17924179 15476868 17974986 16364871 16952015 15505089 17928571 17308081 16651473 16269455 17351982 16731534 17329180
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.9417334414 16243910
MESH:D002386 Cataract Acetaminophen 2.5810977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.5812371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.5818566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1616835633
MESH:D002779 Cholestasis Cyclosporine 7.7619486331
MESH:D002779 Cholestasis pirinixic acid 7.7619176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.108697196 15340226 16354765 12621046 15668235
MESH:D003110 Colonic Neoplasms decitabine 5.9317616700
MESH:D003110 Colonic Neoplasms Fluorouracil 5.9317287894 17725105 18772588 16510598 16340194 15001691 17172411 17016597 17169374 17018589
MESH:D003110 Colonic Neoplasms irinotecan 5.9317287894 17725105
MESH:D015179 Colorectal Neoplasms decitabine 4.8418981723
MESH:D015179 Colorectal Neoplasms Doxorubicin 4.8418802399 18259882
MESH:D015179 Colorectal Neoplasms Fluorouracil 4.8416391804 15289873 18448328 18288408 17695437 17094418 16524972 17255274 16282729 14970324 17401013 18949393 16331619 17594712 18802399 17016601 15148649 16303861 17454858 18383874 20501625 18509181
MESH:D015179 Colorectal Neoplasms irinotecan 4.8417159606 17454858 16391804 18509181 18259882 15273666 16303861
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0614669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2515322242 10048152 20055451
MESH:D003556 Cystitis Cyclophosphamide 5.0218433785 17010015 16413132 18710439 12388444 16651033 18295254 16989017 12913760 10700343 10498854 11948286 18483878 12161096 15643279 15276878 18372110 16614059 17979934 18093676
MESH:D007644 Darier Disease Fluorouracil 4.8116733453
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4318249437
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 4.0710990075 15331540 11751995
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 3.2218772604
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6717107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.4119279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.5117187935
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.9819085960 10915739 19416960 11287661 11834606 10663392 17522070 19739265 16485898 12153990 16781746 16393943 10774834 12540782 16177239 12392966 16081117 19420014 16227642 19370779 14725611 18713872 11421492 19164858 16109766 11529661 11461765 17562736 15968718 12594235 17906064 14550746 12705907 15619225 12958197 11743745 18071297 11739529 14986274 19923254 2444490
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 8.9816177239 3786805 21278145 6884620 17522070 15027814 2869522 7179309 4309450 3732212 19085960 19336974 15968718 7120509 10915739 11566570 7440962 10092053 16227642 15998439 9327722 6623471
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 8.9817416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.9820420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1319426721
MESH:D004362 Drug Toxicity Doxorubicin 8.1218602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.1211462148
MESH:D004487 Edema pirinixic acid 6.5512083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.5512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9318230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.7917692515
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.1519294695
MESH:D016889 Endometrial Neoplasms Doxorubicin 7.5517359293
MESH:D016889 Endometrial Neoplasms Estradiol 7.5519148513 11473722 18566989
MESH:D004715 Endometriosis Mifepristone 15.3616134523
MESH:D004715 Endometriosis Progesterone 15.3616134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 15.3610568697 9294722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.1918037988
MESH:D004802 Eosinophilia Cyclophosphamide 4.2311006010
MESH:D004938 Esophageal Neoplasms Fluorouracil 2.4516337965 17638652 16785472 16481741 15173087
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0111564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 13.0812631006 61145 12795759 16045604 15959796 19224547 17595544 16239168
MESH:D005234 Fatty Liver Cyclosporine 13.0819224547
MESH:D005234 Fatty Liver pirinixic acid 13.0819236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4711858732
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.6119069698
MESH:D005355 Fibrosis Carbon Tetrachloride 14.8018705752
MESH:D005355 Fibrosis Cyclosporine 14.8012639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 14.8020067830
MESH:D005756 Gastritis Acetaminophen 3.7116983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.248708960
MESH:D005909 Glioblastoma Doxorubicin 3.3517150277
MESH:D005910 Glioma Fluorouracil 2.8716145905
MESH:D018316 Gliosarcoma Cyclophosphamide 5.5311389073
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6210696789
MESH:D006086 Graft vs Host Disease Cyclophosphamide 5.0516376943 15172196 11014644
MESH:D006258 Head and Neck Neoplasms decitabine 13.0319215824
MESH:D006258 Head and Neck Neoplasms Doxorubicin 13.0315692506
MESH:D006258 Head and Neck Neoplasms Fluorouracil 13.0315102660 15162350 18337622
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3311294989 10048152
MESH:D006331 Heart Diseases Doxorubicin 3.4818674790 16879835 16244371 12587719 16330681 17888722 16707910 14766674 16244372 18006777 17875725 16144979 16495754
MESH:D006333 Heart Failure Doxorubicin 7.0517481944
MESH:D006333 Heart Failure pirinixic acid 7.0520558911
MESH:D006394 Hemangiosarcoma Doxorubicin 3.9015692506
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4415720958
MESH:D006467 Hemophilia A Cyclophosphamide 5.3011918545
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3411000095
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 5.5614986274
MESH:D006505 Hepatitis Carbon Tetrachloride 3.6019900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 8.3118467677 16221962 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.3116120746 15340226 12621046
MESH:D006558 Herpes Genitalis Estradiol 5.0615709030
MESH:D006689 Hodgkin Disease Cyclophosphamide 7.7216135485 17606976
MESH:D006689 Hodgkin Disease Doxorubicin 7.7218501091 15147373 17606976
MESH:D019584 Hot Flashes Estradiol 3.7817088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0816959395 15340226 8697196 16354765 18606429
MESH:D006930 Hyperalgesia Acetaminophen 2.7016870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.5516899240
MESH:D006943 Hyperglycemia pirinixic acid 3.1920558911
MESH:D006973 Hypertension Cyclosporine 4.9510903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.9518670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.1015338365
MESH:D007154 Immune System Diseases Cyclophosphamide 5.3616076520
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.4115869954
MESH:D007248 Infertility, Male Cyclophosphamide 7.147193160 16517039
MESH:D007248 Infertility, Male decitabine 7.1417581917
MESH:D007249 Inflammation Progesterone 4.9815869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.9812200463 12878042
MESH:D007333 Insulin Resistance Estradiol 7.2016627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 7.2016306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3416580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.4715604871
MESH:D007674 Kidney Diseases Acetaminophen 14.4415629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 14.448314463 10903974 18776723
MESH:D007674 Kidney Diseases Doxorubicin 14.4416775033 15699352 15369732
MESH:D007674 Kidney Diseases Estradiol 14.4415618244
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.1616707910
MESH:D007680 Kidney Neoplasms Cyclosporine 12.4312371664
MESH:D007680 Kidney Neoplasms Estradiol 12.4315610895
MESH:D007680 Kidney Neoplasms Fluorouracil 12.4316985049
MESH:D007938 Leukemia Cyclophosphamide 6.7010602166
MESH:D007938 Leukemia decitabine 6.7018980019 19235587
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.1916085563
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.5017008537 17802794 17658394 17296974 18587576 18172266
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 4.0910373061
MESH:D007951 Leukemia, Myeloid decitabine 4.0119117987 18454857 17236224
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.3819387464 18704418 18206229 19010910 17679729 18460780
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.4918055864
MESH:D007970 Leukopenia Cyclophosphamide 4.9911830472 10052129
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8117157831 17334410 16943688 16239168 11903743 11408273 16221502 21278145 17174718
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.7315338365 14512876 15123356 12649538 18210741 12546737 12958196 12666154 15362042 18472094 15996030 15730626 18339082 15818738 17708605 18277467 17805973 18006644 12632512 18251166 17766677 16136751 17631135 12389079 16192424 12898905 16248980 12632514 18187930 18376398 17761835 14748882 18166357 17481882 12445418 18472332 15650968 17869086 18317297 17823541 15876570 18412020 18481824 17557913 11481614 16638106 12667390 14716496 17721639 18395914 20821823 17922224 16116963 14620537 15052691 15370692 16033810 15931870 12609069 17714472 18054572 15673190 10355542 15925388 18205269 17976157 14724832 18263696 18279442 17944888 18418968 17698563 16027843 12445421 14716833 18429990 17640975 17565644 17900296 16015684 15057751 18395095 16011737 18705752 16097048 12586293 17525996 15959796 15893842 13678700 12741479 18156304 18420326
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 6.7316439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.7314716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.7315474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.7312878042
MESH:D008107 Liver Diseases Acetaminophen 3.9019460945 16610002 19784758 16611625 12969438 12587719 19014921 11587558
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.9015720792 16246199 17285989 16964402 15830285
MESH:D017093 Liver Failure Carbon Tetrachloride 4.1815123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.4216871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.4214706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 10.6919294768
MESH:D008113 Liver Neoplasms Fluorouracil 10.6916603448 17045692 18383874 15113037
MESH:D008113 Liver Neoplasms pirinixic acid 10.6916377806 15890375 20007298
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.6916984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 9.8612014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 9.8617085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.8612151625
MESH:D008175 Lung Neoplasms Doxorubicin 3.466189445 17418594
MESH:D008175 Lung Neoplasms Fluorouracil 3.4615246190
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4611884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.8115086387
MESH:D008223 Lymphoma Cyclophosphamide 12.7012854902
MESH:D008223 Lymphoma decitabine 12.7019470736
MESH:D008223 Lymphoma Doxorubicin 12.7016098063
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 4.6016675587
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 9.0011911406
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 9.0017654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.5815621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 10.0415458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 10.0411807958 17203775 11408345 16891317
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 10.0417203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.5119453300
MESH:D008545 Melanoma decitabine 3.5517785578 16505122
MESH:D008545 Melanoma Doxorubicin 3.5516827129
MESH:D008546 Melanoma, Experimental Acetaminophen 10.8819513568
MESH:D008546 Melanoma, Experimental Cyclophosphamide 10.8816388313
MESH:D008654 Mesothelioma Doxorubicin 3.0617638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8216801185
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.5015792986
MESH:D009062 Mouth Neoplasms Fluorouracil 3.6316757204 18986760
MESH:D052016 Mucositis Doxorubicin 12.4917415656
MESH:D052016 Mucositis irinotecan 12.4917159606
MESH:D009101 Multiple Myeloma decitabine 3.3518172295
MESH:D009135 Muscular Diseases pirinixic acid 3.5216239165
MESH:D009190 Myelodysplastic Syndromes decitabine 3.3816882708 19157545 18608210 19010910
MESH:D009203 Myocardial Infarction Doxorubicin 5.7119429709 15857846
MESH:D009203 Myocardial Infarction pirinixic acid 5.7119151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0212213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.2616810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.2616411023
MESH:D009362 Neoplasm Metastasis Doxorubicin 6.1018259882
MESH:D009362 Neoplasm Metastasis irinotecan 6.1018259882
MESH:D009369 Neoplasms Cyclophosphamide 11.9318854779
MESH:D009369 Neoplasms decitabine 11.9319116145 17925555 19470736
MESH:D009369 Neoplasms Fluorouracil 11.9318239605 18600527 16928823
MESH:D009369 Neoplasms pirinixic acid 11.9317405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.7517289903
MESH:D009401 Nephrosis Doxorubicin 4.7816899518 16636307
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.4717954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 9.3118481113 19348381
MESH:D009404 Nephrotic Syndrome Doxorubicin 9.3115640375 16889571
MESH:D009421 Nervous System Malformations Estradiol 9.5016427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.5014600291
MESH:D009447 Neuroblastoma Cyclophosphamide 16.3315176712 16115947 8761367
MESH:D009447 Neuroblastoma Doxorubicin 16.3315555623
MESH:D009447 Neuroblastoma irinotecan 16.338761367
MESH:D009447 Neuroblastoma Topotecan 16.3315176712
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8718514411
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 11.608761367 12837982
MESH:D017599 Neuroectodermal Tumors irinotecan 11.608761367
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.4416436463
MESH:D009503 Neutropenia Cyclophosphamide 4.338291058
MESH:D009765 Obesity pirinixic acid 1.8120558911
MESH:D009845 Oligospermia Cyclophosphamide 4.7316517039
MESH:D012516 Osteosarcoma Doxorubicin 4.1115930896
MESH:D010051 Ovarian Neoplasms therapeutic 15674352
MESH:D010051 Ovarian Neoplasms decitabine 11.3619331143 19259094
MESH:D010051 Ovarian Neoplasms Estradiol 11.3619401270
MESH:D010051 Ovarian Neoplasms Mifepristone 11.3616525653
MESH:D010051 Ovarian Neoplasms Progesterone 11.3617393432 16525653
MESH:D010146 Pain Acetaminophen 6.8616870215
MESH:D010146 Pain Cyclophosphamide 6.8618093676 12161096
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 8.7811332152
MESH:D010190 Pancreatic Neoplasms decitabine 8.7819294695
MESH:D010190 Pancreatic Neoplasms Fluorouracil 8.7816500647 16929163 19003803 15113037
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2812520081
MESH:D003557 Phyllodes Tumor Doxorubicin 5.1917983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.1917638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5718163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.2212371664
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 3.8021297632
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.2111118676 11222880 11399792 11896295
MESH:D055728 Primary Myelofibrosis decitabine 4.7417616702
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.8920887781
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 1.8917136230
MESH:D011471 Prostatic Neoplasms Doxorubicin 1.8916888761 15897917 15749863 18437689 16868541 16729912
MESH:D011471 Prostatic Neoplasms Estradiol 1.8916740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 1.8918626508 19082440
MESH:D011471 Prostatic Neoplasms methylselenic acid 1.8916205645
MESH:D011565 Psoriasis Cyclosporine 2.2316882103
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 3.2816636934
MESH:D012004 Rectal Neoplasms Fluorouracil 4.0118286688 16160472 15538739 18722050
MESH:D051437 Renal Insufficiency Doxorubicin 4.2317922066
MESH:D015427 Reperfusion Injury pirinixic acid 2.3919058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8518990726
MESH:D012208 Rhabdomyosarcoma decitabine 4.4119155313
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8618045962
MESH:D012509 Sarcoma Doxorubicin 3.9915625365 15675481 18313854 17710206 16767912 17203757
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.2514601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.8117846226
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 4.8316636934
MESH:D012878 Skin Neoplasms Doxorubicin 5.6915692506
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.6916192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.5815625365 17203757 16767912
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 5.5316517039
MESH:D013119 Spinal Cord Injuries Progesterone 4.3015862959 16503802
MESH:D013274 Stomach Neoplasms decitabine 3.5119037991
MESH:D013274 Stomach Neoplasms Fluorouracil 3.5116424979 17522103 19015929 19084572 18396642 17498489 17172411 16951190 15786421 18567086
MESH:D013274 Stomach Neoplasms irinotecan 3.5115723263
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 5.0812837982
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9312697716
MESH:D013964 Thyroid Neoplasms decitabine 7.4317967635
MESH:D013964 Thyroid Neoplasms Doxorubicin 7.4316010429 17909728
MESH:D013978 Tibial Fractures Estradiol 4.7219048282
MESH:D014062 Tongue Neoplasms Fluorouracil 3.9916280240
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 8.5214692829
MESH:D001749 Urinary Bladder Neoplasms decitabine 8.5219087683 17616700
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 8.5217653716
MESH:D014581 Urticaria Acetaminophen 2.9810982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 3.8816803524
MESH:D014604 Uveal Neoplasms decitabine 4.9417785578
MESH:D014605 Uveitis Cyclosporine 4.011336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6212125929
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.2317334414 16364871 17678736 17638931
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2815886252
MESH:D014985 Xerophthalmia Cyclosporine 4.4717120751
Pathway ID Pathway Name
REACT:11044 Signaling by Rho GTPases
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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