AutismKB 2.0

Annotation Detail for NDRG1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:NDRG1 ( CAP43,CMT4D,DRG1,GC4,HMSNL,NDR1,NMSL,PROXY1,RIT42,RTP,TARG1,TDD5 )
Gene Full Name: N-myc downstream regulated 1
Band: 8q24.22
Quick LinksEntrez ID:10397; OMIM: 605262; Uniprot ID:NDRG1_HUMAN; ENSEMBL ID: ENSG00000104419; HGNC ID: 7679
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200171Validated targets of C-MYC transcriptional repression
200172HIF-1-alpha transcription factor network
200101Direct p53 effectors
No data
No data
Related Diseases/Disorders Top
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Desease IDDesease Name
1726Charcot-Marie-Tooth disease
1934Cancer
No data
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Desease Name
Charcot-Marie-Tooth disease, type 4D
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of NDRG1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in decreased expression of NDRG1 mRNAdecreases expression 20406850
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of NDRG1 mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of NDRG1 mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in increased expression of NDRG1 mRNAincreases expression 11264010
C109238 acyline acyline results in decreased expression of NDRG1 mRNAdecreases expression 17510436
D012436 S-Adenosylmethionine S-Adenosylmethionine results in decreased expression of NDRG1 mRNAdecreases expression 18098314
D000968 Antimycin A Antimycin A results in increased expression of NDRG1 mRNAincreases expression 19304788
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of NDRG1 mRNAdecreases expression 19150397
C006780 bisphenol A bisphenol A affects the expression of NDRG1 mRNAaffects expression 20170705
C459604 candoxin candoxin results in decreased expression of NDRG1 mRNAdecreases expression 16309724
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of NDRG1 mRNAdecreases expression 15963578
D003035 Cobalt Cobalt results in increased expression of NDRG1 proteinincreases expression 16386771
C018021 cobaltous chloride cobaltous chloride results in increased expression of NDRG1 proteinincreases expression 16622835
D016572 Cyclosporine Cyclosporine results in increased expression of NDRG1 mRNAincreases expression 20106945
C014347 decitabine decitabine results in increased expression of NDRG1 mRNAincreases expression 17908484
D004041 Dietary Fats Dietary Fats results in increased expression of NDRG1 mRNAincreases expression 18042831
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of NDRG1 mRNAincreases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of NDRG1 mRNA]decreases reaction|increases expression 17942915
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of NDRG1 mRNAaffects cotreatment|decreases expression 19619570
D004958 Estradiol Estradiol results in increased expression of NDRG1 mRNAincreases expression 19619570
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of NDRG1 mRNAincreases expression 17475347
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of NDRG1 mRNAaffects expression 20170705
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NDRG1 mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of NDRG1 mRNAincreases expression 17108234
C051890 irinotecan NDRG1 protein results in decreased susceptibility to irinotecandecreases response to substance 15867226
D008345 Manganese Manganese results in increased expression of NDRG1 proteinincreases expression 16386771
C008493 methylselenic acid methylselenic acid affects the expression of NDRG1 mRNAaffects expression 14617803
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to ACSL3 protein]affects binding|increases reaction 17220478
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to ACTB protein]affects binding|increases reaction 17220478
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to AP1M2 protein]affects binding|increases reaction 17220478
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to AP2M1 protein]affects binding|increases reaction 17220478
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to ATP1A1 protein]affects binding|increases reaction 17220478
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to CANX protein]affects binding|increases reaction 17220478
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to CLTC protein]affects binding|increases reaction 17220478
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to CNDP2 protein]affects binding|increases reaction 17220478
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to COPB2 protein]affects binding|increases reaction 17220478
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to CTNNB1 protein]affects binding|increases reaction 17220478
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to DARS protein]affects binding|increases reaction 17220478
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to DDX1 protein]affects binding|increases reaction 17220478
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to DDX5 protein]affects binding|increases reaction 17220478
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to DLST protein]affects binding|increases reaction 17220478
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to EEF1G protein]affects binding|increases reaction 17220478
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to EEF2 protein]affects binding|increases reaction 17220478
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to EIF2S3 protein]affects binding|increases reaction 17220478
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to EIF3E protein]affects binding|increases reaction 17220478
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to EWSR1 protein]affects binding|increases reaction 17220478
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to FASN protein]affects binding|increases reaction 17220478
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to HNRNPF protein]affects binding|increases reaction 17220478
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to HNRNPH1 protein]affects binding|increases reaction 17220478
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to HNRNPU protein]affects binding|increases reaction 17220478
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to HSD17B4 protein]affects binding|increases reaction 17220478
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to HSP90AA1 protein]affects binding|increases reaction 17220478
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to HSPA5 protein]affects binding|increases reaction 17220478
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to ILF3 protein]affects binding|increases reaction 17220478
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to KIF5B protein]affects binding|increases reaction 17220478
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to LDHA protein]affects binding|increases reaction 17220478
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to MAOA protein]affects binding|increases reaction 17220478
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to MME protein]affects binding|increases reaction 17220478
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to NCL protein]affects binding|increases reaction 17220478
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to NDRG1 protein]affects binding|increases reaction 17220478
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to PABPC1 protein]affects binding|increases reaction 17220478
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to PKM2 protein]affects binding|increases reaction 17220478
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to PPP2R2A protein]affects binding|increases reaction 17220478
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to PSMC2 protein]affects binding|increases reaction 17220478
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to PSMD2 protein]affects binding|increases reaction 17220478
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to RPL24 protein]affects binding|increases reaction 17220478
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to RPL3 protein]affects binding|increases reaction 17220478
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to RPL4 protein]affects binding|increases reaction 17220478
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to RPN2 protein]affects binding|increases reaction 17220478
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to RPS16 protein]affects binding|increases reaction 17220478
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to RPS20 protein]affects binding|increases reaction 17220478
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to RPS26 protein]affects binding|increases reaction 17220478
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to RPS3 protein]affects binding|increases reaction 17220478
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to RPS6 protein]affects binding|increases reaction 17220478
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to RPS8 protein]affects binding|increases reaction 17220478
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to RPS9 protein]affects binding|increases reaction 17220478
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to RUVBL2 protein]affects binding|increases reaction 17220478
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to SEC23A protein]affects binding|increases reaction 17220478
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to SHMT2 protein]affects binding|increases reaction 17220478
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to SLC25A6 protein]affects binding|increases reaction 17220478
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to TARS protein]affects binding|increases reaction 17220478
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to TLE3 protein]affects binding|increases reaction 17220478
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to UPF1 protein]affects binding|increases reaction 17220478
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to VCP protein]affects binding|increases reaction 17220478
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to XRCC6 protein]affects binding|increases reaction 17220478
D015741 Metribolone Metribolone results in increased expression of NDRG1 proteinincreases expression 17220478
C452423 N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine results in increased expression of NDRG1 mRNAincreases expression 16052530
D009532 Nickel Nickel results in increased expression of NDRG1 proteinincreases expression 16386771
C029938 nickel sulfate nickel sulfate affects the expression of NDRG1 mRNAaffects expression 12718980
C041786 palm oil palm oil results in increased expression of NDRG1 mRNAincreases expression 18042831
D010269 Paraquat Paraquat results in increased expression of NDRG1 mRNAincreases expression 12595580
D010634 Phenobarbital Phenobarbital results in increased expression of NDRG1 mRNAincreases expression 19270015
C006253 pirinixic acid pirinixic acid results in increased expression of NDRG1 mRNAincreases expression 17426115
18445702
C030984 pyrene pyrene results in decreased expression of NDRG1 mRNAdecreases expression 15963578
D011794 Quercetin Quercetin results in increased expression of NDRG1 mRNAincreases expression 19729006
C059514 resveratrol resveratrol results in increased expression of NDRG1 mRNAincreases expression 17261084
D012402 Rotenone Rotenone results in increased expression of NDRG1 mRNAincreases expression 19304788
C064116 S-(1,1,2,2-tetrafluoroethyl)cysteine S-(1,1,2,2-tetrafluoroethyl)cysteine results in increased expression of NDRG1 mRNAincreases expression 16678137
D013467 Sulindac Sulindac results in increased expression of NDRG1 mRNAincreases expression 16273229
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of NDRG1 mRNAaffects cotreatment|decreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of NDRG1 mRNAincreases expression 19619570
20106945
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NDRG1 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of NDRG1 mRNAincreases expression 18691609
18796159
D014212 Tretinoin Tretinoin results in increased expression of NDRG1 mRNAincreases expression 17218384
16054129
D014212 Tretinoin Tretinoin affects the expression of NDRG1 proteinaffects expression 15789344
D014212 Tretinoin Tretinoin results in decreased expression of NDRG1 mRNAdecreases expression 16604517
D014635 Valproic Acid Valproic Acid results in increased expression of NDRG1 mRNAincreases expression 19101580
D014639 Vanadium Vanadium results in increased expression of NDRG1 proteinincreases expression 16386771
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Sulindac 5.0714745880
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 11.786195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 11.7815322242 11752688 14514962
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 11.788875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.5519490988
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.5217505938
MESH:D058186 Acute Kidney Injury resveratrol 7.7816538975
MESH:D058186 Acute Kidney Injury Sulindac 7.787897758
MESH:D055371 Acute Lung Injury Nickel 13.1716166738
MESH:D055371 Acute Lung Injury nickel sulfate 13.1719131640 12718980 11954676 16100012
MESH:D055371 Acute Lung Injury pirinixic acid 13.1718653653
MESH:D000230 Adenocarcinoma Estradiol 6.4411473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.4414692618
MESH:D000230 Adenocarcinoma Sulindac 6.4411910360
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 13.973712494
MESH:D000236 Adenoma Diethylnitrosamine 13.976695378 10737359
MESH:D000236 Adenoma resveratrol 13.9715688382
MESH:D000236 Adenoma Sulindac 13.9710223192
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 21.4116434500 18056438 19061943 17620307 19052882 17162532
MESH:D018248 Adenoma, Liver Cell Phenobarbital 21.4117620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 21.4116434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 21.4116835633
MESH:D011125 Adenomatous Polyposis Coli Sulindac 4.2412394442 11535846 19003578 11874996 17611924 15623613 16460482
MESH:D000382 Agricultural Workers' Diseases Paraquat 3.3511874814
MESH:D000505 Alopecia Tretinoin 3.2815955085
MESH:D000544 Alzheimer Disease resveratrol 2.4716183991 16162502
MESH:D000550 Amblyopia Valproic Acid 4.8117688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.5911748828
MESH:D000743 Anemia, Hemolytic Quercetin 3.8717084956
MESH:D000756 Anemia, Sideroblastic Manganese 4.4916910769
MESH:D000799 Angioedema Acetaminophen 3.4210982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.2417497229
MESH:D001161 Arteriosclerosis Dietary Fats 8.5515238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 8.5511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 10.7415885639
MESH:D001169 Arthritis, Experimental resveratrol 10.7417115116
MESH:D001169 Arthritis, Experimental Tretinoin 10.7416412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.1616292516
MESH:D001249 Asthma Tretinoin 2.2116456186
MESH:D001260 Ataxia Telangiectasia Quercetin 4.5615336622
MESH:D050197 Atherosclerosis resveratrol 3.0216873680 17967414
MESH:D001321 Autistic Disorder Acetaminophen 2.2418445737
MESH:D001321 Autistic Disorder S-Adenosylmethionine 2.2419056591 16917939
MESH:D001321 Autistic Disorder Valproic Acid 2.2417157402 18177632 17507914 18775368 18558336 16609825 15238991 19460635 18985861 17688650 18316065 19232924 18396377 20603192 18940202
MESH:D001327 Autoimmune Diseases Quercetin 4.0019761891
MESH:D001471 Barrett Esophagus Tretinoin 4.0016935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.5911289319 1440618
MESH:D001714 Bipolar Disorder Valproic Acid 2.8617594078 20046352
MESH:D001778 Blood Coagulation Disorders pirinixic acid 13.1119483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 13.1112125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 13.1116206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.3615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.1115746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.118888407
MESH:D001862 Bone Resorption bisphenol A 3.4911985600
MESH:D001913 Bowen's Disease Sulindac 4.9311207687
MESH:D002545 Brain Ischemia resveratrol 3.8717600658
MESH:D001943 Breast Neoplasms bisphenol A 10.4117123778
MESH:D001943 Breast Neoplasms Cobalt 10.4115986119
MESH:D001943 Breast Neoplasms decitabine 10.4119208741 18320071
MESH:D001943 Breast Neoplasms Dietary Fats 10.4120435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 10.4117474063
MESH:D001943 Breast Neoplasms Estradiol 10.4114630087 17018787 12948864 16675129 17289903 18497071 17261762 19861407
MESH:D001943 Breast Neoplasms Nickel 10.4115986119
MESH:D001943 Breast Neoplasms Quercetin 10.4118628248
MESH:D001943 Breast Neoplasms resveratrol 10.4117534123 17651959 16393696
MESH:D001943 Breast Neoplasms Sulindac 10.4116642371
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 10.4120435547
MESH:D001943 Breast Neoplasms Tretinoin 10.4116873071 16443354 16166294
MESH:D001943 Breast Neoplasms Vanadium 10.4115565634
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.1716813970
MESH:D002105 Cadmium Poisoning Quercetin 5.1216962696
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.0416111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.3716097048 15721981 10355542 16227642 16050911 15700767 16124888 15673190 16192424 16011737 3786805 18705752
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.4716835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.7316168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 27.3316705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 27.3316705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 27.333581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 27.333084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 27.3318788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 27.3319171122 18210153 20101231 21159647 16502159 18971187 19701751 16807293 19539802 16779866 16288022 11831363 20214788 3581430 16698587 19822196 16878318 19418558 19383236 20512989 16328049 18665156 17978847 20007298 17138121 20935162 16569478 20084675 16935385 10737359 18978308 20432363 16540662 19519916 17173139 20524982 20514400 18056438 19208518 16681979 17761372 18691550 20727157 19052882 18506893 19335982 16830150 17428255 10672840 18785209 17162532 3084413 18788625 19394651 18393292 18494052 19107877 19919837 17055752
MESH:D006528 Carcinoma, Hepatocellular Estradiol 27.3316924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 27.3317173139 1701930 20007298 6705139 20935162
MESH:D006528 Carcinoma, Hepatocellular Quercetin 27.3319519916 12508355
MESH:D006528 Carcinoma, Hepatocellular resveratrol 27.3319321006 16227395
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 27.331917145
MESH:D006528 Carcinoma, Hepatocellular Vanadium 27.3316830150 16878318
MESH:D002278 Carcinoma in Situ bisphenol A 4.5717123778
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.1716675471
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.5517234771
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.477296757
MESH:D002294 Carcinoma, Squamous Cell decitabine 6.8219215824
MESH:D002294 Carcinoma, Squamous Cell resveratrol 6.8216227395
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 6.8216051514 16096774
MESH:D006332 Cardiomegaly Quercetin 6.0019794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.0016120746 18850075 18670907
MESH:D002318 Cardiovascular Diseases resveratrol 3.1815458977
MESH:D002386 Cataract Acetaminophen 6.3810977129
MESH:D002386 Cataract Tretinoin 6.3817460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 27.336135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 27.337505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 27.3320889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 27.3312371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 27.3317174075 7505956 2727394 21159647
MESH:D002471 Cell Transformation, Neoplastic Estradiol 27.3318566989
MESH:D002471 Cell Transformation, Neoplastic Vanadium 27.3317174075
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.844080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.1716129372
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.5520734317
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.1519052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.1516835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 16.669022650 19486331
MESH:D002779 Cholestasis Cyclosporine 16.6619486331
MESH:D002779 Cholestasis Ethinyl Estradiol 16.6617110522 17333356 16105132 11677210 17681005 15861022 16919318
MESH:D002779 Cholestasis pirinixic acid 16.6619176532
MESH:D002822 Choriocarcinoma Tretinoin 4.7316461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.148697196 15668235 12621046 16354765 15340226
MESH:D002972 Cleft Palate Tretinoin 5.149407595
MESH:D003092 Colitis resveratrol 8.2716474422
MESH:D003092 Colitis Tretinoin 8.2717035595
MESH:D003110 Colonic Neoplasms decitabine 12.8917616700
MESH:D003110 Colonic Neoplasms irinotecan 12.8917287894 17725105
MESH:D003110 Colonic Neoplasms Quercetin 12.8916640504 11134977 19056647 19440933 17148506 17191121 15741050
MESH:D003110 Colonic Neoplasms resveratrol 12.8916338953
MESH:D003110 Colonic Neoplasms Sulindac 12.8912902858 12458338
MESH:D003110 Colonic Neoplasms Vanadium 12.8918155637
MESH:D015179 Colorectal Neoplasms decitabine 5.9718981723
MESH:D015179 Colorectal Neoplasms irinotecan 5.9717159606 18259882 16391804 18509181 16303861 17454858 15273666
MESH:D015179 Colorectal Neoplasms Quercetin 5.9718095365 18852136
MESH:D015179 Colorectal Neoplasms resveratrol 5.9716550006
MESH:D015179 Colorectal Neoplasms Sulindac 5.9711197048 10666051 18059344 11076880
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7114669216 17141729
MESH:D003327 Coronary Disease resveratrol 3.4816507316
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.4620055451 15322242 10048152
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.469664655 16925845 14991402 10589399 9224671 17551590 9142499 9125849 8800419 9211117
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.4617688650 16575769 8888407
MESH:D003490 Cyanosis 2,4-dinitrotoluene 9.5318551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 9.5318551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 13.3011906362 12868966 14531868 8156756 2524372 8970840 18759878 11298694
MESH:D017449 Dermatitis, Allergic Contact cobaltous chloride 13.3011298694 15059100 16823706
MESH:D017449 Dermatitis, Allergic Contact Nickel 13.3017244072 19470301 17100760
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 13.3016823706 16780908 11298694
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2218249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 8.262952479 3621924
MESH:D003877 Dermatitis, Contact Nickel 8.262952479
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 7.4319496084
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 7.4316873680
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 3.8320387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 3.8317107852
MESH:D003928 Diabetic Nephropathies Estradiol 7.8519279558
MESH:D003928 Diabetic Nephropathies resveratrol 7.8516286809
MESH:D003930 Diabetic Retinopathy Sulindac 4.7817621415 12861449
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 19.7418551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 19.7421346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 19.7418692083 9653073 9328219 6679447 1440618 8291058 9022650 16192314 7440962 11289319 18648102 6482804 18289764
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 19.7411743745 14725611 10663392 12958197 2444490 14986274 16393943 16081117 11529661 16227642 12153990 16109766 11739529 16177239 15619225 16781746 17906064 19416960 16485898 19739265 14550746 18071297 19923254 11461765 12540782 15968718 11287661 11421492 17562736 11834606 10915739 17522070 19164858 10774834 19420014 19085960 18713872 19370779 12705907 12594235 12392966
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 19.7421278145 3786805 2869522 7179309 17522070 6623471 10915739 19336974 7440962 3732212 15968718 16227642 9327722 16177239 4309450 19085960 7120509 15027814 6884620 10092053 15998439 11566570
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 19.7419107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 19.7420420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 19.741733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.6719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.4511462148
MESH:D050171 Dyslipidemias Dietary Fats 3.1518367378
MESH:D004421 Dystonia Phenobarbital 9.151851702
MESH:D004421 Dystonia Valproic Acid 9.151851702
MESH:D004487 Edema pirinixic acid 9.2912083418
MESH:D004487 Edema resveratrol 9.298985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 9.2912711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.5215322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 10.5218230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 7.8112538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 7.8117872969
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.6919294695
MESH:D016889 Endometrial Neoplasms Estradiol 6.4911473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Tretinoin 6.4916569247
MESH:D004715 Endometriosis Sulindac 7.9915652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 7.999294722 10568697
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.4417923197
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 9.433659116
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 9.4317275665 3659116
MESH:D004828 Epilepsies, Partial Phenobarbital 8.563922381 11558140
MESH:D004828 Epilepsies, Partial Valproic Acid 8.563922381 16628512
MESH:D004827 Epilepsy Phenobarbital 5.9220417680
MESH:D004827 Epilepsy Valproic Acid 5.9218234410 20417680
MESH:D004832 Epilepsy, Absence Phenobarbital 7.706401628
MESH:D004832 Epilepsy, Absence Valproic Acid 7.706254150 6426943 7562514
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 9.947750514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 9.947750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 9.093659116
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 9.093659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.6916302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 6.613581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.6120426865
MESH:D004938 Esophageal Neoplasms Sulindac 6.6112235107
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.8011564622
MESH:D005124 Eye Abnormalities Tretinoin 7.809664655 16938888
MESH:D005234 Fatty Liver Carbon Tetrachloride 31.2312631006 16045604 15959796 19224547 12795759 61145 16239168 17595544
MESH:D005234 Fatty Liver Cyclosporine 31.2319224547
MESH:D005234 Fatty Liver Dietary Fats 31.2317967931 19004024 18296743 19551842
MESH:D005234 Fatty Liver Diethylnitrosamine 31.2321071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 31.2315345470
MESH:D005234 Fatty Liver pirinixic acid 31.2319236843 20131406
MESH:D005234 Fatty Liver Valproic Acid 31.2314986274 19224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.0511858732
MESH:D005315 Fetal Diseases Valproic Acid 4.4616575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.738888407 18558336
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.596705139
MESH:D018221 Fibromatosis, Abdominal Sulindac 5.0614745880
MESH:D018222 Fibromatosis, Aggressive Sulindac 4.7119069698
MESH:D005355 Fibrosis Carbon Tetrachloride 29.1918705752
MESH:D005355 Fibrosis Cyclosporine 29.1912639820 12168785
MESH:D005355 Fibrosis Dietary Fats 29.1918296743
MESH:D005355 Fibrosis Quercetin 29.1919474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 29.1920067830
MESH:D005355 Fibrosis Tretinoin 29.1917994277
MESH:D005756 Gastritis Acetaminophen 3.2516983495
MESH:D005764 Gastroesophageal Reflux Sulindac 4.6111910360
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.808708960
MESH:D005909 Glioblastoma Manganese 10.4217043766
MESH:D005909 Glioblastoma Quercetin 10.4219804834
MESH:D005909 Glioblastoma Tretinoin 10.4217312396
MESH:D005910 Glioma Quercetin 2.8817643826
MESH:D005911 Gliosis Paraquat 4.7411124998
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.657505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.1710696789
MESH:D006258 Head and Neck Neoplasms decitabine 6.8819215824
MESH:D006258 Head and Neck Neoplasms Tretinoin 6.8816096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.7316084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.7710048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 5.779664655 14991402
MESH:D006333 Heart Failure pirinixic acid 2.2820558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.0015720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.9611000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 7.916705139
MESH:D006505 Hepatitis Carbon Tetrachloride 7.9119110552 19900420
MESH:D006529 Hepatomegaly Phenobarbital 12.0216109766
MESH:D006529 Hepatomegaly pirinixic acid 12.0218467677 19772884 16221962 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 12.0215340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 4.6015709030
MESH:D006561 Herpes Simplex resveratrol 3.7616876885
MESH:D015658 HIV Infections Nickel 3.5917263646
MESH:D019584 Hot Flashes Estradiol 3.3317088409
MESH:D006849 Hydrocephalus Valproic Acid 4.4517688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.6216354765 8697196 18606429 16959395 15340226
MESH:D006930 Hyperalgesia Acetaminophen 6.5316870215
MESH:D006930 Hyperalgesia Tretinoin 6.5316870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.1116899240
MESH:D006937 Hypercholesterolemia Dietary Fats 7.9721332399
MESH:D006937 Hypercholesterolemia resveratrol 7.9717188708
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.1616778211
MESH:D006943 Hyperglycemia pirinixic acid 8.0420558911
MESH:D006943 Hyperglycemia Quercetin 8.0418262572 11834736
MESH:D006949 Hyperlipidemias Dietary Fats 8.0121332399
MESH:D006949 Hyperlipidemias resveratrol 8.0116873680
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.5315034207
MESH:D006973 Hypertension Cobalt 11.0017039479
MESH:D006973 Hypertension Cyclosporine 11.0010903974
MESH:D006973 Hypertension Quercetin 11.0018356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 11.0018850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.6815338365
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 3.9417488730
MESH:D007021 Hypospadias Ethinyl Estradiol 3.4016569931 16945680
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.2417600658
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.0812013081
MESH:D007248 Infertility, Male decitabine 9.6217581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 9.6217937319
MESH:D007248 Infertility, Male Paraquat 9.624850670
MESH:D007249 Inflammation Dietary Fats 17.0020412841
MESH:D007249 Inflammation Diethylnitrosamine 17.0018785209
MESH:D007249 Inflammation Nickel 17.0016166738
MESH:D007249 Inflammation resveratrol 17.0016366677
MESH:D007249 Inflammation Sulindac 17.003291741
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 17.0012200463 12878042
MESH:D007251 Influenza, Human Quercetin 9.7716624496
MESH:D007251 Influenza, Human resveratrol 9.7716624496
MESH:D007333 Insulin Resistance bisphenol A 15.3516393666
MESH:D007333 Insulin Resistance Dietary Fats 15.3511836018 18457598
MESH:D007333 Insulin Resistance Estradiol 15.3516393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 15.3516306350
MESH:D007410 Intestinal Diseases Tretinoin 3.3617994277
MESH:D007414 Intestinal Neoplasms Sulindac 4.2710223192 12584176 10213222 12628509 12351151 12663524
MESH:D007417 Intestinal Polyps Sulindac 4.6012394442 11245490
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.599022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.6916580747
MESH:D007569 Jaw Abnormalities Tretinoin 8.6915992940 17551590
MESH:D007627 Keloid Quercetin 4.5517086741
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.0115604871
MESH:D007674 Kidney Diseases Acetaminophen 12.3812587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 12.3818776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 12.3815618244
MESH:D007674 Kidney Diseases Quercetin 12.3816962696
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 19.7316705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 19.7316705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 19.736582329
MESH:D007680 Kidney Neoplasms Cyclosporine 19.7312371664
MESH:D007680 Kidney Neoplasms Estradiol 19.7315610895
MESH:D007938 Leukemia decitabine 9.2718980019 19235587
MESH:D007938 Leukemia Quercetin 9.2717468513
MESH:D007938 Leukemia Tretinoin 9.2717143497
MESH:D007951 Leukemia, Myeloid decitabine 8.3217236224 19117987 18454857
MESH:D007951 Leukemia, Myeloid Tretinoin 8.3216932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute decitabine 5.6117679729 18206229 18460780 19010910 18704418 19387464
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 5.6119850784 17596541 16294345
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 5.6117596541 16294345
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.0318055864
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 6.8416087638
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 6.8419035177 12679006 16823087 19225113 19075265 17506722 17294898 19029980 19642359 17301526 16140955 16788101 16891316 16331271 17107899 16766008 17361223 17368321 17339181 15748426 9834237 16935935 17217047 17649720 17712046
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.019224671
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 13.7817157831 11408273 16943688 11903743 16221502 17174718 21278145 16239168 17334410
MESH:D008103 Liver Cirrhosis Dietary Fats 13.7818296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 13.7818665156 20032147 18522880 19638242 18407596
MESH:D008103 Liver Cirrhosis Phenobarbital 13.7821047994
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 7.629327722 15034207
MESH:D008105 Liver Cirrhosis, Biliary Sulindac 7.6212468960
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 9.9418187930 18279442 14724832 10355542 12958196 17721639 15893842 15123356 17631135 17761835 18156304 12741479 18429990 16136751 17640975 15818738 15959796 14748882 16015684 18339082 14716833 17869086 18263696 18395914 16011737 12649538 15650968 15362042 17565644 12666154 12609069 12898905 18395095 18376398 13678700 17922224 18054572 12389079 17525996 17714472 12445418 15370692 12445421 12632514 17944888 18412020 12667390 18205269 15876570 12586293 18481824 17823541 11481614 16638106 17976157 14512876 17766677 16248980 20821823 12546737 17900296 15730626 18705752 15996030 16097048 17481882 18418968 17557913 16033810 17805973 16192424 15338365 12632512 18006644 18420326 18251166 18317297 15673190 15057751 17708605 16116963 18472332 15052691 18210741 18166357 15925388 16027843 18472094 14620537 15931870 14716496 17698563 18277467
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 9.9414659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 9.9415474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 9.9412741479
MESH:D008106 Liver Cirrhosis, Experimental S-Adenosylmethionine 9.9415983038
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 9.9412878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 9.9416248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 11.1919014921 12587719 12969438 19784758 19460945 11587558 16611625 16610002
MESH:D008107 Liver Diseases Carbon Tetrachloride 11.1916964402 15830285 16246199 17285989 15720792
MESH:D008107 Liver Diseases Diethylnitrosamine 11.1917034775
MESH:D008107 Liver Diseases Phenobarbital 11.1919363144
MESH:D008107 Liver Diseases Sulindac 11.1914986274 16867024
MESH:D017093 Liver Failure Carbon Tetrachloride 3.7515123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.2016871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.2014706259 16899240
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 22.897678174
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 22.8919294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 22.8921047994 20137499 19850985 18977376 10737359 19426721 2422723 19996281 19256749 21278145 19090486 19812893 19833225 19255062 19073162 20101389 20434301 19294768 18754104 15175105 18644402 20452335 9163691 12112319 18978307 21167192 19551842 12771043 20501860 19690152 20118626 19254457 16942905 20583210 21071580 18648771 20405173 19638242 20492335 19499222 19642983 15885732 2862719 19427195
MESH:D008113 Liver Neoplasms Phenobarbital 22.8919812893 8742319 19073162 21047994 15975961 19482888
MESH:D008113 Liver Neoplasms pirinixic acid 22.8916377806 15890375 20007298
MESH:D008113 Liver Neoplasms Quercetin 22.8918980244
MESH:D008113 Liver Neoplasms resveratrol 22.8920405173 19812893 19321006 19073162
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 22.8916984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 28.602876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 28.60598648 1399818 6587162 3712494
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 28.6015583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 28.6016267830 3124819 19539802 9362446 19009564 17854601 18282651 17942915 18079962 2563599 18308698 19519916 16842330 17174075 18544905 18093689 21159647 18775883 19126423 19004024 18253720 18164116
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 28.6018308698 1399818 2563599 17172636 6150874
MESH:D008114 Liver Neoplasms, Experimental Quercetin 28.6019519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 28.6012151625
MESH:D008114 Liver Neoplasms, Experimental Vanadium 28.6017174075
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 3.8417228818
MESH:D008173 Lung Diseases, Obstructive Cobalt 5.456434250
MESH:D008175 Lung Neoplasms Diethylnitrosamine 4.4120512841 20970405 6695378 21163286
MESH:D008175 Lung Neoplasms Quercetin 4.4116280456
MESH:D008175 Lung Neoplasms Sulindac 4.4115713900 19359593
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.4111884234 19555203
MESH:D008223 Lymphoma decitabine 3.1219470736
MESH:D016393 Lymphoma, B-Cell resveratrol 3.9117088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.5314749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 3.8315688416
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.2516891317 11807958 11408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 5.258985016 11606380
MESH:D020149 Manganese Poisoning Estradiol 11.5819453300
MESH:D020149 Manganese Poisoning Manganese 11.5819453300 16551646 16568477
MESH:D008527 Medulloblastoma Tretinoin 2.6117453147
MESH:D008545 Melanoma decitabine 6.6316505122 17785578
MESH:D008545 Melanoma resveratrol 6.6317992120
MESH:D008545 Melanoma Sulindac 6.6316642371
MESH:D008545 Melanoma Tretinoin 6.6316752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.1619513568
MESH:D008591 Meningomyelocele Tretinoin 4.0216940565
MESH:D008659 Metabolic Diseases resveratrol 4.0017112576
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.3616801185
MESH:D008881 Migraine Disorders Valproic Acid 2.8918765137 18803445
MESH:D009069 Movement Disorders Manganese 4.6216551646
MESH:D052016 Mucositis irinotecan 4.5917159606
MESH:D009101 Multiple Myeloma decitabine 6.5118172295
MESH:D009101 Multiple Myeloma resveratrol 6.5117164350 17049120 14749477 16267019 17935668 16490592
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.4517962980
MESH:D009135 Muscular Diseases pirinixic acid 3.1016239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.658888407
MESH:D009190 Myelodysplastic Syndromes decitabine 10.9116882708 19157545 18608210 19010910
MESH:D009190 Myelodysplastic Syndromes Tretinoin 10.9117596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 10.9117596541
MESH:D009203 Myocardial Infarction pirinixic acid 8.4219151258
MESH:D009203 Myocardial Infarction Quercetin 8.4219595682
MESH:D009203 Myocardial Infarction resveratrol 8.4217015251 16525036 17125593 16317513 16456233 17188708
MESH:D017202 Myocardial Ischemia resveratrol 7.9117125593 17015251
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 7.9112213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 12.3316810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 12.3316411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 12.3319207477
MESH:D009205 Myocarditis resveratrol 4.3417322642
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.0617484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 8.9518551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 8.957678174 18551238
MESH:D009362 Neoplasm Metastasis marker/mechanism 15867226
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 8.493581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 8.493581430 9029167
MESH:D009362 Neoplasm Metastasis irinotecan 8.4918259882
MESH:D009369 Neoplasms decitabine 10.0819470736 19116145 17925555
MESH:D009369 Neoplasms pirinixic acid 10.0817405874
MESH:D009369 Neoplasms Quercetin 10.0815185748
MESH:D009369 Neoplasms Tretinoin 10.0816946489 16594593
MESH:D009374 Neoplasms, Experimental resveratrol 3.608985016
MESH:D009389 Neovascularization, Pathologic Estradiol 3.3217289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.0117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.9318481113 19348381
MESH:D009410 Nerve Degeneration Manganese 12.3516551646
MESH:D009410 Nerve Degeneration Paraquat 12.3516893418
MESH:D009410 Nerve Degeneration Rotenone 12.3518619942 15790535 17356569
MESH:D009421 Nervous System Malformations bisphenol A 20.1716427766 11399458
MESH:D009421 Nervous System Malformations Estradiol 20.1716427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 20.1714600291
MESH:D009421 Nervous System Malformations Tretinoin 20.179125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 10.516679447
MESH:D009436 Neural Tube Defects Tretinoin 10.519142499
MESH:D009436 Neural Tube Defects Valproic Acid 10.518888407 16359493
MESH:D009447 Neuroblastoma irinotecan 3.268761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 17.3318514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 17.3320387270
MESH:D019636 Neurodegenerative Diseases resveratrol 17.3317652729
MESH:D019636 Neurodegenerative Diseases Sulindac 17.3316850258 17266991
MESH:D017599 Neuroectodermal Tumors irinotecan 4.318761367
MESH:D020078 Neurogenic Inflammation Quercetin 9.4117929310
MESH:D020078 Neurogenic Inflammation resveratrol 9.4117929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.6920387270
MESH:C535716 Neuropathy, hereditary motor and sensory, LOM type marker/mechanism
MESH:D009765 Obesity Dietary Fats 4.0420132043 19632207 21332399 18674790 20518802 11836018 17217161 16723640 18457598
MESH:D009765 Obesity pirinixic acid 4.0420558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 12.9712819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 12.9716049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 12.974026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.593988306
MESH:D010018 Osteomalacia Phenobarbital 3.9417016548
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 8.9219495926
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 8.9217513867
MESH:D010049 Ovarian Diseases bisphenol A 4.5711985600
MESH:D010051 Ovarian Neoplasms decitabine 10.0919331143 19259094
MESH:D010051 Ovarian Neoplasms Estradiol 10.0919401270
MESH:D010051 Ovarian Neoplasms Quercetin 10.0919005980
MESH:D010051 Ovarian Neoplasms Tretinoin 10.0916936753
MESH:D010146 Pain Acetaminophen 9.3716870215
MESH:D010146 Pain Sulindac 9.373291741
MESH:D010146 Pain Tretinoin 9.3716870215
MESH:D010190 Pancreatic Neoplasms decitabine 18.3619294695
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 18.3616540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 18.3616965848
MESH:D010190 Pancreatic Neoplasms Quercetin 18.3616965848
MESH:D010190 Pancreatic Neoplasms Sulindac 18.3611504793 16820089
MESH:D010190 Pancreatic Neoplasms Tretinoin 18.3615976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.3011578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.087296757
MESH:D010300 Parkinson Disease Manganese 7.8511181820
MESH:D010300 Parkinson Disease Paraquat 7.8511445065 16140633 15451049 11124998 16510128 15824117 12911755 11181820
MESH:D010300 Parkinson Disease Rotenone 7.8515451049 16412576 11535288 18619942 19114014 16140633 11445065 19232380 18191903
MESH:D010302 Parkinson Disease, Secondary Paraquat 4.0216190885
MESH:D020734 Parkinsonian Disorders Manganese 8.3016140633
MESH:D020734 Parkinsonian Disorders Rotenone 8.3015927086 18197244 15795934 15574749
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.8212520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.046228378
MESH:D011014 Pneumonia Paraquat 4.0312504350
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.1618163543
MESH:D011230 Precancerous Conditions Cyclosporine 18.9912371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 18.992563599
MESH:D011230 Precancerous Conditions Phenobarbital 18.992563599
MESH:D011230 Precancerous Conditions Quercetin 18.9919056647
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 19.8110548101
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 19.8116679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 19.8111896295 11399792 11118676 11222880
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 19.8120603192
MESH:D055728 Primary Myelofibrosis decitabine 4.3217616702
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 9.3120887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 9.3120887781
MESH:D011471 Prostatic Neoplasms bisphenol A 1.9216740699
MESH:D011471 Prostatic Neoplasms Estradiol 1.9216740699
MESH:D011471 Prostatic Neoplasms methylselenic acid 1.9216205645
MESH:D011471 Prostatic Neoplasms Quercetin 1.9214715546 17292933
MESH:D011471 Prostatic Neoplasms resveratrol 1.9217718901 16731767 17636462 17804756 15767336 17675339
MESH:D011507 Proteinuria Tretinoin 3.2216636307
MESH:D011537 Pruritus Ethinyl Estradiol 2.9015861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 10.7712752131
MESH:D019310 Pseudolymphoma Valproic Acid 10.7712752131 11422049
MESH:D011565 Psoriasis Cyclosporine 2.0716882103
MESH:D011625 Pterygium Tretinoin 4.3716723453
MESH:D011629 Puberty, Precocious bisphenol A 4.3710548101
MESH:D011658 Pulmonary Fibrosis Cobalt 5.686434250
MESH:D011658 Pulmonary Fibrosis Paraquat 5.6817997886 16324872
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.1616325855
MESH:D015427 Reperfusion Injury pirinixic acid 5.8519058328
MESH:D015427 Reperfusion Injury resveratrol 5.8516317513 16314181 17058453 15827377 17520802
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 3.5211700416
MESH:D012135 Respiratory Sounds Paraquat 3.6511874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4418990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 7.873692021
MESH:D012162 Retinal Degeneration Paraquat 7.8716458197
MESH:D012208 Rhabdomyosarcoma decitabine 16.2819155313
MESH:D012208 Rhabdomyosarcoma Tretinoin 16.2816283617 16116481
MESH:D012208 Rhabdomyosarcoma Valproic Acid 16.2819155313
MESH:D012554 Schistosomiasis japonica Quercetin 5.1216862918
MESH:D012559 Schizophrenia Valproic Acid 2.0115737665 19110320
MESH:D012640 Seizures 2,4-dinitrotoluene 11.7018551238
MESH:D012640 Seizures 2,6-dinitrotoluene 11.7018551238
MESH:D012640 Seizures Phenobarbital 11.703137016 11442880 16876388 4039156
MESH:D012640 Seizures Valproic Acid 11.701511512 11738929 14763951 15475178 11044598 17978042 3137016 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 4.406407741
MESH:D012878 Skin Neoplasms resveratrol 8.268985016 15837718
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.2616192470
MESH:D012878 Skin Neoplasms Tretinoin 8.2616467112
MESH:D013088 Spermatocele Ethinyl Estradiol 3.5216709447
MESH:D016135 Spinal Dysraphism Valproic Acid 3.4619490988
MESH:D013226 Status Epilepticus Valproic Acid 4.1112833885
MESH:D013274 Stomach Neoplasms decitabine 4.3519037991
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.3518456281
MESH:D013274 Stomach Neoplasms irinotecan 4.3515723263
MESH:D013274 Stomach Neoplasms Tretinoin 4.3517261132
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.1216321402
MESH:D019966 Substance-Related Disorders bisphenol A 3.5716045194 16684133
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.2311994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.8015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.4712697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 23.916582329 7505956 6587162 1399818 3712494
MESH:D013964 Thyroid Neoplasms decitabine 23.9117967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 23.917505956
MESH:D013964 Thyroid Neoplasms N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine 23.9116940797
MESH:D013964 Thyroid Neoplasms Phenobarbital 23.911399818
MESH:D013964 Thyroid Neoplasms Tretinoin 23.9116026305 17045167
MESH:D013978 Tibial Fractures Estradiol 4.2619048282
MESH:D014062 Tongue Neoplasms resveratrol 8.7016227395
MESH:D014062 Tongue Neoplasms Tretinoin 8.7016051514
MESH:D014178 Translocation, Genetic Valproic Acid 4.8117262798
MESH:D014376 Tuberculosis Tretinoin 2.9616040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.103119515
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 13.9016049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 13.9016049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 13.908074119
MESH:D001749 Urinary Bladder Neoplasms decitabine 13.9019087683 17616700
MESH:D001749 Urinary Bladder Neoplasms Quercetin 13.9016720314
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.238888407
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 10.5910091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 10.5910091137
MESH:D014581 Urticaria Acetaminophen 2.6010982225
MESH:D002583 Uterine Cervical Neoplasms resveratrol 8.3317473185
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 8.3316129372
MESH:D014591 Uterine Diseases bisphenol A 4.5814652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 13.8414692618
MESH:D014594 Uterine Neoplasms resveratrol 13.8417044934
MESH:D014594 Uterine Neoplasms Sulindac 13.8418645019
MESH:D014604 Uveal Neoplasms decitabine 11.4017785578
MESH:D014604 Uveal Neoplasms Tretinoin 11.4016752155
MESH:D014605 Uveitis Cyclosporine 3.561336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.1712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.1614671159 15869587
MESH:D018487 Ventricular Dysfunction, Left resveratrol 3.8917488730
MESH:D014820 Vitiligo Tretinoin 3.6616761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8215886252
MESH:D015430 Weight Gain Dietary Fats 3.3916723640
MESH:D009396 Wilms Tumor Tretinoin 3.6116287080
MESH:D014985 Xerophthalmia Cyclosporine 4.0117120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA31482
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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