AutismKB 2.0

Annotation Detail for ADARB1


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Basic Information Top
Gene Symbol:ADARB1 ( ADAR2,DRABA2,DRADA2,RED1 )
Gene Full Name: adenosine deaminase, RNA-specific, B1
Band: 21q22.3
Quick LinksEntrez ID:104; OMIM: 601218; Uniprot ID:RED1_HUMAN; ENSEMBL ID: ENSG00000197381; HGNC ID: 226
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
mRNA Processing
No data
No data
Pathway IDPathway Name
500709Formation of editosomes by ADAR proteins
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1860Brain tumor
1869Behcet syndrome
2045Bipolar disorder
2161Hodgkin's disease
Desease Name
CARDIOVASCULAR
pulmonary function traits (other)
Desease Name
Pulmonary function traits (other)
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of ADARB1 mRNAdecreases expression 19933214
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of ADARB1 mRNAaffects expression 21346803
C000188 alachlor alachlor results in increased expression of ADARB1 mRNAincreases expression 12419858
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ADARB1 mRNAaffects expression 16483693
D016718 Arachidonic Acid Arachidonic Acid results in decreased expression of ADARB1 mRNAdecreases expression 16704987
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of ADARB1 mRNAdecreases expression 20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ADARB1 mRNAdecreases expression 19150397
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of ADARB1 mRNAincreases expression 17484886
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ADARB1 mRNAaffects cotreatment|increases expression 17942748
D008942 Mitoxantrone ADARB1 protein affects the susceptibility to Mitoxantroneaffects response to substance 16217747
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ADARB1 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ADARB1 mRNAdecreases expression 19933214
16962184
C034613 triacsin C triacsin C results in decreased expression of ADARB1 mRNAdecreases expression 16704987
D002762 Cholecalciferol Cholecalciferol results in increased expression of ADARB1 mRNAincreases expression 16508948
D014810 Vitamin E Vitamin E results in decreased expression of ADARB1 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9314514962 15322242 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.6418287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0417505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.2220464547 20127859
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.2214692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.686695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4616835633
MESH:D000382 Agricultural Workers' Diseases alachlor 4.7414769641 11874814
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0011748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1519183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6915885639
MESH:D001321 Autistic Disorder Arachidonic Acid 3.0218582451
MESH:D001327 Autoimmune Diseases Cholecalciferol 5.1016142846
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1012125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8015746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8920146248 17474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8920435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 10.1818705752 16050911 16011737 10355542 15721981 3786805 15700767 16097048 16227642 16192424 15673190 16124888
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 10.1816050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8416835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 3.0116705839
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.0118788625
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0620419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3916120746 18670907 18850075
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.776135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.7720889678
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2116835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.9117681005 15861022 11677210 17110522 17333356 16919318 16105132
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1216354765 15340226 12621046 8697196 15668235
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5010048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.5019769572
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.0918551238
MESH:D017449 Dermatitis, Allergic Contact alachlor 4.268428444
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.2621346803 18551238
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.2617522070 6623471 16227642 19336974 2869522 15998439 9327722 15968718 4309450 7440962 21278145 19085960 15027814 7120509 6884620 3786805 7179309 11566570 10092053 16177239 10915739 3732212
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.2620420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8011462148
MESH:C538011 Eales disease Vitamin E 4.809068938
MESH:D004487 Edema Arachidonic Acid 7.2916716910 11698051 15177302 9831321 7990266 9599246
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.2912711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0018230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2512538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.079294722 10568697
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.3920426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.3916530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0511564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 7.8716239168 61145 17595544 19224547 16045604 12795759 15959796 12631006
MESH:D005234 Fatty Liver Ethinyl Estradiol 7.8715345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5311858732
MESH:D005334 Fever Arachidonic Acid 4.7111852909
MESH:D005355 Fibrosis Carbon Tetrachloride 8.8418705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.8420067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6910696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 11.2620471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 11.2611294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin E 11.2616080930
MESH:D006331 Heart Diseases Mitoxantrone 4.1916019553
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3911000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.6619900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.9612621046 15340226 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7216490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.0714716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1416354765 18606429 8697196 15340226 16959395
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.6116899240
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9218670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.1615338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8816945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5212013081
MESH:D007248 Infertility, Male alachlor 7.1816466525 12948887 17049205
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.1817937319
MESH:D007249 Inflammation Arachidonic Acid 5.409831321 15177302 17371808
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.4012200463 12878042
MESH:D007251 Influenza, Human Vitamin E 4.3116624496
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3916580747
MESH:D007674 Kidney Diseases Vitamin E 2.8312488133
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.0216705839
MESH:D007938 Leukemia alachlor 4.0414769641
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Mitoxantrone 3.8118172266
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8311408273 16221502 16943688 17334410 17157831 16239168 11903743 17174718 21278145
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.4916136751 17708605 18472332 17721639 18705752 18205269 16033810 18418968 12649538 12666154 18472094 10355542 15931870 14716496 17922224 18412020 16638106 14620537 18420326 15818738 12609069 12667390 18395095 17525996 14716833 18251166 15925388 15730626 18054572 17805973 20821823 12546737 14748882 18395914 15057751 17823541 18006644 17761835 16097048 12898905 11481614 12445421 12445418 18279442 17869086 18376398 18277467 17640975 17900296 17557913 17481882 18429990 16015684 18210741 14724832 12632514 18317297 15673190 17631135 12389079 12632512 18156304 16192424 13678700 15052691 15338365 17565644 17714472 17766677 17698563 15123356 16248980 15362042 15370692 18263696 15876570 18187930 14512876 18481824 18339082 18166357 16027843 16011737 15650968 15893842 15959796 12586293 12741479 17976157 16116963 12958196 15996030 17944888
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4912878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.4916169303
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.0915830285 15720792 16246199 16964402 17285989
MESH:D017093 Liver Failure Carbon Tetrachloride 4.2415123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.7416899240 14706259
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 10.847678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 10.8421137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 10.8419294768
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.8416984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 9.982876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 9.9812014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.9812151625
MESH:D008171 Lung Diseases Vitamin E 3.2116863852
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.3918569708 18520028 18816296 17053015 20064080 20464547 20135361 20869020 6695378
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.3911884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 3.3911062179
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2316381670
MESH:D009101 Multiple Myeloma alachlor 4.3214769641
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0612213967
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.9418551238 7678174
MESH:D009369 Neoplasms Benzo(a)pyrene 5.4511141357
MESH:D009369 Neoplasms Mitoxantrone 5.4516640825
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.2814600291
MESH:D009669 Nose Neoplasms alachlor 4.9014563481 15580706 16178123 16698726 11127290
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.4816049721
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7511578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3512520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6218163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.2711896295 11118676 11399792 11222880
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.6717292933
MESH:D011471 Prostatic Neoplasms Cholecalciferol 2.6717024972
MESH:D011471 Prostatic Neoplasms Vitamin E 2.6715084515
MESH:D011537 Pruritus Ethinyl Estradiol 3.3916919318 15861022
MESH:D012135 Respiratory Sounds alachlor 5.0211874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9018990726
MESH:D012640 Seizures 2,6-dinitrotoluene 2.5718551238
MESH:D012871 Skin Diseases Vitamin E 2.4518709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.5510029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.5516192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0416709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D020521 Stroke Vitamin E 3.5616517955
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0012697716
MESH:D013964 Thyroid Neoplasms alachlor 4.318812207
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.0416049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.0417053015
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.4010091137
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3614692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6912125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5914671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3515886252
Pathway ID Pathway Name
REACT:1675 mRNA Processing
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24556
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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