AutismKB 2.0

Annotation Detail for ST3GAL6


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Basic Information Top
Gene Symbol:ST3GAL6 ( SIAT10,ST3GALVI )
Gene Full Name: ST3 beta-galactoside alpha-2,3-sialyltransferase 6
Band: 3q12.1
Quick LinksEntrez ID:10402; OMIM: 607156; Uniprot ID:SIA10_HUMAN; ENSEMBL ID: ENSG00000064225; HGNC ID: 18080
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00601Glycosphingolipid biosynthesis - lacto and neolacto series
hsa01100Metabolic pathways
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1934Cancer
1841Stomach cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of ST3GAL6 mRNAincreases expression 19933214
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in increased expression of ST3GAL6 mRNAincreases expression 20406850
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of ST3GAL6 mRNAaffects expression 21346803
D000638 Amiodarone Amiodarone affects the expression of ST3GAL6 mRNAaffects expression 19483382
D001374 Azacitidine Azacitidine results in increased expression of ST3GAL6 mRNAincreases expression 19194470
D001553 Benzbromarone Benzbromarone affects the expression of ST3GAL6 mRNAaffects expression 19483382
D019324 beta-Naphthoflavone beta-Naphthoflavone results in increased expression of ST3GAL6 mRNAincreases expression 19737606
D002994 Clofibrate Clofibrate affects the expression of ST3GAL6 mRNAaffects expression 19483382
D016572 Cyclosporine Cyclosporine results in decreased expression of ST3GAL6 mRNAdecreases expression 20106945
D002117 Calcitriol Calcitriol results in increased expression of ST3GAL6 mRNAincreases expression 16002434
D005001 Ethionine Ethionine affects the expression of ST3GAL6 mRNAaffects expression 19483382
D009853 Omeprazole Omeprazole affects the expression of ST3GAL6 mRNAaffects expression 19483382
C006253 pirinixic acid pirinixic acid results in increased expression of ST3GAL6 mRNAincreases expression 18301758
17426115
C006253 pirinixic acid pirinixic acid affects the expression of ST3GAL6 mRNAaffects expression 19483382
D011441 Propylthiouracil Propylthiouracil affects the expression of ST3GAL6 mRNAaffects expression 19483382
C009131 pyrimidin-2-one beta-ribofuranoside pyrimidin-2-one beta-ribofuranoside results in increased expression of ST3GAL6 mRNAincreases expression 19194470
D018038 Sodium Selenite Sodium Selenite results in decreased expression of ST3GAL6 mRNAdecreases expression 18175754
C004648 testosterone enanthate testosterone enanthate affects the expression of ST3GAL6 mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ST3GAL6 mRNAincreases expression 19933214
D013853 Thioacetamide Thioacetamide affects the expression of ST3GAL6 mRNAaffects expression 19483382
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.8111752688 14514962 15322242
MESH:D055371 Acute Lung Injury pirinixic acid 3.0818653653
MESH:D000236 Adenoma beta-Naphthoflavone 3.3119389873
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.7816434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.7816835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9111748828
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.7618218290 20041841 18057881
MESH:D001281 Atrial Fibrillation Amiodarone 3.8719698954 18651412
MESH:D001778 Blood Coagulation Disorders Amiodarone 57.8419483382
MESH:D001778 Blood Coagulation Disorders Benzbromarone 57.8419483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 57.8419483382
MESH:D001778 Blood Coagulation Disorders Ethionine 57.8419483382
MESH:D001778 Blood Coagulation Disorders Omeprazole 57.8419483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 57.8419483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 57.8419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 57.8412125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 57.8419483382
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7315746008
MESH:D001943 Breast Neoplasms Calcitriol 2.1211237771
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.1220435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7616835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.7416705839
MESH:D006528 Carcinoma, Hepatocellular Benzbromarone 4.741701930
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 4.7417997003
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 2.6111237771
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3418850075 16120746 18670907
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.8819225199 15710769
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.0518974383
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.076135515
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 11.071399818
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.0712371664
MESH:D002637 Chest Pain Omeprazole 5.0815447763
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.4216835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 9.4218291259
MESH:D002779 Cholestasis Cyclosporine 7.6519486331
MESH:D002779 Cholestasis pirinixic acid 7.6519176532
MESH:D019457 Chromosome Breakage Sodium Selenite 4.7115894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0816354765 12621046 15668235 15340226 8697196
MESH:D015179 Colorectal Neoplasms Azacitidine 2.7219934284
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0217141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2510048152 20055451 15322242
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.9818551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4018249437
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.7416285004
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6617107852
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 11.9018551238 21346803
MESH:D056486 Drug-Induced Liver Injury Amiodarone 11.9015265979 18218290
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 11.9015131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.9020420201
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 11.9012963478
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7311462148
MESH:D004381 Duodenal Ulcer Omeprazole 4.2917151854 21218061 15991576 16613094
MESH:D050171 Dyslipidemias Clofibrate 4.0316707586
MESH:D004487 Edema pirinixic acid 6.4012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.4011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8715322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 3.8915138306
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.989294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9811564622
MESH:D005218 Fat Necrosis Thioacetamide 5.6916456712
MESH:D005234 Fatty Liver Amiodarone 18.4714986274
MESH:D005234 Fatty Liver Clofibrate 18.4719224547
MESH:D005234 Fatty Liver Cyclosporine 18.4719224547
MESH:D005234 Fatty Liver pirinixic acid 18.4720131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4211858732
MESH:D005355 Fibrosis Cyclosporine 8.3512639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.3520067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.188708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3110048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.5120558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3915720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2911000095
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.5317276928 18665440 15929193
MESH:D006505 Hepatitis Thioacetamide 4.1716456712
MESH:D006529 Hepatomegaly Amiodarone 14.1915265979
MESH:D006529 Hepatomegaly pirinixic acid 14.1918467677 19176532 19772884 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 14.1915340226 12621046 16120746
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.7217440010
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.028697196 15340226 16354765 18606429 16959395
MESH:D006937 Hypercholesterolemia Amiodarone 3.838137927 9751232
MESH:D006943 Hyperglycemia pirinixic acid 3.1420558911
MESH:D006973 Hypertension Cyclosporine 4.8910903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.8918850075 18670907
MESH:D007037 Hypothyroidism Amiodarone 11.4818020914 17991464
MESH:D007037 Hypothyroidism Propylthiouracil 11.488137927 18031379
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.8312200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 7.2116306350
MESH:D007333 Insulin Resistance Sodium Selenite 7.2114714311
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2916580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.4115604871
MESH:D007674 Kidney Diseases Cyclosporine 2.318314463 10903974 18776723
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.1516705839
MESH:D007680 Kidney Neoplasms Cyclosporine 7.1512371664
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 4.0619248655
MESH:D007938 Leukemia Azacitidine 3.6719148494
MESH:D007951 Leukemia, Myeloid Azacitidine 4.5819077051
MESH:D015470 Leukemia, Myeloid, Acute Azacitidine 2.9918720364 17596541
MESH:D054429 Leukemia, Myelomonocytic, Juvenile Azacitidine 5.1519299654
MESH:D008064 Lipidoses Amiodarone 3.4815342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4415474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4412878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 3.4415362042 11481614 15465738 12891558 18458672 18032466 12175628 17127702 18031379 15095483 16489207 15078482 17355460 18416461 15158331 16126171 18295389 11682029 16248980 16511523 15716488 15474484 18380797 14739098 15288472 18395095 17292413 16098781 16343077 12557150 10677585 18263696 12085344 18615449 16097051 11172339 12531686 15288473 15334695 12679928 17629604 18606216 15075984 17050028 15316131
MESH:D008107 Liver Diseases Thioacetamide 2.6915158337 16337175 18374380
MESH:D017114 Liver Failure, Acute Thioacetamide 4.2715313186 12479984 15633222 17276928
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 10.567678174
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 10.5619389873 21295105
MESH:D008113 Liver Neoplasms pirinixic acid 10.5620007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.5616984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 9.692876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 9.6918164116
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.6912151625
MESH:D008133 Long QT Syndrome Amiodarone 3.5411989578 15350150 17391786
MESH:D008171 Lung Diseases Amiodarone 3.3412587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.4518516814
MESH:D008175 Lung Neoplasms Azacitidine 2.6021224363
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.6011884234 19555203
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.0214737004
MESH:D008545 Melanoma pyrimidin-2-one beta-ribofuranoside 3.7416505122
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7616801185
MESH:D009006 Monosomy Azacitidine 6.0519299654
MESH:D009101 Multiple Myeloma Azacitidine 3.9319549372 18443271
MESH:D009135 Muscular Diseases pirinixic acid 3.4716239165
MESH:D009181 Mycoses Amiodarone 4.8712754197 17974566
MESH:D009190 Myelodysplastic Syndromes Azacitidine 3.9818720364 17611569 19805378 17596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1219151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9812213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9116411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.837678174 18551238
MESH:D009369 Neoplasms pirinixic acid 1.9317405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.4117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2419348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.1714600291
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 4.909802331
MESH:D009765 Obesity pirinixic acid 1.8020558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.3916049721
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5218163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.1812371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.1611118676 11399792 11896295 11222880
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.7415572423
MESH:D011471 Prostatic Neoplasms Azacitidine 2.7718324645
MESH:D011471 Prostatic Neoplasms Calcitriol 2.7716644109 16289102 12479363 15754350 18247401
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.7718760546
MESH:D011565 Psoriasis Cyclosporine 2.2116882103
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.8411597910 12490602 12832656
MESH:D015427 Reperfusion Injury pirinixic acid 2.3619058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8018990726
MESH:D012640 Seizures 2,6-dinitrotoluene 2.5018551238
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.0518724381
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0216192470
MESH:D013272 Stomach Diseases Omeprazole 4.5818545984
MESH:D013276 Stomach Ulcer Amiodarone 7.4418087811
MESH:D013276 Stomach Ulcer Omeprazole 7.4416755016 15991576 17977527 11906479 18237397 10750652
MESH:D013610 Tachycardia Amiodarone 4.2511238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.1519225199
MESH:D013959 Thyroid Diseases Amiodarone 11.9619731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 11.9612697716
MESH:D013964 Thyroid Neoplasms Propylthiouracil 3.6515710170
MESH:D013971 Thyrotoxicosis Amiodarone 4.8219584973 18020914
MESH:D016171 Torsades de Pointes Amiodarone 4.1511989578 17467628
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.2716049721
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.2810091137
MESH:D014605 Uveitis Cyclosporine 3.961336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5712125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2215886252
MESH:D014985 Xerophthalmia Cyclosporine 4.4117120751
Pathway ID Pathway Name
KEGG:00601 Glycosphingolipid biosynthesis - lacto and neolacto series
KEGG:01100 Metabolic pathways
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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