AutismKB 2.0

Annotation Detail for NDC80


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Basic Information Top
Gene Symbol:NDC80 ( HEC,HEC1,KNTC2,TID3,hsNDC80 )
Gene Full Name: NDC80 homolog, kinetochore complex component (S. cerevisiae)
Band: 18p11.32
Quick LinksEntrez ID:10403; OMIM: 607272; Uniprot ID:NDC80_HUMAN; ENSEMBL ID: ENSG00000080986; HGNC ID: 16909
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Cell Cycle, Mitotic
DNA Replication
Pathway IDPathway Name
200087PLK1 signaling events
200010Aurora B signaling
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of NDC80 proteinaffects expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of NDC80 mRNAdecreases expression 20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of NDC80 mRNAdecreases expression 20382639
20018196
C006780 bisphenol A bisphenol A results in decreased expression of NDC80 mRNAdecreases expression 15223131
C006780 bisphenol A bisphenol A results in increased expression of NDC80 mRNAincreases expression 16474171
D016572 Cyclosporine Cyclosporine results in decreased expression of NDC80 mRNAdecreases expression 20106945
D003561 Cytarabine Cytarabine results in increased expression of NDC80 mRNAincreases expression 19194470
D004317 Doxorubicin NDC80 protein affects the susceptibility to Doxorubicinaffects response to substance 16217747
D004958 Estradiol Estradiol results in increased expression of NDC80 mRNAincreases expression 20106945
16474171
C065180 fluvastatin [zoledronic acid co-treated with fluvastatin] results in increased expression of NDC80 mRNAaffects cotreatment|increases expression 16996129
D019833 Genistein Genistein results in increased expression of NDC80 mRNAincreases expression 16474171
D011078 Polychlorinated Biphenyls Polychlorinated Biphenyls analog results in increased expression of NDC80 mRNAincreases expression 16474171
D011374 Progesterone Progesterone results in increased expression of NDC80 mRNAincreases expression 18070364
C059514 resveratrol resveratrol results in decreased expression of NDC80 mRNAdecreases expression 15767336
C410733 scriptaid scriptaid affects the expression of NDC80 mRNAaffects expression 18813790
C017947 sodium arsenite sodium arsenite results in decreased expression of NDC80 mRNAdecreases expression 17998272
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of NDC80 mRNAdecreases expression 16714409
D014212 Tretinoin Tretinoin results in decreased expression of NDC80 mRNAdecreases expression 18230668
D014635 Valproic Acid Valproic Acid results in decreased expression of NDC80 mRNAdecreases expression 19101580
D014747 Vinblastine NDC80 protein affects the susceptibility to Vinblastineaffects response to substance 16217747
C088658 zoledronic acid [zoledronic acid co-treated with fluvastatin] results in increased expression of NDC80 mRNAaffects cotreatment|increases expression 16996129
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.0315322242 14514962 11752688
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 8.038875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.8419490988
MESH:D058186 Acute Kidney Injury resveratrol 8.8016538975
MESH:D058186 Acute Kidney Injury zoledronic acid 8.8019715164
MESH:D000210 Acute-Phase Reaction zoledronic acid 5.4020200999
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 10.0220464547 20127859
MESH:D000230 Adenocarcinoma Doxorubicin 10.0217418594
MESH:D000230 Adenocarcinoma Estradiol 10.0211473722
MESH:D000230 Adenocarcinoma Genistein 10.0211473722
MESH:D000236 Adenoma Benzo(a)pyrene 6.636695378
MESH:D000236 Adenoma resveratrol 6.6315688382
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.2916835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.6215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.8216712894 17306315
MESH:D000419 Albuminuria Doxorubicin 4.4621441931
MESH:D000505 Alopecia Tretinoin 3.5415955085
MESH:D000544 Alzheimer Disease resveratrol 2.5516183991 16162502
MESH:D000550 Amblyopia Valproic Acid 5.1517688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8711748828
MESH:D001008 Anxiety Disorders Valproic Acid 3.5017497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9919183758
MESH:D001169 Arthritis, Experimental resveratrol 7.3317115116
MESH:D001169 Arthritis, Experimental Tretinoin 7.3316412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2416292516
MESH:D001249 Asthma Tretinoin 2.3216456186
MESH:D050197 Atherosclerosis resveratrol 3.2217967414 16873680
MESH:D001321 Autistic Disorder Valproic Acid 2.0118177632 18985861 18940202 18316065 20603192 17688650 16609825 17507914 18775368 18558336 19232924 19460635 17157402 18396377 15238991
MESH:D001471 Barrett Esophagus Tretinoin 4.3216935849
MESH:D001714 Bipolar Disorder Valproic Acid 3.0317594078 20046352
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.6612125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 8.6616206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.8315746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.838888407
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.6214601052
MESH:D001859 Bone Neoplasms zoledronic acid 4.8719442620 15867366 17312309 16778634 16121404 11697798
MESH:D001862 Bone Resorption bisphenol A 9.5211985600
MESH:D001862 Bone Resorption zoledronic acid 9.5218404659 8053405 16769263 15845617 18496637 11869084
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.2617868700
MESH:D001930 Brain Injuries Progesterone 4.1715665606 15845082 15380490
MESH:D002545 Brain Ischemia resveratrol 4.2017600658
MESH:D001932 Brain Neoplasms Doxorubicin 3.7317150277
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 6.9520146248 17474063
MESH:D001943 Breast Neoplasms bisphenol A 6.9517123778
MESH:D001943 Breast Neoplasms Doxorubicin 6.9519526202 18234424 16264153 17983394 16096432 15994142 11325840 15692762 16115903 15567936 15668708 17426702 18628466 16826403 18695136 16322301 15136595 16935488 16595493 17369602 15634643 15993339 15939500 18382427
MESH:D001943 Breast Neoplasms Estradiol 6.9518497071 19861407 12948864 16675129 14630087 17261762 17018787 17289903
MESH:D001943 Breast Neoplasms Genistein 6.9517200150 16873071 16541309
MESH:D001943 Breast Neoplasms Progesterone 6.9516175315 17614352 15562024
MESH:D001943 Breast Neoplasms resveratrol 6.9516393696 17651959 17534123
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 6.9520435547
MESH:D001943 Breast Neoplasms Tretinoin 6.9516873071 16443354 16166294
MESH:D001943 Breast Neoplasms zoledronic acid 6.9518695136 16096432
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.5016813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.3816111702
MESH:D002276 Carcinoid Tumor Doxorubicin 4.7316051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7316835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.0816168501
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 13.8921507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 13.8916023760 18059187 17876044 16234567
MESH:D006528 Carcinoma, Hepatocellular Estradiol 13.8916924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 13.8916924424
MESH:D006528 Carcinoma, Hepatocellular resveratrol 13.8919321006 16227395
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 13.8916507464 17306315 15276417
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 13.891917145
MESH:D002278 Carcinoma in Situ bisphenol A 4.9017123778
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.5116675471
MESH:D002289 Carcinoma, Non-Small-Cell Lung zoledronic acid 3.5119233551
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 10.811485588 16201981
MESH:D002292 Carcinoma, Renal Cell Vinblastine 10.811485588
MESH:D002292 Carcinoma, Renal Cell zoledronic acid 10.8118507039
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 14.0720419170
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 14.076189445
MESH:D002294 Carcinoma, Squamous Cell resveratrol 14.0716227395
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 14.0718572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 14.0716051514 16096774
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3216120746 18850075 18670907
MESH:D009202 Cardiomyopathies Doxorubicin 3.4717131338 17974986 16651473 16731534 17519947 16278810 17351982 15792986 17329180 16952015 16364871 17924179 15476868 15811867 16242529 17382496 15505089 17928571 16109756 17007740 18627295 16612575 16455267 17308081 16269455
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.9216243910 17334414
MESH:D002318 Cardiovascular Diseases Genistein 7.3116332659
MESH:D002318 Cardiovascular Diseases resveratrol 7.3115458977
MESH:D002386 Cataract Tretinoin 3.0417460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 20.4620889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 20.4612371664
MESH:D002471 Cell Transformation, Neoplastic Cytarabine 20.468243401
MESH:D002471 Cell Transformation, Neoplastic Estradiol 20.4618566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 20.4619524636 20056578
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.5016129372
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.6820734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0816835633
MESH:D002779 Cholestasis Cyclosporine 2.8519486331
MESH:D002822 Choriocarcinoma Tretinoin 5.0816461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.6415668235 12621046 16354765 8697196 15340226
MESH:D002972 Cleft Palate Tretinoin 5.649407595
MESH:D003092 Colitis resveratrol 9.3416474422
MESH:D003092 Colitis Tretinoin 9.3417035595
MESH:D003110 Colonic Neoplasms Genistein 3.8817182828
MESH:D003110 Colonic Neoplasms resveratrol 3.8816338953
MESH:D015179 Colorectal Neoplasms Doxorubicin 4.8318259882 18802399
MESH:D015179 Colorectal Neoplasms Polychlorinated Biphenyls 4.8315531428
MESH:D015179 Colorectal Neoplasms resveratrol 4.8316550006
MESH:D015179 Colorectal Neoplasms Vinblastine 4.8318802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9814669216 17141729
MESH:D003327 Coronary Disease fluvastatin 8.7116142594
MESH:D003327 Coronary Disease resveratrol 8.7116507316
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.7120055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.719125849 16925845 9211117 10589399 14991402 17551590 9664655 8800419 9224671 9142499
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.7117688650 16575769 8888407
MESH:D003704 Dementia Polychlorinated Biphenyls 4.6216140633
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.6916873680
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.2616647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.2617107852
MESH:D003928 Diabetic Nephropathies Estradiol 8.7619279558
MESH:D003928 Diabetic Nephropathies resveratrol 8.7616286809
MESH:D003929 Diabetic Neuropathies Progesterone 4.4117187935
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 6.1117416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.1120420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 6.111733752 19641884
MESH:D004362 Drug Toxicity Doxorubicin 7.8918602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.8911462148
MESH:D004421 Dystonia Valproic Acid 3.961851702
MESH:D004487 Edema resveratrol 6.598985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.5911000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.6716714409 18230668 15322242
MESH:D004489 Edema, Cardiac Tretinoin 11.6718230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 9.0617692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 9.0617872969
MESH:D004714 Endometrial Hyperplasia Genistein 4.5016402032
MESH:D016889 Endometrial Neoplasms Doxorubicin 17.3217359293
MESH:D016889 Endometrial Neoplasms Estradiol 17.3218566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Genistein 17.3211473722
MESH:D016889 Endometrial Neoplasms Tretinoin 17.3216569247
MESH:D004715 Endometriosis Progesterone 8.6616134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.669294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.0818037988
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.7617923197
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.0717275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 3.843922381 16628512
MESH:D004827 Epilepsy Valproic Acid 2.8920417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.517562514 6426943 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.217750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.983659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.2720426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.2716530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.6111564622
MESH:D005124 Eye Abnormalities Tretinoin 8.619664655 16938888
MESH:D005234 Fatty Liver Cyclosporine 7.4919224547
MESH:D005234 Fatty Liver Valproic Acid 7.4914986274 19224547
MESH:D005264 Femoral Fractures zoledronic acid 5.7416234978
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3711858732
MESH:D005315 Fetal Diseases Valproic Acid 4.8116575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.048888407 18558336
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.5019069698
MESH:D005355 Fibrosis Cyclosporine 14.2212639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 14.2220067830
MESH:D005355 Fibrosis Tretinoin 14.2217994277
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.5916452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.138708960
MESH:D005909 Glioblastoma Doxorubicin 11.6017150277
MESH:D005909 Glioblastoma Genistein 11.6016598420
MESH:D005909 Glioblastoma Tretinoin 11.6017312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5110696789
MESH:D006258 Head and Neck Neoplasms Doxorubicin 7.6515692506
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.6516096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.0816084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 10.8220471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.8210048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 10.8214991402 9664655
MESH:D006331 Heart Diseases Doxorubicin 3.4217888722 16879835 16244372 16244371 16330681 18674790 16707910 14766674 12587719 16495754 16144979 18006777 17875725
MESH:D006333 Heart Failure Doxorubicin 3.2917481944
MESH:D006394 Hemangiosarcoma Doxorubicin 3.8215692506
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3415720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2511000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.8115340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 4.9515709030
MESH:D006561 Herpes Simplex resveratrol 4.0916876885
MESH:D006689 Hodgkin Disease Cytarabine 16.9416200630
MESH:D006689 Hodgkin Disease Doxorubicin 16.9418501091 17606976 15147373
MESH:D006689 Hodgkin Disease sodium arsenite 16.9412676792
MESH:D006689 Hodgkin Disease Vinblastine 16.9418180244 18501091
MESH:D019584 Hot Flashes Estradiol 3.6717088409
MESH:D006849 Hydrocephalus Valproic Acid 4.7817688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9616959395 8697196 18606429 15340226 16354765
MESH:D006930 Hyperalgesia Tretinoin 7.9616870215
MESH:D006930 Hyperalgesia zoledronic acid 7.9616769263
MESH:D006934 Hypercalcemia zoledronic acid 4.9619622757 18089816
MESH:D006937 Hypercholesterolemia resveratrol 3.9217188708
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.4816778211
MESH:D006949 Hyperlipidemias resveratrol 3.9416873680
MESH:D006973 Hypertension Cyclosporine 4.8310903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.8318850075 18670907
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.2217488730
MESH:D006996 Hypocalcemia zoledronic acid 6.1112669777
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 11.2015869954
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 11.2017600658
MESH:D007248 Infertility, Male sodium arsenite 2.9315346721 12646999
MESH:D007249 Inflammation Progesterone 8.1015869954
MESH:D007249 Inflammation resveratrol 8.1016366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.1012878042 12200463
MESH:D007251 Influenza, Human resveratrol 4.4616624496
MESH:D007333 Insulin Resistance bisphenol A 7.2416393666
MESH:D007333 Insulin Resistance Estradiol 7.2416393666 16627594
MESH:D007410 Intestinal Diseases Tretinoin 3.6817994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.6616580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.6615992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.3615604871
MESH:D007674 Kidney Diseases Cyclosporine 14.0418776723 10903974 8314463
MESH:D007674 Kidney Diseases Doxorubicin 14.0416775033 15699352 15369732
MESH:D007674 Kidney Diseases Estradiol 14.0415618244
MESH:D007674 Kidney Diseases sodium arsenite 14.0420008137
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.0716707910
MESH:D007680 Kidney Neoplasms Cyclosporine 7.0312371664
MESH:D007680 Kidney Neoplasms Estradiol 7.0315610895
MESH:D007938 Leukemia Genistein 6.2718980019 17468513
MESH:D007938 Leukemia Tretinoin 6.2717143497
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.0816085563
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell zoledronic acid 4.6918089816
MESH:D007951 Leukemia, Myeloid Tretinoin 3.6216932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.8316294345 19850784 17596541
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.8316294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 7.5716087638
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.5717649720 17506722 16788101 19029980 17712046 19225113 17107899 12679006 17339181 17301526 19075265 16935935 17294898 15748426 19642359 16331271 19035177 17368321 16140955 16766008 17361223 17217047 9834237 16891316 16823087
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.249224671
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 6.6316439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.6314716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 6.6317823541
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.6312878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 6.6318397230 16248980
MESH:D008113 Liver Neoplasms Aflatoxin B1 13.8918177683 9163691 2125692 15890375
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 13.8920195826 21137059
MESH:D008113 Liver Neoplasms resveratrol 13.8919812893 20405173 19073162 19321006
MESH:D008113 Liver Neoplasms sodium arsenite 13.8916712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 13.8916984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 13.728603461
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 13.7217085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Polychlorinated Biphenyls 13.721423854
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 13.7212151625
MESH:D008171 Lung Diseases sodium arsenite 3.1119095001
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.1817228818
MESH:D008175 Lung Neoplasms Aflatoxin B1 6.4714755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.4718569708 20869020 20464547 20135361 18816296 18520028 6695378 17053015 20064080
MESH:D008175 Lung Neoplasms Doxorubicin 6.4717418594 6189445
MESH:D008175 Lung Neoplasms sodium arsenite 6.4716712894 17077188 17306315 15276417 19931552
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.4711884234 19555203
MESH:D008223 Lymphoma Doxorubicin 3.4016098063
MESH:D016393 Lymphoma, B-Cell resveratrol 4.2117088997
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 8.6317654614
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 8.6314749477
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.4815621674
MESH:D015674 Mammary Neoplasms, Animal resveratrol 4.1615688416
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 22.8615458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 22.8617203775 11408345 16891317 11807958
MESH:D008325 Mammary Neoplasms, Experimental Genistein 22.8614578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 22.8617203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 22.868985016 11606380
MESH:D008325 Mammary Neoplasms, Experimental zoledronic acid 22.8617312309
MESH:D020149 Manganese Poisoning Estradiol 4.4019453300
MESH:D008527 Medulloblastoma Tretinoin 2.7517453147
MESH:D008545 Melanoma Doxorubicin 9.6616827129
MESH:D008545 Melanoma resveratrol 9.6617992120
MESH:D008545 Melanoma sodium arsenite 9.6619082730 16487513
MESH:D008545 Melanoma Tretinoin 9.6616752155
MESH:D008545 Melanoma Vinblastine 9.6615577320 18332650 15577323 18505091 18176117 16432458 17761969 12374674 16248763 16809738
MESH:D008591 Meningomyelocele Tretinoin 4.3416940565
MESH:D008654 Mesothelioma Doxorubicin 6.5317638057
MESH:D008654 Mesothelioma zoledronic acid 6.5316675582
MESH:D008659 Metabolic Diseases resveratrol 4.2917112576
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7116801185
MESH:D008881 Migraine Disorders Valproic Acid 3.1318765137 18803445
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.4215792986
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1216381670
MESH:D052016 Mucositis Doxorubicin 4.7017415656
MESH:D009101 Multiple Myeloma fluvastatin 12.1016996129
MESH:D009101 Multiple Myeloma resveratrol 12.1014749477 16267019 17049120 16490592 17935668 17164350
MESH:D009101 Multiple Myeloma zoledronic acid 12.1016996129 18089719 19621390
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.7817962980
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.948888407
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.2317596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.2317596541
MESH:D009203 Myocardial Infarction Doxorubicin 9.3915857846 19429709
MESH:D009203 Myocardial Infarction Genistein 9.3917141266
MESH:D009203 Myocardial Infarction resveratrol 9.3916456233 16317513 17015251 16525036 17125593 17188708
MESH:D017202 Myocardial Ischemia resveratrol 8.7717015251 17125593
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.7712213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.2816810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 8.2817141266
MESH:D009205 Myocarditis resveratrol 4.6717322642
MESH:D009362 Neoplasm Metastasis Doxorubicin 6.1618259882
MESH:D009362 Neoplasm Metastasis zoledronic acid 6.1619139120 17312309 15867366
MESH:D009369 Neoplasms Benzo(a)pyrene 8.0111141357
MESH:D009369 Neoplasms sodium arsenite 8.0111559025
MESH:D009369 Neoplasms Tretinoin 8.0116594593 16946489
MESH:D009374 Neoplasms, Experimental resveratrol 8.948985016
MESH:D009374 Neoplasms, Experimental sodium arsenite 8.9420056578
MESH:D009389 Neovascularization, Pathologic Estradiol 3.6517289903
MESH:D009401 Nephrosis Doxorubicin 4.6816636307 16899518
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.3617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 9.0418481113 19348381
MESH:D009404 Nephrotic Syndrome Doxorubicin 9.0416889571 15640375
MESH:D009421 Nervous System Malformations bisphenol A 29.8311399458 16427766
MESH:D009421 Nervous System Malformations Estradiol 29.8311399458 16427766
MESH:D009421 Nervous System Malformations Genistein 29.8316427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 29.8314600291
MESH:D009421 Nervous System Malformations Tretinoin 29.839125849
MESH:D009436 Neural Tube Defects sodium arsenite 11.8212854658
MESH:D009436 Neural Tube Defects Tretinoin 11.829142499
MESH:D009436 Neural Tube Defects Valproic Acid 11.8216359493 8888407
MESH:D009447 Neuroblastoma Doxorubicin 3.2215555623
MESH:D019636 Neurodegenerative Diseases resveratrol 3.7317652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.3117929310
MESH:D009503 Neutropenia Vinblastine 4.4917378895
MESH:D010014 Osteolysis zoledronic acid 5.2815867366
MESH:D010024 Osteoporosis Genistein 7.3919401787
MESH:D010024 Osteoporosis zoledronic acid 7.3917882678
MESH:D015663 Osteoporosis, Postmenopausal Genistein 9.8716169203
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 9.8717513867
MESH:D012516 Osteosarcoma Doxorubicin 4.0415930896
MESH:D010049 Ovarian Diseases bisphenol A 4.9011985600
MESH:D010051 Ovarian Neoplasms Estradiol 14.6919401270
MESH:D010051 Ovarian Neoplasms Genistein 14.6919005980
MESH:D010051 Ovarian Neoplasms Progesterone 14.6917393432 16525653
MESH:D010051 Ovarian Neoplasms sodium arsenite 14.6917306315 15276417
MESH:D010051 Ovarian Neoplasms Tretinoin 14.6916936753
MESH:D010146 Pain Tretinoin 6.9116870215
MESH:D010146 Pain zoledronic acid 6.9116475674
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.4315976015
MESH:D010300 Parkinson Disease Polychlorinated Biphenyls 3.3616702228
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1712520081
MESH:D003557 Phyllodes Tumor Doxorubicin 5.0817983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.0817638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4718163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.1412371664
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cytarabine 4.3921297632
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 22.5610548101
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 22.5616679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 22.5611118676 11399792 11896295 11222880
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 22.5620603192
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 10.2820887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 10.2820887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9417292933
MESH:D011471 Prostatic Neoplasms bisphenol A 2.9416740699
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.9415749863 15897917 16868541 16729912 16888761 18437689
MESH:D011471 Prostatic Neoplasms Estradiol 2.9416740699
MESH:D011471 Prostatic Neoplasms Genistein 2.9415378649 16925846 15256057
MESH:D011471 Prostatic Neoplasms Polychlorinated Biphenyls 2.9415721890
MESH:D011471 Prostatic Neoplasms resveratrol 2.9417675339 15767336 17804756 17636462 16731767 17718901
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.9416039940
MESH:D011471 Prostatic Neoplasms zoledronic acid 2.9412438248 19103299
MESH:D011507 Proteinuria Tretinoin 3.5216636307
MESH:D019310 Pseudolymphoma Valproic Acid 4.4611422049 12752131
MESH:D011565 Psoriasis Cyclosporine 2.2016882103
MESH:D011625 Pterygium Tretinoin 4.7116723453
MESH:D011629 Puberty, Precocious bisphenol A 4.7010548101
MESH:D051437 Renal Insufficiency Doxorubicin 4.1317922066
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.5016325855
MESH:D015427 Reperfusion Injury resveratrol 3.2317520802 15827377 16314181 16317513 17058453
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7518990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 10.5816116481 16283617
MESH:D012208 Rhabdomyosarcoma Valproic Acid 10.5819155313
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8318045962
MESH:D012509 Sarcoma Doxorubicin 3.9117203757 15625365 18313854 16767912 17710206 15675481
MESH:D012512 Sarcoma, Ewing's Doxorubicin 10.3516326096 14601052
MESH:D012512 Sarcoma, Ewing's zoledronic acid 10.3516121404
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.7017846226
MESH:D012559 Schizophrenia Valproic Acid 2.0619110320 15737665
MESH:D012640 Seizures Valproic Acid 2.6814763951 15475178 1511512 11738929 11044598 16876388 3137016 17978042
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 21.9519755658 10029692
MESH:D012878 Skin Neoplasms Doxorubicin 21.9515692506
MESH:D012878 Skin Neoplasms resveratrol 21.9515837718 8985016
MESH:D012878 Skin Neoplasms sodium arsenite 21.9519524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 21.9516192470
MESH:D012878 Skin Neoplasms Tretinoin 21.9516467112
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.4817203757 15625365 16767912
MESH:D013119 Spinal Cord Injuries Progesterone 4.1916503802 15862959
MESH:D016135 Spinal Dysraphism sodium arsenite 9.3112854658
MESH:D016135 Spinal Dysraphism Valproic Acid 9.3119490988
MESH:D013226 Status Epilepticus Valproic Acid 4.4612833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.322093021 20155912
MESH:D013274 Stomach Neoplasms Tretinoin 2.3217261132
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.4016321402
MESH:D019966 Substance-Related Disorders bisphenol A 3.9016684133 16045194
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8212697716
MESH:D013964 Thyroid Neoplasms Doxorubicin 7.0816010429 17909728
MESH:D013964 Thyroid Neoplasms Tretinoin 7.0817045167 16026305
MESH:D013978 Tibial Fractures Estradiol 4.6019048282
MESH:D014062 Tongue Neoplasms resveratrol 9.6516227395
MESH:D014062 Tongue Neoplasms Tretinoin 9.6516051514
MESH:D014178 Translocation, Genetic Valproic Acid 5.1517262798
MESH:D014376 Tuberculosis Tretinoin 3.1716040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.443119515
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.1617053015
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 8.1617653716
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 8.1617306315 11723127 16452187 16712894
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.568888407
MESH:D002583 Uterine Cervical Neoplasms resveratrol 15.4317473185
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 15.4311813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 15.4316129372
MESH:D014591 Uterine Diseases bisphenol A 4.9314652134
MESH:D014594 Uterine Neoplasms resveratrol 4.0517044934
MESH:D014604 Uveal Neoplasms Tretinoin 4.5316752155
MESH:D014605 Uveitis Cyclosporine 3.901336536
MESH:D014625 Vaginal Neoplasms Vinblastine 4.9615577323
MESH:D014652 Vascular Diseases sodium arsenite 4.3417056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5112125929
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 10.0517334414 16364871 17678736 17638931
MESH:D018487 Ventricular Dysfunction, Left resveratrol 10.0517488730
MESH:D014820 Vitiligo Tretinoin 3.9716761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1715886252
MESH:D009396 Wilms Tumor Tretinoin 3.8916287080
MESH:D014985 Xerophthalmia Cyclosporine 4.3617120751
Pathway ID Pathway Name
REACT:152 Cell Cycle, Mitotic
REACT:383 DNA Replication
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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