AutismKB 2.0

Annotation Detail for SPON2


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Basic Information Top
Gene Symbol:SPON2 ( DIL-1,DIL1,DKFZp686G21139,FLJ16313,FLJ22401,FLJ34460,M-spondin,Mindin )
Gene Full Name: spondin 2, extracellular matrix protein
Band: 4p16.3
Quick LinksEntrez ID:10417; OMIM: 605918; Uniprot ID:SPON2_HUMAN; ENSEMBL ID: ENSG00000159674; HGNC ID: 11253
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
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Desease Name
recombination rate (males)
recombination rate (females)
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of SPON2 mRNAincreases expression 19933214
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of SPON2 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of SPON2 mRNAaffects expression 17562736
C109238 acyline acyline results in decreased expression of SPON2 mRNAdecreases expression 17510436
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SPON2 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in decreased expression of SPON2 mRNAdecreases expression 19128835
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of SPON2 mRNAincreases expression 20127859
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of SPON2 mRNAaffects expression 17484886
D016572 Cyclosporine Cyclosporine results in decreased expression of SPON2 mRNAdecreases expression 20106945
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SPON2 mRNAaffects cotreatment|increases expression 17942748
D015741 Metribolone Metribolone results in increased expression of SPON2 mRNAincreases expression 17010196
D008942 Mitoxantrone SPON2 protein affects the susceptibility to Mitoxantroneaffects response to substance 16217747
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SPON2 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of SPON2 mRNAincreases expression 18301758
D011374 Progesterone Progesterone results in decreased expression of SPON2 mRNAdecreases expression 18070364
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SPON2 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of SPON2 mRNAincreases expression 19933214
D014212 Tretinoin Tretinoin results in increased expression of SPON2 mRNAincreases expression 16249480
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.8711752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.5818287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9717505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.1218653653
MESH:D000230 Adenocarcinoma arsenic trioxide 7.0311798837 19825857
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.0320464547 20127859
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.0314692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.656695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.9716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.9716835633
MESH:D000505 Alopecia Tretinoin 3.6215955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9511748828
MESH:D000799 Angioedema Acetaminophen 3.8710982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0919183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.2115885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.2116412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2616292516
MESH:D001249 Asthma Tretinoin 2.3416456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001471 Barrett Esophagus Tretinoin 4.4116935849
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 22.0016206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 22.0019483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 22.0012125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 22.0016197459 16206674
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7615746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.3717868700
MESH:D001930 Brain Injuries Progesterone 4.2715665606 15845082 15380490
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9317474063 20146248
MESH:D001943 Breast Neoplasms Progesterone 1.9315562024 16175315 17614352
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9320435547
MESH:D001943 Breast Neoplasms Tretinoin 1.9316166294 16873071 16443354
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.6116813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.3411589617
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.7916097048 10355542 15700767 16192424 18705752 16227642 15673190 16050911 16124888 15721981 16011737 3786805
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8016835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.1916168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 8.8716705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.873084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 8.8715553829 16217749 11135700 14691202 15073043
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 8.8718788625
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 8.871917145
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.9019014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.1212490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.5720419170
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.5716096774 16051514
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3718850075 16120746 18670907
MESH:D002386 Cataract Acetaminophen 7.2310977129
MESH:D002386 Cataract Tretinoin 7.2317460283
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.5312371664
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.6116129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1616835633
MESH:D002779 Cholestasis Cyclosporine 13.3619486331
MESH:D002779 Cholestasis Ethinyl Estradiol 13.3616919318 16105132 17333356 15861022 17681005 17110522 11677210
MESH:D002779 Cholestasis pirinixic acid 13.3619176532
MESH:D002822 Choriocarcinoma Tretinoin 5.1916461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.7715340226 12621046 8697196 15668235 16354765
MESH:D002972 Cleft Palate Tretinoin 5.779407595
MESH:D003092 Colitis Tretinoin 3.7217035595
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0617141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 4.1912609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.7610525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.7620055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.768800419 9125849 9224671 16925845 9142499 9664655 9211117 17551590 10589399 14991402
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.0318551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.1015213294
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4318249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6717107852
MESH:D003929 Diabetic Neuropathies Progesterone 4.5117187935
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 8.9518551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.9516393943 11461765 17522070 10663392 11421492 16781746 16227642 14550746 12594235 14725611 19164858 12153990 15968718 11739529 19923254 19420014 2444490 12540782 16177239 18713872 16485898 12392966 19370779 18071297 10915739 17906064 17562736 11287661 12958197 11743745 11834606 11529661 16081117 19739265 16109766 19416960 14986274 10774834 19085960 15619225 12705907
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 8.957179309 4309450 21278145 11566570 6884620 6623471 10915739 10092053 16227642 7120509 9327722 3786805 2869522 19336974 19085960 15027814 15968718 17522070 15998439 7440962 3732212 16177239
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.9520420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7611462148
MESH:D004487 Edema pirinixic acid 6.5512083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.5512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 12.0516714409 15322242 18230668
MESH:D004489 Edema, Cardiac Tretinoin 12.0518230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.0712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 9.0717692515
MESH:D016889 Endometrial Neoplasms Tretinoin 3.1116569247
MESH:D004715 Endometriosis Progesterone 8.9416134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.9410568697 9294722
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.4412903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.4416530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.8411564622
MESH:D005124 Eye Abnormalities Tretinoin 8.849664655 16938888
MESH:D005234 Fatty Liver arsenic trioxide 24.7115073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 24.7112795759 17595544 12631006 15959796 16045604 16239168 19224547 61145
MESH:D005234 Fatty Liver Cyclosporine 24.7119224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 24.7115345470
MESH:D005234 Fatty Liver pirinixic acid 24.7119236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4711858732
MESH:D005355 Fibrosis Carbon Tetrachloride 21.2718705752
MESH:D005355 Fibrosis Cyclosporine 21.2712168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 21.2720067830
MESH:D005355 Fibrosis Tretinoin 21.2717994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.2716904648
MESH:D005756 Gastritis Acetaminophen 3.7116983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.248708960
MESH:D005909 Glioblastoma Tretinoin 3.0117312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6210696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.1916096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.1916084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 11.1020471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 11.1010048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 11.109664655 14991402
MESH:D006331 Heart Diseases Mitoxantrone 4.1516019553
MESH:D006333 Heart Failure pirinixic acid 2.5420558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4415720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3411000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.6019110552 19900420
MESH:D006529 Hepatomegaly pirinixic acid 8.3119772884 18467677 16221962 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.3115340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0816354765 16959395 8697196 15340226 18606429
MESH:D006930 Hyperalgesia Acetaminophen 7.6316870215
MESH:D006930 Hyperalgesia Tretinoin 7.6316870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.5516899240
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.5816778211
MESH:D006943 Hyperglycemia pirinixic acid 3.1920558911
MESH:D006973 Hypertension Cyclosporine 4.9510903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.9518670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.1015338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8216945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.4115869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.4917937319
MESH:D007249 Inflammation Progesterone 4.9815869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.9812200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.6316306350
MESH:D007410 Intestinal Diseases Tretinoin 3.7817994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.9516580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.9517551590 15992940
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.4715604871
MESH:D007674 Kidney Diseases Acetaminophen 5.8015629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 5.808314463 18776723 10903974
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.2816705839
MESH:D007680 Kidney Neoplasms Cyclosporine 7.2812371664
MESH:D007938 Leukemia arsenic trioxide 6.3415070760
MESH:D007938 Leukemia Tretinoin 6.3417143497
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Mitoxantrone 3.7918172266
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.8012560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.3316972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.4314633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 9.4919077051
MESH:D007951 Leukemia, Myeloid Tretinoin 9.4916482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.8816467208 17050201 19850784 20471514 16968895
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.8817596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 7.6416966277 17712046 15748426 19035177 16331271 17217047 19075265 15213294 17869043 17649720 16330433 17107899 12679006 11468182 16823087 16891316 19225113 16112521 11161223 15336539 15622746 12018890 9834237 12712474 19642359
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.6416891316 9834237 16935935 16766008 19225113 16331271 17217047 15748426 17301526 16788101 17649720 17368321 17506722 19035177 12679006 19642359 16823087 17339181 19029980 17107899 17361223 19075265 17294898 17712046 16140955
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.3616882451
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.319224671
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8111903743 21278145 11408273 16221502 16943688 16239168 17157831 17174718 17334410
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 4.9218339082 16027843 17976157 12445418 18705752 18156304 16116963 17869086 18317297 16248980 18472332 18412020 20821823 18205269 16011737 16136751 15057751 12586293 14716496 18395914 15959796 18251166 17565644 12632512 16097048 15876570 14716833 12632514 18166357 18054572 18277467 12445421 18420326 17631135 12609069 16192424 17944888 17721639 15362042 17640975 15650968 12546737 15893842 12958196 14748882 18472094 17766677 17922224 11481614 12898905 15052691 15730626 17900296 15996030 17823541 15673190 18187930 12741479 16033810 15370692 14724832 14512876 18481824 12389079 18263696 16015684 15123356 17557913 12666154 17714472 18395095 17525996 17698563 16638106 15925388 18376398 18006644 17805973 15338365 17708605 12649538 12667390 14620537 18210741 18418968 18279442 17761835 15818738 10355542 18429990 13678700 15931870 17481882
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.9215474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.9212878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 4.9216248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 3.9012969438 19784758 16611625 19460945 12587719 11587558 16610002 19014921
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.9017285989 16964402 15830285 15720792 16246199
MESH:D017093 Liver Failure Carbon Tetrachloride 4.1815123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.4217185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.4216899240 14706259
MESH:D008113 Liver Neoplasms arsenic trioxide 14.2414682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 14.2421137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 14.2419294768
MESH:D008113 Liver Neoplasms pirinixic acid 14.2416377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.2416984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 9.8220377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 9.8212014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.8212151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.3515213294
MESH:D008175 Lung Neoplasms arsenic trioxide 3.3619825857 11798837
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.3618816296 20464547 20064080 17053015 20869020 18520028 6695378 18569708 20135361
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.3619555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 2.8717203775 11408345
MESH:D008527 Medulloblastoma Tretinoin 2.7817453147
MESH:D008545 Melanoma Tretinoin 1.9416752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5819513568
MESH:D008591 Meningomyelocele Tretinoin 4.4416940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8216801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1916381670
MESH:D009101 Multiple Myeloma arsenic trioxide 3.1119417148 19549372 15949261 14977855 11468182
MESH:D009135 Muscular Diseases pirinixic acid 3.5216239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.7018349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.3916105982 16882451
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.3917596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1419151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0212213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9516411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.8818551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.9716624393
MESH:D009369 Neoplasms Benzo(a)pyrene 11.9011141357
MESH:D009369 Neoplasms Mitoxantrone 11.9016640825
MESH:D009369 Neoplasms pirinixic acid 11.9017405874
MESH:D009369 Neoplasms Tretinoin 11.9016946489 16594593
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.4717954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2919348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.5414600291
MESH:D009421 Nervous System Malformations Tretinoin 9.549125849
MESH:D009436 Neural Tube Defects arsenic trioxide 7.3110525206
MESH:D009436 Neural Tube Defects Tretinoin 7.319142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8718514411
MESH:D009765 Obesity pirinixic acid 1.8120558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.4312819281 16049721
MESH:D010051 Ovarian Neoplasms arsenic trioxide 7.9216624393 19769630 12452020
MESH:D010051 Ovarian Neoplasms Progesterone 7.9216525653 17393432
MESH:D010051 Ovarian Neoplasms Tretinoin 7.9216936753
MESH:D010146 Pain Acetaminophen 6.5916870215
MESH:D010146 Pain Tretinoin 6.5916870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.2915580305
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.2915976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6911578682
MESH:D010235 Paraganglioma arsenic trioxide 4.1719927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2812520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5718163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.2212371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.2111896295 11399792 11118676 11222880
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.1819131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1817292933
MESH:D011507 Proteinuria Tretinoin 3.6116636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.3316919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.2316882103
MESH:D011625 Pterygium Tretinoin 4.8116723453
MESH:D015427 Reperfusion Injury pirinixic acid 2.3919058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8518990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.1116283617 16116481
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8618045962
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.9716646077
MESH:D012640 Seizures 2,4-dinitrotoluene 2.5318551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.3919755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.3916192470
MESH:D012878 Skin Neoplasms Tretinoin 9.3916467112
MESH:D013088 Spermatocele Ethinyl Estradiol 3.9716709447
MESH:D013119 Spinal Cord Injuries Progesterone 4.3015862959 16503802
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.3417007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.3420155912 2093021
MESH:D013274 Stomach Neoplasms Tretinoin 3.3417261132
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6311994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9312697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.2119014326
MESH:D013964 Thyroid Neoplasms Tretinoin 7.2116026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.7916051514
MESH:D016171 Torsades de Pointes arsenic trioxide 3.9815213294
MESH:D014376 Tuberculosis Tretinoin 3.2316040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.3016049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 8.3020435036 12845720 11780464 12973940
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.3017053015
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.3310091137
MESH:D014581 Urticaria Acetaminophen 2.9810982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.6816129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3114692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.6416752155
MESH:D014605 Uveitis Cyclosporine 4.011336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6212125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5414671159 15869587
MESH:D014820 Vitiligo Tretinoin 4.0716761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2815886252
MESH:D009396 Wilms Tumor Tretinoin 3.9716287080
MESH:D014985 Xerophthalmia Cyclosporine 4.4717120751
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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