AutismKB 2.0

Annotation Detail for PRMT5


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Basic Information Top
Gene Symbol:PRMT5 ( HRMT1L5,IBP72,JBP1,SKB1,SKB1Hs )
Gene Full Name: protein arginine methyltransferase 5
Band: 14q11.2
Quick LinksEntrez ID:10419; OMIM: 604045; Uniprot ID:ANM5_HUMAN; ENSEMBL ID: ENSG00000100462; HGNC ID: 10894
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Metabolism of RNA
Pathway IDPathway Name
200070Signaling events mediated by HDAC Class I
200027E2F transcription factor network
200175p53 pathway
No data
Pathway IDPathway Name
500858snRNP Assembly
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1783Testicular tumor
1841Stomach cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PRMT5 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of PRMT5 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of PRMT5 mRNAincreases expression 18648102
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of PRMT5 mRNAaffects expression 21346803
D020111 Chlorodiphenyl (54% Chlorine) Chlorodiphenyl (54% Chlorine) results in increased expression of PRMT5 mRNAincreases expression 16934159
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PRMT5 mRNAaffects cotreatment|affects expression 17602206
D016572 Cyclosporine Cyclosporine results in increased expression of PRMT5 mRNAincreases expression 20106945
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PRMT5 mRNAaffects cotreatment|affects expression 17602206
D012643 Selenium Selenium results in increased expression of PRMT5 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 4.237525203
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 7.043712494
MESH:D000236 Adenoma Diethylnitrosamine 7.0410737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.1819052882 17162532 18056438 19061943 17620307 16434500
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.3411289319 1440618
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2117474063
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.8016705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.8016705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.803581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.8019539802 18056438 17173139 18691550 19171122 16681979 18393292 16935385 17138121 21159647 19394651 19335982 18785209 3581430 17055752 19208518 16288022 18978308 3084413 18971187 20935162 20007298 10672840 16779866 18788625 19418558 20524982 11831363 20084675 20512989 19701751 18665156 19919837 16328049 18210153 16540662 16502159 16569478 16878318 10737359 19519916 20214788 19052882 20727157 20514400 19822196 16807293 17162532 17428255 20101231 18506893 16830150 17761372 19383236 17978847 19107877 16698587 20432363 18494052
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.767296757
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 3.7414694615
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 17.176135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 17.177505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 17.1712371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 17.1717174075 2727394 21159647 7505956
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.8719052882
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.389022650 19486331
MESH:D002779 Cholestasis Cyclosporine 8.3819486331
MESH:D003092 Colitis Selenium 4.0417936198
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 4.3415095906
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.7718551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.7718551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.0618759878 8970840 12868966 8156756 14531868 11906362 11298694 2524372
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.713621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2320387270
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 19.5618551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 19.5618551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 19.5618289764 1440618 18692083 8291058 9653073 6679447 18648102 9022650 9328219 11289319 16192314 7440962 6482804
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 19.5621346803
MESH:D056486 Drug-Induced Liver Injury Chlorodiphenyl (54% Chlorine) 19.5617851650
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 19.5619107877
MESH:D056486 Drug-Induced Liver Injury Selenium 19.5615131321
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.4416302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.153581430
MESH:D005234 Fatty Liver Cyclosporine 8.4119224547
MESH:D005234 Fatty Liver Diethylnitrosamine 8.4120387270 21071580
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.346705139
MESH:D005355 Fibrosis Cyclosporine 3.4012639820 12168785
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.508708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.267505956
MESH:D006333 Heart Failure Selenium 3.1917162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7115720958
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.756705139
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.2015034207
MESH:D006973 Hypertension Cyclosporine 2.1610903974
MESH:D007249 Inflammation Diethylnitrosamine 2.4718785209
MESH:D007251 Influenza, Human Selenium 4.5116624496
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.348074119 9022650
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7615604871
MESH:D007674 Kidney Diseases Cyclosporine 2.4418776723 10903974 8314463
MESH:D007676 Kidney Failure, Chronic Selenium 4.0916518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 19.2216705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 19.2216705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 19.226582329
MESH:D007680 Kidney Neoplasms Cyclosporine 19.2212371664
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9318522880 18407596 20032147 19638242 18665156
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3115034207 9327722
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1417034775
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.917678174
MESH:D008113 Liver Neoplasms Clofibric Acid 7.9117602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 7.9120137499 19294768 20405173 21071580 18754104 19254457 21278145 2422723 12771043 20101389 19690152 19090486 19638242 19073162 19426721 16942905 19256749 19642983 10737359 2862719 20492335 20434301 18644402 19996281 20452335 18648771 12112319 19255062 19499222 19551842 19812893 19850985 9163691 20583210 20501860 18977376 19427195 18978307 21167192 20118626 15175105 19833225 21047994 15885732
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.566135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 10.561399818 3712494 598648 6587162
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.5619004024 18775883 18308698 16267830 18093689 19009564 17854601 18164116 9362446 17942915 16842330 18544905 19126423 18079962 19519916 18253720 2563599 19539802 21159647 17174075 18282651 3124819
MESH:D008175 Lung Neoplasms Diethylnitrosamine 1.7620512841 21163286 6695378 20970405
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.8815318939
MESH:D008654 Mesothelioma Selenium 2.8615107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1116801185
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.3218551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.327678174 18551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.943581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.943581430 9029167
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4719348381 18481113
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.046679447
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.5120387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.4420387270
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 23.2612819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 23.2616049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 23.266482804 4026338
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 23.2614694615
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.343988306
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4816540662
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.747296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.796228378
MESH:D010954 Plasmacytoma Selenium 5.2115087411
MESH:D011230 Precancerous Conditions Cyclosporine 9.5612371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.562563599
MESH:D011565 Psoriasis Cyclosporine 2.2916882103
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.523692021
MESH:D012640 Seizures 2,4-dinitrotoluene 6.3218551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.3218551238
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.641399818 6582329 3712494 6587162 7505956
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.647505956
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.6916049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.6916049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.698074119
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.9610091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.9610091137
MESH:D014605 Uveitis Cyclosporine 4.301336536
MESH:D014985 Xerophthalmia Cyclosporine 4.7617120751
Pathway ID Pathway Name
REACT:21257 Metabolism of RNA
KEGG:03013 RNA transport
Pharmacogenomics Knowledge Base Top
Drug Bank Top

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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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