AutismKB 2.0

Annotation Detail for CD2BP2


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Basic Information Top
Gene Symbol:CD2BP2 ( FWP010,LIN1,Snu40,U5-52K )
Gene Full Name: CD2 (cytoplasmic tail) binding protein 2
Band: 16p11.2
Quick LinksEntrez ID:10421; OMIM: 604470; Uniprot ID:CD2B2_HUMAN; ENSEMBL ID: ENSG00000169217; HGNC ID: 1656
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
mRNA Processing
Gene Expression
No data
No data
Pathway IDPathway Name
500866mRNA Splicing - Major Pathway
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of CD2BP2 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of CD2BP2 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of CD2BP2 mRNAaffects expression 17562736
D001104 Arbutin Arbutin results in decreased expression of CD2BP2 mRNAdecreases expression 17103032
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of CD2BP2 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CD2BP2 mRNAaffects cotreatment|increases expression 17942748
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CD2BP2 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of CD2BP2 mRNAincreases expression 18301758
D012402 Rotenone Rotenone results in increased expression of CD2BP2 mRNAincreases expression 19013527
D012643 Selenium Selenium results in increased expression of CD2BP2 mRNAincreases expression 19244175
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CD2BP2 mRNAaffects cotreatment|increases expression 17942748
D014303 Trinitrotoluene Trinitrotoluene affects the expression of CD2BP2 mRNAaffects expression 21346803
C025643 vinclozolin vinclozolin affects the expression of CD2BP2 mRNAaffects expression 19015723
D014810 Vitamin E Vitamin E results in increased expression of CD2BP2 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.0911752688 14514962 15322242
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 9.097525203
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1217505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.2318653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8314692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.4216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.4216835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0511748828
MESH:D000799 Angioedema Acetaminophen 4.0210982225
MESH:D001008 Anxiety Disorders vinclozolin 3.7319015723
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7315885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.1419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.1412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8315746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.7020435547
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.0716050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8916835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.6016705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.6016705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.603084413
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4218670907 16120746 18850075
MESH:D002386 Cataract Acetaminophen 7.7110977129
MESH:D002386 Cataract Trinitrotoluene 7.7114694615 15817613
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.846135515
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2616835633
MESH:D002779 Cholestasis Ethinyl Estradiol 8.0117110522 16919318 17333356 16105132 17681005 15861022 11677210
MESH:D002779 Cholestasis pirinixic acid 8.0119176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1412621046 8697196 16354765 15668235 15340226
MESH:D003092 Colitis Selenium 3.9217936198
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 9.6014669216 17141729
MESH:D000013 Congenital Abnormalities Trinitrotoluene 9.6015095906
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5115322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.5119769572
MESH:D003456 Cryptorchidism vinclozolin 4.4714966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 19.6518551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 19.6518551238
MESH:D003490 Cyanosis Trinitrotoluene 19.6518551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4718249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 15.6821346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 15.6821346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 15.6811421492 18071297 11287661 11529661 19085960 14725611 16227642 11743745 10915739 19416960 11834606 11461765 19420014 12705907 16109766 11739529 15619225 16781746 12594235 17562736 15968718 14550746 14986274 10774834 17906064 12540782 12958197 12153990 2444490 16393943 16177239 18713872 19739265 12392966 19164858 10663392 19923254 16485898 17522070 19370779 16081117
MESH:D056486 Drug-Induced Liver Injury Selenium 15.6815131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 15.6820420201
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 15.6818551238 21346803
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8411462148
MESH:C538011 Eales disease Vitamin E 4.889068938
MESH:D004487 Edema pirinixic acid 6.9012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.9011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0818230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3112538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.129294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0911564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 7.9115345470
MESH:D005234 Fatty Liver pirinixic acid 7.9120131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5911858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.0920067830
MESH:D005756 Gastritis Acetaminophen 3.8516983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.0916973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.4716417039
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.7511294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin E 6.7516080930
MESH:D006333 Heart Failure pirinixic acid 7.1720558911
MESH:D006333 Heart Failure Selenium 7.1717162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4411000095
MESH:D006529 Hepatomegaly pirinixic acid 15.3219772884 16221962 19176532 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 15.3212621046 15340226 16120746
MESH:D006529 Hepatomegaly Trinitrotoluene 15.3215817613
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7316863852 16490937
MESH:D019584 Hot Flashes Vitamin E 4.1514716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2216354765 18606429 8697196 16959395 15340226
MESH:D006930 Hyperalgesia Acetaminophen 2.7916870215
MESH:D006943 Hyperglycemia pirinixic acid 3.2920558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9418850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9516569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 11.7217937319
MESH:D007248 Infertility, Male Trinitrotoluene 11.7212150543
MESH:D007248 Infertility, Male vinclozolin 11.7216467254
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9112200463 12878042
MESH:D007251 Influenza, Human Selenium 11.5516624496
MESH:D007251 Influenza, Human Vitamin E 11.5516624496
MESH:D007333 Insulin Resistance pirinixic acid 2.7016306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4416580747
MESH:D007674 Kidney Diseases Acetaminophen 6.1715629191 12587719
MESH:D007674 Kidney Diseases Vitamin E 6.1712488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.9916518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.6716705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.6716705839
MESH:D007984 Leydig Cell Tumor vinclozolin 4.8916417039
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4715474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4712878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.4716169303
MESH:D008107 Liver Diseases Acetaminophen 1.6512587719 19784758 11587558 12969438 16611625 19460945 16610002 19014921
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3416871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.557678174
MESH:D008113 Liver Neoplasms pirinixic acid 7.5520007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.5516984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 5.956135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.9512151625
MESH:D008171 Lung Diseases Vitamin E 3.2516863852
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3319555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 2.3311062179
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.8315318939
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7119513568
MESH:D008654 Mesothelioma Selenium 2.8315107826
MESH:D009135 Muscular Diseases pirinixic acid 3.6416239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1819151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1112213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0316411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 18.7318551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 18.737678174 18551238
MESH:D009336 Necrosis Trinitrotoluene 18.7318551238
MESH:D009369 Neoplasms pirinixic acid 1.9917405874
MESH:D009410 Nerve Degeneration Rotenone 3.9618619942 15790535 17356569
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3414600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9618514411
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 15.8116049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 15.8116049721
MESH:D009784 Occupational Diseases Trinitrotoluene 15.8117852074 12819281 14694615
MESH:D010146 Pain Acetaminophen 2.4816870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8011578682
MESH:D010300 Parkinson Disease Rotenone 3.0111535288 19232380 19114014 16412576 15451049 18619942 11445065 18191903 16140633
MESH:D020734 Parkinsonian Disorders Rotenone 4.1818197244 15927086 15574749 15795934
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4212520081
MESH:D010954 Plasmacytoma Selenium 5.0615087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6918163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.0111896295 11222880 11399792 11118676
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 10.0118042343 19015723 18220299
MESH:D011469 Prostatic Diseases vinclozolin 5.0918220299
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2915084515
MESH:D011472 Prostatitis vinclozolin 5.0918629315
MESH:D011537 Pruritus Ethinyl Estradiol 3.4716919318 15861022
MESH:D015427 Reperfusion Injury pirinixic acid 2.4319058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9618990726
MESH:D012640 Seizures 2,4-dinitrotoluene 10.3518551238
MESH:D012640 Seizures 2,6-dinitrotoluene 10.3518551238
MESH:D012640 Seizures Trinitrotoluene 10.3518551238
MESH:D012871 Skin Diseases Vitamin E 2.4618709164
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0916192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.1216709447
MESH:D013163 Splenomegaly Trinitrotoluene 5.3415817613
MESH:D020521 Stroke Vitamin E 3.6116517955
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0812697716
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.1416049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.1416049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.5110091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.5110091137
MESH:D014581 Urticaria Acetaminophen 3.0910982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4214692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6514671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4215886252
Pathway ID Pathway Name
REACT:71 Gene Expression
REACT:1675 mRNA Processing
Pharmacogenomics Knowledge Base Top
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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