AutismKB 2.0

Annotation Detail for UBAC1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:UBAC1 ( GBDR1,RP11-432J22.3,UBADC1 )
Gene Full Name: UBA domain containing 1
Band: 9q34.3
Quick LinksEntrez ID:10422; OMIM: 608129; Uniprot ID:UBAC1_HUMAN; ENSEMBL ID: ENSG00000130560; HGNC ID: 30221
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of UBAC1 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of UBAC1 mRNAaffects expression 17562736
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of UBAC1 mRNAaffects cotreatment|decreases expression 18164116
D016572 Cyclosporine Cyclosporine results in decreased expression of UBAC1 mRNAdecreases expression 20106945
C014347 decitabine decitabine results in increased expression of UBAC1 mRNAincreases expression 17908484
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of UBAC1 mRNAaffects cotreatment|decreases expression 18164116
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of UBAC1 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of UBAC1 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of UBAC1 mRNAaffects cotreatment|decreases expression 17942748
D013629 Tamoxifen Tamoxifen affects the expression of UBAC1 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of UBAC1 mRNAaffects cotreatment|decreases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.8714745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1311752688 14514962 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2617505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8514692618
MESH:D000236 Adenoma beta-Naphthoflavone 7.2519389873
MESH:D000236 Adenoma Diethylnitrosamine 7.2510737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 11.0317620307 19052882 17162532 18056438 16434500 19061943
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.0316835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1411748828
MESH:D000799 Angioedema Acetaminophen 4.1610982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7815885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8915746008
MESH:D001943 Breast Neoplasms decitabine 1.9719208741 18320071
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9717474063
MESH:D001943 Breast Neoplasms Tamoxifen 1.9720065188 19189212 19155303 20859285 20135344 20390343 18997820 19221464 19066611 19410462 19103187 20544844 20005174 19200415 11161223 19011961 16818667 19487384 18984771 17261762 16273361 17440819 19244106 17893378 18425577 18815881 18821012 18351453 19059307 19288272 17242785 15565566 15668708 19289846 17049068 21138602 16202921 19084267 21152245 19115204 19142967 16873071 19189210 18855134 18629630
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9720435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.7619066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.7816705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.783084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.7817761372 18788625 19701751 19919837 16288022 19208518 18393292 10737359 16779866 20935162 3581430 16698587 18506893 20101231 17978847 20524982 17138121 16540662 19822196 16878318 20007298 16830150 3084413 16681979 18210153 17055752 19052882 16935385 19171122 20514400 21159647 20512989 19539802 16502159 17173139 18665156 19335982 18691550 20214788 19107877 20084675 16569478 17162532 19394651 10672840 18971187 18785209 11831363 16328049 18494052 18978308 16807293 19418558 19519916 20432363 17428255 19383236 18056438 20727157
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.7816924424
MESH:D002294 Carcinoma, Squamous Cell decitabine 2.6419215824
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.8117572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4718850075 16120746 18670907
MESH:D002386 Cataract Acetaminophen 2.6910977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.0612371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 7.062727394 7505956 21159647 17174075
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.9419052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.9416835633
MESH:D002779 Cholestasis Cyclosporine 8.2819486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.2815861022 17681005 17333356 16105132 17110522 11677210 16919318
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1812621046 15340226 15668235 8697196 16354765
MESH:D003110 Colonic Neoplasms decitabine 2.3617616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2417141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 10048152 15322242
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.2718551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.6219031437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.3620387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3617107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.6619279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.3921346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.3919164858 17522070 10774834 16781746 14986274 14550746 16485898 11743745 19370779 17906064 19420014 12540782 16227642 18071297 16109766 19416960 12594235 11739529 16393943 11461765 11834606 18713872 12392966 15968718 19923254 19085960 12958197 11287661 15619225 12705907 16081117 19739265 2444490 11529661 17562736 10663392 10915739 11421492 14725611 12153990 16177239
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 9.3919107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.3920420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9111462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2218230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.7512538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.7519031437
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.4319294695
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1719155303 20544844 16202921 17893378
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2110568697 9294722
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.4416302075
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005234 Fatty Liver Cyclosporine 20.5419224547
MESH:D005234 Fatty Liver Diethylnitrosamine 20.5420387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 20.5415345470
MESH:D005234 Fatty Liver Tamoxifen 20.5419224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3516709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.8114745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.4719069698
MESH:D005355 Fibrosis Cyclosporine 9.3612639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.3620067830
MESH:D005756 Gastritis Acetaminophen 3.9916983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.508708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006258 Head and Neck Neoplasms decitabine 3.6219215824
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4311294989 10048152
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7115720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1516120746 15340226 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3616959395 8697196 16354765 18606429 15340226
MESH:D006930 Hyperalgesia Acetaminophen 2.8616870215
MESH:D006973 Hypertension Cyclosporine 5.1710903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1718670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0716945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6812013081
MESH:D007248 Infertility, Male decitabine 7.1617581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.1617937319
MESH:D007249 Inflammation Diethylnitrosamine 8.8418785209
MESH:D007249 Inflammation Tamoxifen 8.8419457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.8412200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5416580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7615604871
MESH:D007674 Kidney Diseases Acetaminophen 6.1612587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 6.168314463 18776723 10903974
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.4016705839
MESH:D007680 Kidney Neoplasms Cyclosporine 13.4012371664
MESH:D007680 Kidney Neoplasms Tamoxifen 13.4018625569
MESH:D007938 Leukemia decitabine 3.1619235587 18980019
MESH:D007951 Leukemia, Myeloid decitabine 4.2117236224 18454857 19117987
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.4117679729 19010910 18704418 19387464 18206229 18460780
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.7818055864
MESH:D008064 Lipidoses Tamoxifen 3.3017567588 15342952
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9318522880 18407596 20032147 19638242 18665156
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.3318564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3312878042
MESH:D008107 Liver Diseases Acetaminophen 4.0519784758 12969438 11587558 16611625 19460945 19014921 12587719 16610002
MESH:D008107 Liver Diseases Diethylnitrosamine 4.0517034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4316871587 17185352
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 11.2921295105 19389873
MESH:D008113 Liver Neoplasms Diethylnitrosamine 11.2919499222 20101389 21278145 18648771 19426721 19996281 19073162 19090486 12112319 20434301 12771043 18977376 16942905 19255062 18644402 19256749 19638242 20583210 18754104 20118626 20452335 18978307 19690152 20492335 21047994 19254457 20137499 2422723 19427195 19551842 19812893 19294768 19850985 2862719 15175105 20501860 10737359 19642983 9163691 21167192 15885732 20405173 21071580 19833225
MESH:D008113 Liver Neoplasms Tamoxifen 11.2916684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.2916984957
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 10.5818164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.5819519916 3124819 19539802 19126423 17174075 18079962 17854601 18544905 2563599 18775883 19009564 18282651 18093689 19004024 18253720 17942915 18164116 16842330 21159647 9362446 18308698 16267830
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.5812151625
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.4820970405 6695378 21163286 20512841
MESH:D008175 Lung Neoplasms Tamoxifen 3.4818625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4819555203 11884234
MESH:D008223 Lymphoma decitabine 3.5619470736
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.0419428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.7411731420 16827153 14580682 19196723 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.8719453300
MESH:D008545 Melanoma decitabine 3.4917785578 16505122
MESH:D008545 Melanoma Tamoxifen 3.4912393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.4715990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8319513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1116801185
MESH:D009101 Multiple Myeloma decitabine 3.4918172295
MESH:D009190 Myelodysplastic Syndromes decitabine 3.4919010910 19157545 18608210 16882708
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.1418551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.973581430 9029167
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.9719393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5719410462
MESH:D009369 Neoplasms decitabine 2.8019116145 19470736 17925555
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.3219189210 19196722 19200415
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4719348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4514600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.7618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.7620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.4420387270
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.6216049721 12819281
MESH:D010051 Ovarian Neoplasms decitabine 2.7019331143 19259094
MESH:D010146 Pain Acetaminophen 2.5616870215
MESH:D010190 Pancreatic Neoplasms decitabine 5.5719294695
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.5716540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9111578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011230 Precancerous Conditions Cyclosporine 9.5612371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.562563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4811118676 11222880 11399792 11896295
MESH:D055728 Primary Myelofibrosis decitabine 4.9917616702
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.1115067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.6016919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.2916882103
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012208 Rhabdomyosarcoma decitabine 4.6219155313
MESH:D012640 Seizures 2,4-dinitrotoluene 2.6618551238
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1316192470
MESH:D013088 Spermatocele Ethinyl Estradiol 12.6516709447
MESH:D013088 Spermatocele Tamoxifen 12.6516709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.3219457130
MESH:D013274 Stomach Neoplasms decitabine 2.5719037991
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.5718456281
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3315669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D013964 Thyroid Neoplasms decitabine 7.8017967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.807505956
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.7616049721
MESH:D001749 Urinary Bladder Neoplasms decitabine 8.7619087683 17616700
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.768653321 16712894 17572228
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.6010091137
MESH:D014581 Urticaria Acetaminophen 3.2010982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5414692618
MESH:D014604 Uveal Neoplasms decitabine 5.2317785578
MESH:D014605 Uveitis Cyclosporine 4.301336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7514671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
MESH:D014985 Xerophthalmia Cyclosporine 4.7617120751
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved