AutismKB 2.0

Annotation Detail for CDIPT


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:CDIPT ( MGC1328,PIS,PIS1 )
Gene Full Name: CDP-diacylglycerol--inositol 3-phosphatidyltransferase
Band: 16p11.2
Quick LinksEntrez ID:10423; OMIM: 605893; Uniprot ID:CDIPT_HUMAN; ENSEMBL ID: ENSG00000103502; HGNC ID: 1769
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-63523-phosphoinositide biosynthesis
PWY-6351D-myo-inositol (1,4,5)-trisphosphate biosynthesis
Pathway IDPathway Name
hsa00562Inositol phosphate metabolism
hsa00564Glycerophospholipid metabolism
hsa01100Metabolic pathways
hsa04070Phosphatidylinositol signaling system
No data
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of CDIPT mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of CDIPT mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of CDIPT mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of CDIPT mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CDIPT mRNAaffects expression 16483693
D016572 Cyclosporine Cyclosporine results in decreased expression of CDIPT mRNAdecreases expression 20106945
D005472 Fluorouracil Fluorouracil affects the expression of CDIPT mRNAaffects expression 16584549
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of CDIPT mRNAaffects binding|increases expression 16214954
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CDIPT mRNAincreases expression 18796159
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1811752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.9018287403
MESH:D000230 Adenocarcinoma Fluorouracil 2.4717638652
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.883712494
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7116835633
MESH:D000740 Anemia Fluorouracil 9.4515504547 17963324 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 9.4511748828
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.4011289319 1440618
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9115746008
MESH:D001943 Breast Neoplasms Fluorouracil 2.0319217205 16110121 16595493 16557594 15136595 18357371 18608205
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0320435547
MESH:D002276 Carcinoid Tumor Fluorouracil 5.0416051944
MESH:D002277 Carcinoma Fluorouracil 8.8317121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.8316835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 9.2116705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 9.2116705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 9.213581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 9.213084413
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 9.2118930000 16799960 16332177 17971768 17045692 17088986
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 6.827296757
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 6.8218695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 2.5517066447 16280240 18986760 16757204
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4918850075 16120746 18670907
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 12.096135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 12.097505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 12.0912371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3816835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.479022650 19486331
MESH:D002779 Cholestasis Cyclosporine 8.4719486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1912621046 8697196 15668235 16354765 15340226
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2616340194 17725105 17018589 18772588 17016597 16510598 17169374 15001691 17287894 17172411
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0018288408 18448328 16303861 17094418 17454858 14970324 17016601 16391804 15289873 18802399 18383874 17695437 17401013 16524972 17594712 20501625 18949393 17255274 18509181 16282729 15148649 16331619
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2714669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.9418551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.9418551238
MESH:D007644 Darier Disease Fluorouracil 5.1316733453
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.1012868966 8970840 2524372 11298694 8156756 11906362 18759878 14531868
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.752952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 12.6721346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 12.6721346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 12.6718289764 16192314 18692083 1440618 11289319 7440962 6482804 9328219 8291058 9022650 9653073 6679447 18648102
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.6712958197 16177239 17522070 16109766 16781746 19085960 14550746 12392966 14986274 15968718 10663392 19420014 16227642 10774834 17906064 16081117 14725611 11739529 18071297 12540782 11287661 12594235 19739265 15619225 11421492 19164858 12153990 16485898 11461765 19370779 10915739 17562736 11834606 2444490 11529661 18713872 19416960 19923254 12705907 16393943 11743745
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.6720420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9311462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2818230668 15322242 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2510568697 9294722
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.703581430
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.7015173087 16785472 17638652 16337965 16481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1911564622
MESH:D005234 Fatty Liver Cyclosporine 3.1019224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.406705139
MESH:D005355 Fibrosis Cyclosporine 9.5212639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.5220067830
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.568708960
MESH:D005910 Glioma Fluorouracil 2.9516145905
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.307505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.5418337622 15162350 15102660
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4410048152 11294989
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.796705139
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2015340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4216354765 15340226 16959395 18606429 8697196
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.2515034207
MESH:D006973 Hypertension Cyclosporine 5.2110903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.2118670907 18850075
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9612878042 12200463
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.408074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5816580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8215604871
MESH:D007674 Kidney Diseases Acetaminophen 6.2215629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 6.2218776723 10903974 8314463
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 25.6216705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 25.6216705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 25.626582329
MESH:D007680 Kidney Neoplasms Cyclosporine 25.6212371664
MESH:D007680 Kidney Neoplasms Fluorouracil 25.6216985049
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.339327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008107 Liver Diseases Acetaminophen 1.6712969438 12587719 19014921 11587558 19784758 16611625 19460945 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4617185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.877678174
MESH:D008113 Liver Neoplasms Fluorouracil 7.8715113037 16603448 18383874 17045692
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.8716984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.606135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 10.603712494 6587162 1399818 598648
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.6012151625
MESH:D008175 Lung Neoplasms Fluorouracil 2.4015246190
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.4011884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.1315086387
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1616801185
MESH:D009062 Mouth Neoplasms Fluorouracil 3.8118986760 16757204
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2112213967
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.5018551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.507678174 18551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.553581430
MESH:D009369 Neoplasms Fluorouracil 2.7116928823 18600527 18239605
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5018481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4914600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.066679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.5916436463
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 16.4316049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 16.4316049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 16.434026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.403988306
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.7316929163 19003803 15113037 16500647
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.797296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.856228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.4412371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5311896295 11222880 11118676 11399792
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.3718626508 19082440
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D012004 Rectal Neoplasms Fluorouracil 4.2318722050 16160472 18286688 15538739
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.553692021
MESH:D012640 Seizures 2,4-dinitrotoluene 6.3918551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.3918551238
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1416192470
MESH:D013274 Stomach Neoplasms Fluorouracil 2.0017522103 17498489 15786421 18567086 19084572 19015929 17172411 16951190 18396642 16424979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2812697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.061399818 3712494 6587162 6582329 7505956
MESH:D014062 Tongue Neoplasms Fluorouracil 4.2216280240
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.7616049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.7616049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.768074119
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 13.1410091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 13.1410091137
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.1116803524
MESH:D014605 Uveitis Cyclosporine 4.361336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
MESH:D014985 Xerophthalmia Cyclosporine 4.8217120751
Pathway ID Pathway Name
KEGG:00564 Glycerophospholipid metabolism
KEGG:00562 Inositol phosphate metabolism
KEGG:01100 Metabolic pathways
KEGG:04070 Phosphatidylinositol signaling system
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB03106 inhibitor Myo-Inositol Vitamin B Complex
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved