AutismKB 2.0

Annotation Detail for PGRMC2


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Basic Information Top
Gene Symbol:PGRMC2 ( DG6,PMBP )
Gene Full Name: progesterone receptor membrane component 2
Band: 4q28.2
Quick LinksEntrez ID:10424; OMIM: 607735; Uniprot ID:; ENSEMBL ID: ENSG00000164040; HGNC ID: 16089
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PGRMC2 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of PGRMC2 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of PGRMC2 mRNAaffects expression 17562736
D003314 Corn Oil Corn Oil affects the expression of PGRMC2 mRNAaffects expression 16360708
D004040 Dietary Carbohydrates Dietary Carbohydrates results in decreased expression of PGRMC2 mRNAdecreases expression 17490981
D004041 Dietary Fats Dietary Fats results in increased expression of PGRMC2 mRNAincreases expression 15238619
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of PGRMC2 mRNAaffects expression 17555576
D005492 Folic Acid Folic Acid affects the expression of PGRMC2 mRNAaffects expression 17320366
C006253 pirinixic acid pirinixic acid results in increased expression of PGRMC2 mRNAincreases expression 18301758
17426115
D013629 Tamoxifen Tamoxifen affects the expression of PGRMC2 mRNAaffects expression 17555576
C025643 vinclozolin vinclozolin affects the expression of PGRMC2 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.7614745880
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1617505938
MESH:D058186 Acute Kidney Injury Folic Acid 4.4717003819 16316344 16595132
MESH:D055371 Acute Lung Injury pirinixic acid 3.2718653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8414692618
MESH:D000236 Adenoma Folic Acid 3.8716963246
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.6716434500
MESH:D000544 Alzheimer Disease Folic Acid 3.0717116317
MESH:D000799 Angioedema Acetaminophen 4.0610982225
MESH:D001008 Anxiety Disorders vinclozolin 3.7519015723
MESH:D001161 Arteriosclerosis Dietary Fats 10.5015238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 10.5011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7415885639
MESH:D001321 Autistic Disorder Acetaminophen 2.1618445737
MESH:D001321 Autistic Disorder Folic Acid 2.1621388746
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2919483382
MESH:D001943 Breast Neoplasms Dietary Fats 2.0320435547
MESH:D001943 Breast Neoplasms Folic Acid 2.0316777985
MESH:D001943 Breast Neoplasms Tamoxifen 2.0319487384 19084267 18425577 16202921 17242785 19221464 19410462 19142967 20859285 20135344 19288272 19011961 17049068 16273361 15565566 19189210 19066611 19115204 17440819 18629630 19289846 11161223 21138602 19189212 17261762 19059307 21152245 18855134 20065188 18351453 18984771 17893378 19200415 19155303 18997820 19103187 20005174 19244106 20544844 18815881 18821012 20390343 15668708 16818667 16873071
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.6819066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.7116705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.7116705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.713084413
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.7116924424
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.7517572228
MESH:D002318 Cardiovascular Diseases Folic Acid 4.0416755160
MESH:D002386 Cataract Acetaminophen 2.6610977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.866135515
MESH:D002779 Cholestasis Ethinyl Estradiol 8.0917681005 16919318 17110522 16105132 15861022 17333356 11677210
MESH:D002779 Cholestasis pirinixic acid 8.0919176532
MESH:D002971 Cleft Lip Folic Acid 4.0421254359
MESH:D002972 Cleft Palate Folic Acid 3.6221254359 8946559
MESH:D015179 Colorectal Neoplasms Folic Acid 2.7016985020 17087956 17245555 17116713 16963246
MESH:D003456 Cryptorchidism vinclozolin 4.5014966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.4918551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.4918551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.5419031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4818249437
MESH:D003924 Diabetes Mellitus, Type 2 Folic Acid 3.1616886840
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.6019279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.3918551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.3921346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.3911461765 15968718 12153990 16109766 19420014 16177239 12540782 10915739 18713872 17522070 14550746 14725611 11743745 16485898 11739529 2444490 10774834 16393943 18071297 11834606 10663392 19923254 12392966 12594235 15619225 16081117 11529661 17562736 12705907 16227642 19416960 14986274 19739265 19164858 11287661 19370779 17906064 11421492 16781746 19085960 12958197
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3219426721
MESH:D050171 Dyslipidemias Dietary Fats 3.5518367378
MESH:D004487 Edema pirinixic acid 2.6212083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.4912538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.4919031437
MESH:D016889 Endometrial Neoplasms Folic Acid 8.0617301261
MESH:D016889 Endometrial Neoplasms Tamoxifen 8.0616202921 17893378 19155303 20544844
MESH:D017889 Exfoliation Syndrome Folic Acid 5.6916504073
MESH:D005234 Fatty Liver Dietary Fats 19.9619551842 17967931 19004024 18296743
MESH:D005234 Fatty Liver Ethinyl Estradiol 19.9615345470
MESH:D005234 Fatty Liver pirinixic acid 19.9619236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 19.9619224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3116709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.7214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.3819069698
MESH:D005355 Fibrosis Dietary Fats 3.7018296743
MESH:D005756 Gastritis Acetaminophen 12.0116983495
MESH:D005756 Gastritis Folic Acid 12.0117171786
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.1316973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.5216417039
MESH:D005901 Glaucoma Folic Acid 5.2316504073
MESH:D006330 Heart Defects, Congenital Folic Acid 3.8617286298 16524890
MESH:D006333 Heart Failure pirinixic acid 2.6220558911
MESH:D006529 Hepatomegaly pirinixic acid 3.1719176532 16221962 19772884 18467677
MESH:D006679 HIV Seropositivity Folic Acid 5.6917209195
MESH:D006930 Hyperalgesia Acetaminophen 2.8116870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.7321332399
MESH:D006943 Hyperglycemia pirinixic acid 3.3120558911
MESH:D020138 Hyperhomocysteinemia Folic Acid 4.6216865747 16755160 16397167 16395265 16433478
MESH:D006949 Hyperlipidemias Dietary Fats 3.7621332399
MESH:D006968 Hypersensitivity, Delayed Corn Oil 6.0311484837
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9816569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.9617937319
MESH:D007248 Infertility, Male vinclozolin 6.9616467254
MESH:D007249 Inflammation Dietary Fats 5.3220412841
MESH:D007249 Inflammation Tamoxifen 5.3219457130
MESH:D007333 Insulin Resistance Dietary Fats 7.5411836018 18457598
MESH:D007333 Insulin Resistance pirinixic acid 7.5416306350
MESH:D007674 Kidney Diseases Acetaminophen 2.2712587719 15629191
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.1116705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 13.1116705839
MESH:D007680 Kidney Neoplasms Tamoxifen 13.1118625569
MESH:D007984 Leydig Cell Tumor vinclozolin 4.9316417039
MESH:D008064 Lipidoses Tamoxifen 3.2517567588 15342952
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9518296743
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3615474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.3618564211
MESH:D008107 Liver Diseases Acetaminophen 4.3612587719 12969438 11587558 19784758 19460945 16611625 16610002 19014921
MESH:D008107 Liver Diseases Folic Acid 4.3616877991
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3717185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.677678174
MESH:D008113 Liver Neoplasms pirinixic acid 7.6720007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tamoxifen 7.6716684651
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.626135515 2876784 2876786
MESH:D008175 Lung Neoplasms Tamoxifen 1.7418625569
MESH:D008180 Lupus Erythematosus, Systemic Folic Acid 3.3717718048
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.9519428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.7111731420 19196723 14580682 16827153 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.7619453300
MESH:D019767 Maxillofacial Abnormalities Folic Acid 5.8916832597
MESH:D008545 Melanoma Tamoxifen 1.9012393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.3815990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7419513568
MESH:D009135 Muscular Diseases pirinixic acid 3.6816239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1919151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0516411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.0018551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.0018551238 7678174
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.5919393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5519410462
MESH:D009369 Neoplasms pirinixic acid 2.0117405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.2219189210 19196722 19200415
MESH:D009436 Neural Tube Defects Folic Acid 4.0417438019
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9918514411
MESH:D009503 Neutropenia Folic Acid 4.6516322990
MESH:D009765 Obesity Dietary Fats 4.5419632207 18457598 20132043 17217161 20518802 21332399 18674790 16723640 11836018
MESH:D009765 Obesity pirinixic acid 4.5420558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.3316049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.3316049721
MESH:D010146 Pain Acetaminophen 2.5016870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8411578682
MESH:D011230 Precancerous Conditions Corn Oil 5.1714668109
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.0919015723 18220299 18042343
MESH:D011469 Prostatic Diseases vinclozolin 5.1318220299
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.1215067354
MESH:D011472 Prostatitis vinclozolin 5.1318629315
MESH:D011537 Pruritus Ethinyl Estradiol 3.5116919318 15861022
MESH:D051437 Renal Insufficiency Folic Acid 4.9515728788
MESH:D015427 Reperfusion Injury pirinixic acid 2.4519058328
MESH:D012559 Schizophrenia Folic Acid 2.9116641680
MESH:D012640 Seizures 2,4-dinitrotoluene 6.1818551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.1818551238
MESH:D012871 Skin Diseases Folic Acid 3.2818709164
MESH:D013088 Spermatocele Ethinyl Estradiol 12.3016709447
MESH:D013088 Spermatocele Tamoxifen 12.3016709447
MESH:D013118 Spinal Cord Diseases Folic Acid 5.6916361298
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.2319457130
MESH:D013274 Stomach Neoplasms Folic Acid 2.7017171786
MESH:D020521 Stroke Folic Acid 4.4416517955
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2815669648
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.5816049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.5816049721
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.5817572228 8653321 16712894
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.6510091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.6510091137
MESH:D014581 Urticaria Acetaminophen 3.1210982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4614692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6814671159 15869587
MESH:D015430 Weight Gain Dietary Fats 3.8616723640
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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