AutismKB 2.0

Annotation Detail for CDX2


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Basic Information Top
Gene Symbol:CDX2 ( CDX-3,CDX3 )
Gene Full Name: caudal type homeobox 2
Band: 13q12.2
Quick LinksEntrez ID:1045; OMIM: 600297; Uniprot ID:CDX2_HUMAN; ENSEMBL ID: ENSG00000165556; HGNC ID: 1806
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1847Alimentary system disease
1934Cancer
1998Enteritis
2164Barrett's esophagus
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [CDX2 protein results in increased expression of IL1B mRNA]decreases reaction|increases expression 15350541
D000143 Acids Acids results in decreased methylation of CDX2 mRNAdecreases methylation 16990345
D000143 Acids [Acids results in decreased methylation of CDX2 mRNA] which results in increased expression of CDX2 mRNAdecreases methylation|increases expression 16990345
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CDX2 mRNAaffects cotreatment|decreases expression 18164116
D002635 Chenodeoxycholic Acid Chenodeoxycholic Acid results in increased expression of CDX2 mRNAincreases expression 20818264
D002793 Cholic Acids Cholic Acids results in decreased methylation of CDX2 mRNAdecreases methylation 16990345
D002793 Cholic Acids [Cholic Acids results in decreased methylation of CDX2 mRNA] which results in increased expression of CDX2 mRNAdecreases methylation|increases expression 16990345
D003474 Curcumin Curcumin results in increased expression of CDX2 mRNAincreases expression 18299980
C014347 decitabine [decitabine co-treated with CDX2 protein] results in increased expression of KRT20 mRNAaffects cotreatment|increases expression 18845559
C014347 decitabine [decitabine co-treated with CDX2 protein] results in increased expression of RETNLB mRNAaffects cotreatment|increases expression 18845559
C014347 decitabine [decitabine co-treated with CDX2 protein] results in increased expression of SLC26A3 mRNAaffects cotreatment|increases expression 18845559
C014347 decitabine [decitabine co-treated with CDX2 protein] results in increased expression of SLC9A2 mRNAaffects cotreatment|increases expression 18845559
C014347 decitabine [decitabine results in decreased methylation of CDX2 mRNA] which results in increased expression of CDX2 mRNAdecreases methylation|increases expression 16990345
C014347 decitabine decitabine results in decreased methylation of CDX2 promoterdecreases methylation 16990345
C014347 decitabine decitabine results in increased expression of CDX2 mRNAincreases expression 16990345
18845559
C014347 decitabine Methyl Methanesulfonate inhibits the reaction [decitabine results in increased expression of CDX2 mRNA]decreases reaction|increases expression 16990345
C014347 decitabine trichostatin A promotes the reaction [decitabine results in increased expression of CDX2 mRNA]increases expression|increases reaction 16990345
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CDX2 mRNAaffects cotreatment|decreases expression 18164116
D005419 Flavonoids Flavonoids results in increased expression of CDX2 mRNAincreases expression 18035473
D008741 Methyl Methanesulfonate Methyl Methanesulfonate inhibits the reaction [decitabine results in increased expression of CDX2 mRNA]decreases reaction|increases expression 16990345
D008741 Methyl Methanesulfonate Methyl Methanesulfonate results in decreased expression of CDX2 mRNAdecreases expression 16990345
C009166 retinol acetate retinol acetate results in increased expression of CDX2 mRNAincreases expression 16772331
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CDX2 mRNAincreases expression 20106945
C012589 trichostatin A trichostatin A promotes the reaction [decitabine results in increased expression of CDX2 mRNA]increases expression|increases reaction 16990345
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9611752688 15322242 14514962
MESH:D000236 Adenoma beta-Naphthoflavone 7.0319389873
MESH:D000236 Adenoma Diethylnitrosamine 7.0310737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 10.4516434500 19052882 19061943 17162532 17620307 18056438
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.4516835633
MESH:D019973 Alcohol-Related Disorders Curcumin 5.2217887948
MESH:D000544 Alzheimer Disease Curcumin 2.6315590663
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0211748828
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.7516807698
MESH:D050197 Atherosclerosis Curcumin 3.3618704882
MESH:D001327 Autoimmune Diseases Curcumin 4.6019761891
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8115746008
MESH:D002545 Brain Ischemia Curcumin 4.4516770732
MESH:D001932 Brain Neoplasms Curcumin 4.0117596214
MESH:D001943 Breast Neoplasms Curcumin 1.9818593918 16243823 19250217 18462866
MESH:D001943 Breast Neoplasms decitabine 1.9819208741 18320071
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9817474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9820435547
MESH:D002277 Carcinoma Curcumin 8.5018593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.5016835633
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 1.8510672840 18210153 18691550 20432363 20214788 16779866 16681979 17162532 19208518 20935162 16540662 17761372 19919837 20524982 16569478 16807293 18978308 3581430 16830150 19519916 16698587 11831363 16935385 10737359 16328049 18056438 16288022 18785209 17173139 20101231 20514400 18393292 16502159 18971187 17055752 18494052 19171122 20007298 17138121 19383236 19539802 20512989 17978847 19394651 18788625 19052882 18506893 19335982 16878318 20084675 20727157 19107877 19701751 19822196 3084413 18665156 19418558 17428255 21159647
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 3.0018414057
MESH:D002294 Carcinoma, Squamous Cell Curcumin 5.0118462866
MESH:D002294 Carcinoma, Squamous Cell decitabine 5.0119215824
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4118850075 16120746 18670907
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 2.917505956 2727394 21159647 17174075
MESH:D002637 Chest Pain Acids 6.5415447763
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.5719052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.5716835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1315668235 15340226 8697196 12621046 16354765
MESH:D003092 Colitis Curcumin 4.2816782535 18200517 16804969
MESH:D003103 Coloboma Curcumin 4.6318809619
MESH:D003110 Colonic Neoplasms Curcumin 4.0119359593 16340194
MESH:D003110 Colonic Neoplasms decitabine 4.0117616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1314669216 17141729
MESH:D016510 Corneal Neovascularization Curcumin 5.0018497527
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 7.2518403477
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 7.2520387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 7.2517107852
MESH:D003928 Diabetic Nephropathies Curcumin 4.0818204486
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 3.8019107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.8020420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8211462148
MESH:D004381 Duodenal Ulcer Curcumin 4.1417351913
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4612711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0418230668 16714409 15322242
MESH:D004701 Endocrine Gland Neoplasms decitabine 14.4819294695
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 14.4819294695
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1010568697 9294722
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.2516302075
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0711564622
MESH:D005234 Fatty Liver Curcumin 8.3019297423
MESH:D005234 Fatty Liver Diethylnitrosamine 8.3020387270 21071580
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D005355 Fibrosis Curcumin 9.1418705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.1420067830
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.8018462866
MESH:D005909 Glioblastoma Curcumin 7.7617596214
MESH:D005909 Glioblastoma trichostatin A 7.7618801729
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006258 Head and Neck Neoplasms Curcumin 8.1818829502 18462866
MESH:D006258 Head and Neck Neoplasms decitabine 8.1819215824
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3710048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0012621046 16120746 15340226
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 5.1417701891
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1816354765 15340226 18606429 8697196 16959395
MESH:D006937 Hypercholesterolemia Curcumin 4.1318704882
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9318670907 18850075
MESH:D007248 Infertility, Male decitabine 3.2517581917
MESH:D007249 Inflammation Curcumin 12.3216956363 17151092 18403477
MESH:D007249 Inflammation Diethylnitrosamine 12.3218785209
MESH:D007249 Inflammation Flavonoids 12.3217296493
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 12.3212878042 12200463
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.2418596194 18200517
MESH:D007414 Intestinal Neoplasms Curcumin 4.2910783313
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4216580747
MESH:D007889 Leiomyoma Curcumin 4.6618555241
MESH:D007938 Leukemia 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 10.9212970779
MESH:D007938 Leukemia Curcumin 10.9218462866
MESH:D007938 Leukemia decitabine 10.9218980019 19235587
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 4.2816106398
MESH:D007951 Leukemia, Myeloid decitabine 4.0819117987 18454857 17236224
MESH:D015470 Leukemia, Myeloid, Acute decitabine 4.3219387464 18704418 18206229 19010910 17679729 18460780
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 4.3218206229
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.6018055864
MESH:D015458 Leukemia, T-Cell Curcumin 4.8616106398
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8719638242 18665156 18407596 18522880 20032147
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 2.5018006644 17355460 18705752
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.5012878042
MESH:D008107 Liver Diseases Curcumin 4.3316956363
MESH:D008107 Liver Diseases Diethylnitrosamine 4.3317034775
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 7.6319389873 21295105
MESH:D008113 Liver Neoplasms Diethylnitrosamine 7.6315175105 16942905 19996281 21047994 20583210 19833225 21071580 15885732 2862719 2422723 18977376 9163691 19255062 18644402 19642983 19427195 20101389 19551842 18648771 19090486 21167192 20405173 19254457 18754104 19638242 20492335 20137499 20501860 12771043 19073162 19294768 10737359 19690152 19850985 12112319 19256749 21278145 19812893 19426721 20434301 19499222 20452335 20118626 18978307
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.6316984957
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 10.1518164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.1519009564 18253720 16267830 21159647 19539802 18093689 19519916 18544905 19004024 18775883 18308698 3124819 16842330 19126423 9362446 18164116 18282651 17854601 17174075 18079962 2563599 17942915
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.1512151625
MESH:D008175 Lung Neoplasms Curcumin 3.4919359593 18462866 16243823
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.4921163286 20970405 20512841 6695378
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4911884234 19555203
MESH:D008223 Lymphoma Curcumin 7.9718462866
MESH:D008223 Lymphoma decitabine 7.9719470736
MESH:D016399 Lymphoma, T-Cell Curcumin 4.8016173963
MESH:D008545 Melanoma Curcumin 5.3917885582 18462866
MESH:D008545 Melanoma decitabine 5.3917785578 16505122
MESH:D008545 Melanoma trichostatin A 5.3916505122
MESH:D008569 Memory Disorders Curcumin 4.2517263510
MESH:D009101 Multiple Myeloma Curcumin 12.6319372569
MESH:D009101 Multiple Myeloma decitabine 12.6318172295
MESH:D009101 Multiple Myeloma trichostatin A 12.6318172295
MESH:D009134 Muscular Atrophy, Spinal Curcumin 5.0317962980
MESH:D009190 Myelodysplastic Syndromes decitabine 3.4319157545 16882708 19010910 18608210
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0812213967
MESH:D009361 Neoplasm Invasiveness Curcumin 4.4618495463
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.599029167 3581430
MESH:D009369 Neoplasms decitabine 2.7519116145 19470736 17925555
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.6712497104
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3114600291
MESH:D009423 Nervous System Neoplasms Curcumin 5.7618462866
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.4120387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.2520387270
MESH:D009765 Obesity Curcumin 2.7619297423
MESH:D010024 Osteoporosis Curcumin 3.5218719352
MESH:D010051 Ovarian Neoplasms 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 11.6216211241
MESH:D010051 Ovarian Neoplasms Curcumin 11.6218462866 19020741
MESH:D010051 Ovarian Neoplasms decitabine 11.6219331143 19259094
MESH:D010051 Ovarian Neoplasms trichostatin A 11.6219331143
MESH:D010190 Pancreatic Neoplasms Curcumin 12.6319196508 17440100 19401701
MESH:D010190 Pancreatic Neoplasms decitabine 12.6319294695
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 12.6316540662
MESH:D010190 Pancreatic Neoplasms trichostatin A 12.6319294695
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.622563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3111399792 11896295 11222880 11118676
MESH:D055728 Primary Myelofibrosis decitabine 12.7817616702
MESH:D055728 Primary Myelofibrosis trichostatin A 12.7817616702
MESH:D011471 Prostatic Neoplasms Curcumin 3.7018226269 12497104 11398177 15129424 18769126 10851300 18156803
MESH:D011471 Prostatic Neoplasms trichostatin A 3.7018798265 19789329
MESH:D011656 Pulmonary Emphysema Curcumin 4.6019168576
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 4.1110666014 18379247
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012208 Rhabdomyosarcoma decitabine 4.4919155313
MESH:D012509 Sarcoma Curcumin 4.1918462866
MESH:D018805 Sepsis Curcumin 4.1418389075
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0816192470
MESH:D013274 Stomach Neoplasms decitabine 2.5519037991
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.5518456281
MESH:D013276 Stomach Ulcer Curcumin 3.5819188055 16631530
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D013964 Thyroid Neoplasms decitabine 7.4917967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.497505956
MESH:D014376 Tuberculosis Chenodeoxycholic Acid 5.0816040207
MESH:D001749 Urinary Bladder Neoplasms Curcumin 5.4918593936
MESH:D001749 Urinary Bladder Neoplasms decitabine 5.4919087683 17616700
MESH:D014565 Urogenital Neoplasms Curcumin 5.3818462866
MESH:D014604 Uveal Neoplasms decitabine 5.0517785578
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26352
    • Releated gene ID Related gene Name
    PA30696MCM6
    No data
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    Drug Bank Top

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      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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