AutismKB 2.0

Annotation Detail for VAV3


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Basic Information Top
Gene Symbol:VAV3 ( FLJ40431 )
Gene Full Name: vav 3 guanine nucleotide exchange factor
Band: 1p13.3
Quick LinksEntrez ID:10451; OMIM: 605541; Uniprot ID:VAV3_HUMAN; ENSEMBL ID: ENSG00000134215; HGNC ID: 12659
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04670Leukocyte transendothelial migration
hsa04650Natural killer cell mediated cytotoxicity
hsa04810Regulation of actin cytoskeleton
hsa04510Focal adhesion
hsa04062Chemokine signaling pathway
hsa04660T cell receptor signaling pathway
hsa04662B cell receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
Pathway IDPathway Name
Signaling by GPCR
Signalling by NGF
Hemostasis
Signaling by Rho GTPases
Pathway IDPathway Name
200038Coregulation of Androgen receptor activity
200185EPHA2 forward signaling
200121EPHA forward signaling
200165Regulation of RAC1 activity
200042Osteopontin-mediated events
200109Integrins in angiogenesis
200050Regulation of RhoA activity
200059Regulation of CDC42 activity
Pathway IDPathway Name
P00053T cell activation
P00010B cell activation
P00047PDGF signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of VAV3 mRNAincreases expression 19933214
C061133 Am 80 Am 80 results in decreased expression of VAV3 mRNAdecreases expression 17229644
C006632 arsenic trioxide arsenic trioxide results in increased expression of VAV3 mRNAincreases expression 20458559
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in decreased expression of VAV3 mRNAdecreases expression 18687144
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of VAV3 mRNAdecreases expression 20064835
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of VAV3 mRNAincreases expression 20713471
D001966 Bromine Bromine results in decreased expression of VAV3 mRNAdecreases expression 18790026
D002945 Cisplatin VAV3 protein affects the susceptibility to Cisplatinaffects response to substance 16217747
D002117 Calcitriol Calcitriol results in decreased expression of VAV3 mRNAdecreases expression 16002434
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of VAV3 mRNAaffects cotreatment|decreases expression 19619570
D004958 Estradiol Estradiol results in increased expression of VAV3 mRNAincreases expression 19619570
D005472 Fluorouracil Fluorouracil results in decreased expression of VAV3 mRNAdecreases expression 16557594
C533894 LG 100815 LG 100815 results in decreased expression of VAV3 mRNAdecreases expression 16951191
D047311 Luteolin Luteolin results in decreased expression of VAV3 mRNAdecreases expression 19397994
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of VAV3 mRNAincreases expression 20713471
D009151 Mustard Gas Mustard Gas results in decreased expression of VAV3 mRNAdecreases expression 18988085
C062198 octa-2,4,6-trienoic acid octa-2,4,6-trienoic acid results in decreased expression of VAV3 mRNAdecreases expression 16951191
C006253 pirinixic acid pirinixic acid results in increased expression of VAV3 mRNAincreases expression 17426115
C059514 resveratrol resveratrol results in decreased expression of VAV3 mRNAdecreases expression 19371625
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of VAV3 mRNAaffects cotreatment|decreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of VAV3 mRNAdecreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of VAV3 mRNAincreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of VAV3 mRNAdecreases expression 19465110
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of VAV3 mRNAincreases expression 19933214
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.8114514962 11752688 15322242
MESH:D058186 Acute Kidney Injury Cisplatin 8.7517670903 12690470 15814532
MESH:D058186 Acute Kidney Injury resveratrol 8.7516538975
MESH:D055371 Acute Lung Injury pirinixic acid 3.0818653653
MESH:D000230 Adenocarcinoma arsenic trioxide 13.4511798837 19825857
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 13.4520127859 20464547
MESH:D000230 Adenocarcinoma Cisplatin 13.4517638652 11798837
MESH:D000230 Adenocarcinoma Estradiol 13.4511473722
MESH:D000230 Adenocarcinoma Fluorouracil 13.4517638652
MESH:D000236 Adenoma Benzo(a)pyrene 11.156695378
MESH:D000236 Adenoma Methylcholanthrene 11.156695378 10545420
MESH:D000236 Adenoma resveratrol 11.1515688382
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.7816434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.7816835633
MESH:D000544 Alzheimer Disease resveratrol 2.5616183991 16162502
MESH:D000740 Anemia Fluorouracil 8.5515504547 17963324 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.5511748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0319183758
MESH:D001169 Arthritis, Experimental resveratrol 3.4717115116
MESH:D001172 Arthritis, Rheumatoid Am 80 3.7416819260
MESH:D001249 Asthma Mustard Gas 2.7010378619
MESH:D050197 Atherosclerosis Am 80 11.1216484594
MESH:D050197 Atherosclerosis Methylcholanthrene 11.1211922910
MESH:D050197 Atherosclerosis resveratrol 11.1217967414 16873680
MESH:D001768 Blister Mustard Gas 5.1219167455
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 15.0516206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 15.0519483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 15.0512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7315746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 4.8614601052
MESH:D002545 Brain Ischemia resveratrol 4.2517600658
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 4.7117474063 20146248
MESH:D001943 Breast Neoplasms Calcitriol 4.7111237771
MESH:D001943 Breast Neoplasms Cisplatin 4.7119526202 18382427
MESH:D001943 Breast Neoplasms Estradiol 4.7114630087 12948864 17289903 17261762 16675129 17018787 18497071 19861407
MESH:D001943 Breast Neoplasms Fluorouracil 4.7116557594 18357371 19217205 16595493 15136595 18608205 16110121
MESH:D001943 Breast Neoplasms Methylcholanthrene 4.7117474063
MESH:D001943 Breast Neoplasms resveratrol 4.7116393696 17534123 17651959
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.7120435547
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.1215286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.9517687719 10378619
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.2911589617
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.4316111702
MESH:D002276 Carcinoid Tumor Fluorouracil 4.6416051944
MESH:D002277 Carcinoma Fluorouracil 13.7817121937
MESH:D002277 Carcinoma Methylcholanthrene 13.7810545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 13.7816835633
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 8.8216217749 15073043 11135700 15553829 14691202
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 8.8217982673
MESH:D006528 Carcinoma, Hepatocellular Estradiol 8.8216924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 8.8217045692 16332177 18930000 17971768 16799960 17088986
MESH:D006528 Carcinoma, Hepatocellular resveratrol 8.8219321006 16227395
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.5616675471
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 3.0212023789 16685392
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.8519014326
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.0018695887
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.0812490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 14.2320419170
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 14.2311237771
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 14.236189445 18337622 17066447
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 14.2318986760 16757204 17066447 16280240
MESH:D002294 Carcinoma, Squamous Cell resveratrol 14.2316227395
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3418850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases resveratrol 3.4415458977
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.8318566989
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 6.8316192471
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1216835633
MESH:D002779 Cholestasis pirinixic acid 2.7919176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0816354765 15668235 12621046 15340226 8697196
MESH:D003092 Colitis resveratrol 4.0916474422
MESH:D003110 Colonic Neoplasms Fluorouracil 3.8916340194 17172411 16510598 17018589 17725105 17016597 15001691 17287894 18772588 17169374
MESH:D003110 Colonic Neoplasms resveratrol 3.8916338953
MESH:D015179 Colorectal Neoplasms arsenic trioxide 4.7920501625
MESH:D015179 Colorectal Neoplasms Cisplatin 4.7915273666
MESH:D015179 Colorectal Neoplasms Fluorouracil 4.7920501625 18288408 17695437 17094418 16282729 15289873 18448328 17454858 18802399 15148649 16524972 17594712 18949393 16391804 17401013 18509181 17016601 16331619 18383874 17255274 16303861 14970324
MESH:D015179 Colorectal Neoplasms resveratrol 4.7916550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0214669216 17141729
MESH:D003327 Coronary Disease resveratrol 3.7216507316
MESH:D023903 Coronary Restenosis arsenic trioxide 4.1412609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.4610525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4610048152 15322242 20055451
MESH:D007644 Darier Disease Fluorouracil 4.7616733453
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.0515213294
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4018249437
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.7316873680
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6617107852
MESH:D003928 Diabetic Nephropathies Estradiol 8.8919279558
MESH:D003928 Diabetic Nephropathies resveratrol 8.8916286809
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5220420201
MESH:D004362 Drug Toxicity Cisplatin 8.0719839026 15033597 12231392 12649298
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.0711462148
MESH:D004487 Edema Mustard Gas 16.1211428647 11402378 9260866 11428631
MESH:D004487 Edema pirinixic acid 16.1212083418
MESH:D004487 Edema resveratrol 16.128985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 16.1211000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8716714409 18230668 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Am 80 15.4416819260
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 15.4415138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 15.4417872969
MESH:D016889 Endometrial Neoplasms Estradiol 2.9518566989 19148513 11473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.989294722 10568697
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.8117923197
MESH:D004890 Erythema Mustard Gas 5.129357497
MESH:D004938 Esophageal Neoplasms arsenic trioxide 10.3412903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 10.3416530937
MESH:D004938 Esophageal Neoplasms Cisplatin 10.3417638652 16785472 16481741 15173087 15464296
MESH:D004938 Esophageal Neoplasms Fluorouracil 10.3416785472 17638652 16337965 16481741 15173087
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9811564622
MESH:D005234 Fatty Liver arsenic trioxide 7.5815073043
MESH:D005234 Fatty Liver pirinixic acid 7.5819236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4211858732
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.9014633661 10962813
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.9120067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.2216904648
MESH:D005910 Glioma Fluorouracil 2.8516145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5710696789
MESH:D006258 Head and Neck Neoplasms Cisplatin 7.8915464296 15102660
MESH:D006258 Head and Neck Neoplasms Fluorouracil 7.8918337622 15162350 15102660
MESH:D034381 Hearing Loss Cisplatin 4.2619898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.3815464296
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.3720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.3710048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.5120558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2911000095
MESH:D006529 Hepatomegaly pirinixic acid 8.1316221962 18467677 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.1315340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 5.0015709030
MESH:D006561 Herpes Simplex resveratrol 4.1416876885
MESH:D006689 Hodgkin Disease Cisplatin 3.5616170182 16200630
MESH:D019584 Hot Flashes Estradiol 3.7217088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.028697196 15340226 16959395 18606429 16354765
MESH:D006937 Hypercholesterolemia resveratrol 3.9617188708
MESH:D006943 Hyperglycemia pirinixic acid 3.1420558911
MESH:D006949 Hyperlipidemias resveratrol 3.9916873680
MESH:D006973 Hypertension marker/mechanism 21115475
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8918670907 18850075
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.2617488730
MESH:D006985 Hyperventilation marker/mechanism 21115475
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.6117600658
MESH:D007249 Inflammation Mustard Gas 8.2611428647 8975870 11428620 17524151 11402378 11428631 16001271 9357497 9260866
MESH:D007249 Inflammation resveratrol 8.2616366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.2612878042 12200463
MESH:D007251 Influenza, Human resveratrol 4.5216624496
MESH:D007333 Insulin Resistance Estradiol 7.1016393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 7.1016306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2916580747
MESH:D007673 Kidney Cortex Necrosis Cisplatin 5.1115464296
MESH:D007674 Kidney Diseases Cisplatin 6.1819839026 12649298 15190930 18289764 12231392
MESH:D007674 Kidney Diseases Estradiol 6.1815618244
MESH:D007680 Kidney Neoplasms Estradiol 7.3615610895
MESH:D007680 Kidney Neoplasms Fluorouracil 7.3616985049
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.7711231351
MESH:D007938 Leukemia arsenic trioxide 2.8115070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.7512560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.2716972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.3914633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.7219077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1317050201 19850784 20471514 16968895 16467208
MESH:D015473 Leukemia, Promyelocytic, Acute Am 80 12.8216531727 16819260
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 12.8216823087 11468182 15622746 16112521 11161223 19075265 19225113 16330433 17649720 17217047 12679006 16891316 16966277 15213294 17869043 16331271 17712046 17107899 9834237 12712474 12018890 15336539 19035177 15748426 19642359
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 12.8216087638
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.3116882451
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.3514716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.3515474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.3512878042
MESH:D008113 Liver Neoplasms arsenic trioxide 17.7814682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 17.7821137059 20195826
MESH:D008113 Liver Neoplasms Fluorouracil 17.7815113037 16603448 18383874 17045692
MESH:D008113 Liver Neoplasms pirinixic acid 17.7816377806 20007298 15890375
MESH:D008113 Liver Neoplasms resveratrol 17.7819321006 19073162 20405173 19812893
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 17.7816984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 9.7420377131
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 9.741399818 598648
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.7412151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.3115213294
MESH:D008171 Lung Diseases Mustard Gas 3.4218702808 18161513
MESH:D055370 Lung Injury Asbestos, Crocidolite 3.9817365036
MESH:D008175 Lung Neoplasms arsenic trioxide 10.6411798837 19825857
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 10.6418816296 20064080 18520028 6695378 20464547 18569708 17053015 20869020 20135361
MESH:D008175 Lung Neoplasms Cisplatin 10.646189445 11798837 17225452
MESH:D008175 Lung Neoplasms Fluorouracil 10.6415246190
MESH:D008175 Lung Neoplasms Methylcholanthrene 10.6416271038 10545420 9230183 6695378 20512841 11893704 7750092 17909032 1399818 21163286 15390079 16337739 20970405
MESH:D008175 Lung Neoplasms Mustard Gas 10.648781369 3148597
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 10.6419555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.7615086387
MESH:D016393 Lymphoma, B-Cell resveratrol 4.2617088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.8314749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 4.2115688416
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.0516891317 17203775 11807958 11408345
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 6.0511606380 8985016
MESH:D020149 Manganese Poisoning Estradiol 4.4519453300
MESH:D008545 Melanoma Cisplatin 3.6318176117 12374674 16809738 16248763 12393984 11135225 18332650 17761969 15577323 18505091 17023156 16432458 12883367
MESH:D008545 Melanoma resveratrol 3.6317992120
MESH:D018328 Melanoma, Amelanotic Cisplatin 4.7415990972
MESH:D008654 Mesothelioma Asbestos, Crocidolite 6.4416966607 16166281 18303189
MESH:D008654 Mesothelioma Cisplatin 6.4417638057
MESH:D008659 Metabolic Diseases resveratrol 4.3417112576
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.4116381670
MESH:D009062 Mouth Neoplasms Fluorouracil 8.4116757204 18986760
MESH:D009101 Multiple Myeloma Am 80 12.1617229644
MESH:D009101 Multiple Myeloma arsenic trioxide 12.1615949261 19549372 19417148 11468182 14977855
MESH:D009101 Multiple Myeloma resveratrol 12.1616267019 17935668 17164350 14749477 16490592 17049120
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.8317962980
MESH:D009135 Muscular Diseases pirinixic acid 3.4716239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.6418349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.1216105982 16882451
MESH:D009203 Myocardial Infarction pirinixic acid 5.6819151258
MESH:D009203 Myocardial Infarction resveratrol 5.6816456233 16525036 17015251 17188708 16317513 17125593
MESH:D017202 Myocardial Ischemia resveratrol 8.8917125593 17015251
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.8912213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.1316810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.1316411023
MESH:D009205 Myocarditis resveratrol 4.7217322642
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.9216624393
MESH:D009369 Neoplasms Benzo(a)pyrene 11.7011141357
MESH:D009369 Neoplasms Cisplatin 11.7016773208
MESH:D009369 Neoplasms Fluorouracil 11.7016928823 18239605 18600527
MESH:D009369 Neoplasms pirinixic acid 11.7017405874
MESH:D009374 Neoplasms, Experimental resveratrol 3.968985016
MESH:D009389 Neovascularization, Pathologic Estradiol 3.7017289903
MESH:D009395 Nephritis, Interstitial Cisplatin 4.4615464296
MESH:D009421 Nervous System Malformations Estradiol 9.3316427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.3314600291
MESH:D009436 Neural Tube Defects arsenic trioxide 3.0910525206
MESH:D009447 Neuroblastoma Cisplatin 3.438761367
MESH:D019636 Neurodegenerative Diseases resveratrol 3.7717652729
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.668761367
MESH:D020078 Neurogenic Inflammation resveratrol 4.3617929310
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.4116436463
MESH:D009503 Neutropenia Mustard Gas 3.9316761898 7688884
MESH:D009765 Obesity pirinixic acid 1.8020558911
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 4.2117513867
MESH:D010051 Ovarian Neoplasms arsenic trioxide 11.2712452020 16624393 19769630
MESH:D010051 Ovarian Neoplasms Cisplatin 11.2719769630 15464296 17225452 6897625
MESH:D010051 Ovarian Neoplasms Estradiol 11.2719401270
MESH:D010051 Ovarian Neoplasms Luteolin 11.2719005980
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 8.6315580305
MESH:D010190 Pancreatic Neoplasms Cisplatin 8.6319003803
MESH:D010190 Pancreatic Neoplasms Fluorouracil 8.6315113037 16500647 19003803 16929163
MESH:D010235 Paraganglioma arsenic trioxide 4.1219927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2212520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.2715464296
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.8510923243
MESH:D010997 Pleural Neoplasms Cisplatin 5.3117638057
MESH:D011041 Poisoning Mustard Gas 3.7615727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5218163543
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 9.4716679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.4711399792 11118676 11222880 11896295
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.7415572423
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.8420887781
MESH:D011471 Prostatic Neoplasms marker/mechanism 17909013
MESH:D011471 Prostatic Neoplasms Am 80 2.1016289102
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.1019131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.1017292933
MESH:D011471 Prostatic Neoplasms Calcitriol 2.1016289102 15754350 18247401 16644109 12479363
MESH:D011471 Prostatic Neoplasms Estradiol 2.1016740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.1018626508 19082440
MESH:D011471 Prostatic Neoplasms resveratrol 2.1016731767 17804756 17675339 17718901 15767336 17636462
MESH:D011537 Pruritus Mustard Gas 4.0618058305
MESH:D011565 Psoriasis Am 80 4.0716819260
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 5.8617322281 17975199 15814490 17365031
MESH:D011658 Pulmonary Fibrosis Mustard Gas 5.8617894541 17620002 17720292 10334151 17266442
MESH:D012004 Rectal Neoplasms Fluorouracil 3.9715538739 18286688 16160472 18722050
MESH:D051437 Renal Insufficiency Cisplatin 4.3715464296
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.5516325855
MESH:D015427 Reperfusion Injury pirinixic acid 6.5019058328
MESH:D015427 Reperfusion Injury resveratrol 6.5015827377 16314181 17520802 17058453 16317513
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8018990726
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 10.2116646077
MESH:D012512 Sarcoma, Ewing's Cisplatin 10.2114601052
MESH:D012871 Skin Diseases Mustard Gas 2.7015451306 16961503 12880345
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.3210029692 19755658
MESH:D012878 Skin Neoplasms resveratrol 9.328985016 15837718
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.3216192470
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.3115464296
MESH:D013274 Stomach Neoplasms arsenic trioxide 4.7117007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.712093021 20155912
MESH:D013274 Stomach Neoplasms Cisplatin 4.7118396642 17522103 15958060
MESH:D013274 Stomach Neoplasms Fluorouracil 4.7119015929 16424979 18396642 18567086 16951190 17498489 17172411 19084572 17522103 15786421
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.4416321402
MESH:D013610 Tachycardia marker/mechanism 21115475
MESH:D013736 Testicular Neoplasms Cisplatin 4.5917225452 15464296
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8712697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.0519014326
MESH:D013978 Tibial Fractures Estradiol 4.6619048282
MESH:D014062 Tongue Neoplasms Fluorouracil 9.8516280240
MESH:D014062 Tongue Neoplasms resveratrol 9.8516227395
MESH:D016171 Torsades de Pointes arsenic trioxide 3.9315213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 8.2811780464 12845720 12973940 20435036
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.2817053015
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 8.2817225452 12973940 15464296
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 15.7516803524
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 15.7516803524
MESH:D002583 Uterine Cervical Neoplasms resveratrol 15.7517473185
MESH:D014594 Uterine Neoplasms resveratrol 4.0917044934
MESH:D014625 Vaginal Neoplasms Cisplatin 4.5715577323
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5712125929
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.2617488730
MESH:D014839 Vomiting Cisplatin 4.6911897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2215886252
Pathway ID Pathway Name
KEGG:04662 B cell receptor signaling pathway
KEGG:04062 Chemokine signaling pathway
KEGG:04664 Fc epsilon RI signaling pathway
KEGG:04666 Fc gamma R-mediated phagocytosis
KEGG:04510 Focal adhesion
REACT:604 Hemostasis
KEGG:04670 Leukocyte transendothelial migration
KEGG:04650 Natural killer cell mediated cytotoxicity
KEGG:04810 Regulation of actin cytoskeleton
REACT:14797 Signaling by GPCR
REACT:11044 Signaling by Rho GTPases
REACT:11061 Signalling by NGF
KEGG:04660 T cell receptor signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA37282
    • No data
    Releated disease ID Related disease Name
    PA444281Glaucoma
    Releated drug ID Related drug Name
    PA449177cytarabine
    PA449748gemcitabine
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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