AutismKB 2.0

Annotation Detail for GPNMB


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Basic Information Top
Gene Symbol:GPNMB ( HGFIN,NMB )
Gene Full Name: glycoprotein (transmembrane) nmb
Band: 7p15.3
Quick LinksEntrez ID:10457; OMIM: 604368; Uniprot ID:GPNMB_HUMAN; ENSEMBL ID: ENSG00000136235; HGNC ID: 4462
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1934Cancer
2025Polyarthritis
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C010914 2,4-diaminotoluene 2,4-diaminotoluene results in increased expression of GPNMB mRNAincreases expression 20713471
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of GPNMB mRNAincreases expression 18648102
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GPNMB mRNAaffects expression 16483693
D001151 Arsenic Arsenic affects the expression of GPNMB mRNAaffects expression 18315880
D001151 Arsenic Arsenic results in increased expression of GPNMB mRNAincreases expression 18315880
C053541 bicalutamide bicalutamide results in increased expression of GPNMB mRNAincreases expression 15638997
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of GPNMB mRNAdecreases expression 15336504
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of GPNMB mRNAaffects expression 17484886
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of GPNMB mRNAincreases expression 15763343
D016572 Cyclosporine Cyclosporine results in decreased expression of GPNMB mRNAdecreases expression 20106945
D003907 Dexamethasone Dexamethasone results in decreased expression of GPNMB mRNAdecreases expression 15763343
D004041 Dietary Fats Dietary Fats results in decreased expression of GPNMB mRNAdecreases expression 18042831
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of GPNMB mRNAincreases expression 19638242
D004137 Dinitrochlorobenzene Dinitrochlorobenzene results in increased expression of GPNMB mRNAincreases expression 16314067
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of GPNMB mRNAaffects cotreatment|decreases expression 19619570
D004958 Estradiol Estradiol results in decreased expression of GPNMB mRNAdecreases expression 19619570
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of GPNMB mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of GPNMB mRNAincreases expression 17351261
D008070 Lipopolysaccharides Lipopolysaccharides results in decreased expression of GPNMB mRNAdecreases expression 15763343
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of GPNMB mRNAincreases expression 20713471
C029938 nickel sulfate nickel sulfate results in increased expression of GPNMB mRNAincreases expression 16314067
C041786 palm oil palm oil results in decreased expression of GPNMB mRNAdecreases expression 18042831
D010615 Phenacetin Phenacetin results in increased expression of GPNMB mRNAincreases expression 17082564
17698508
C030299 phenylhydrazine phenylhydrazine results in increased expression of GPNMB mRNAincreases expression 17698508
17082564
C010327 salinomycin salinomycin results in decreased expression of GPNMB mRNAdecreases expression 19682730
D013629 Tamoxifen Tamoxifen affects the expression of GPNMB mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of GPNMB mRNAaffects cotreatment|decreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of GPNMB mRNAdecreases expression 19619570
D014028 Tobacco Smoke Pollution Tobacco Smoke Pollution results in increased expression of GPNMB mRNAincreases expression 18087596
C496197 trans-10,cis-12-conjugated linoleic acid trans-10,cis-12-conjugated linoleic acid results in increased expression of GPNMB mRNAincreases expression 17951470
D014212 Tretinoin Tretinoin results in increased expression of GPNMB mRNAincreases expression 16249480
D014241 Trichloroethylene Trichloroethylene results in decreased expression of GPNMB mRNAdecreases expression 17905399
C025643 vinclozolin vinclozolin affects the expression of GPNMB mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.3014745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.6115322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.3118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6917505938
MESH:D055371 Acute Lung Injury Lipopolysaccharides 8.7218653653 11850527
MESH:D055371 Acute Lung Injury nickel sulfate 8.7212718980 16100012 19131640 11954676
MESH:D000230 Adenocarcinoma Estradiol 4.0011473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.0014692618
MESH:D002282 Adenocarcinoma, Bronchiolo-Alveolar Tobacco Smoke Pollution 5.2815814487
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 10.423712494
MESH:D000236 Adenoma Diethylnitrosamine 10.426695378 10737359
MESH:D000236 Adenoma Methylcholanthrene 10.4210545420 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 9.2319052882 17620307 18056438 19061943 17162532 16434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.2316835633
MESH:D018246 Adrenocortical Adenoma Arsenic 4.9617306315
MESH:D000505 Alopecia Tretinoin 3.4215955085
MESH:D000740 Anemia Phenacetin 13.912444515
MESH:D000740 Anemia phenylhydrazine 13.912444515
MESH:D000740 Anemia Tetrachlorodibenzodioxin 13.9111748828
MESH:D000743 Anemia, Hemolytic Phenacetin 10.3217698508 17082564 1949026
MESH:D000743 Anemia, Hemolytic phenylhydrazine 10.3217084956 17698508 17082564
MESH:D001008 Anxiety Disorders vinclozolin 3.4519015723
MESH:D020261 Arsenic Poisoning Arsenic 2.8012569548 16835338 18414634 16251483
MESH:D001161 Arteriosclerosis Dietary Fats 9.1015238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.1011256880
MESH:D001169 Arthritis, Experimental Dexamethasone 11.4117659584
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 11.4115885639
MESH:D001169 Arthritis, Experimental Tretinoin 11.4116412693
MESH:D001172 Arthritis, Rheumatoid Tobacco Smoke Pollution 4.6919898480
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.6916292516
MESH:D001249 Asthma Tretinoin 2.2716456186
MESH:D050197 Atherosclerosis Arsenic 6.4812928151 19371607
MESH:D050197 Atherosclerosis Methylcholanthrene 6.4811922910
MESH:D001471 Barrett Esophagus Tretinoin 4.1716935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.771440618 11289319
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.2112125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 8.2116206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6115746008
MESH:D001943 Breast Neoplasms marker/mechanism 18507500
MESH:D001943 Breast Neoplasms 2,4-diaminotoluene 6.7511921183
MESH:D001943 Breast Neoplasms Dietary Fats 6.7520435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 6.7517474063
MESH:D001943 Breast Neoplasms Estradiol 6.7512948864 19861407 17289903 16675129 18497071 14630087 17261762 17018787
MESH:D001943 Breast Neoplasms Methylcholanthrene 6.7517474063
MESH:D001943 Breast Neoplasms salinomycin 6.7519682730
MESH:D001943 Breast Neoplasms Tamoxifen 6.7519189210 18815881 19189212 17261762 20544844 17049068 18984771 19288272 19115204 20390343 15668708 19487384 18351453 17893378 18629630 19221464 20005174 16873071 19011961 17242785 16202921 19059307 19084267 21138602 11161223 19410462 19142967 19200415 15565566 19103187 18855134 18425577 19155303 21152245 20135344 20065188 17440819 19289846 18997820 16273361 18821012 19244106 16818667 19066611 20859285
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 6.7520435547
MESH:D001943 Breast Neoplasms Tretinoin 6.7516873071 16443354 16166294
MESH:D001943 Breast Neoplasms Trichloroethylene 6.7515986119
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.3416813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2216111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.5418705752 15673190 16192424 16124888 3786805 16097048 16050911 15721981 16011737 15700767 16227642 10355542
MESH:D002277 Carcinoma Methylcholanthrene 7.6910545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.6916835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.4515504454 17687452
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.2619066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.9116168501
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 13.443581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Arsenic 13.4417306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 13.4418788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 13.4417428255 18210153 11831363 17173139 17162532 16288022 20432363 18788625 20101231 19701751 18494052 19052882 19383236 19919837 19418558 18506893 19519916 19208518 19335982 18393292 19394651 17055752 20512989 3084413 20524982 17978847 16681979 19539802 18665156 16569478 16807293 20214788 16698587 10672840 3581430 17138121 18691550 19171122 19107877 16935385 17761372 16878318 10737359 16502159 18971187 16830150 21159647 16328049 18056438 16540662 18785209 20727157 20007298 20514400 20084675 20935162 16779866 19822196 18978308
MESH:D006528 Carcinoma, Hepatocellular Estradiol 13.4416924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 13.4416924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 13.441917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung Tobacco Smoke Pollution 3.3411212258
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.567296757
MESH:D002294 Carcinoma, Squamous Cell Arsenic 7.2715504454 17687452 18922899
MESH:D002294 Carcinoma, Squamous Cell Tobacco Smoke Pollution 7.2711212258
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.2716096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Arsenic 8.7918640142
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 8.7917572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2316120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases Arsenic 3.2815738583 19152805 17938729
MESH:D002340 Carotid Artery Diseases Arsenic 4.1018022660 16973168
MESH:D002386 Cataract Tretinoin 2.9517460283
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 19.327505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 19.3212371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 19.3217174075 7505956 21159647 2727394
MESH:D002471 Cell Transformation, Neoplastic Estradiol 19.3218566989
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 19.3216192471
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.3416129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.6419052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.6416835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 12.3419486331 9022650
MESH:D002779 Cholestasis Cyclosporine 12.3419486331
MESH:D002779 Cholestasis Ethinyl Estradiol 12.3417333356 17110522 17681005 15861022 16919318 11677210 16105132
MESH:D002822 Choriocarcinoma Tretinoin 4.9116461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.4215668235 15340226 12621046 8697196 16354765
MESH:D002972 Cleft Palate Tretinoin 5.429407595
MESH:D003092 Colitis Tretinoin 3.4617035595
MESH:D003093 Colitis, Ulcerative Dinitrochlorobenzene 3.7717373747 19159591
MESH:D003110 Colonic Neoplasms Dexamethasone 2.4515824018
MESH:D015179 Colorectal Neoplasms marker/mechanism 21278247 18507500
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8514669216 17141729
MESH:D019465 Craniofacial Abnormalities Dexamethasone 3.6517728286
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.6510048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.6516925845 14991402 10589399 9125849 17551590 9142499 9224671 8800419 9664655 9211117
MESH:D003456 Cryptorchidism vinclozolin 4.1114966744
MESH:D003711 Demyelinating Diseases Tamoxifen 4.1219031437
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 14.6312868966 2524372 11906362 8970840 8156756 11298694 18759878 14531868
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 14.6312438553
MESH:D017449 Dermatitis, Allergic Contact Dinitrochlorobenzene 14.6315491423
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 14.6311298694 16823706 16780908
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.262952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.0120387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.0117107852
MESH:D003928 Diabetic Nephropathies Estradiol 8.1619279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.1619279558
MESH:D003967 Diarrhea Dexamethasone 3.477237001
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 11.2218289764 6482804 18692083 7440962 11289319 6679447 9328219 9022650 9653073 18648102 16192314 8291058 1440618
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 11.226623471 16177239 10092053 7440962 6884620 17522070 11566570 15968718 15998439 10915739 7179309 21278145 15027814 2869522 4309450 19085960 3786805 9327722 3732212 16227642 19336974 7120509
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 11.2219107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.2220420201
MESH:D056486 Drug-Induced Liver Injury Trichloroethylene 11.227120509
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5811462148
MESH:D050171 Dyslipidemias Dietary Fats 3.2818367378
MESH:D004485 Eczema Dexamethasone 4.2212438553
MESH:D004487 Edema Dexamethasone 6.1619703484
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.1612711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.1115322242 18230668 16714409
MESH:D004489 Edema, Cardiac Tretinoin 11.1118230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.1712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.1719031437
MESH:D016889 Endometrial Neoplasms Estradiol 11.5119148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Tamoxifen 11.5117893378 16202921 19155303 20544844
MESH:D016889 Endometrial Neoplasms Tretinoin 11.5116569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.819294722 10568697
MESH:D019446 Endotoxemia Lipopolysaccharides 4.1515328337 17637181 15821434
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.8716302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.053581430
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.2411564622
MESH:D005124 Eye Abnormalities Tretinoin 8.249664655 16938888
MESH:D005234 Fatty Liver Carbon Tetrachloride 27.8415959796 17595544 16045604 16239168 12795759 61145 12631006 19224547
MESH:D005234 Fatty Liver Cyclosporine 27.8419224547
MESH:D005234 Fatty Liver Dietary Fats 27.8417967931 18296743 19004024 19551842
MESH:D005234 Fatty Liver Diethylnitrosamine 27.8421071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 27.8415345470
MESH:D005234 Fatty Liver Tamoxifen 27.8414986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.0916709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2111858732
MESH:D005334 Fever Lipopolysaccharides 3.809205823 11852909
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.776705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.2814745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.9419069698
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.6914633661 10962813
MESH:D005355 Fibrosis Carbon Tetrachloride 25.1518705752
MESH:D005355 Fibrosis Cyclosporine 25.1512168785 12639820
MESH:D005355 Fibrosis Dietary Fats 25.1518296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 25.1520067830
MESH:D005355 Fibrosis Tretinoin 25.1517994277
MESH:D005534 Foot Diseases Arsenic 5.316392382
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.6916973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.0516417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.978708960
MESH:D005909 Glioblastoma Tretinoin 2.8517312396
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.817505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3410696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.0216096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.9116084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.1111294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 6.119664655 14991402
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1715720958
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.1716366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1211000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 8.446705139
MESH:D006505 Hepatitis Carbon Tetrachloride 8.4419900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.6512621046 15340226 16120746
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 2.997520565
MESH:D006558 Herpes Genitalis Estradiol 4.7815709030
MESH:D019584 Hot Flashes Estradiol 3.5017088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.808697196 16354765 15340226 16959395 18606429
MESH:D006930 Hyperalgesia Tretinoin 3.0216870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.2816899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.3721332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.3316778211
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.2417050553
MESH:D006949 Hyperlipidemias Dietary Fats 3.3921332399
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.7015034207
MESH:D006973 Hypertension Arsenic 11.6016076760 11953799 9931084
MESH:D006973 Hypertension Cyclosporine 11.6010903974
MESH:D006973 Hypertension Dexamethasone 11.6017042910
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 11.6018850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.8515338365
MESH:D006987 Hypesthesia Arsenic 5.3116093927
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5716569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2312013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.1217937319
MESH:D007248 Infertility, Male vinclozolin 6.1216467254
MESH:D007249 Inflammation Dexamethasone 22.298960868 11099482
MESH:D007249 Inflammation Dietary Fats 22.2920412841
MESH:D007249 Inflammation Diethylnitrosamine 22.2918785209
MESH:D007249 Inflammation Lipopolysaccharides 22.2917255318 12878042 17963957 17237260 9205823
MESH:D007249 Inflammation Tamoxifen 22.2919457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 22.2912878042 12200463
MESH:D007249 Inflammation Tobacco Smoke Pollution 22.2918590791
MESH:D007333 Insulin Resistance Dietary Fats 6.8418457598 11836018
MESH:D007333 Insulin Resistance Estradiol 6.8416627594 16393666
MESH:D007410 Intestinal Diseases Tretinoin 3.5317994277
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.4017255318
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.779022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.2016580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.2015992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.1915604871
MESH:D007642 Keratosis Arsenic 4.7412749816 16930632
MESH:D007674 Kidney Diseases Cyclosporine 5.4718776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 5.4715618244
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 16.116582329
MESH:D007680 Kidney Neoplasms Cyclosporine 16.1112371664
MESH:D007680 Kidney Neoplasms Estradiol 16.1115610895
MESH:D007680 Kidney Neoplasms Tamoxifen 16.1118625569
MESH:D007938 Leukemia Tretinoin 2.6517143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.4816482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0419850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 7.2317339181
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.2319035177 15748426 16788101 16331271 17649720 17368321 17294898 17217047 16891316 17301526 16823087 16935935 9834237 16766008 19642359 16140955 17107899 17506722 19075265 19029980 17339181 19225113 17361223 12679006 17712046
MESH:D007970 Leukopenia Lipopolysaccharides 4.4515821434
MESH:D007984 Leydig Cell Tumor vinclozolin 4.4816417039
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.139224671
MESH:D008064 Lipidoses Tamoxifen 2.9817567588 15342952
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 10.2416943688 16239168 11408273 17174718 16221502 17334410 21278145 11903743 17157831
MESH:D008103 Liver Cirrhosis Dietary Fats 10.2418296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 10.2419638242 18407596 18522880 20032147 18665156
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.049327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 10.4217708605 17640975 18472094 12609069 15931870 16192424 16015684 14716833 16248980 16116963 16638106 15650968 18210741 16027843 18006644 16097048 17922224 17823541 15925388 15362042 12445418 18263696 12632514 10355542 14620537 18481824 17805973 11481614 15338365 18156304 18412020 15370692 14748882 15123356 15673190 16011737 16136751 12632512 17698563 15893842 17761835 17525996 17869086 17900296 18472332 18317297 15730626 18205269 17481882 14724832 12649538 18420326 12389079 20821823 18054572 14512876 18395914 18395095 18277467 17565644 12741479 17766677 18376398 12666154 12898905 13678700 15818738 18429990 17557913 17721639 12546737 18418968 12586293 16033810 18251166 18339082 17714472 14716496 15876570 12445421 15057751 18705752 18279442 17631135 17976157 18166357 15052691 15996030 17944888 18187930 15959796 12958196 12667390
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 10.4216718785
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 10.4214716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 10.4212878042
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 10.4218564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 10.4212878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 10.4218397230 16248980
MESH:D008107 Liver Diseases Arsenic 6.2011134558
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.2016246199 16964402 15830285 17285989 15720792
MESH:D008107 Liver Diseases Diethylnitrosamine 6.2017034775
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9215123358
MESH:D017114 Liver Failure, Acute marker/mechanism 15763343
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.4814706259 16899240
MESH:D008113 Liver Neoplasms Arsenic 13.2316368122
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 13.2319294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 13.2320137499 19294768 12771043 19996281 20452335 19255062 18754104 20583210 15175105 19427195 18977376 19642983 19638242 20501860 19254457 19073162 19499222 18978307 19426721 19256749 21278145 21047994 20101389 16942905 18644402 20492335 12112319 21071580 19690152 19833225 18648771 19551842 21167192 2422723 20434301 15885732 19850985 10737359 19090486 20118626 20405173 2862719 19812893 9163691
MESH:D008113 Liver Neoplasms Tamoxifen 13.2316684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 13.2316984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 21.406587162 3712494 598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 21.4012014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 21.4017174075 16267830 18308698 19009564 2563599 18079962 9362446 18775883 18253720 19539802 19004024 19519916 3124819 21159647 17854601 18282651 18544905 18093689 19126423 17942915 16842330 18164116
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 21.401399818 598648
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 21.4012151625
MESH:D008114 Liver Neoplasms, Experimental Trichloroethylene 21.407955063
MESH:D055370 Lung Injury Lipopolysaccharides 3.7721114838
MESH:D008175 Lung Neoplasms Arsenic 10.2117306315 19168569 17976673
MESH:D008175 Lung Neoplasms Dexamethasone 10.2111195469 15824018
MESH:D008175 Lung Neoplasms Diethylnitrosamine 10.2120970405 21163286 20512841 6695378
MESH:D008175 Lung Neoplasms Methylcholanthrene 10.2116337739 6695378 15390079 20512841 20970405 21163286 16271038 11893704 9230183 17909032 7750092 10545420 1399818
MESH:D008175 Lung Neoplasms Tamoxifen 10.2118625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 10.2119555203 11884234
MESH:D008175 Lung Neoplasms Tobacco Smoke Pollution 10.2112111688 11091918 3440675 16288123
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.5119428831
MESH:D008325 Mammary Neoplasms, Experimental 2,4-diaminotoluene 13.0711921183
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 13.0711408345 11807958 17203775 16891317
MESH:D008325 Mammary Neoplasms, Experimental salinomycin 13.0719682730
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 13.0714580682 19196722 11731420 16827153 19196723
MESH:D020149 Manganese Poisoning Estradiol 11.8119453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.8119453300
MESH:D008527 Medulloblastoma Tretinoin 2.6917453147
MESH:D008545 Melanoma Dinitrochlorobenzene 4.9812202904 17334785
MESH:D008545 Melanoma Tamoxifen 4.9819393235 12393984
MESH:D008545 Melanoma Tretinoin 4.9816752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.9415990972
MESH:D008591 Meningomyelocele Tretinoin 4.1816940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5416801185
MESH:D008708 Methemoglobinemia Phenacetin 4.724834387 1949026 16296465 3537620
MESH:D009062 Mouth Neoplasms Tobacco Smoke Pollution 4.1615006635
MESH:D009101 Multiple Myeloma Dexamethasone 3.3315744524 15867202 16118317
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 7.079809623
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.0717596541
MESH:D017202 Myocardial Ischemia Arsenic 8.3615371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.3612213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.0916810080
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 8.883581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 8.883581430 9029167
MESH:D009362 Neoplasm Metastasis Tamoxifen 8.8819393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4419410462
MESH:D009369 Neoplasms Tretinoin 5.1016594593 16946489
MESH:D009369 Neoplasms Trichloroethylene 5.1011911487
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.7519189210 19200415 19196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.4917289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.1917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0819348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 14.9716427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 14.9714600291
MESH:D009421 Nervous System Malformations Tretinoin 14.979125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 11.256679447
MESH:D009436 Neural Tube Defects Arsenic 11.2516620997
MESH:D009436 Neural Tube Defects Tretinoin 11.259142499
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.1420387270
MESH:D020078 Neurogenic Inflammation Arsenic 4.1517056641
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.8720387270
MESH:D009765 Obesity Dietary Fats 2.2311836018 17217161 20132043 19632207 16723640 18457598 18674790 20518802 21332399
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.214026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.773988306
MESH:D010051 Ovarian Neoplasms Arsenic 7.4517306315
MESH:D010051 Ovarian Neoplasms Estradiol 7.4519401270
MESH:D010051 Ovarian Neoplasms Tretinoin 7.4516936753
MESH:D010146 Pain Tretinoin 2.7116870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 4.9516540662
MESH:D010190 Pancreatic Neoplasms Tretinoin 4.9515976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4611578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.247296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0012520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 3.9416093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.746392382 16905509 15371236
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.226228378
MESH:D011014 Pneumonia Lipopolysaccharides 4.3111605937 12224865
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3218163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.2612371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.262563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.4121297632
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.6711896295 11399792 11118676 11222880
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 8.6718220299 19015723 18042343
MESH:D011469 Prostatic Diseases vinclozolin 4.6918220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6620887781
MESH:D011471 Prostatic Neoplasms Arsenic 2.1816140617
MESH:D011471 Prostatic Neoplasms bicalutamide 2.1815638997 19240160 19011039 17914592 18487222
MESH:D011471 Prostatic Neoplasms Estradiol 2.1816740699
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.1815067354
MESH:D011472 Prostatitis vinclozolin 4.6918629315
MESH:D011507 Proteinuria Arsenic 8.5221343184
MESH:D011507 Proteinuria Tretinoin 8.5216636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.0716919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.1416882103
MESH:D011625 Pterygium Tretinoin 4.5516723453
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 3.7918379247 11700416
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.5710835634
MESH:D012135 Respiratory Sounds Tobacco Smoke Pollution 4.3818410779
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6018990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.193692021
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.8716116481 16283617
MESH:D012871 Skin Diseases Arsenic 2.6816702368 17453740 16759981 15952646 6392382 18709164 19834688 16353154 17938729 17548696 17050553
MESH:D012878 Skin Neoplasms Arsenic 16.7117976673 15504454 17029826 19538983 16251483 17050553
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 16.718532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 16.7116192470
MESH:D012878 Skin Neoplasms Tobacco Smoke Pollution 16.7118590791
MESH:D012878 Skin Neoplasms Tretinoin 16.7116467112
MESH:D013088 Spermatocele Ethinyl Estradiol 10.7316709447
MESH:D013088 Spermatocele Tamoxifen 10.7316709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.7919457130
MESH:D013272 Stomach Diseases Dexamethasone 4.0815472012
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.3618456281
MESH:D013274 Stomach Neoplasms Tretinoin 2.3617261132
MESH:D013276 Stomach Ulcer Dexamethasone 3.2715138204
MESH:D013436 Sulfhemoglobinemia Phenacetin 6.31978859
MESH:D013921 Thrombocytopenia Lipopolysaccharides 3.9515821434
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3911994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6512697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 10.881399818 6582329 6587162 3712494 7505956
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 10.887505956
MESH:D013964 Thyroid Neoplasms Tretinoin 10.8816026305 17045167
MESH:D013978 Tibial Fractures Estradiol 4.4419048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.5716051514
MESH:D014376 Tuberculosis Tretinoin 3.0816040207
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 14.818074119
MESH:D001749 Urinary Bladder Neoplasms Arsenic 14.8117976673 19429237 11144890 18640142 17306315 15987713 19322015
MESH:D001749 Urinary Bladder Neoplasms Phenacetin 14.8111144890
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 14.818653321 16712894 17572228
MESH:D001749 Urinary Bladder Neoplasms Tobacco Smoke Pollution 14.8112846360
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.4616129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.0614692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.3616752155
MESH:D014605 Uveitis Cyclosporine 10.941336536
MESH:D014605 Uveitis Dexamethasone 10.941336536
MESH:D014652 Vascular Diseases Arsenic 4.4917056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3214671159 15869587
MESH:D014820 Vitiligo Tretinoin 3.8216761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0015886252
MESH:D015430 Weight Gain Dietary Fats 3.5316723640
MESH:D009396 Wilms Tumor Tretinoin 3.7616287080
MESH:D014985 Xerophthalmia Cyclosporine 4.1917120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28845
    • No data
    Releated disease ID Related disease Name
    PA443560Breast Neoplasms
    Releated drug ID Related drug Name
    PA450196letrozole
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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